Erwan Bezard

Université de Bordeaux, Talence, Nouvelle-Aquitaine, France 
neurodegenerative disorders
"Erwan Bezard"

Bezard has authored or co-authored over 90 professional publications in the field of neurobiology, most of which are on Parkinson's disease and related disorders. He is perhaps best known for the reappraisal of both the identification of the nature of compensatory mechanisms that mask the progression Parkinson's disease and their sequential activation in non-human primate models that mimic Parkinson’s progression. His current research interests include the study of the compensatory mechanisms, the levodopa-induced dyskinesia, the basic pathophysiology of basal ganglia circuitry, and the development of new strategies to alleviate symptoms and/or to slow disease progression.

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Mean distance: 15.8 (cluster 6)
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Yu X, Persillet M, Zhang L, et al. (2021) Evaluation of blood flow as a route for propagation in experimental synucleinopathy. Neurobiology of Disease. 105255
Delamarre A, MacSweeney C, Suzuki R, et al. (2020) Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson's disease. Heliyon. 6: e05771
Deffains M, Canron MH, Teil M, et al. (2020) L-DOPA regulates α-synuclein accumulation in experimental parkinsonism. Neuropathology and Applied Neurobiology
Laferrière F, He X, Zinghirino F, et al. (2020) Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy. Cells. 9
De Giorgi F, Laferrière F, Zinghirino F, et al. (2020) Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons. Science Advances. 6
Bengoa-Vergniory N, Faggiani E, Ramos-Gonzalez P, et al. (2020) CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nature Communications. 11: 4885
Bezard E, Li Q, Hulme H, et al. (2020) µ opioid receptor agonism for L-DOPA-induced dyskinesia in Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Soria FN, Paviolo C, Doudnikoff E, et al. (2020) Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling. Nature Communications. 11: 3440
Maxan A, Sciacca G, Alpaugh M, et al. (2020) Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates. Neurobiology of Disease. 104951
Eshraghi M, Ramírez-Jarquín UN, Shahani N, et al. (2020) RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease. Science Advances. 6: eaaz7001
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