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L. M. Viranga Tillekeratne

Affiliations: 
Medicinal Chemistry The University of Toledo 
Area:
Organic Chemistry, Pharmacology
Website:
http://www.utoledo.edu/pharmacy/depts/mbc/faculty-vtillekeratne.html
Google:
"L. M. Viranga Tillekeratne"
Bio:

http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.475235

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Parents

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Francis John Schmitz post-doc 1982 University of Oklahoma

Children

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Mamoun Alhamadsheh grad student 2004 The University of Toledo
Pravin R. Bhansali grad student 2011 The University of Toledo
Sara R. Fedorka grad student 2012 The University of Toledo
Jehad Almaliti grad student 2013 The University of Toledo

Collaborators

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Lalith Perera collaborator
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Publications

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Almaliti J, Al-Hamashi AA, Negmeldin AT, et al. (2016) Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. Journal of Medicinal Chemistry
Bhansali P, Hanigan CL, Perera L, et al. (2014) Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. European Journal of Medicinal Chemistry. 86: 528-41
Ahmed S, Riegsecker S, Beamer M, et al. (2013) Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts. Toxicology and Applied Pharmacology. 270: 87-96
Almaliti J, Nada SE, Carter B, et al. (2013) Natural products inspired synthesis of neuroprotective agents against Hâ‚‚Oâ‚‚-induced cell death. Bioorganic & Medicinal Chemistry Letters. 23: 1232-7
Bhansali P, Hanigan CL, Casero RA, et al. (2011) Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation. Journal of Medicinal Chemistry. 54: 7453-63
Gupta S, Poeppelman L, Hinman CL, et al. (2010) Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL. Bioorganic & Medicinal Chemistry. 18: 849-54
Alhamadsheh MM, Gupta S, Hudson RA, et al. (2008) Total synthesis and selective activity of a new class of conformationally restrained epothilones. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 570-81
Cai S, Mukherjee J, Tillekeratne LM, et al. (2007) Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents. Bioorganic & Medicinal Chemistry. 15: 7042-7
Nacario R, Kotakonda S, Fouchard DM, et al. (2005) Reductive monoalkylation of aromatic and aliphatic nitro compounds and the corresponding amines with nitriles. Organic Letters. 7: 471-4
Khobzaoui M, Tillekeratne LM, Hudson RA. (2004) Potent isothiocyanate inhibitors of carbonic anhydrase: synthesis and evaluation. Biochemical and Biophysical Research Communications. 318: 1-3
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