Carlos Cruchaga

Affiliations: 
Washington University School of Medicine, St. Louis, MO, United States 
Area:
Alzheimer's, genetics, genomics, quantitative traits, WES, WGS, proteomics
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"Carlos Cruchaga"
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Publications

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Dammer EB, Shantaraman A, Ping L, et al. (2024) Proteomic analysis of Alzheimer's disease cerebrospinal fluid reveals alterations associated with ε4 and atomoxetine treatment. Science Translational Medicine. 16: eadn3504
Narasimhan S, Holtzman DM, Apostolova LG, et al. (2024) Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway. Nature Neuroscience
Manzoni C, Kia DA, Ferrari R, et al. (2024) Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia. American Journal of Human Genetics
Cruchaga C, Bradley J, Western D, et al. (2024) Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways. Research Square
Panyard DJ, Reus LM, Ali M, et al. (2024) Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Hermes S, Cady J, Armentrout S, et al. (2024) Epistatic Features and Machine Learning Improve Alzheimer's Disease Risk Prediction Over Polygenic Risk Scores. Journal of Alzheimer's Disease : Jad
Wagemann O, Liu H, Wang G, et al. (2024) Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial. Jama Neurology
Levin J, Baiardi S, Quadalti C, et al. (2024) α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Wisch JK, McKay NS, Boerwinkle AH, et al. (2024) Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. 23: 500-510
Yi H, Yang Q, Repaci C, et al. (2024) TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma. Scientific Data. 11: 387
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