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Philippe Sarret, PhD

Affiliations: 
Physiology and Biophysics Université de Sherbrooke, Sherbrooke, Québec, Canada 
Area:
Pain, Neurotensin receptors, Neurophysiology
Website:
http://sarretpainlab.com
Google:
"Philippe Sarret"
Mean distance: 17.91 (cluster 11)
 
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Publications

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Brouillette RL, Mona CE, Desgagné M, et al. (2025) A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor. Pharmacological Research. 107597
Breault É, Desgagné M, Neve J, et al. (2024) Multitarget Ligands that Comprise Opioid/Nonopioid Pharmacophores for Pain Management: Current State of the Science. Pharmacological Research. 107408
De Neve J, Breault É, Previti S, et al. (2024) Design, Synthesis, and Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics. Acs Pharmacology & Translational Science. 7: 2784-2798
Desgagné M, Chartier M, Lagard C, et al. (2024) Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid-Free Analgesics. Angewandte Chemie (International Ed. in English). e202405941
Midavaine É, Brouillette RL, Théberge E, et al. (2024) Discovery of a CCR2-targeting pepducin therapy for chronic pain. Pharmacological Research. 107242
Previti S, Desgagné M, Tourwé D, et al. (2022) Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3471
Tran K, Sainsily X, Côté J, et al. (2022) Size-Reduced Macrocyclic Analogues of [Pyr]-apelin-13 Showing Negative Gα Bias Still Produce Prolonged Cardiac Effects. Journal of Medicinal Chemistry. 65: 531-551
Chartier M, Desgagné M, Sousbie M, et al. (2021) Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 141: 111861
Michaelian N, Sadybekov A, Besserer-Offroy É, et al. (2021) Structural insights on ligand recognition at the human leukotriene B4 receptor 1. Nature Communications. 12: 2971
Vivancos M, Fanelli R, Besserer-Offroy É, et al. (2021) Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia Without Hypothermia. Behavioural Brain Research. 113189
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