Nathaniel Safren, Ph.D.
Affiliations: | 2014 | Neuroscience | University of Maryland School of Medicine, Baltimore, MD, United States |
Area:
Neuroscience Biology, Cell Biology, BiochemistryGoogle:
"Nathaniel Safren"Mean distance: 35622
Parents
Sign in to add mentorMervyn Monteiro | grad student | 2014 | University of Maryland Medical School | |
(Characterization of Ubiquilin Proteins and Assessment of Ubiquilin-1 Overexpression as a Therapy for Huntington's Disease.) |
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Publications
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Safren N, Dao TP, Mohan HM, et al. (2024) Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity. Scientific Reports. 14: 6049 |
Safren N, Sharkey LM, Barmada SJ. (2022) Neuronal Puncta/Aggregate Formation by WT and Mutant UBQLN2. Methods in Molecular Biology (Clifton, N.J.). 2551: 561-573 |
Mohan HM, Trzeciakiewicz H, Pithadia A, et al. (2022) RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control. Cellular and Molecular Life Sciences : Cmls. 79: 176 |
Safren N, Tank EM, Malik AM, et al. (2021) Development of a specific live-cell assay for native autophagic flux. The Journal of Biological Chemistry. 101003 |
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382 |
Gerson JE, Linton H, Xing J, et al. (2021) Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins. Scientific Reports. 11: 287 |
Gerson JE, Safren N, Fischer S, et al. (2020) Ubiquilin-2 differentially regulates polyglutamine disease proteins. Human Molecular Genetics |
Sharkey LM, Safren N, Pithadia AS, et al. (2018) Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly. Proceedings of the National Academy of Sciences of the United States of America |
Al-Ramahi I, Giridharan SSP, Chen YC, et al. (2017) Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 6 |
Gupta R, Lan M, Mojsilovic-Petrovic J, et al. (2017) The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome. Eneuro. 4 |