William Rudolf Kobertz, PhD
Affiliations: | 1997 | Chemistry | University of Massachusetts Medical School, Worcester, MA, United States |
Area:
Ion ChannelsWebsite:
https://profiles.umassmed.edu/display/133220Google:
"William Kobertz"Bio:
Kobertz, William Rudolf, Total synthesis of a Furan-side psoralen-thymidine monoadduct and its biochemical applications Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
Our laboratory investigates the glycosylation, assembly, structure, trafficking and function of ion channel complexes. We rely on traditional electrophysiological, biochemical, and imaging modalities, but we also design, develop, and utilize novel chemical tools to interrogate a wide variety of ion channels and membrane transport proteins responsible for cardiac and neuronal function. Thus, we have synthetic organic chemists, glycobiologists, membrane protein biochemists, and electrophysiologists working together to elucidate the molecular underpinnings of these membrane transport proteins in both healthy and diseased tissues.
Mean distance: (not calculated yet)
Parents
Sign in to add mentor| John M. Essigmann | grad student | 1998 | MIT (Chemistry Tree) | |
| (Total synthesis of a Furan-side psoralen-thymidine monoadduct and its biochemical applications.) | ||||
| Gerald Norman Wogan | grad student | 1998 | MIT (Chemistry Tree) | |
| (co-advisor) | ||||
| Christopher Miller | post-doc | Brandeis (Chemistry Tree) | ||
Children
Sign in to add trainee| Lejie Zhang | grad student | 2012- | University of Massachusetts Medical School |
| Daniel Armon Gutierrez | grad student | 2015- | University of Massachusetts Medical School |
| Karen Mruk | grad student | 2005-2012 | University of Massachusetts Medical School |
| Kevin Michael O'Brien | post-doc | 2016- | University of Massachusetts Medical School |
Publications
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| Zhang L, Zhang M, Bellve K, et al. (2020) Wheat germ agglutinin-conjugated fluorescent pH sensors for visualizing proton fluxes. The Journal of General Physiology. 152 |
| Kobertz WR. (2018) Oddballs in the Shaker family: Kv2-related regulatory subunits. The Journal of General Physiology |
| Velentzas PD, Zhang L, Das G, et al. (2018) The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. Developmental Cell |
| Bandara HMD, Hua Z, Zhang M, et al. (2017) Palladium-mediated Synthesis of a Near-IR Fluorescent K(+) Sensor. The Journal of Organic Chemistry |
| Zhang L, Bellve K, Fogarty K, et al. (2016) Fluorescent Visualization of Cellular Proton Fluxes. Cell Chemical Biology. 23: 1449-1457 |
| Öktem EK, Mruk K, Chang J, et al. (2016) Erratum to: Mutant SOD1 protein increases Nav1.3 channel excitability. Journal of Biological Physics |
| Kubat Öktem E, Mruk K, Chang J, et al. (2016) Mutant SOD1 protein increases Nav1.3 channel excitability. Journal of Biological Physics |
| Bandara D, Hua Z, Pauff S, et al. (2016) A Near-Ir Fluorescent Sensor for Detecting Cellular Potassium Efflux Biophysical Journal. 110 |
| Mruk K, Kobertz WR. (2015) Bioreactive Tethers. Advances in Experimental Medicine and Biology. 869: 77-100 |
| Mruk K, Farley BM, Ritacco AW, et al. (2014) Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering. The Journal of General Physiology. 144: 105-14 |