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Bin Z He, Ph.D.

Affiliations: 
2006-2012 Ecology and Evolution University of Chicago, Chicago, IL 
 2012-2017 FAS Center for Systems Biology Harvard University, Cambridge, MA, United States 
 2018- Biology University of Iowa, Iowa City, IA 
Area:
Gene regulatory evolution, stress response, pathogenic fungi
Website:
binhe-lab.org
Google:
"https://scholar.google.com/citations?user=UgChk1QAAAAJ&hl=en"
Bio:

As a molecular and evolutionary geneticist, I study how organisms adapt to their environment, especially through changes in gene regulatory networks. Using different yeast species as my model system, I seek to unravel general principles of how gene regulation evolves during adaptation; in particular, I’m interested in how evolution in stress response pathways contribute to some species adapting to a novel, commensal lifestyle, with a potential consequence of pathogenicity. Thanks to my training in two academic environments, I uniquely combine population genetic and molecular biology approaches to arrive at a mechanistic understanding of the genetic-phenotypic variation relationship, which I see as lacking in the current field.

Mean distance: 19.59 (cluster 33)
 		SNBCP
Cross-listing: FlyTree

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Parents

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Martin Kreitman grad student 2006-2012 Chicago (FlyTree)
 (Using Drosophila natural variation to study the role of positive selection in cis-regulatory evolution and the genetic basis of a complex disease trait.)

Children

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Publications

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Liu X, Matrenec R, Gack MU, et al. (2019) Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy. Journal of Virology
Liu X, He B. (2018) Selective Editing of HSV-1 Enables IFN Induction and Viral Replication That Destruct Malignant Cells. Journal of Virology
Pan S, Liu X, Ma Y, et al. (2018) The Herpes Simplex Virus 1 γ34.5 Protein Inhibits STING Activation That Restricts Viral Replication. Journal of Virology
Liu X, Main D, Ma Y, et al. (2018) Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex. Journal of Virology
Xiao X, Lei X, Zhang Z, et al. (2017) Enterovirus 3A facilitates viral replication by promoting PI4KB-ACBD3 interaction. Journal of Virology
Lei X, Zhang Z, Xiao X, et al. (2017) Enterovirus 71 inhibits pyroptosis through cleavage of GSDMD. Journal of Virology
Wang H, Lei X, Xiao X, et al. (2015) Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome. Cell Reports
Yang Y, Wu S, Wang Y, et al. (2015) The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein. The Journal of Biological Chemistry. 290: 15670-8
Wang Y, Yang Y, Wu S, et al. (2014) p32 is a novel target for viral protein ICP34.5 of herpes simplex virus type 1 and facilitates viral nuclear egress. The Journal of Biological Chemistry. 289: 35795-805
Lei X, Han N, Xiao X, et al. (2014) Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex. Journal of Virology. 88: 9830-41
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