Matthew A. Seager

Affiliations: 
Bristol-Myers Squibb Company, New York, NY, United States 
 Yale University, New Haven, CT 
Area:
Alzheimer's disease, schizophrenia, depression, learning, memory, cognition, hippocampus
Website:
http://www.linkedin.com/in/matthewseager
Google:
"Matthew Seager"
Mean distance: 14.99 (cluster 17)
 
SNBCP
Cross-listing: Alzheimer's Tree

BETA: Related publications

Publications

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Yang ZQ, Shu Y, Ma L, et al. (2014) Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators. Acs Medicinal Chemistry Letters. 5: 604-8
Kuduk SD, Chang RK, Greshock TJ, et al. (2012) Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators. Acs Medicinal Chemistry Letters. 3: 1070-4
Kuduk SD, Chang RK, Di Marco CN, et al. (2011) Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. Journal of Medicinal Chemistry. 54: 4773-80
Kuduk SD, Chang RK, Di Marco CN, et al. (2011) Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series. Bioorganic & Medicinal Chemistry Letters. 21: 1710-5
Kuduk SD, Di Marco CN, Cofre V, et al. (2011) Fused heterocyclic M1 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 21: 2769-72
Kuduk SD, Chang RK, Di Marco CN, et al. (2010) Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators. Acs Medicinal Chemistry Letters. 1: 263-7
Kuduk SD, DiPardo RM, Beshore DC, et al. (2010) Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 2538-41
Kuduk SD, Di Marco CN, Chang RK, et al. (2010) Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 2533-7
Kuduk SD, Di Marco CN, Cofre V, et al. (2010) N-heterocyclic derived M1 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 1334-7
Zhao WQ, Santini F, Breese R, et al. (2010) Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. The Journal of Biological Chemistry. 285: 7619-32
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