Frances H. Arnold
Affiliations: | California Institute of Technology, Pasadena, CA |
Area:
Protein engineering, directed protein evolution, structure-guided protein recombination, biocatalysis, biofuelsWebsite:
http://www.che.caltech.edu/faculty/arnold_f/index.htmlGoogle:
"Frances Arnold"Bio:
http://www.nasonline.org/member-directory/members/2534069.html
http://scholar.google.com/citations?user=wil5NhcAAAAJ&hl=en
The Nobel Prize in Chemistry 2018 was divided, one half awarded to Frances H. Arnold "for the directed evolution of enzymes", the other half jointly to George P. Smith and Sir Gregory P. Winter "for the phage display of peptides and antibodies."
Mean distance: 7.74
Parents
Sign in to add mentor| Harvey W. Blanch | grad student | 1985 | UC Berkeley | |
| (Design and scale-up of affinity separations) | ||||
| Ignacio Tinoco | post-doc | 1986 | UC Berkeley | |
Children
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Publications
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| Johnston KE, Almhjell PJ, Watkins-Dulaney EJ, et al. (2024) A combinatorially complete epistatic fitness landscape in an enzyme active site. Proceedings of the National Academy of Sciences of the United States of America. 121: e2400439121 |
| Mao R, Gao S, Qin ZY, et al. (2024) Biocatalytic, Enantioenriched Primary Amination of Tertiary C-H Bonds. Nature Catalysis. 7: 585-592 |
| Yang J, Li FZ, Arnold FH. (2024) Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering. Acs Central Science. 10: 226-241 |
| Wackelin DJ, Mao R, Sicinski KM, et al. (2024) Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society |
| Mao R, Taylor DM, Wackelin DJ, et al. (2023) Biocatalytic, Stereoconvergent Alkylation of ()-Trisubstituted Silyl Enol Ethers. Nature Synthesis. 3: 256-264 |
| Qin ZY, Gao S, Zou Y, et al. (2023) Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp)-H Amination. Acs Central Science. 9: 2333-2338 |
| Mao R, Wackelin DJ, Jamieson CS, et al. (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (/)-Trisubstituted Enol Acetates. Journal of the American Chemical Society |
| Calvó-Tusell C, Liu Z, Chen K, et al. (2023) Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering. Angewandte Chemie (International Ed. in English). e202303879 |
| Mao R, Wackelin DJ, Jamieson CS, et al. (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Research Square |
| Zhang J, Maggiolo AO, Alfonzo E, et al. (2023) Chemodivergent C(sp)-H and C(sp)-H Cyanomethylation Using Engineered Carbene Transferases. Nature Catalysis. 6: 152-160 |