Nathaniel Safren, Ph.D.

2014 Neuroscience University of Maryland School of Medicine, Baltimore, MD, United States 
Neuroscience Biology, Cell Biology, Biochemistry
"Nathaniel Safren"
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Mervyn Monteiro grad student 2014 University of Maryland Medical School
 (Characterization of Ubiquilin Proteins and Assessment of Ubiquilin-1 Overexpression as a Therapy for Huntington's Disease.)
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Safren N, Sharkey LM, Barmada SJ. (2022) Neuronal Puncta/Aggregate Formation by WT and Mutant UBQLN2. Methods in Molecular Biology (Clifton, N.J.). 2551: 561-573
Mohan HM, Trzeciakiewicz H, Pithadia A, et al. (2022) RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control. Cellular and Molecular Life Sciences : Cmls. 79: 176
Safren N, Tank EM, Malik AM, et al. (2021) Development of a specific live-cell assay for native autophagic flux. The Journal of Biological Chemistry. 101003
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382
Gerson JE, Linton H, Xing J, et al. (2021) Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins. Scientific Reports. 11: 287
Gerson JE, Safren N, Fischer S, et al. (2020) Ubiquilin-2 differentially regulates polyglutamine disease proteins. Human Molecular Genetics
Sharkey LM, Safren N, Pithadia AS, et al. (2018) Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly. Proceedings of the National Academy of Sciences of the United States of America
Al-Ramahi I, Giridharan SSP, Chen YC, et al. (2017) Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 6
Gupta R, Lan M, Mojsilovic-Petrovic J, et al. (2017) The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome. Eneuro. 4
Le NT, Chang L, Kovlyagina I, et al. (2016) Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proceedings of the National Academy of Sciences of the United States of America
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