Greg M. Delgoffe, Ph.D.
Affiliations: | 2010 | Johns Hopkins University, Baltimore, MD |
Area:
ImmunologyGoogle:
"Greg Delgoffe"Parents
Sign in to add mentor| Jonathan Powell | grad student | 2010 | Johns Hopkins | |
| (mTOR signaling dictates T cell fate.) | ||||
Collaborators
Sign in to add collaborator| Utku M. Sönmez | collaborator | 2018- | University of Pittsburgh (Biomechanics Tree) |
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Publications
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| Kumar A, Delgoffe GM. (2023) Redox and detox: Malate shuttle metabolism keeps exhausted T cells fit. Cell Metabolism. 35: 2101-2103 |
| Lontos K, Wang Y, Joshi SK, et al. (2023) Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors. Journal For Immunotherapy of Cancer. 11 |
| Ding J, Guyette S, Schrand B, et al. (2023) Mesothelin-targeting T cells bearing a novel T cell receptor fusion construct (TRuC) exhibit potent antitumor efficacy against solid tumors. Oncoimmunology. 12: 2182058 |
| Vendetti FP, Pandya P, Clump DA, et al. (2023) The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy. Jci Insight. 8 |
| Vignali PDA, DePeaux K, Watson MJ, et al. (2022) Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity. Nature Immunology |
| Lontos K, Wang Y, Colbert M, et al. (2022) Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology. Oncoimmunology. 11: 2131229 |
| Sugitani N, Vendetti FP, Cipriano AJ, et al. (2022) Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression. Cell Reports. 40: 111371 |
| Ford BR, Vignali PDA, Rittenhouse NL, et al. (2022) Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells. Science Immunology. 7: eabj9123 |
| Banerjee H, Nieves-Rosado H, Kulkarni A, et al. (2021) Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment. Cell Reports. 36: 109699 |
| Zhao S, Peralta RM, Avina-Ochoa N, et al. (2021) Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet. Seminars in Immunology. 101485 |