Filip Van Petegem, Ph.D.
Affiliations: | Biochemistry and Molecular Biology | University of British Columbia, Vancouver, Vancouver, BC, Canada |
Area:
voltage-gated sodium and calcium channels, Ryanodine ReceptorsWebsite:
http://crg.ubc.ca/VanPetegem/Google:
"Filip Van Petegem"Mean distance: 15.68 (cluster 6) | S | N | B | C | P |
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Publications
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| Joseph TT, Bu W, Haji-Ghassemi O, et al. (2024) Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1). Biorxiv : the Preprint Server For Biology |
| Šeflová J, Schwarz JA, Smith AN, et al. (2023) RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET. Acs Chemical Biology |
| Haji-Ghassemi O, Chen YS, Woll K, et al. (2023) Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Science Advances. 9: eadf4936 |
| Cholak S, Saville JW, Zhu X, et al. (2023) Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure (London, England : 1993) |
| Chen YS, Van Petegem F. (2022) Structural and functional conservation of the activating Ca binding site in inositol 1,4.5-trisphosphate and ryanodine receptors. Cell Calcium. 108: 102671 |
| Rayani K, Hantz ER, Haji-Ghassemi O, et al. (2022) The effect of Mg on Ca binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants. The Febs Journal |
| Willegems K, Eldstrom J, Kyriakis E, et al. (2022) Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277. Nature Communications. 13: 3760 |
| Qin J, Zhang J, Lin L, et al. (2022) Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife. 11 |
| Yang ZF, Panwar P, McFarlane CR, et al. (2022) Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120416119 |
| Zhang J, Singh DP, Ko CY, et al. (2021) Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. The Journal of Biological Chemistry. 101412 |