Carvell T. Nguyen, Ph.D.

Affiliations: 
2002 University of Southern California, Los Angeles, CA, United States 
Area:
DNA methylation, cancer, epigenetics
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"Carvell Nguyen"
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Parents

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Peter A. Jones grad student 2002 USC
 (Investigation of the role of epigenetic modification of DNA and chromatin in aberrant gene silencing in cancer cells.)
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Publications

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Liang G, Lin JC, Wei V, et al. (2004) Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 101: 7357-62
Nguyen CT, Weisenberger DJ, Velicescu M, et al. (2002) Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Research. 62: 6456-61
Daskalakis M, Nguyen TT, Nguyen C, et al. (2002) Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Blood. 100: 2957-64
Velicescu M, Weisenberger DJ, Gonzales FA, et al. (2002) Cell division is required for de novo methylation of CpG islands in bladder cancer cells. Cancer Research. 62: 2378-84
Nguyen CT, Gonzales FA, Jones PA. (2001) Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Research. 29: 4598-606
Nguyen C, Liang G, Nguyen TT, et al. (2001) Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. Journal of the National Cancer Institute. 93: 1465-72
Nguyen TT, Nguyen CT, Gonzales FA, et al. (2000) Analysis of cyclin-dependent kinase inhibitor expression and methylation patterns in human prostate cancers. The Prostate. 43: 233-42
Bender CM, Gonzalgo ML, Gonzales FA, et al. (1999) Roles of cell division and gene transcription in the methylation of CpG islands. Molecular and Cellular Biology. 19: 6690-8
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