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Jochen Schacht, Ph.D.

Affiliations: 
Kresge Hearing Research Institute University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Inner Ear Biochemistry
Website:
http://www.khri.med.umich.edu/research/schacht_lab/
Google:
"Jochen Schacht"
Mean distance: 17.07 (cluster 11)
 
SNBCP
Cross-listing: Chemistry Tree

Parents

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Joachim Knappe grad student University of Heidelberg (Chemistry Tree) (dcoling) Delete Edit
Bernard Agranoff post-doc University of Michigan (dcoling) Delete Edit

Children

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Nontima Vardhanabhuti grad student 1995 University of Michigan (KANOKPOLOGY) Delete Edit
Don Coling post-doc 1989-1994 Krege Hearing Research Institute, University of Michigan, Ann Arbor (dcoling) Delete Edit
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Publications

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Yang CH, Schrepfer T, Schacht J. (2015) Age-related hearing impairment and the triad of acquired hearing loss. Frontiers in Cellular Neuroscience. 9: 276
Shalev M, Rozenberg H, Smolkin B, et al. (2015) Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics. Nucleic Acids Research. 43: 8601-13
Oishi N, Duscha S, Boukari H, et al. (2015) XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. Cell Death & Disease. 6: e1763
Altschuler RA, Dolan DF, Halsey K, et al. (2015) Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice. Neuroscience. 292: 22-33
Kendall A, Schacht J. (2014) Disparities in auditory physiology and pathology between C57BL/6J and C57BL/6N substrains. Hearing Research. 318: 18-22
Duscha S, Boukari H, Shcherbakov D, et al. (2014) Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics. Mbio. 5: e01827-14
Oishi N, Kendall A, Schacht J. (2014) Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo. Neuroscience Letters. 583: 65-9
Shulman E, Belakhov V, Wei G, et al. (2014) Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases. The Journal of Biological Chemistry. 289: 2318-30
Xue X, Mutyam V, Tang L, et al. (2014) Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor. American Journal of Respiratory Cell and Molecular Biology. 50: 805-16
Oishi N, Chen J, Zheng HW, et al. (2013) Tumor necrosis factor-alpha-mutant mice exhibit high frequency hearing loss. Journal of the Association For Research in Otolaryngology : Jaro. 14: 801-11
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