☰ Chemistry Tree

William F. Trager

Affiliations:	1967-1972	Pharmacy	University of California, San Francisco, San Francisco, CA
	1972-2009		University of Washington, Seattle, Seattle, WA

Area:

Biochemistry

Website:

https://sop.washington.edu/william-f-trager-ph-d-remembrance/

Google:

"William Frank Trager"

Bio:

(1937 - 2009)

Mean distance: (not calculated yet)

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Parents

Alain C. Huitric	grad student	1965	University of Washington
(NMR analysis of substituted cyclohexylamine and nitrocyclohexanes; strong coupling and solvent effects in conformational analysis of mobile six-membered ring compounds.)
Arnold Heyworth Beckett	post-doc	1967	University of London

Children

Sidney D. Nelson	grad student	1974	UCSF
Ronald G. Aoyama	grad student	2003	University of Washington
Michael J. Trnka	grad student	2004	University of Washington
Allan E. Rettie	post-doc	1987	University of Washington

Collaborators

BETA: Related publications

Publications

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Trnka MJ, Doneanu CE, Trager WF. (2006) Photoaffinity labeling of P450Cam by an imidazole-tethered benzophenone probe. Archives of Biochemistry and Biophysics. 445: 95-107
Suzuki H, Kneller MB, Rock DA, et al. (2004) Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors. Archives of Biochemistry and Biophysics. 429: 1-15
Nelson SD, Trager WF. (2003) The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1481-98
Lightning LK, Trager WF. (2002) Characterization of covalent adducts to intact cytochrome P450s by mass spectrometry. Methods in Enzymology. 357: 296-300
Suzuki H, Kneller MB, Haining RL, et al. (2002) (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 235-9
Henne KR, Fisher MB, Iyer KR, et al. (2001) Active site characteristics of CYP4B1 probed with aromatic ligands. Biochemistry. 40: 8597-605
He M, Rettie AE, Neal J, et al. (2001) Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 701-11
Rao S, Aoyama R, Schrag M, et al. (2000) A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions. Journal of Medicinal Chemistry. 43: 2789-96
Lightning LK, Jones JP, Friedberg T, et al. (2000) Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394. Biochemistry. 39: 4276-87
He M, Korzekwa KR, Jones JP, et al. (1999) Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9. Archives of Biochemistry and Biophysics. 372: 16-28

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