Pamela J. McLean, Ph.D.

Neuroscience Mayo Clinic Florida 
Parkinson's disease, alpha-synuclein
"Pamela J. McLean"
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Sun J, Carlson-Stevermer J, Das U, et al. (2019) CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nature Communications. 10: 53
Jiang P, Gan M, Yen SH, et al. (2017) Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates. Scientific Reports. 7: 7690
von Einem B, Eschbach J, Kiechle M, et al. (2017) The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion. Aging
Delenclos M, Faroqi AH, Yue M, et al. (2017) Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain. Acta Neuropathologica Communications. 5: 51
Delenclos M, Trendafilova T, Mahesh D, et al. (2017) Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein. Frontiers in Neuroscience. 11: 172
Jiang P, Gan M, Yen SH, et al. (2016) Histones facilitate α-synuclein aggregation during neuronal apoptosis. Acta Neuropathologica
Helferich AM, McLean PJ, Weishaupt JH, et al. (2016) Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization. Journal of Neurology & Neuromedicine. 1: 28-30
Levin J, Hillmer AS, Högen T, et al. (2016) Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy. Biochemical and Biophysical Research Communications
Jiang P, Gan M, Yen SH, et al. (2016) Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons. Acta Neuropathologica
Delenclos M, Trendafilova T, Jones DR, et al. (2015) A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo. Frontiers in Neuroscience. 9: 511
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