Jochen Schacht, Ph.D. - Publications

Affiliations: 
Kresge Hearing Research Institute University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Inner Ear Biochemistry
Website:
http://www.khri.med.umich.edu/research/schacht_lab/

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Yang CH, Schrepfer T, Schacht J. Age-related hearing impairment and the triad of acquired hearing loss. Frontiers in Cellular Neuroscience. 9: 276. PMID 26283913 DOI: 10.3389/Fncel.2015.00276  0.324
2015 Oishi N, Duscha S, Boukari H, Meyer M, Xie J, Wei G, Schrepfer T, Roschitzki B, Boettger EC, Schacht J. XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. Cell Death & Disease. 6: e1763. PMID 25973683 DOI: 10.1038/Cddis.2015.108  0.301
2015 Altschuler RA, Dolan DF, Halsey K, Kanicki A, Deng N, Martin C, Eberle J, Kohrman DC, Miller RA, Schacht J. Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice. Neuroscience. 292: 22-33. PMID 25665752 DOI: 10.1016/J.Neuroscience.2015.01.068  0.322
2014 Oishi N, Kendall A, Schacht J. Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo. Neuroscience Letters. 583: 65-9. PMID 25240593 DOI: 10.1016/J.Neulet.2014.09.028  0.328
2013 Chen FQ, Zheng HW, Schacht J, Sha SH. Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea. Plos One. 8: e61999. PMID 23626763 DOI: 10.1371/Journal.Pone.0061999  0.332
2012 Schacht J, Talaska AE, Rybak LP. Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention. Anatomical Record (Hoboken, N.J. : 2007). 295: 1837-50. PMID 23045231 DOI: 10.1002/Ar.22578  0.341
2012 Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC. Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin. Proceedings of the National Academy of Sciences of the United States of America. 109: 10984-9. PMID 22699498 DOI: 10.1073/Pnas.1204073109  0.315
2012 Chen FQ, Hill K, Guan YJ, Schacht J, Sha SH. Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line. Hearing Research. 284: 33-41. PMID 22240458 DOI: 10.1016/J.Heares.2011.12.007  0.336
2012 Sha SH, Kanicki A, Halsey K, Wearne KA, Schacht J. Antioxidant-enriched diet does not delay the progression of age-related hearing loss. Neurobiology of Aging. 33: 1010.e15-6. PMID 22154190 DOI: 10.1016/J.Neurobiolaging.2011.10.023  0.31
2011 Op de Beeck K, Schacht J, Van Camp G. Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cell. Hearing Research. 281: 18-27. PMID 21782914 DOI: 10.1016/J.Heares.2011.07.002  0.308
2010 Sha SH, Chen FQ, Schacht J. PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse. Hearing Research. 264: 86-92. PMID 19761823 DOI: 10.1016/J.Heares.2009.09.002  0.312
2009 Sha SH, Chen FQ, Schacht J. Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hearing Research. 254: 92-9. PMID 19422898 DOI: 10.1016/J.Heares.2009.04.019  0.313
2008 Sha SH, Kanicki A, Dootz G, Talaska AE, Halsey K, Dolan D, Altschuler R, Schacht J. Age-related auditory pathology in the CBA/J mouse. Hearing Research. 243: 87-94. PMID 18573325 DOI: 10.1016/J.Heares.2008.06.001  0.31
2008 Samson J, Wiktorek-Smagur A, Politanski P, Rajkowska E, Pawlaczyk-Luszczynska M, Dudarewicz A, Sha SH, Schacht J, Sliwinska-Kowalska M. Noise-induced time-dependent changes in oxidative stress in the mouse cochlea and attenuation by D-methionine. Neuroscience. 152: 146-50. PMID 18234425 DOI: 10.1016/J.Neuroscience.2007.11.015  0.303
2007 Jiang H, Talaska AE, Schacht J, Sha SH. Oxidative imbalance in the aging inner ear. Neurobiology of Aging. 28: 1605-12. PMID 16920227 DOI: 10.1016/J.Neurobiolaging.2006.06.025  0.313
2007 Chen Y, Huang WG, Zha DJ, Qiu JH, Wang JL, Sha SH, Schacht J. Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic. Hearing Research. 226: 178-82. PMID 16844331 DOI: 10.1016/J.Heares.2006.05.008  0.319
2007 Talaska AE, Schacht J. Mechanisms of noise damage to the cochlea Audiological Medicine. 5: 3-9. DOI: 10.1080/16513860601158887  0.313
2006 Jiang H, Sha SH, Schacht J. Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo. Journal of Neurochemistry. 99: 269-76. PMID 16903869 DOI: 10.1111/J.1471-4159.2006.04117.X  0.34
2006 Sha SH, Qiu JH, Schacht J. Aspirin to prevent gentamicin-induced hearing loss. The New England Journal of Medicine. 354: 1856-7. PMID 16641409 DOI: 10.1056/Nejmc053428  0.303
2006 Jiang H, Sha SH, Schacht J. Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. Journal of Neuroscience Research. 83: 1544-51. PMID 16521128 DOI: 10.1002/Jnr.20833  0.323
2006 Vicente-Torres MA, Schacht J. A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss. Journal of Neuroscience Research. 83: 1564-72. PMID 16521126 DOI: 10.1002/Jnr.20832  0.347
2006 Schacht J, Hawkins JE. Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss. Audiology & Neuro-Otology. 11: 1-6. PMID 16219991 DOI: 10.1159/000088850  0.301
2005 Jiang H, Sha SH, Schacht J. NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. Journal of Neuroscience Research. 79: 644-51. PMID 15672440 DOI: 10.1002/Jnr.20392  0.344
2004 Yamashita D, Jiang HY, Schacht J, Miller JM. Delayed production of free radicals following noise exposure. Brain Research. 1019: 201-9. PMID 15306254 DOI: 10.1016/J.Brainres.2004.05.104  0.321
2004 Lautermann J, Dehne N, Schacht J, Jahnke K. [Aminoglycoside- and cisplatin-ototoxicity: from basic science to clinics]. Laryngo- Rhino- Otologie. 83: 317-23. PMID 15143449 DOI: 10.1055/S-2004-814280  0.305
2004 Kawamoto K, Sha SH, Minoda R, Izumikawa M, Kuriyama H, Schacht J, Raphael Y. Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 173-81. PMID 14759801 DOI: 10.1016/J.Ymthe.2003.11.020  0.301
2004 Matsunobu T, Ogita K, Schacht J. Modulation of activator protein 1/DNA binding activity by acoustic overstimulation in the guinea-pig cochlea. Neuroscience. 123: 1037-43. PMID 14751294 DOI: 10.1016/J.Neuroscience.2003.10.022  0.308
2003 Ohinata Y, Miller JM, Schacht J. Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea. Brain Research. 966: 265-73. PMID 12618349 DOI: 10.1016/S0006-8993(02)04205-1  0.321
2002 Wu WJ, Sha SH, Schacht J. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiology & Neuro-Otology. 7: 171-4. PMID 12053140 DOI: 10.1159/000058305  0.315
2002 Li G, Sha SH, Zotova E, Arezzo J, Van de Water T, Schacht J. Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. Laboratory Investigation; a Journal of Technical Methods and Pathology. 82: 585-96. PMID 12003999 DOI: 10.1038/Labinvest.3780453  0.302
2001 Chung JW, Schacht J. ATP and nitric oxide modulate intracellular calcium in isolated pillar cells of the guinea pig cochlea. Journal of the Association For Research in Otolaryngology : Jaro. 2: 399-407. PMID 11833612 DOI: 10.1007/S101620010058  0.331
2001 Wu WJ, Sha SH, McLaren JD, Kawamoto K, Raphael Y, Schacht J. Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hearing Research. 158: 165-78. PMID 11506949 DOI: 10.1016/S0378-5955(01)00303-3  0.302
2001 Sha SH, Zajic G, Epstein CJ, Schacht J. Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing loss. Audiology & Neuro-Otology. 6: 117-23. PMID 11474137 DOI: 10.1159/000046818  0.3
2001 Sha SH, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hearing Research. 155: 1-8. PMID 11335071 DOI: 10.1016/S0378-5955(01)00224-6  0.322
2001 Matsunobu T, Chung JW, Schacht J. Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest alpha9-like receptors. Journal of Neuroscience Research. 63: 252-6. PMID 11170174 DOI: 10.1002/1097-4547(20010201)63:3<252::Aid-Jnr1018>3.0.Co;2-0  0.304
2000 Ohinata Y, Miller JM, Altschuler RA, Schacht J. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Research. 878: 163-73. PMID 10996147 DOI: 10.1016/S0006-8993(00)02733-5  0.332
2000 Ohinata Y, Yamasoba T, Schacht J, Miller JM. Glutathione limits noise-induced hearing loss. Hearing Research. 146: 28-34. PMID 10913881 DOI: 10.1016/S0378-5955(00)00096-4  0.307
2000 Matsunobu T, Schacht J. Nitric oxide/cyclic GMP pathway attenuates ATP-evoked intracellular calcium increase in supporting cells of the guinea pig cochlea. The Journal of Comparative Neurology. 423: 452-61. PMID 10870085 DOI: 10.1002/1096-9861(20000731)423:3<452::Aid-Cne8>3.0.Co;2-Y  0.334
1999 Tian F, Fessenden JD, Schacht J. Cyclic GMP-dependent protein kinase-I in the guinea pig cochlea. Hearing Research. 131: 63-70. PMID 10355605 DOI: 10.1016/S0378-5955(99)00015-5  0.323
1999 Sha SH, Schacht J. Stimulation of free radical formation by aminoglycoside antibiotics. Hearing Research. 128: 112-8. PMID 10082291 DOI: 10.1016/S0378-5955(98)00200-7  0.319
1999 Ogawa K, Schacht J. Aging does not alter phosphoinositide hydrolysis in the rat cochlear lateral wall. Auris, Nasus, Larynx. 26: 1-4. PMID 10077249 DOI: 10.1016/S0385-8146(98)00054-6  0.303
1999 Sha SH, Schacht J. Formation of reactive oxygen species following bioactivation of gentamicin. Free Radical Biology & Medicine. 26: 341-7. PMID 9895225 DOI: 10.1016/S0891-5849(98)00207-X  0.301
1998 Sha SH, Schacht J. Are aminoglycoside antibiotics excitotoxic? Neuroreport. 9: 3893-5. PMID 9875724 DOI: 10.1097/00001756-199812010-00023  0.33
1997 Lautermann J, Crann SA, McLaren J, Schacht J. Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise. Hearing Research. 114: 75-82. PMID 9447921 DOI: 10.1016/S0378-5955(97)00154-8  0.338
1997 Sha SH, Schacht J. Prevention of aminoglycoside-induced hearing loss. The Keio Journal of Medicine. 46: 115-9. PMID 9339638 DOI: 10.2302/Kjm.46.115  0.317
1997 Fessenden JD, Schacht J. Localization of soluble guanylate cyclase activity in the guinea pig cochlea suggests involvement in regulation of blood flow and supporting cell physiology. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 45: 1401-8. PMID 9313801 DOI: 10.1177/002215549704501008  0.351
1997 Puschner B, Schacht J. Calmodulin-dependent protein kinases mediate calcium-induced slow motility of mammalian outer hair cells. Hearing Research. 110: 251-8. PMID 9282907 DOI: 10.1016/S0378-5955(97)00086-5  0.335
1997 Vardhanabhuti N, Ramachandran C, Schacht J, Weiner N. Preparation of Liposomes with Asymmetric Distribution of Phosphyatidylinositol 4,5-Bisphosphate Across the Bilayer Journal of Liposome Research. 7: 301-314. DOI: 10.3109/08982109709035503  0.754
1996 Crann SA, Schacht J. Activation of aminoglycoside antibiotics to cytotoxins. Audiology & Neuro-Otology. 1: 80-5. PMID 9390792 DOI: 10.1159/000259187  0.319
1996 Lautermann J, Schacht J. A sensitive animal model to assess acute and chronic ototoxic effects. Archives of Otolaryngology--Head & Neck Surgery. 122: 837-40. PMID 8703385 DOI: 10.1001/Archotol.1996.01890200027005  0.302
1995 López-Escámez JA, Schacht J. Mechanically induced calcium increases in isolated vestibular hair cells of the guinea pig. Acta Oto-Laryngologica. 115: 759-64. PMID 8749197 DOI: 10.3109/00016489509139399  0.303
1995 Coling DE, Schacht J. Second messengers in the cochlea. Acta Oto-Laryngologica. 115: 218-21. PMID 7610808 DOI: 10.3109/00016489509139295  0.666
1995 Ogawa K, Schacht J. P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall. Neuroreport. 6: 1538-40. PMID 7579143 DOI: 10.1097/00001756-199507310-00018  0.312
1994 Ogawa K, McLaren J, Schacht J. Effect of aging on myo-inositol and phosphoinositide metabolism in the cochlear and vestibular sensory epithelia of the rat. Hearing Research. 73: 155-62. PMID 8188544 DOI: 10.1016/0378-5955(94)90230-5  0.305
1994 Garetz SL, Rhee DJ, Schacht J. Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hearing Research. 77: 75-80. PMID 7928739 DOI: 10.1016/0378-5955(94)90254-2  0.327
1994 Fessenden JD, Coling DE, Schacht J. Detection and characterization of nitric oxide synthase in the mammalian cochlea. Brain Research. 668: 9-15. PMID 7535658 DOI: 10.1016/0006-8993(94)90505-3  0.666
1994 Coling DE, Naik RM, Schacht J. Calcium and calmodulin inhibit phosphorylation of a novel auditory nerve protein. Hearing Research. 72: 197-205. PMID 7512086 DOI: 10.1016/0378-5955(94)90219-4  0.674
1993 Forge A, Zajic G, Li L, Nevill G, Schacht J. Structural variability of the sub-surface cisternae in intact, isolated outer hair cells shown by fluorescent labelling of intracellular membranes and freeze-fracture. Hearing Research. 64: 175-83. PMID 8432688 DOI: 10.1016/0378-5955(93)90003-J  0.313
1993 Schacht J. Biochemical basis of aminoglycoside ototoxicity. Otolaryngologic Clinics of North America. 26: 845-56. PMID 8233493 DOI: 10.1016/S0030-6665(20)30771-4  0.317
1993 Ogawa K, Schacht J. Receptor-mediated release of inositol phosphates in the cochlear and vestibular sensory epithelia of the rat. Hearing Research. 69: 207-14. PMID 8226341 DOI: 10.1016/0378-5955(93)90109-E  0.314
1993 el Barbary A, Altschuler RA, Schacht J. Glutathione S-transferases in the organ of Corti of the rat: enzymatic activity, subunit composition and immunohistochemical localization. Hearing Research. 71: 80-90. PMID 8113147 DOI: 10.1016/0378-5955(93)90023-T  0.324
1993 Zajic G, Forge A, Schacht J. Membrane stains as an objective means to distinguish isolated inner and outer hair cells. Hearing Research. 66: 53-7. PMID 7682544 DOI: 10.1016/0378-5955(93)90259-4  0.33
1992 Crann SA, Huang MY, McLaren JD, Schacht J. Formation of a toxic metabolite from gentamicin by a hepatic cytosolic fraction. Biochemical Pharmacology. 43: 1835-9. PMID 1575776 DOI: 10.1016/0006-2952(92)90718-X  0.319
1992 Niedzielski AS, Schacht J. P2 purinoceptors stimulate inositol phosphate release in the organ of Corti. Neuroreport. 3: 273-5. PMID 1515584 DOI: 10.1097/00001756-199203000-00015  0.307
1992 Niedzielski AS, Ono T, Schacht J. Cholinergic regulation of the phosphoinositide second messenger system in the guinea pig organ of Corti. Hearing Research. 59: 250-4. PMID 1319989 DOI: 10.1016/0378-5955(92)90121-3  0.362
1991 Dulon D, Zajic G, Schacht J. Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions. Hearing Research. 52: 225-31. PMID 2061210 DOI: 10.1016/0378-5955(91)90202-K  0.346
1991 Pujol R, Zajic G, Dulon D, Raphael Y, Altschuler RA, Schacht J. First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea. Hearing Research. 57: 129-41. PMID 1774204 DOI: 10.1016/0378-5955(91)90082-K  0.333
1991 Coling DE, Schacht J. Protein phosphorylation in the organ of Corti: differential regulation by second messengers between base and apex. Hearing Research. 57: 113-20. PMID 1774202 DOI: 10.1016/0378-5955(91)90080-S  0.664
1991 Niedzielski AS, Schacht J. Phospholipid metabolism in the cochlea: differences between base and apex. Hearing Research. 57: 107-12. PMID 1663501 DOI: 10.1016/0378-5955(91)90079-O  0.327
1990 Huang M, Dulon D, Schacht J. Outer hair cells as potential targets of inflammatory mediators. The Annals of Otology, Rhinology & Laryngology. Supplement. 148: 35-8. PMID 2112361 DOI: 10.1177/00034894900990S610  0.343
1990 Dulon D, Zajic G, Schacht J. Increasing intracellular free calcium induces circumferential contractions in isolated cochlear outer hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 1388-97. PMID 2109787 DOI: 10.1523/Jneurosci.10-04-01388.1990  0.332
1989 Ono T, Schacht J. Acoustic stimulation increases phosphoinositide breakdown in the guinea pig cochlea. Neurochemistry International. 14: 327-30. PMID 20504433 DOI: 10.1016/0197-0186(89)90058-2  0.379
1989 Dulon D, Zajic G, Aran JM, Schacht J. Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells. Journal of Neuroscience Research. 24: 338-46. PMID 2585554 DOI: 10.1002/Jnr.490240226  0.323
1989 Riaz M, Weiner ND, Schacht J. Separation of liposome populations differing in phosphoinositide content by chromatography on immobilized neomycin. Journal of Pharmaceutical Sciences. 78: 172-5. PMID 2541241 DOI: 10.1002/Jps.2600780220  0.586
1989 Forge A, Zajic G, Davies S, Weiner N, Schacht J. Gentamicin alters membrane structure as shown by freeze-fracture of liposomes. Hearing Research. 37: 129-39. PMID 2536649 DOI: 10.1016/0378-5955(89)90035-X  0.616
1988 Dulon D, Aran JM, Schacht J. Potassium-depolarization induces motility in isolated outer hair cells by an osmotic mechanism. Hearing Research. 32: 123-9. PMID 3360672 DOI: 10.1016/0378-5955(88)90084-6  0.328
1987 Williams SE, Zenner HP, Schacht J. Three molecular steps of aminoglycoside ototoxicity demonstrated in outer hair cells. Hearing Research. 30: 11-8. PMID 3680049 DOI: 10.1016/0378-5955(87)90177-8  0.396
1987 Dulon D, Aran JM, Schacht J. Osmotically induced motility of outer hair cells: implications for Menière's disease. Archives of Oto-Rhino-Laryngology. 244: 104-7. PMID 3662921 DOI: 10.1007/Bf00458558  0.317
1987 Zajic G, Schacht J. Comparison of isolated outer hair cells from five mammalian species. Hearing Research. 26: 249-56. PMID 3583926 DOI: 10.1016/0378-5955(87)90061-X  0.315
1987 Henley CM, Gerhardt HJ, Schacht J. Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro. Brain Research Bulletin. 19: 695-8. PMID 3125950 DOI: 10.1016/0361-9230(87)90056-6  0.36
1987 Au S, Weiner ND, Schacht J. Aminoglycoside antibiotics preferentially increase permeability in phosphoinositide-containing membranes: a study with carboxyfluorescein in liposomes. Biochimica Et Biophysica Acta. 902: 80-6. PMID 3038190 DOI: 10.1016/0005-2736(87)90137-4  0.626
1987 Schacht J, Zenner HP. Evidence that phosphoinositides mediate motility in cochlear outer hair cells. Hearing Research. 31: 155-9. PMID 2833486 DOI: 10.1016/0378-5955(87)90121-3  0.361
1986 Au S, Weiner N, Schacht J. Membrane perturbation by aminoglycosides as a simple screen of their toxicity. Antimicrobial Agents and Chemotherapy. 30: 395-7. PMID 3777905 DOI: 10.1128/Aac.30.3.395  0.324
1986 Williams SE, Schacht J. Binding of neomycin and calcium to phospholipids and other anionic compounds. The Journal of Antibiotics. 39: 457-62. PMID 3700247 DOI: 10.7164/Antibiotics.39.457  0.315
1986 Au S, Schacht J, Weiner N. Membrane effects of aminoglycoside antibiotics measured in liposomes containing the fluorescent probe, 1-anilino-8-naphthalene sulfonate. Biochimica Et Biophysica Acta. 862: 205-10. PMID 3021220 DOI: 10.1016/0005-2736(86)90484-0  0.623
1986 Schacht J. Molecular mechanisms of drug-induced hearing loss. Hearing Research. 22: 297-304. PMID 3015857 DOI: 10.1016/0378-5955(86)90105-X  0.337
1986 Schacht J, Weiner N. Aminoglycoside-induced hearing loss: a molecular hypothesis. Orl; Journal For Oto-Rhino-Laryngology and Its Related Specialties. 48: 116-23. PMID 3010214 DOI: 10.1159/000275856  0.625
1986 Schacht J, Zenner HP. The phosphoinositide cascade in isolated outer hair cells: possible role as second messenger for motile responses Hearing Research. 22: 94. DOI: 10.1016/0378-5955(86)90086-9  0.388
1985 Takada A, Bledsoe S, Schacht J. An energy-dependent step in aminoglycoside ototoxicity: prevention of gentamicin ototoxicity during reduced endolymphatic potential. Hearing Research. 19: 245-51. PMID 4066523 DOI: 10.1016/0378-5955(85)90144-3  0.301
1984 Wang BM, Weiner ND, Ganesan MG, Schacht J. Interaction of calcium and neomycin with anionic phospholipid-lecithin liposomes. A differential scanning calorimetry study. Biochemical Pharmacology. 33: 3787-91. PMID 6508834 DOI: 10.1016/0006-2952(84)90041-8  0.609
1984 Wang BM, Weiner ND, Takada A, Schacht J. Characterization of aminoglycoside-lipid interactions and development of a refined model for ototoxicity testing. Biochemical Pharmacology. 33: 3257-62. PMID 6487373 DOI: 10.1016/0006-2952(84)90087-X  0.603
1983 Ganesan MG, Weiner ND, Schacht J. Effects of calcium and neomycin on phase behavior of phospholipid bilayers. Journal of Pharmaceutical Sciences. 72: 1465-7. PMID 6663487 DOI: 10.1002/Jps.2600721224  0.601
1983 Tachibana M, Anniko M, Schacht J. Effects of perilymphatically perfused gentamicin on microphonic potential, lipid labeling and morphology of cochlear tissues. Acta Oto-Laryngologica. 96: 31-8. PMID 6613550 DOI: 10.3109/00016488309132872  0.371
1983 Zajic G, Anniko M, Schacht J. Cellular localization of adenylate cyclase in the developing and mature inner ear of the mouse. Hearing Research. 10: 249-61. PMID 6307962 DOI: 10.1016/0378-5955(83)90090-4  0.323
1983 Canlon B, Schacht J. Acoustic stimulation alters deoxyglucose uptake in the mouse cochlea and inferior colliculus. Hearing Research. 10: 217-26. PMID 6305901 DOI: 10.1016/0378-5955(83)90055-2  0.317
1983 Zajic G, Schacht J. Cytochemical demonstration of adenylate cyclase with strontium chloride in the rat pancreas. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 31: 25-8. PMID 6187800 DOI: 10.1177/31.1.6187800  0.309
1982 Anniko M, Takada A, Schacht J. Comparative ototoxicities of gentamicin and netilmicin in three model systems. American Journal of Otolaryngology. 3: 422-33. PMID 7158707 DOI: 10.1016/S0196-0709(82)80020-3  0.346
1982 Desrochers CS, Schacht J. Neomycin concentrations in inner ear tissues and other organs of the guinea pig after chronic drug administration. Acta Oto-Laryngologica. 93: 233-6. PMID 7064707 DOI: 10.3109/00016488209130877  0.301
1982 Orsulakova A, Schacht J. A biochemical mechanism of the ototoxic interaction between neomycin and ethacrynic acid. Acta Oto-Laryngologica. 93: 43-8. PMID 7064694 DOI: 10.3109/00016488209130850  0.328
1982 Takada A, Lodhi S, Weiner ND, Schacht J. Lysine and polylysine: correlation of their effects on polyphosphoinositides in vitro with ototoxic action in vivo. Journal of Pharmaceutical Sciences. 71: 1410-1. PMID 6296353 DOI: 10.1002/Jps.2600711226  0.568
1982 Schacht J. Adenylate cyclase and cochlear fluid balance. American Journal of Otolaryngology. 3: 328-31. PMID 6293328 DOI: 10.1016/S0196-0709(82)80005-7  0.324
1980 Kilian PL, Schacht J. Sound stimulates labeling of polyphosphoinositides in the auditory organ of the noctuid moth. Journal of Neurochemistry. 34: 709-12. PMID 7354344 DOI: 10.1111/J.1471-4159.1980.Tb11201.X  0.323
1980 Bagger-Sjöbäck D, Filipek CS, Schacht J. Characteristics and drug responses of cochlear and vestibular adenylate cyclase. Archives of Oto-Rhino-Laryngology. 228: 217-22. PMID 6968555 DOI: 10.1007/Bf00454231  0.318
1980 Lodhi S, Weiner ND, Mechigian I, Schacht J. Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides. Biochemical Pharmacology. 29: 597-601. PMID 6245656 DOI: 10.1016/0006-2952(80)90382-2  0.609
1979 Mechigian I, Preston RE, Johnsson LG, Schacht J. Incorporation of radioactive calcium into otolithic membranes of the guinea pig after aminoglycoside treatment. Acta Oto-Laryngologica. 88: 56-60. PMID 474121 DOI: 10.3109/00016487909137140  0.321
1979 Lodhi S, Weiner ND, Schacht J. Interactions of neomycin with monomolecular films of polyphosphoinositides and other lipids. Biochimica Et Biophysica Acta. 557: 1-8. PMID 232987 DOI: 10.1016/0005-2736(79)90084-1  0.591
1979 Schacht J. Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney. Archives of Oto-Rhino-Laryngology. 224: 129-34. PMID 226045 DOI: 10.1007/Bf00455236  0.307
1977 Stockhorst E, Schacht J. Radioactive labeling of phospholipids and proteins by cochlear perfusion in the guinea pig and the effect of neomycin. Acta Oto-Laryngologica. 83: 401-9. PMID 888675 DOI: 10.3109/00016487709128864  0.335
1977 Schibeci A, Schacht J. Action of neomycin on the metabolism of polyphosphoinositides in the guinea pig kidney. Biochemical Pharmacology. 26: 1769-74. PMID 199196 DOI: 10.1016/0006-2952(77)90344-6  0.328
1977 Schacht J, Lodhi S, Weiner ND. Effects of neomycin on polyphosphoinositides in inner ear tissues and monomolecular films. Advances in Experimental Medicine and Biology. 84: 191-208. PMID 197827 DOI: 10.1007/978-1-4684-3279-4_9  0.617
1976 Schacht J. Inhibition by neomycin of polyphosphoinositide turnover in subcellular fractions of guinea-pig cerebral cortex in vitro. Journal of Neurochemistry. 27: 1119-24. PMID 12170598 DOI: 10.1111/J.1471-4159.1976.Tb00318.X  0.372
1976 Lodhi S, Weiner ND, Schacht J. Interactions of neomycin and calcium in synaptosomal membranes and polyphosphoinostide monolayers. Biochimica Et Biophysica Acta. 426: 781-5. PMID 1259992 DOI: 10.1016/0005-2736(76)90147-4  0.614
1976 Springer AD, Schacht J, Agranoff BW. The effect of memory blocking antibiotics and their analogs on acetylcholinesterase. Pharmacology, Biochemistry, and Behavior. 5: 1-3. PMID 996038 DOI: 10.1016/0091-3057(76)90278-1  0.503
1976 Schacht J. Biochemistry of neomycin ototoxicity. The Journal of the Acoustical Society of America. 59: 940-4. PMID 177473 DOI: 10.1121/1.380929  0.382
1976 Orsulakova A, Stockhorst E, Schacht J. Effect of neomycin on phosphoinositide labelling and calcium binding in guinea-pig inner ear tissues in vivo and in vitro. Journal of Neurochemistry. 26: 285-90. PMID 176322 DOI: 10.1111/J.1471-4159.1976.Tb04478.X  0.364
1975 Preston RE, Johnsson LG, Hill JH, Schacht J. Incorporation of radioactive calcium into otolithic membranes and middle ear ossicles of the gerbil. Acta Oto-Laryngologica. 80: 269-75. PMID 1180040 DOI: 10.3109/00016487509121327  0.302
1975 Kerr TP, Schacht J. Adenyl cyclase in the guinea pig cochlea The Journal of the Acoustical Society of America. 57: S61-S61. DOI: 10.1121/1.1995336  0.36
1974 Schacht J, Neale EA, Agranoff BW. Cholinergic stimulation of phospholipid labelling from (32P) orthophosphate in guinea-pig cortex synaptosomes in vitro: subsynaptosomal localization. Journal of Neurochemistry. 23: 211-8. PMID 4368498 DOI: 10.1111/J.1471-4159.1974.Tb06936.X  0.552
1974 Schacht J, Agranoff BW. Detergent-like action of tetraphenylborate on phospholipid labelling in guinea pig cortex subfractions. Journal of Neurochemistry. 22: 473-8. PMID 4364346 DOI: 10.1111/J.1471-4159.1974.Tb06881.X  0.55
1974 Schacht J, Agranoff BW. Stimulation of hydrolysis of phosphatidic acid by cholinergic agents in guinea pig synaptosomes. The Journal of Biological Chemistry. 249: 1551-7. PMID 4361741  0.452
1973 Schacht J, Agranoff BW. Acetylcholine stimulates hydrolysis of 32 P-labeled phosphatidic acid in guinea pig synaptosomes. Biochemical and Biophysical Research Communications. 50: 934-41. PMID 4347533 DOI: 10.1016/0006-291X(73)91335-1  0.532
1972 Schacht J, Agranoff BW. Phospholipid labelling by ( 32 P)-orthophosphate and ( 3 H)-myo-inositol in the stimulated goldfish brain in vivo. Journal of Neurochemistry. 19: 1417-21. PMID 4337116 DOI: 10.1111/J.1471-4159.1972.Tb01470.X  0.513
1972 Schacht J, Agranoff BW. Effects of acetylcholine on labeling of phosphatidate and phosphoinositides by ( 32 P) orthophosphate in nerve ending fractions of guinea pig cortex. The Journal of Biological Chemistry. 247: 771-7. PMID 4333513  0.46
1969 Knappe J, Schacht J, Möckel W, Höpner T, Vetter H, Edenharder R. Pyruvate formate-lyase reaction in Escherichia coli. The enzymatic system converting an inactive form of the lyase into the catalytically active enzyme. European Journal of Biochemistry / Febs. 11: 316-27. PMID 4902610 DOI: 10.1111/J.1432-1033.1969.TB00775.X  0.496
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