Christopher J. Holler, Ph.D.
Affiliations: | 2012 | Molecular and Cellular Biochemistry | University of Kentucky, Lexington, KY |
Area:
Alzheimer\'s diseaseGoogle:
"Christopher Holler"Mean distance: 19.49 (cluster 28) | S | N | B | C | P |
Parents
Sign in to add mentor| Michael Paul Murphy | grad student | 2012 | University of Kentucky | |
| (The cellular nucleic acid binding protein regulates the Alzheimer's disease beta-secretase protein BACE1.) | ||||
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Publications
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| Root J, Mendsaikhan A, Taylor G, et al. (2024) Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency. Cell Reports. 43: 114985 |
| Root J, Mendsaikhan A, Nandy S, et al. (2023) Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency. Biorxiv : the Preprint Server For Biology |
| Huang M, Modeste E, Dammer E, et al. (2020) Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations. Acta Neuropathologica Communications. 8: 163 |
| McEachin ZT, Gendron TF, Raj N, et al. (2020) Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36. Neuron |
| Holler C, Taylor G, Kukar T. (2017) GRANULINS ARE STABLE LYSOSOMAL PROTEINS: IMPLICATIONS FOR THE ROLE OF PROGRANULIN IN ALZHEIMER’S DISEASE Alzheimer's & Dementia. 13: P556-P557 |
| Holler CJ, Taylor G, McEachin ZT, et al. (2016) Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Molecular Neurodegeneration. 11: 46 |
| Holler CJ, Davis PR, Beckett TL, et al. (2014) Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. Journal of Alzheimer's Disease : Jad. 42: 1221-7 |
| Holler CJ, Murphy MP. (2013) BACE1: Expression, regulation, and therapeutic potential of the major Alzheimer's disease beta-Secretase Current Enzyme Inhibition. 9: 3-14 |
| Beckett TL, Webb RL, Niedowicz DM, et al. (2012) Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression. Journal of Alzheimer's Disease : Jad. 32: 127-38 |
| Holler CJ, Webb RL, Laux AL, et al. (2012) BACE2 expression increases in human neurodegenerative disease. The American Journal of Pathology. 180: 337-50 |