Ralph A. Nixon, MD

Affiliations: 
Psychiatry New York University, New York, NY, United States 
Area:
neurodegeneration, Alzheimer's disease, Autophagy
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"Ralph Nixon"
Bio:

NYU SCH MED NATHAN KLINE INST
PSYCHIATRIC RES DEPT
140 OLD ORANGEBURG RD
ORANGEBURG, NY 109621157
United States

Mean distance: 18.25 (cluster 50)
 
Cross-listing: Alzheimer's Tree

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Publications

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Lee JH, Yang DS, Goulbourne CN, et al. (2022) Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nature Neuroscience. 25: 688-701
Lie PPY, Yoo L, Goulbourne CN, et al. (2022) Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca efflux and disrupted by PSEN1 loss of function. Science Advances. 8: eabj5716
Pensalfini A, Jiang Y, Kim S, et al. (2021) Assessing Rab5 Activation in Health and Disease. Methods in Molecular Biology (Clifton, N.J.). 2293: 273-294
Knopman DS, Amieva H, Petersen RC, et al. (2021) Alzheimer disease. Nature Reviews. Disease Primers. 7: 33
Pensalfini A, Kim S, Subbanna S, et al. (2020) Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Reports. 33: 108420
Nixon RA. (2020) The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140443
Gafson AR, Barthélemy NR, Bomont P, et al. (2020) Neurofilaments: neurobiological foundations for biomarker applications. Brain : a Journal of Neurology
Lee JH, Wolfe DM, Darji S, et al. (2020) β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7. Journal of Molecular Biology
Bordi M, Darji S, Sato Y, et al. (2019) mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy. Cell Death & Disease. 10: 563
Ying J, Sato Y, Im E, et al. (2019) Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
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