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Craig Cameron Mello, Ph.D.

Affiliations: 
Molecular Medicine University of Massachusetts Medical School, Worcester, MA, United States 
Area:
Regulation of gene expression
Website:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/2006/mello-bio.html
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"Craig C. Mello"
Bio:

The Nobel Prize in Physiology or Medicine 2006 was awarded jointly to Andrew Z. Fire and Craig C. Mello "for their discovery of RNA interference - gene silencing by double-stranded RNA"
http://www.nasonline.org/member-directory/members/20005471.html
http://profiles.umassmed.edu/profiles/ProfileDetails.aspx?From=Pinfo&Person=1009
http://www.umassmed.edu/pmm/faculty/mello.cfm
http://www.kosmix.com/topic/Craig_Mello
http://www.hhmi.org/research/investigators/mello_bio.html

Mean distance: 15.85 (cluster 32)
 		SNBCP
Cross-listing: Chemistry Tree - DevTree

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Parents

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David I. Hirsh grad student 1982 CU Boulder
 (Transfered to Harvard after one year)
Victor Ambros grad student 1990 Harvard
Dan Stinchcomb grad student 1990 Harvard
 (C. elegans DNA transformation)
James Priess post-doc 1994 Fred Hutchinson Cancer Center

Children

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Pedro J Batista grad student (Chemistry Tree)
En-Zhi Shen grad student University of Massachusetts Medical School
yuehe ding post-doc 2016- UMass Med School
Julie M. Claycomb post-doc 2004-2011 University of Massachusetts Medical School (FlyTree)
Gregoriy A Dokshin post-doc 2015-2018 University Of Massachusetts Med Sch Worcester (DevTree)

Collaborators

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Publications

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Sun B, Kim H, Mello CC, et al. (2023) The CERV protein of Cer1, a C. elegans LTR retrotransposon, is required for nuclear export of viral genomic RNA and can form giant nuclear rods. Plos Genetics. 19: e1010804
Ding YH, Ochoa HJ, Ishidate T, et al. (2023) The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Cell Reports. 42: 112408
Dai S, Tang X, Li L, et al. (2022) A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing. Cell Reports. 40: 111265
Ghanta KS, Chen Z, Mir A, et al. (2021) 5' modifications improve potency and efficacy of DNA donors for precision genome editing. Elife. 10
Makeyeva YV, Shirayama M, Mello CC. (2021) Cues from mRNA splicing prevent default Argonaute silencing in C. elegans. Developmental Cell
Kim H, Ding YH, Lu S, et al. (2021) PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in . Elife. 10
Kim H, Ding YH, Zhang G, et al. (2021) HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in . Elife. 10
Spichal M, Heestand B, Billmyre KK, et al. (2021) Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility. Nature Communications. 12: 1420
Chaves DA, Dai H, Li L, et al. (2020) The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans. Molecular Cell
Ghanta KS, Mello CC. (2020) Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in . Genetics
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