Paula I. Lario, Ph.D.

Affiliations: 
2003 McGill University, Montreal, QC, Canada 
Area:
Biochemistry
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"Paula Lario"
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Parents

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Alice Vrielink grad student 2003 McGill
 (Towards understanding flavin reactivity: A structural study of cholesterol oxidase.)
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Publications

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Okon M, Moraes TF, Lario PI, et al. (2008) Structural characterization of the type-III pilot-secretin complex from Shigella flexneri. Structure (London, England : 1993). 16: 1544-54
Lyubimov AY, Lario PI, Moustafa I, et al. (2006) Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment. Nature Chemical Biology. 2: 259-64
Lario PI, Pfuetzner RA, Frey EA, et al. (2005) Structure and biochemical analysis of a secretin pilot protein. The Embo Journal. 24: 1111-21
Schubert M, Edge RE, Lario P, et al. (2004) Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces. Journal of Molecular Biology. 341: 37-54
Lario PI, Vrielink A. (2003) Atomic resolution density maps reveal secondary structure dependent differences in electronic distribution. Journal of the American Chemical Society. 125: 12787-94
Lario PI, Sampson N, Vrielink A. (2003) Sub-atomic resolution crystal structure of cholesterol oxidase: What atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox activity Journal of Molecular Biology. 326: 1635-1650
Burns CS, Aronoff-Spencer E, Dunham CM, et al. (2002) Molecular features of the copper binding sites in the octarepeat domain of the prion protein. Biochemistry. 41: 3991-4001
Liu S, Gorseth E, Bobechko B, et al. (2002) In vitro PKA phosphorylation-mediated human PDE4A4 activation Febs Letters. 512: 205-208
Yin Y, Sampson NS, Vrielink A, et al. (2001) The presence of a hydrogen bond between asparagine 485 and the pi system of FAD modulates the redox potential in the reaction catalyzed by cholesterol oxidase. Biochemistry. 40: 13779-87
Lario PI, Bobechko B, Bateman K, et al. (2001) Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells. Archives of Biochemistry and Biophysics. 394: 54-60
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