Sascha Weggen, Dr. rer. nat.

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Fritzen L, Wienken K, Wagner L, et al. (2024) Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier. Fluids and Barriers of the Cns. 21: 74
Wirths O, Lehnen C, Fricke M, et al. (2024) Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains. Neuropathology and Applied Neurobiology. 50: e12991
Kurth V, Ogorek I, Münch C, et al. (2023) Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild type PSEN1. The Journal of Biological Chemistry. 104997
Klecker PH, Fritzen L, Mazura AD, et al. (2023) Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy. Journal of Cellular Biochemistry
Bader AS, Gnädig MU, Fricke M, et al. (2023) Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice. Life (Basel, Switzerland). 13
Mazura AD, Ohler A, Storck SE, et al. (2022) PCSK9 acts as a key regulator of Aβ clearance across the blood-brain barrier. Cellular and Molecular Life Sciences : Cmls. 79: 212
Marengo L, Armbrust F, Schoenherr C, et al. (2022) Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Cellular and Molecular Life Sciences : Cmls. 79: 168
Stazi M, Lehmann S, Sakib MS, et al. (2021) Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis. Cellular and Molecular Life Sciences : Cmls. 79: 55
Aichholzer F, Klafki HW, Ogorek I, et al. (2021) Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer's disease. Alzheimer's Research & Therapy. 13: 94
Walter S, Jumpertz T, Hüttenrauch M, et al. (2018) The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Acta Neuropathologica