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Yam B. Poudel, Ph D

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Organic chemistry
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"Yam Poudel"
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http://proquest.umi.com/pqdlink?did=2265894741&Fmt=7&clientI d=79356&RQT=309&VName=PQD

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Parents

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Gary Eugene Keck grad student 2011 University of Utah
 (The total synthesis and biological evaluation of bryostatin 1 and its analogues)
Dale L. Boger post-doc 2011- Scripps Institute

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Publications

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Poudel YB, Rao C, Kotapati S, et al. (2019) Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates. Bioorganic & Medicinal Chemistry Letters. 126782
Nicolaou KC, Wang Y, Lu M, et al. (2016) Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations. Journal of the American Chemical Society
Lee K, Poudel YB, Glinkerman CM, et al. (2015) Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs. Tetrahedron. 71: 5897-5905
Lee K, Poudel YB, Glinkerman CM, et al. (2015) Total synthesis of dihydrolysergic acid and dihydrolysergol: Development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs Tetrahedron
Kraft MB, Poudel YB, Kedei N, et al. (2014) Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core. Journal of the American Chemical Society. 136: 13202-8
Kedei N, Lewin NE, Géczy T, et al. (2013) Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1. Acs Chemical Biology. 8: 767-77
Breazzano SP, Poudel YB, Boger DL. (2013) A Pd(0)-mediated indole (macro)cyclization reaction. Journal of the American Chemical Society. 135: 1600-6
Kedei N, Telek A, Michalowski AM, et al. (2013) Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochemical Pharmacology. 85: 313-24
Keck GE, Poudel YB, Rudra A, et al. (2012) Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity. Bioorganic & Medicinal Chemistry Letters. 22: 4084-8
Kedei N, Telek A, Michalowski AM, et al. (2012) Abstract 3815: Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogues in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action Cancer Research. 72: 3815-3815
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