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John Tallman

Affiliations: 
Yale University School of Medicine, New Haven, CT 
Area:
pharmacology, damage & disease
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"John Tallman"
Bio:

John received his undergraduate degree and doctorate in biochemistry from Georgetown University in 1972 and rapidly gained preeminence in the field for his work on Tay-Sachs Disease in the laboratory of Roscoe O Brady at the NINCDS. Mentored in neuropharmacological research by Dr Julius Axelrod at the NIMH, Dr Tallman went on to become Chief of the Section on Biochemistry and Pharmacology in the Biological Psychiatry Branch of the NIMH. During this period, John focused his attentions on the role of neurotransmitter receptors in psychiatric disorders and treatments. In 1978, John and his longtime colleague, Dr Dorothy Gallager, elucidated the modulatory role of benzodiazepines on the GABA neurotransmitter system. Over the next 15 years, Dr Tallman continued his pioneering work investigating properties of the GABAA neurotransmitter receptor using pharmacological and molecular biological probes.

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Mean distance: 13.8 (cluster 6)
 		SNBCP
Cross-listing: Chemistry Tree

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Parents

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Julius Axelrod post-doc NIMH
Roscoe O. Brady post-doc NIH

Children

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Ronald S. Duman post-doc Yale School of Medicine

Collaborators

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Publications

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Duman RS, Fishman PH, Tallman JF. (1994) Induction of beta 2-adrenergic receptor mRNA and ligand binding in HeLa cells. Journal of Receptor Research. 14: 1-10
Vaccarino FM, Hayward MD, Nestler EJ, et al. (1992) Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons. Brain Research. Molecular Brain Research. 12: 233-41
Garrett KM, Saito N, Duman RS, et al. (1990) Differential expression of gamma-aminobutyric acidA receptor subunits. Molecular Pharmacology. 37: 652-7
Nestler EJ, McMahon A, Sabban EL, et al. (1990) Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus. Proceedings of the National Academy of Sciences of the United States of America. 87: 7522-6
Heninger C, Saito N, Tallman JF, et al. (1990) Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain. Journal of Molecular Neuroscience : Mn. 2: 101-7
Nestler EJ, McMahon A, Sabban EL, et al. (1990) Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus Proceedings of the National Academy of Sciences of the United States of America. 87: 7527-7531
Duman RS, Saito N, Tallman JF. (1989) Development of beta-adrenergic receptor and G protein messenger RNA in rat brain. Brain Research. Molecular Brain Research. 5: 289-96
Duman RS, Terwilliger RZ, Nestler EJ, et al. (1989) Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain. Biochemical Pharmacology. 38: 1909-14
Saito N, Guitart X, Hayward M, et al. (1989) Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America. 86: 3906-10
Nestler EJ, Erdos JJ, Terwilliger R, et al. (1989) Regulation of G proteins by chronic morphine in the rat locus coeruleus. Brain Research. 476: 230-9
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