Matthew L. Hemming, Ph.D.

2007 Harvard University, Cambridge, MA, United States 
"Matthew Hemming"
Mean distance: 17.66 (cluster 31)


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Dennis J. Selkoe grad student 2007 Harvard
 (Regulation of amyloid -beta protein levels by proteolytic degradation and its implications for Alzheimer's disease.)
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Hemming ML, Elias JE, Gygi SP, et al. (2009) Identification of beta-secretase (BACE1) substrates using quantitative proteomics. Plos One. 4: e8477
Hemming ML, Elias JE, Gygi SP, et al. (2008) Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. Plos Biology. 6: e257
Hemming ML, Patterson M, Reske-Nielsen C, et al. (2007) Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. Plos Medicine. 4: e262
Hemming ML, Selkoe DJ, Farris W. (2007) Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiology of Disease. 26: 273-81
Hemming ML, Selkoe DJ. (2005) Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. The Journal of Biological Chemistry. 280: 37644-50
Farris W, Leissring MA, Hemming ML, et al. (2005) Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 44: 6513-25
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