Ralph A. Nixon, MD
Affiliations: | Psychiatry | New York University, New York, NY, United States |
Area:
neurodegeneration, Alzheimer's disease, AutophagyGoogle:
"Ralph Nixon"Bio:
NYU SCH MED NATHAN KLINE INST
PSYCHIATRIC RES DEPT
140 OLD ORANGEBURG RD
ORANGEBURG, NY 109621157
United States
Mean distance: 18.25 (cluster 50)
Cross-listing: Alzheimer's Tree
Children
Sign in to add trainee| Seonil Kim | grad student | 2011 | NYU |
| Ju-hyun Lee | post-doc | Nathan Kline Institute, New York University Medical School | |
| Paul Marshall Mathews | post-doc | 1995-1997 | McLean Hospital, Harvard Medical School |
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Publications
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| Im E, Jiang Y, Stavrides PH, et al. (2023) Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr-phosphorylated APP βCTF. Science Advances. 9: eadg1925 |
| Rao MV, Darji S, Stavrides PH, et al. (2022) Autophagy is a novel pathway for neurofilament protein degradation . Autophagy. 1-16 |
| Lee JH, Nixon RA. (2022) Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis. Autophagy. 1-2 |
| Lee JH, Yang DS, Goulbourne CN, et al. (2022) Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nature Neuroscience. 25: 688-701 |
| Lie PPY, Yoo L, Goulbourne CN, et al. (2022) Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca efflux and disrupted by PSEN1 loss of function. Science Advances. 8: eabj5716 |
| Pensalfini A, Jiang Y, Kim S, et al. (2021) Assessing Rab5 Activation in Health and Disease. Methods in Molecular Biology (Clifton, N.J.). 2293: 273-294 |
| Knopman DS, Amieva H, Petersen RC, et al. (2021) Alzheimer disease. Nature Reviews. Disease Primers. 7: 33 |
| Pensalfini A, Kim S, Subbanna S, et al. (2020) Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Reports. 33: 108420 |
| Nixon RA. (2020) The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140443 |
| Gafson AR, Barthélemy NR, Bomont P, et al. (2020) Neurofilaments: neurobiological foundations for biomarker applications. Brain : a Journal of Neurology |