David Malcolm MacLean, PhD

2017- Pharmacology and Physiology University of Rochester Medical Center, Rochester, NY, United States 
Biophysics of iGluRs and ASICs, pharmacology
"David MacLean"
Mean distance: 16.58 (cluster 11)
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Durham RJ, Paudyal N, Carrillo E, et al. (2020) Conformational spread and dynamics in allostery of NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America
Carrillo E, Shaikh SA, Berka V, et al. (2019) Mechanism of modulation of AMPA receptors by TARP-γ8. The Journal of General Physiology
MacLean DM, Durham RJ, Jayaraman V. (2018) Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET. Trends in Neurosciences
Chen J, Li L, Chen SR, et al. (2018) The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Reports. 22: 2307-2321
Dolino DM, Chatterjee S, MacLean DM, et al. (2017) The structure-energy landscape of NMDA receptor gating. Nature Chemical Biology
Coombs ID, MacLean DM, Jayaraman V, et al. (2017) Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation. Cell Reports. 20: 1123-1135
MacLean DM, Jayaraman V. (2017) Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive. Proceedings of the National Academy of Sciences of the United States of America
Vitrac H, MacLean DM, Karlstaedt A, et al. (2016) Dynamic lipid-dependent modulation of protein topology by post-translational phosphorylation. The Journal of Biological Chemistry
Shaikh SA, Dolino DM, Lee G, et al. (2016) Stargazin Modulation of AMPA Receptors. Cell Reports. 17: 328-335
MacLean DM, Jayaraman V. (2016) Acid sensing ion channels are tuned to follow high frequency stimuli. The Journal of Physiology
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