Pamela J. McLean, Ph.D.

Neuroscience Mayo Clinic Florida 
Parkinson's disease, alpha-synuclein
"Pamela J. McLean"
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Soto-Beasley AI, Walton RL, Valentino RR, et al. (2020) Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease. Parkinsonism & Related Disorders. 78: 138-144
Zhao N, Attrebi ON, Ren Y, et al. (2020) APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Science Translational Medicine. 12
Park JH, Burgess JD, Faroqi AH, et al. (2020) Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway. Molecular Neurodegeneration. 15: 5
Kiechle M, von Einem B, Höfs L, et al. (2019) In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species. Cell Reports. 29: 2862-2874.e9
Grozdanov V, Bousset L, Hoffmeister M, et al. (2019) Increased immune activation by pathologic alpha-synuclein in Parkinson's Disease. Annals of Neurology
Delenclos M, Burgess JD, Lamprokostopoulou A, et al. (2019) Cellular models of alpha-synuclein toxicity and aggregation. Journal of Neurochemistry
Sun J, Carlson-Stevermer J, Das U, et al. (2019) CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nature Communications. 10: 53
Jiang P, Gan M, Yen SH, et al. (2017) Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates. Scientific Reports. 7: 7690
von Einem B, Eschbach J, Kiechle M, et al. (2017) The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion. Aging
Delenclos M, Faroqi AH, Yue M, et al. (2017) Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain. Acta Neuropathologica Communications. 5: 51
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