Jachinta E. Rooney, Ph.D.

Affiliations: 
2008 Cell and Molecular Pharmacology and Physiology University of Nevada, Reno, Reno, NV, United States 
Area:
Molecular Biology, Neuroscience Biology
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"Jachinta Rooney"
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Parents

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Dean J. Burkin grad student 2008 University of Nevada, Reno
 (The alpha7beta1 integrin and laminin in skeletal muscle: Roles in pathophysiology and therapy of muscular dystrophy.)
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Publications

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Rooney JE, Knapp JR, Hodges BL, et al. (2012) Laminin-111 protein therapy reduces muscle pathology and improves viability of a mouse model of merosin-deficient congenital muscular dystrophy. The American Journal of Pathology. 180: 1593-602
Doe JA, Wuebbles RD, Allred ET, et al. (2011) Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A. Journal of Cell Science. 124: 2287-97
Welser JV, Rooney JE, Cohen NC, et al. (2009) Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin. The American Journal of Pathology. 175: 1545-54
Rooney JE, Gurpur PB, Burkin DJ. (2009) Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 106: 7991-6
Rooney JE, Gurpur PB, Yablonka-Reuveni Z, et al. (2009) Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy. The American Journal of Pathology. 174: 256-64
Rooney JE, Welser JV, Dechert MA, et al. (2006) Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin. Journal of Cell Science. 119: 2185-95
Flintoff-Dye NL, Welser J, Rooney J, et al. (2005) Role for the alpha7beta1 integrin in vascular development and integrity. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 234: 11-21
Fertala A, Westerhausen A, Morris G, et al. (1993) Two cysteine substitutions in procollagen I: a glycine replacement near the N-terminus of alpha 1(I) chain causes lethal osteogenesis imperfecta and a glycine replacement in the alpha 2(I) chain markedly destabilizes the triple helix. The Biochemical Journal. 289: 195-9
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