| Year |
Citation |
Score |
| 2024 |
Doering S, McCullough A, Gordon BA, Chen CD, McKay N, Hobbs D, Keefe S, Flores S, Scott J, Smith H, Jarman S, Jackson K, Hornbeck RC, Ances BM, Xiong C, ... ... Cruchaga C, et al. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging. Ebiomedicine. 103: 105080. PMID 38552342 DOI: 10.1016/j.ebiom.2024.105080 |
0.337 |
|
| 2024 |
Meeker KL, Luckett PH, Barthélemy NR, Hobbs DA, Chen C, Bollinger J, Ovod V, Flores S, Keefe S, Henson RL, Herries EM, McDade E, Hassenstab JJ, Xiong C, Cruchaga C, et al. Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer's disease. Brain Communications. 6: fcae081. PMID 38505230 DOI: 10.1093/braincomms/fcae081 |
0.335 |
|
| 2024 |
Cruchaga C, Ali M, Shen Y, Do A, Wang L, Western D, Liu M, Beric A, Budde J, Gentsch J, Schindler S, Morris J, Holtzman D, Fernández M, Ruiz A, et al. Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research Square. PMID 38410465 DOI: 10.21203/rs.3.rs-3631708/v1 |
0.359 |
|
| 2024 |
Joseph-Mathurin N, Feldman RL, Lu R, Shirzadi Z, Toomer C, Saint Clair JR, Ma Y, McKay NS, Strain JF, Kilgore C, Friedrichsen KA, Chen CD, Gordon BA, Chen G, Hornbeck RC, ... ... Cruchaga C, et al. Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38380882 DOI: 10.1002/alz.13729 |
0.309 |
|
| 2024 |
Wang Q, Schindler SE, Chen G, Mckay NS, McCullough A, Flores S, Liu J, Sun Z, Wang S, Wang W, Hassenstab J, Cruchaga C, Perrin RJ, Fagan AM, Morris JC, et al. Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging. Neurology. 102: e208013. PMID 38315956 DOI: 10.1212/WNL.0000000000208013 |
0.355 |
|
| 2024 |
Shen Y, Ali M, Timsina J, Wang C, Do A, Western D, Liu M, Gorijala P, Budde J, Liu H, Gordon B, McDade E, Morris JC, Llibre-Guerra JJ, Bateman RJ, ... ... Cruchaga C, et al. Systematic proteomics in Autosomal dominant Alzheimer's disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathways. Medrxiv : the Preprint Server For Health Sciences. PMID 38260583 DOI: 10.1101/2024.01.12.24301242 |
0.62 |
|
| 2024 |
Vance JM, Farrer LA, Huang Y, Cruchaga C, Hyman BT, Pericak-Vance MA, Goate AM, Greicius MD, Griswold AJ, Haines JL, Tcw J, Schellenberg GD, Tsai LH, Herz J, Holtzman DM. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of Neurology. PMID 38180638 DOI: 10.1002/ana.26864 |
0.665 |
|
| 2024 |
Wang L, Nykänen NP, Western D, Gorijala P, Timsina J, Li F, Wang Z, Ali M, Yang C, Liu M, Brock W, Marquié M, Boada M, Alvarez I, Aguilar M, ... ... Cruchaga C, et al. Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease. Molecular Neurodegeneration. 19: 1. PMID 38172904 DOI: 10.1186/s13024-023-00687-4 |
0.857 |
|
| 2023 |
Gunasekaran TI, Reyes-Dumeyer D, Faber KM, Goate A, Boeve B, Cruchaga C, Pericak-Vance M, Haines JL, Rosenberg R, Tsuang D, Mejia DR, Medrano M, Lantigua RA, Sweet RA, Bennett DA, et al. Identification of Rare Damaging Missense and Loss of Function Variants in GWAS Loci Using Genome Sequencing Data from Two Cohorts of Familial Late-Onset Alzheimer's Disease. Medrxiv : the Preprint Server For Health Sciences. PMID 38196599 DOI: 10.1101/2023.12.18.23300145 |
0.667 |
|
| 2023 |
Millar PR, Gordon BA, Wisch JK, Schultz SA, Benzinger TL, Cruchaga C, Hassenstab JJ, Ibanez L, Karch C, Llibre-Guerra JJ, Morris JC, Perrin RJ, Supnet-Bell C, Xiong C, Allegri RF, et al. Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease. Molecular Neurodegeneration. 18: 98. PMID 38111006 DOI: 10.1186/s13024-023-00688-3 |
0.762 |
|
| 2023 |
Cisterna-García A, Beric A, Ali M, Pardo JA, Chen HH, Fernandez MV, Norton J, Gentsch J, Bergmann K, Budde J, Perlmutter JS, Morris JC, Cruchaga C, Botia JA, Ibanez L. Cell-free RNA signatures predict Alzheimer's disease. Iscience. 26: 108534. PMID 38089583 DOI: 10.1016/j.isci.2023.108534 |
0.769 |
|
| 2023 |
Timsina J, Ali M, Do A, Wang L, Western D, Sung YJ, Cruchaga C. Harmonization of CSF and imaging biomarkers in Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification. Neurobiology of Disease. 190: 106373. PMID 38072165 DOI: 10.1016/j.nbd.2023.106373 |
0.317 |
|
| 2023 |
Dammer EB, Shantaraman A, Ping L, Duong DM, Gerasimov ES, Ravindran SP, Gudmundsdottir V, Frick EA, Gomez GT, Walker KA, Emilsson V, Jennings LL, Gudnason V, Western D, Cruchaga C, et al. Proteomic Network Analysis of Alzheimer's Disease Cerebrospinal Fluid Reveals Alterations Associated with ε4 Genotype and Atomoxetine Treatment. Medrxiv : the Preprint Server For Health Sciences. PMID 37961720 DOI: 10.1101/2023.10.29.23297651 |
0.386 |
|
| 2023 |
Iglesia MD, Jayasinghe RG, Chen S, Terekhanova NV, Herndon JM, Storrs E, Karpova A, Zhou DC, Al Deen NN, Shinkle AT, Lu RJ, Caravan W, Houston A, Zhao Y, Sato K, ... ... Cruchaga C, et al. Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages. Biorxiv : the Preprint Server For Biology. PMID 37961519 DOI: 10.1101/2023.10.31.565031 |
0.697 |
|
| 2023 |
Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, et al. Frequency of Variants in Mendelian Alzheimer's Disease Genes within the Alzheimer's Disease Sequencing Project (ADSP). Medrxiv : the Preprint Server For Health Sciences. PMID 37961373 DOI: 10.1101/2023.10.24.23297227 |
0.65 |
|
| 2023 |
Gorijala P, Aslam MM, Dang LT, Xicota L, Fernandez MV, Sung YJ, Fan KH, Feingold E, Surace EI, Chhatwal JP, Hom CL, Hartley SL, Hassenstab J, Perrin RJ, Mapstone M, ... ... Cruchaga C, et al. Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37855447 DOI: 10.1002/alz.13506 |
0.609 |
|
| 2023 |
Shirzadi Z, Schultz SA, Yau WW, Joseph-Mathurin N, Fitzpatrick CD, Levin R, Kantarci K, Preboske GM, Jack CR, Farlow MR, Hassenstab J, Jucker M, Morris JC, Xiong C, Karch CM, ... ... Cruchaga C, et al. Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease. Jama Neurology. PMID 37843849 DOI: 10.1001/jamaneurol.2023.3618 |
0.746 |
|
| 2023 |
Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, ... ... Cruchaga C, et al. Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning. Genome Medicine. 15: 79. PMID 37794492 DOI: 10.1186/s13073-023-01233-z |
0.457 |
|
| 2023 |
Wagemann O, Li Y, Hassenstab J, Aschenbrenner AJ, McKay NS, Gordon BA, Benzinger TLS, Xiong C, Cruchaga C, Renton AE, Perrin RJ, Berman SB, Chhatwal JP, Farlow MR, Day GS, et al. Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37740921 DOI: 10.1002/alz.13460 |
0.339 |
|
| 2023 |
Quintá HR, Ibanez L, Cruchaga C, Maschi D. Editorial: Molecular and cellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways in neurological disorders. Frontiers in Aging Neuroscience. 15: 1267033. PMID 37637960 DOI: 10.3389/fnagi.2023.1267033 |
0.575 |
|
| 2023 |
Johnson ECB, Bian S, Haque RU, Carter EK, Watson CM, Gordon BA, Ping L, Duong DM, Epstein MP, McDade E, Barthélemy NR, Karch CM, Xiong C, Cruchaga C, Perrin RJ, et al. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease. Nature Medicine. PMID 37550416 DOI: 10.1038/s41591-023-02476-4 |
0.664 |
|
| 2023 |
Dawson T, Rentia U, Sanford J, Cruchaga C, Kauwe JSK, Crandall KA. Locus specific endogenous retroviral expression associated with Alzheimer's disease. Frontiers in Aging Neuroscience. 15: 1186470. PMID 37484691 DOI: 10.3389/fnagi.2023.1186470 |
0.358 |
|
| 2023 |
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, ... ... Cruchaga C, et al. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. Medrxiv : the Preprint Server For Health Sciences. PMID 37461624 DOI: 10.1101/2023.07.06.23292311 |
0.843 |
|
| 2023 |
McKay NS, Gordon BA, Hornbeck RC, Dincer A, Flores S, Keefe SJ, Joseph-Mathurin N, Jack CR, Koeppe R, Millar PR, Ances BM, Chen CD, Daniels A, Hobbs DA, Jackson K, ... ... Cruchaga C, et al. Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nature Neuroscience. PMID 37429916 DOI: 10.1038/s41593-023-01359-8 |
0.639 |
|
| 2023 |
Phillips B, Western D, Wang L, Timsina J, Sun Y, Gorijala P, Yang C, Do A, Nykänen NP, Alvarez I, Aguilar M, Pastor P, Morris JC, Schindler SE, Fagan AM, ... ... Cruchaga C, et al. Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease. Npj Parkinson's Disease. 9: 107. PMID 37422510 DOI: 10.1038/s41531-023-00555-4 |
0.804 |
|
| 2023 |
Sung YJ, Yang C, Norton J, Johnson M, Fagan A, Bateman RJ, Perrin RJ, Morris JC, Farlow MR, Chhatwal JP, Schofield PR, Chui H, Wang F, Novotny B, Eteleeb A, ... ... Cruchaga C, et al. Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease. Science Translational Medicine. 15: eabq5923. PMID 37406134 DOI: 10.1126/scitranslmed.abq5923 |
0.85 |
|
| 2023 |
Ray NR, Ayodele T, Jean-Francois M, Baez P, Fernandez V, Bradley J, Crane PK, Dalgard CL, Kuzma A, Nicaretta H, Sims R, Williams J, Cuccaro ML, Pericak-Vance MA, Mayeux R, ... ... Cruchaga C, et al. The Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37390458 DOI: 10.1002/alz.13370 |
0.43 |
|
| 2023 |
Cruchaga C, Western D, Timsina J, Wang L, Wang C, Yang C, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey A, Morris J, Perrin R, Ruiz A, et al. Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease. Research Square. PMID 37333337 DOI: 10.21203/rs.3.rs-2814616/v1 |
0.853 |
|
| 2023 |
Wang C, Western D, Yang C, Ali M, Wang L, Gorijala P, Timsina J, Ruiz A, Pastor P, Fernandez M, Panyard D, Engelman C, Deming Y, Boada M, Cano A, ... ... Cruchaga C, et al. Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness. Research Square. PMID 37333177 DOI: 10.21203/rs.3.rs-2923409/v1 |
0.805 |
|
| 2023 |
Ferreiro AL, Choi J, Ryou J, Newcomer EP, Thompson R, Bollinger RM, Hall-Moore C, Ndao IM, Sax L, Benzinger TLS, Stark SL, Holtzman DM, Fagan AM, Schindler SE, Cruchaga C, et al. Gut microbiome composition may be an indicator of preclinical Alzheimer's disease. Science Translational Medicine. 15: eabo2984. PMID 37315112 DOI: 10.1126/scitranslmed.abo2984 |
0.381 |
|
| 2023 |
Timsina J, Ali M, Do A, Wang L, Sung YJ, Cruchaga C. Harmonization of CSF and imaging biomarkers for Alzheimer's disease biomarkers: need and practical applications for genetics studies and preclinical classification. Biorxiv : the Preprint Server For Biology. PMID 37292823 DOI: 10.1101/2023.05.24.542118 |
0.377 |
|
| 2023 |
Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, et al. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging Cell. e13871. PMID 37291760 DOI: 10.1111/acel.13871 |
0.736 |
|
| 2023 |
Panyard DJ, McKetney J, Deming YK, Morrow AR, Ennis GE, Jonaitis EM, Van Hulle CA, Yang C, Sung YJ, Ali M, Kollmorgen G, Suridjan I, Bayfield A, Bendlin BB, Zetterberg H, ... ... Cruchaga C, et al. Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37218097 DOI: 10.1002/alz.13130 |
0.835 |
|
| 2023 |
Bradley J, Gorijala P, Schindler SE, Sung YJ, Ances B, Neuroimaging Initiative The Human Connectome Project TAD, Fernandez MV, Cruchaga C. Genetic architecture of plasma Alzheimer disease biomarkers. Human Molecular Genetics. PMID 37208024 DOI: 10.1093/hmg/ddad087 |
0.631 |
|
| 2023 |
Ali M, Archer DB, Gorijala P, Western D, Timsina J, Fernández MV, Wang TC, Satizabal CL, Yang Q, Beiser AS, Wang R, Chen G, Gordon B, Benzinger TLS, Xiong C, ... ... Cruchaga C, et al. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. Acta Neuropathologica Communications. 11: 68. PMID 37101235 DOI: 10.1186/s40478-023-01563-4 |
0.796 |
|
| 2023 |
Aschenbrenner AJ, Hassenstab J, Morris JC, Cruchaga C, Jackson JJ. Relationships between hourly cognitive variability and risk of Alzheimer's disease revealed with mixed-effects location scale models. Neuropsychology. PMID 37079810 DOI: 10.1037/neu0000905 |
0.317 |
|
| 2023 |
Chen CD, McCullough A, Gordon B, Joseph-Mathurin N, Flores S, McKay NS, Hobbs DA, Hornbeck R, Fagan AM, Cruchaga C, Goate AM, Perrin RJ, Wang G, Li Y, Shi X, et al. Longitudinal head-to-head comparison of C-PiB and F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. PMID 37017737 DOI: 10.1007/s00259-023-06209-0 |
0.547 |
|
| 2023 |
Nho K, Risacher SL, Apostolova L, Bice PJ, Brosch J, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, ... ... Cruchaga C, et al. Novel Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET. Medrxiv : the Preprint Server For Health Sciences. PMID 36993271 DOI: 10.1101/2023.02.27.23286048 |
0.428 |
|
| 2023 |
Pettigrew C, Nazarovs J, Soldan A, Singh V, Wang J, Hohman T, Dumitrescu L, Libby J, Kunkle B, Gross AL, Johnson S, Lu Q, Engelman C, Masters CL, Maruff P, ... ... Cruchaga C, et al. Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals. Alzheimer's Research & Therapy. 15: 66. PMID 36978190 DOI: 10.1186/s13195-023-01206-9 |
0.596 |
|
| 2023 |
Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton-Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, ... ... Cruchaga C, et al. Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36951251 DOI: 10.1002/alz.13021 |
0.74 |
|
| 2023 |
Qiao M, Lee AJ, Reyes-Dumeyer D, Tosto G, Faber K, Goate A, Renton A, Chao M, Boeve B, Cruchaga C, Pericak-Vance M, Haines JL, Rosenberg R, Tsuang D, Sweet RA, et al. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. Annals of Clinical and Translational Neurology. PMID 36946865 DOI: 10.1002/acn3.51757 |
0.606 |
|
| 2023 |
Xiong C, McCue LM, Buckles V, Grant E, Agboola F, Coble D, Bateman RJ, Fagan AM, Benzinger TLS, Hassenstab J, Schindler SE, McDade E, Moulder K, Gordon BA, Cruchaga C, et al. Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36640138 DOI: 10.1002/alz.12912 |
0.348 |
|
| 2023 |
Wheelock MD, Strain JF, Mansfield P, Tu JC, Tanenbaum A, Preische O, Chhatwal JP, Cash DM, Cruchaga C, Fagan AM, Fox NC, Graff-Radford NR, Hassenstab J, Jack CR, Karch CM, et al. Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease. Brain : a Journal of Neurology. PMID 36625756 DOI: 10.1093/brain/awac498 |
0.543 |
|
| 2022 |
Chatterjee P, Vermunt L, Gordon BA, Pedrini S, Boonkamp L, Armstrong NJ, Xiong C, Singh AK, Li Y, Sohrabi HR, Taddei K, Molloy M, Benzinger TLS, Morris JC, Karch C, ... ... Cruchaga C, et al. Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36576155 DOI: 10.1002/alz.12879 |
0.752 |
|
| 2022 |
Wisch JK, Butt OH, Gordon BA, Schindler SE, Fagan AM, Henson RL, Yang C, Boerwinkle AH, Benzinger TLS, Holtzman DM, Morris JC, Cruchaga C, Ances BM. Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression. Brain : a Journal of Neurology. PMID 36542469 DOI: 10.1093/brain/awac484 |
0.806 |
|
| 2022 |
O'Connor A, Rice H, Barnes J, Ryan NS, Liu KY, Allegri RF, Berman S, Ringman JM, Cruchaga C, Farlow MR, Hassenstab J, Lee JH, Perrin RJ, Xiong C, Gordon B, et al. First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 36522155 DOI: 10.1136/jnnp-2022-329843 |
0.605 |
|
| 2022 |
Jung SH, Kim HR, Chun MY, Jang H, Cho M, Kim B, Kim S, Jeong JH, Yoon SJ, Park KW, Kim EJ, Yoon B, Jang JW, Kim Y, Hong JY, ... ... Cruchaga C, et al. Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes. Jama Network Open. 5: e2247162. PMID 36520433 DOI: 10.1001/jamanetworkopen.2022.47162 |
0.424 |
|
| 2022 |
Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, ... ... Cruchaga C, et al. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. 22: 55-65. PMID 36517172 DOI: 10.1016/S1474-4422(22)00408-2 |
0.369 |
|
| 2022 |
Yang C, Fagan AM, Perrin RJ, Rhinn H, Harari O, Cruchaga C. Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes. Genome Medicine. 14: 140. PMID 36510323 DOI: 10.1186/s13073-022-01140-9 |
0.812 |
|
| 2022 |
Holstege H, Hulsman M, Charbonnier C, Grenier-Boley B, Quenez O, Grozeva D, van Rooij JGJ, Sims R, Ahmad S, Amin N, Norsworthy PJ, Dols-Icardo O, Hummerich H, Kawalia A, Amouyel P, ... ... Cruchaga C, et al. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease. Nature Genetics. PMID 36411364 DOI: 10.1038/s41588-022-01208-7 |
0.831 |
|
| 2022 |
Novotny BC, Fernandez MV, Wang C, Budde JP, Bergmann K, Eteleeb AM, Bradley J, Webster C, Ebl C, Norton J, Gentsch J, Dube U, Wang F, Morris JC, Bateman RJ, ... ... Cruchaga C, et al. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36251323 DOI: 10.1002/alz.12800 |
0.849 |
|
| 2022 |
Li F, Eteleeb AM, Buchser W, Sohn C, Wang G, Xiong C, Payne PR, McDade E, Karch CM, Harari O, Cruchaga C. Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease. Frontiers in Aging Neuroscience. 14: 935279. PMID 36238934 DOI: 10.3389/fnagi.2022.935279 |
0.834 |
|
| 2022 |
Hartz SM, Mozersky J, Schindler SE, Linnenbringer E, Wang J, Gordon BA, Raji CA, Moulder KL, West T, Benzinger TLS, Cruchaga C, Hassenstab JJ, Bierut LJ, Xiong C, Morris JC. A flexible modeling approach for biomarker-based computation of absolute risk of Alzheimer's disease dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36178120 DOI: 10.1002/alz.12781 |
0.4 |
|
| 2022 |
Jansen IE, van der Lee SJ, Gomez-Fonseca D, de Rojas I, Dalmasso MC, Grenier-Boley B, Zettergren A, Mishra A, Ali M, Andrade V, Bellenguez C, Kleineidam L, Küçükali F, Sung YJ, Tesí N, ... ... Cruchaga C, et al. Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers. Acta Neuropathologica. PMID 36066633 DOI: 10.1007/s00401-022-02454-z |
0.77 |
|
| 2022 |
Takada LT, Aláez-Verson C, Burgute BD, Nitrini R, Sosa AL, Castilhos RM, Chaves MF, Longoria EM, Carrillo-Sánchez K, Brucki SMD, Flores-Lagunes LL, Molina C, Olivares MJ, Ziegemeier E, Petranek J, ... ... Cruchaga C, et al. Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America. Alzheimer's Research & Therapy. 14: 108. PMID 35932032 DOI: 10.1186/s13195-022-01052-1 |
0.795 |
|
| 2022 |
Luo J, Agboola F, Grant E, Morris JC, Masters CL, Albert MS, Johnson SC, McDade EM, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Wang G, Li Y, ... ... Cruchaga C, et al. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a Journal of Neurology. PMID 35925685 DOI: 10.1093/brain/awac238 |
0.304 |
|
| 2022 |
Cárcel-Márquez J, Muiño E, Gallego-Fabrega C, Cullell N, Lledós M, Llucià-Carol L, Sobrino T, Campos F, Castillo J, Freijo M, Arenillas JF, Obach V, Álvarez-Sabín J, Molina CA, Ribó M, ... ... Cruchaga C, et al. A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype. Frontiers in Cardiovascular Medicine. 9: 940696. PMID 35872910 DOI: 10.3389/fcvm.2022.940696 |
0.593 |
|
| 2022 |
Timsina J, Gomez-Fonseca D, Wang L, Do A, Western D, Alvarez I, Aguilar M, Pastor P, Henson RL, Herries E, Xiong C, Schindler SE, Fagan AM, Bateman RJ, Farlow M, ... ... Cruchaga C, et al. Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach. Journal of Alzheimer's Disease : Jad. PMID 35871346 DOI: 10.3233/JAD-220399 |
0.666 |
|
| 2022 |
Long JM, Coble DW, Xiong C, Schindler SE, Perrin RJ, Gordon BA, Benzinger TLS, Grant E, Fagan AM, Harari O, Cruchaga C, Holtzman DM, Morris JC. Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes. Brain : a Journal of Neurology. PMID 35867858 DOI: 10.1093/brain/awac250 |
0.835 |
|
| 2022 |
Ali M, Sung YJ, Wang F, Fernández MV, Morris JC, Fagan AM, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleó A, Alcolea D, Clarimon J, ... ... Cruchaga C, et al. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. Plos One. 17: e0267298. PMID 35617280 DOI: 10.1371/journal.pone.0267298 |
0.647 |
|
| 2022 |
Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, et al. Autosomal dominant and sporadic late onset Alzheimer disease share a common in vivo pathophysiology. Brain : a Journal of Neurology. PMID 35580594 DOI: 10.1093/brain/awac181 |
0.663 |
|
| 2022 |
Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, ... ... Cruchaga C, et al. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain : a Journal of Neurology. PMID 35552371 DOI: 10.1093/brain/awac177 |
0.629 |
|
| 2022 |
Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, et al. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Science Translational Medicine. 14: eabk0135. PMID 35442704 DOI: 10.1126/scitranslmed.abk0135 |
0.579 |
|
| 2022 |
Myers PS, O'Donnell JL, Jackson JJ, Lessov-Schlaggar CN, Miller RL, Foster ER, Cruchaga C, Benitez BA, Kotzbauer PT, Perlmutter JS, Campbell MC. Proteinopathy and Longitudinal Cognitive Decline in Parkinson Disease. Neurology. PMID 35418463 DOI: 10.1212/WNL.0000000000200344 |
0.627 |
|
| 2022 |
Couto B, Martinez-Valbuena I, Lee S, Alfradique-Dunham I, Perrin RJ, Perlmutter JS, Cruchaga C, Kim A, Visanji N, Sato C, Rogaeva E, Lang AE, Kovacs GG. Protracted Course-Progressive Supranuclear Palsy (PC-PSP). European Journal of Neurology. PMID 35384155 DOI: 10.1111/ene.15346 |
0.339 |
|
| 2022 |
Luckett PH, Chen C, Gordon BA, Wisch J, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, et al. Biomarker clustering in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35362200 DOI: 10.1002/alz.12661 |
0.647 |
|
| 2022 |
Strain JF, Barthelemy N, Horie K, Gordon BA, Kilgore C, Aschenbrenner A, Cruchaga C, Xiong C, Joseph-Mathurin N, Hassenstab J, Fagan AM, Li Y, Karch CM, Perrin RJ, Berman SB, et al. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease. Neurobiology of Disease. 168: 105714. PMID 35358703 DOI: 10.1016/j.nbd.2022.105714 |
0.645 |
|
| 2022 |
Wang Q, Chen G, Schindler SE, Christensen J, McKay NS, Liu J, Wang S, Sun Z, Hassenstab J, Su Y, Flores S, Hornbeck R, Cash L, Cruchaga C, Fagan AM, et al. Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease. Neurology(R) Neuroimmunology & Neuroinflammation. 9. PMID 35260470 DOI: 10.1212/NXI.0000000000001152 |
0.361 |
|
| 2022 |
Chen HH, Eteleeb A, Wang C, Fernandez MV, Budde JP, Bergmann K, Norton J, Wang F, Ebl C, Morris JC, Perrin RJ, Bateman RJ, McDade E, Xiong C, Goate A, ... ... Cruchaga C, et al. Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease. Acta Neuropathologica Communications. 10: 29. PMID 35246267 DOI: 10.1186/s40478-022-01328-5 |
0.826 |
|
| 2022 |
Ibanez L, Heitsch L, Carrera C, Farias FHG, Del Aguila JL, Dhar R, Budde J, Bergmann K, Bradley J, Harari O, Phuah CL, Lemmens R, Viana Oliveira Souza AA, Moniche F, Cabezas-Juan A, ... ... Cruchaga C, et al. Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke. Brain : a Journal of Neurology. PMID 35213696 DOI: 10.1093/brain/awac080 |
0.799 |
|
| 2022 |
Neupane A, Lenny B, Budde JP, Wang F, Norton J, Morris JC, Cruchaga C, Fernández MV. Replication study of AD-associated rare variants. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35103389 DOI: 10.1002/alz.12583 |
0.6 |
|
| 2022 |
Lim YY, Maruff P, Barthélemy NR, Goate A, Hassenstab J, Sato C, Fagan AM, Benzinger TLS, Xiong C, Cruchaga C, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, et al. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. Jama Neurology. PMID 35099506 DOI: 10.1001/jamaneurol.2021.5181 |
0.607 |
|
| 2022 |
Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, ... ... Cruchaga C, et al. Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study. The Lancet. Neurology. 21: 140-152. PMID 35065037 DOI: 10.1016/S1474-4422(21)00375-6 |
0.813 |
|
| 2022 |
Bigley TM, Xiong M, Ali M, Chen Y, Wang C, Serrano JR, Eteleeb A, Harari O, Yang L, Patel SJ, Cruchaga C, Yokoyama WM, Holtzman DM. Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains. Molecular Neurodegeneration. 17: 10. PMID 35033173 DOI: 10.1186/s13024-021-00514-8 |
0.836 |
|
| 2022 |
Reyes-Dumeyer D, Faber K, Vardarajan B, Goate A, Renton A, Chao M, Boeve B, Cruchaga C, Pericak-Vance M, Haines JL, Rosenberg R, Tsuang D, Sweet RA, Bennett DA, Wilson RS, et al. The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34978149 DOI: 10.1002/alz.12514 |
0.649 |
|
| 2021 |
Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, Gauthier S, Benzinger TLS, Morris JC, Bateman RJ, Breitner JCS, et al. Accelerated functional brain aging in pre-clinical familial Alzheimer's disease. Nature Communications. 12: 5346. PMID 34504080 DOI: 10.1038/s41467-021-25492-9 |
0.361 |
|
| 2021 |
Li F, Eteleeb A, Buchser W, Wang G, Xiong C, Payne PR, McDade E, Karch CM, Harari O, Cruchaga C. Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 34494019 DOI: 10.1101/2021.08.30.458295 |
0.805 |
|
| 2021 |
Ibanez L, Cruchaga C, Fernández MV. Advances in Genetic and Molecular Understanding of Alzheimer's Disease. Genes. 12. PMID 34440421 DOI: 10.3390/genes12081247 |
0.788 |
|
| 2021 |
Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, et al. Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta Neuropathologica. PMID 34319442 DOI: 10.1007/s00401-021-02342-y |
0.681 |
|
| 2021 |
Muiño E, Cárcel-Márquez J, Carrera C, Llucià-Carol L, Gallego-Fabrega C, Cullell N, Lledós M, Castillo J, Sobrino T, Campos F, Rodríguez-Castro E, Millán M, Muñoz-Narbona L, Bustamante A, López-Cancio E, ... ... Cruchaga C, et al. Genetic Variation Is Associated with Post-Reperfusion Therapy Parenchymal Hematoma. A GWAS Meta-Analysis. Journal of Clinical Medicine. 10. PMID 34300314 DOI: 10.3390/jcm10143137 |
0.677 |
|
| 2021 |
Wani A, Zhu J, Ulrich JD, Eteleeb A, Sauerbeck AD, Reitz SJ, Arhzaouy K, Ikenaga C, Yuede CM, Pittman SK, Wang F, Li S, Benitez BA, Cruchaga C, Kummer TT, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Reports. 36: 109399. PMID 34289347 DOI: 10.1016/j.celrep.2021.109399 |
0.807 |
|
| 2021 |
Yang C, Farias FHG, Ibanez L, Suhy A, Sadler B, Fernandez MV, Wang F, Bradley JL, Eiffert B, Bahena JA, Budde JP, Li Z, Dube U, Sung YJ, Mihindukulasuriya KA, ... ... Cruchaga C, et al. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nature Neuroscience. PMID 34239129 DOI: 10.1038/s41593-021-00886-6 |
0.818 |
|
| 2021 |
Damotte V, van der Lee SJ, Chouraki V, Grenier-Boley B, Simino J, Adams H, Tosto G, White C, Terzikhan N, Cruchaga C, Knol MJ, Li S, Schraen S, Grove ML, Satizabal C, et al. Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34002480 DOI: 10.1002/alz.12333 |
0.336 |
|
| 2021 |
Butt OH, Meeker KL, Wisch JK, Schindler SE, Fagan AM, Benzinger TLS, Cruchaga C, Holtzman DM, Morris JC, Ances BM. Network dysfunction in cognitively normal APOE ε4 carriers is related to subclinical tau. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34002449 DOI: 10.1002/alz.12375 |
0.347 |
|
| 2021 |
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, ... ... Cruchaga C, et al. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature. PMID 33911285 DOI: 10.1038/s41586-021-03489-0 |
0.828 |
|
| 2021 |
Cárcel-Márquez J, Cullell N, Muiño E, Gallego-Fabrega C, Lledós M, Ibañez L, Krupinski J, Montaner J, Cruchaga C, Lee JM, Gill D, Paré G, Mola-Caminal M, Roquer J, Jimenez-Conde J, et al. Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study. Stroke. STROKEAHA120033041. PMID 33902302 DOI: 10.1161/STROKEAHA.120.033041 |
0.576 |
|
| 2021 |
Schindler SE, Cruchaga C, Joseph A, McCue L, Farias FHG, Wilkins CH, Deming Y, Henson RL, Mikesell RJ, Piccio L, Llibre-Guerra JJ, Moulder KL, Fagan AM, Ances BM, Benzinger TLS, et al. African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants. Neurology. Genetics. 7: e571. PMID 33884297 DOI: 10.1212/NXG.0000000000000571 |
0.804 |
|
| 2021 |
Qin W, Zhou A, Zuo X, Jia L, Li F, Wang Q, Li Y, Wei Y, Jin H, Cruchaga C, Benitez BA, Jia J. Exome sequencing revealed PDE11A as a novel candidate gene for early-onset Alzheimer's disease. Human Molecular Genetics. PMID 33835157 DOI: 10.1093/hmg/ddab090 |
0.731 |
|
| 2021 |
Butt OH, Long JM, Henson RL, Herries E, Sutphen CL, Fagan AM, Cruchaga C, Ladenson JH, Holtzman DM, Morris JC, Ances BM, Schindler SE. Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25. Neurobiology of Aging. 102: 64-72. PMID 33765432 DOI: 10.1016/j.neurobiolaging.2021.02.008 |
0.344 |
|
| 2021 |
Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, Hassenstab J, Gordon BA, Chhatwal JP, Levin J, Schofield P, Benzinger TLS, Morris JC, Goate A, Karch CM, ... ... Cruchaga C, et al. Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain : a Journal of Neurology. PMID 33725114 DOI: 10.1093/brain/awab112 |
0.734 |
|
| 2021 |
Carrera C, Cárcel-Márquez J, Cullell N, Torres-Águila N, Muiño E, Castillo J, Sobrino T, Campos F, Rodríguez-Castro E, Llucia-Carol L, Millán M, Muñoz-Narbona L, López-Cancio E, Bustamante A, Ribó M, ... ... Cruchaga C, et al. Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma. Brain : a Journal of Neurology. PMID 33723576 DOI: 10.1093/brain/awab090 |
0.666 |
|
| 2021 |
Saito ER, Miller JB, Harari O, Cruchaga C, Mihindukulasuriya KA, Kauwe JSK, Bikman BT. Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33650792 DOI: 10.1002/alz.12310 |
0.848 |
|
| 2021 |
Moreno-Grau S, Fernández MV, de Rojas I, Garcia-González P, Hernández I, Farias F, Budde JP, Quintela I, Madrid L, González-Pérez A, Montrreal L, Alarcón-Martín E, Alegret M, Maroñas O, Pineda JA, ... ... Cruchaga C, et al. Long runs of homozygosity are associated with Alzheimer's disease. Translational Psychiatry. 11: 142. PMID 33627629 DOI: 10.1038/s41398-020-01145-1 |
0.797 |
|
| 2021 |
Kirola L, Budde JP, Wang F, Norton J, Morris JC, Cruchaga C, Fernández MV. Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population. Acta Neuropathologica. PMID 33591372 DOI: 10.1007/s00401-021-02271-w |
0.575 |
|
| 2021 |
Joseph-Mathurin N, Wang G, Kantarci K, Jack CR, McDade E, Hassenstab J, Blazey TM, Gordon BA, Su Y, Chen G, Massoumzadeh P, Hornbeck RC, Allegri RF, Ances BM, Berman SB, ... ... Cruchaga C, et al. Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease. Neurology. PMID 33495373 DOI: 10.1212/WNL.0000000000011542 |
0.635 |
|
| 2021 |
Luckett PH, McCullough A, Gordon BA, Strain J, Flores S, Dincer A, McCarthy J, Kuffner T, Stern A, Meeker KL, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, et al. Modeling autosomal dominant Alzheimer's disease with machine learning. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33480178 DOI: 10.1002/alz.12259 |
0.584 |
|
| 2021 |
Farias FHG, Benitez BA, Cruchaga C. Quantitative endophenotypes as an alternative approach to understanding genetic risk in neurodegenerative diseases. Neurobiology of Disease. 105247. PMID 33429041 DOI: 10.1016/j.nbd.2020.105247 |
0.701 |
|
| 2020 |
Lananna BV, McKee CA, King MW, Del-Aguila JL, Dimitry JM, Farias FHG, Nadarajah CJ, Xiong DD, Guo C, Cammack AJ, Elias JA, Zhang J, Cruchaga C, Musiek ES. /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis. Science Translational Medicine. 12. PMID 33328329 DOI: 10.1126/scitranslmed.aax3519 |
0.349 |
|
| 2020 |
Heitsch L, Ibanez L, Carrera C, Binkley MM, Strbian D, Tatlisumak T, Bustamante A, Ribó M, Molina C, Dávalos A, López-Cancio E, Muñoz-Narbona L, Soriano-Tárraga C, Giralt-Steinhauer E, Obach V, ... ... Cruchaga C, et al. Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome. Stroke. STROKEAHA119028687. PMID 33317415 DOI: 10.1161/STROKEAHA.119.028687 |
0.58 |
|
| 2020 |
Diez-Fairen M, Houle G, Ortega-Cubero S, Bandres-Ciga S, Alvarez I, Carcel M, Ibañez L, Fernandez MV, Budde JP, Trotta JR, Tonda R, Chong JX, Bamshad MJ, Nickerson DA, ... ... Cruchaga C, et al. Exome-wide rare variant analysis in familial essential tremor. Parkinsonism & Related Disorders. 82: 109-116. PMID 33279834 DOI: 10.1016/j.parkreldis.2020.11.021 |
0.799 |
|
| 2020 |
Ibanez L, Bahena JA, Yang C, Dube U, Farias FHG, Budde JP, Bergmann K, Brenner-Webster C, Morris JC, Perrin RJ, Cairns NJ, O'Donnell J, Álvarez I, Diez-Fairen M, Aguilar M, ... ... Cruchaga C, et al. Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease. Acta Neuropathologica Communications. 8: 196. PMID 33213513 DOI: 10.1186/s40478-020-01072-8 |
0.836 |
|
| 2020 |
Montal V, Vilaplana E, Pegueroles J, Bejanin A, Alcolea D, Carmona-Iragui M, Clarimón J, Levin J, Cruchaga C, Graff-Radford NR, Noble JM, Lee JH, Allegri R, Karch CM, Laske C, et al. Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33196147 DOI: 10.1002/alz.12224 |
0.652 |
|
| 2020 |
Ibanez L, Heitsch L, Carrera C, Farias FHG, Dhar R, Budde J, Bergmann K, Bradley J, Harari O, Phuah CL, Lemmens R, Oliveira Souza AAV, Moniche F, Cabezas-Juan A, Arenillas JF, ... ... Cruchaga C, et al. Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke. Medrxiv : the Preprint Server For Health Sciences. PMID 33173895 DOI: 10.1101/2020.10.29.20222257 |
0.796 |
|
| 2020 |
Meeker KL, Wisch JK, Hudson D, Coble D, Xiong C, Babulal GM, Gordon BA, Schindler SE, Cruchaga C, Flores S, Dincer A, Benzinger TL, Morris JC, Ances BM. Socioeconomic Status Mediates Racial Differences Seen Using the AT(N) Framework. Annals of Neurology. PMID 33111990 DOI: 10.1002/ana.25948 |
0.368 |
|
| 2020 |
Vermunt L, Dicks E, Wang G, Dincer A, Flores S, Keefe SJ, Berman SB, Cash DM, Chhatwal JP, Cruchaga C, Fox NC, Ghetti B, Graff-Radford NR, Hassenstab J, Karch CM, et al. Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer's disease. Brain Communications. 2: fcaa102. PMID 32954344 DOI: 10.1093/braincomms/fcaa102 |
0.589 |
|
| 2020 |
Costa B, Manzoni C, Bernal-Quiros M, Kia DA, Aguilar M, Alvarez I, Alvarez V, Andreassen O, Anfossi M, Bagnoli S, Benussi L, Bernardi L, Binetti G, Blackburn D, Boada M, ... ... Cruchaga C, et al. , AAO and ancestry help discriminating behavioural from language variants in FTLD cohorts. Neurology. PMID 32943482 DOI: 10.1212/Wnl.0000000000010914 |
0.698 |
|
| 2020 |
Olive C, Ibanez L, Farias FHG, Wang F, Budde JP, Norton JB, Gentsch J, Morris JC, Li Z, Dube U, Del-Aguila J, Bergmann K, Bradley J, Benitez BA, Harari O, ... ... Cruchaga C, et al. Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes. Journal of Alzheimer's Disease : Jad. PMID 32894242 DOI: 10.3233/Jad-200019 |
0.817 |
|
| 2020 |
Luo J, Agboola F, Grant E, Masters CL, Albert MS, Johnson SC, McDade EM, Vöglein J, Fagan AM, Benzinger T, Massoumzadeh P, Hassenstab J, Bateman RJ, Morris JC, Perrin RJ, ... ... Cruchaga C, et al. Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study. Neurology. PMID 32873693 DOI: 10.1212/Wnl.0000000000010747 |
0.42 |
|
| 2020 |
Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, ... ... Cruchaga C, et al. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain : a Journal of Neurology. 143: 2561-2575. PMID 32844198 DOI: 10.1093/Brain/Awaa209 |
0.68 |
|
| 2020 |
Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M, et al. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. Embo Molecular Medicine. e12308. PMID 32790063 DOI: 10.15252/Emmm.202012308 |
0.821 |
|
| 2020 |
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, Manis M, Ibrahim A, Deng L, Benitez BA, Cruchaga C, Licastro D, Mihindukulasuriya K, Harari O, Buckland M, et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathologica. PMID 32772264 DOI: 10.1007/S00401-020-02193-Z |
0.766 |
|
| 2020 |
Aschenbrenner AJ, Petros J, McDade E, Wang G, Balota DA, Benzinger TL, Cruchaga C, Goate A, Xiong C, Perrin R, Fagan AM, Graff-Radford N, Ghetti B, Levin J, Weidinger E, et al. Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12038. PMID 32587883 DOI: 10.1002/Dad2.12038 |
0.687 |
|
| 2020 |
Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Dufouil C, Bennett DA, Chibnik L, Cruchaga C, Del-Aguila J, Farrer LA, Mayeux R, Munsie L, Winslow A, et al. Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32573913 DOI: 10.1002/Alz.12106 |
0.497 |
|
| 2020 |
Schultz SA, Strain JF, Adedokun A, Wang Q, Preische O, Kuhle J, Flores S, Keefe S, Dincer A, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal J, Cruchaga C, et al. Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of Disease. 104960. PMID 32522711 DOI: 10.1016/J.Nbd.2020.104960 |
0.71 |
|
| 2020 |
Stojanovic M, Jin Y, Fagan AM, Benzinger TL, Hassenstab J, Cruchaga C, Morris JC, Head D. Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning. Alzheimer Disease and Associated Disorders. PMID 32520736 DOI: 10.1097/Wad.0000000000000385 |
0.362 |
|
| 2020 |
Castillo-Barnes D, Su L, Ramírez J, Salas-Gonzalez D, Martinez-Murcia FJ, Illan IA, Segovia F, Ortiz A, Cruchaga C, Farlow MR, Xiong C, Graff-Radford NR, Schofield PR, Masters CL, Salloway S, et al. Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning. An International Journal On Information Fusion. 58: 153-167. PMID 32284705 DOI: 10.1016/J.Inffus.2020.01.001 |
0.411 |
|
| 2020 |
Dube U, Ibanez L, Budde JP, Benitez BA, Davis AA, Harari O, Iles MM, Law MH, Brown KM, Cruchaga C. Correction to: Overlapping genetic architecture between Parkinson disease and melanoma. Acta Neuropathologica. PMID 32172342 DOI: 10.1007/S00401-020-02143-9 |
0.794 |
|
| 2020 |
Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA, Sullivan PM, Cruchaga C, Perlmutter JS, Ulrich JD, Benitez BA, et al. genotype regulates pathology and disease progression in synucleinopathy. Science Translational Medicine. 12. PMID 32024799 DOI: 10.1126/Scitranslmed.Aay3069 |
0.802 |
|
| 2020 |
Faura J, Bustamante A, Penalba A, Giralt D, Simats A, Martínez-Sáez E, Alcolea D, Fortea J, Lleó A, Teunissen CE, van der Flier WM, Ibañez L, Harari O, Cruchaga C, Hernández-Guillamón M, et al. CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31958084 DOI: 10.3233/Jad-190753 |
0.838 |
|
| 2020 |
Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, et al. Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 219-228. PMID 31914221 DOI: 10.1002/Alz.12010 |
0.723 |
|
| 2019 |
Dube U, Ibanez L, Budde JP, Benitez BA, Davis AA, Harari O, Iles MM, Law MH, Brown KM, Cruchaga C. Overlapping genetic architecture between Parkinson disease and melanoma. Acta Neuropathologica. PMID 31845298 DOI: 10.1007/S00401-019-02110-Z |
0.802 |
|
| 2019 |
Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, ... ... Cruchaga C, et al. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry. PMID 31636380 DOI: 10.1038/s41380-019-0529-7 |
0.56 |
|
| 2019 |
Day GS, Cruchaga C, Wingo T, Schindler SE, Coble D, Morris JC. Association of Acquired and Heritable Factors With Intergenerational Differences in Age at Symptomatic Onset of Alzheimer Disease Between Offspring and Parents With Dementia. Jama Network Open. 2: e1913491. PMID 31617930 DOI: 10.1001/jamanetworkopen.2019.13491 |
0.397 |
|
| 2019 |
Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, Gentsch J, Wang F, Salloway S, Masters CL, ... ... Cruchaga C, et al. An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nature Neuroscience. PMID 31591557 DOI: 10.1038/S41593-019-0501-5 |
0.829 |
|
| 2019 |
Torres-Aguila NP, Carrera C, Muiño E, Cullell N, Cárcel-Márquez J, Gallego-Fabrega C, González-Sánchez J, Bustamante A, Delgado P, Ibañez L, Heitsch L, Krupinski J, Montaner J, Martí-Fàbregas J, Cruchaga C, et al. Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review. Journal of Stroke. 21: 276-289. PMID 31590472 DOI: 10.5853/Jos.2019.01522 |
0.64 |
|
| 2019 |
Torres-Aguila NP, Carrera C, Giese AK, Cullell N, Muiño E, Cárcel-Márquez J, Gallego-Fabrega C, González-Sánchez J, Del Mar Freijo M, Álvarez-Sabín J, Molina C, Ribó M, Jimenez-Conde J, Roquer J, Sobrino T, ... ... Cruchaga C, et al. Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke. Stroke. STROKEAHA119026593. PMID 31587654 DOI: 10.1161/Strokeaha.119.026593 |
0.655 |
|
| 2019 |
Cammack AJ, Atassi N, Hyman T, van den Berg LH, Harms M, Baloh RH, Brown RH, van Es MA, Veldink JH, de Vries BS, Rothstein JD, Drain C, Jockel-Balsarotti J, Malcolm A, Boodram S, ... ... Cruchaga C, et al. Prospective natural history study of ALS clinical characteristics and biomarkers. Neurology. PMID 31578300 DOI: 10.1212/Wnl.0000000000008359 |
0.305 |
|
| 2019 |
Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, ... ... Cruchaga C, et al. Sex differences in the genetic predictors of Alzheimer's pathology. Brain : a Journal of Neurology. 142: 2581-2589. PMID 31497858 DOI: 10.1093/Brain/Awz206 |
0.839 |
|
| 2019 |
Ewers M, Franzmeier N, Suárez-Calvet M, Morenas-Rodriguez E, Caballero MAA, Kleinberger G, Piccio L, Cruchaga C, Deming Y, Dichgans M, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science Translational Medicine. 11. PMID 31462511 DOI: 10.1126/Scitranslmed.Aav6221 |
0.833 |
|
| 2019 |
Li Z, Farias FHG, Dube U, Del-Aguila JL, Mihindukulasuriya KA, Fernandez MV, Ibanez L, Budde JP, Wang F, Lake AM, Deming Y, Perez J, Yang C, Bahena JA, Qin W, ... ... Cruchaga C, et al. The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion. Acta Neuropathologica. PMID 31456032 DOI: 10.1007/S00401-019-02066-0 |
0.823 |
|
| 2019 |
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Cruchaga C, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7 |
0.837 |
|
| 2019 |
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, ... ... Cruchaga C, et al. The gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science Translational Medicine. 11. PMID 31413141 DOI: 10.1126/Scitranslmed.Aau2291 |
0.857 |
|
| 2019 |
Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernandez MV, Ibanez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, ... ... Cruchaga C, et al. A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain. Alzheimer's Research & Therapy. 11: 71. PMID 31399126 DOI: 10.1186/S13195-019-0524-X |
0.837 |
|
| 2019 |
Carrera C, Cullell N, Torres-Águila N, Muiño E, Bustamante A, Dávalos A, López-Cancio E, Ribó M, Molina CA, Giralt-Steinhauer E, Soriano-Tárraga C, Mola-Caminal M, Jiménez-Conde J, Roquer J, Vives-Bauza C, ... ... Cruchaga C, et al. Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA. Neurology. PMID 31366724 DOI: 10.1212/Wnl.0000000000007997 |
0.632 |
|
| 2019 |
Baker E, Sims R, Leonenko G, Frizzati A, Harwood JC, Grozeva D, Morgan K, Passmore P, Holmes C, Powell J, ... ... Cruchaga C, et al. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. Plos One. 14: e0218111. PMID 31283791 DOI: 10.1371/Journal.Pone.0218111 |
0.741 |
|
| 2019 |
Thirunavu V, McCullough A, Su Y, Flores S, Dincer A, Morris JC, Cruchaga C, Benzinger TLS, Gordon BA. Higher Body Mass Index Is Associated with Lower Cortical Amyloid-β Burden in Cognitively Normal Individuals in Late-Life. Journal of Alzheimer's Disease : Jad. PMID 31156169 DOI: 10.3233/Jad-190154 |
0.426 |
|
| 2019 |
Ibanez L, Heitsch L, Dube U, Farias FHG, Budde J, Bergmann K, Davenport R, Bradley J, Carrera C, Kinnunen J, Sallinen H, Strbian D, Slowik A, Fernandez-Cadenas I, Montaner J, ... ... Cruchaga C, et al. Overlap in the Genetic Architecture of Stroke Risk, Early Neurological Changes, and Cardiovascular Risk Factors. Stroke. STROKEAHA118023097. PMID 31084338 DOI: 10.1161/Strokeaha.118.023097 |
0.78 |
|
| 2019 |
Del-Aguila JL, Benitez BA, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Farias FHG, Fernández MV, Ibanez L, Jiang S, Perrin RJ, Cairns NJ, Morris JC, Harari O, Cruchaga C. TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers. Molecular Neurodegeneration. 14: 18. PMID 31068200 DOI: 10.1186/S13024-019-0319-3 |
0.837 |
|
| 2019 |
Wang Q, Wang Y, Liu J, Sutphen CL, Cruchaga C, Blazey T, Gordon BA, Su Y, Chen C, Shimony JS, Ances BM, Cairns NJ, Fagan AM, Morris JC, Benzinger TLS. Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease. Neuroimage. Clinical. 22: 101767. PMID 30901713 DOI: 10.1016/J.Nicl.2019.101767 |
0.429 |
|
| 2019 |
Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, et al. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30846386 DOI: 10.1016/J.Jalz.2018.12.019 |
0.476 |
|
| 2019 |
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Cruchaga C, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2 |
0.85 |
|
| 2019 |
Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Cruchaga C, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/S00401-019-01962-9 |
0.446 |
|
| 2019 |
Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Caballero MÁA, Franzmeier N, Capell A, Fellerer K, Nuscher B, Eren E, Levin J, Deming Y, Piccio L, Karch CM, Cruchaga C, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular Neurodegeneration. 14: 1. PMID 30630532 DOI: 10.1186/S13024-018-0301-5 |
0.846 |
|
| 2019 |
Morris JC, Schindler SE, McCue LM, Moulder KL, Benzinger TLS, Cruchaga C, Fagan AM, Grant E, Gordon BA, Holtzman DM, Xiong C. Assessment of Racial Disparities in Biomarkers for Alzheimer Disease. Jama Neurology. PMID 30615028 DOI: 10.1001/Jamaneurol.2018.4249 |
0.443 |
|
| 2019 |
Renton AE, Charney AW, Liu Y, Wang M, Fernandez MV, Cruchaga C, Crary JF, Zhang B, Goate AM. P4-487: BRAIN SOMATIC MOSAICISM IN 17Q21.31 MAPT
H1-ASSOCIATED ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P1499-P1499. DOI: 10.1016/J.Jalz.2019.08.033 |
0.727 |
|
| 2019 |
Olive C, Fernandez V, Wang F, Ibanez L, Farias FH, Budde JP, Cruchaga C. P1-136: REPLICATION OF RARE VARIANTS IN PLCG2
, ABI3
AND TREM2
FOR ALZHEIMER DISEASE IN A EUROPEAN AMERICAN COHORT Alzheimer's & Dementia. 15: P289-P289. DOI: 10.1016/J.Jalz.2019.06.691 |
0.742 |
|
| 2019 |
Robles Y, Hunt JF, Lu Q, Hohman TJ, Darst BF, Farias FH, Cruchaga C, Asthana S, Johnson SC, Bendlin BB, Engelman CD. P1-133: THE ATN FRAMEWORK AND POLYGENIC SCORES OF AD ENDOPHENOTYPES Alzheimer's & Dementia. 15: P288-P288. DOI: 10.1016/J.Jalz.2019.06.688 |
0.721 |
|
| 2019 |
Bahena JA, Farias FH, Mihindukulasuriya KA, Budde JP, Cruchaga C, Harari O. P1-130: HIGH-THROUGHPUT OMICS EXPLORER FOR ALZHEIMER'S DISEASE AND COMPLEX TRAITS GENETIC ANALYSIS Alzheimer's & Dementia. 15: P285-P286. DOI: 10.1016/J.Jalz.2019.06.685 |
0.805 |
|
| 2019 |
Cruchaga C, Benitez B, Karch CM, Piccio L. O3-13-06: The Ms4A Gene Cluster Is A Key Modulator Of Soluble Trem2 And Alzheimer Disease Risk Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4701 |
0.767 |
|
| 2019 |
Ewers M, Franzmeier N, Suárez-Calvet M, Morenas E, Piccio L, Cruchaga C, Robles Y, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. O3-12-05: Increased Csf Soluble Trem2 Is Associated With Ameliorated Longitudinal Cognitive And Clinical Decline In Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4694 |
0.416 |
|
| 2019 |
Mahali S, Jiang S, Hsu S, Benitez B, Harari O, Cruchaga C, Karch CM. O3-07-02: LYSOSOMAL DYSFUNCTION IN STEM CELL MODELS OF TAUOPATHY Alzheimer's & Dementia. 15: P897-P898. DOI: 10.1016/J.Jalz.2019.06.4661 |
0.756 |
|
| 2019 |
Fernandez V, Huey D, Budde JP, Farias FHG, Harari O, Norton J, Gentsch J, Morris JC, Goate A, Rademakers R, Graff-Radford NR, Boeve BF, Kauwe J, Cruchaga C, Nia-Load. O2-10-02: Whole Exome Sequencing Analysis In Early Onset Alzheimer Reveals Novel Candidate Genes Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4506 |
0.807 |
|
| 2019 |
Butt OH, Wisch J, Schindler SE, Fagan AM, Benzinger TL, Cruchaga C, Morris JC, Ances BM. IC-P-023: EARLY RESTING-STATE NETWORK DYSFUNCTION IN APOE
ε4 CARRIERS WITHOUT BIOMARKER EVIDENCE OF ALZHEIMER'S DISEASE IS RELATED TO SUBCLINICAL TAU CHANGES Alzheimer's & Dementia. 15: P30-P31. DOI: 10.1016/J.Jalz.2019.06.4185 |
0.426 |
|
| 2019 |
Fernandez V, Del-Aguila JL, Li Z, Dube U, Davenport R, Bradley J, Mihindukulasuriya KA, Farias FH, Budde JP, Norton J, Gentsch J, Morris JC, Harari O, Cruchaga C. P4-106: INTEGRATIVE ANALYSIS POINTS TO AGFG2
AS A NOVEL PLAYER IN THE PATHOLOGY OF ALZHEIMER DISEASE Alzheimer's & Dementia. 15: P1315-P1316. DOI: 10.1016/J.Jalz.2019.06.3767 |
0.831 |
|
| 2019 |
Li Z, Farias FH, Dube U, Del-Aguila JL, Fernandez V, Ibanez L, Budde JP, Wang F, Lake AM, Robles Y, Perez J, Yang C, Mihindukulasuriya KA, Bradley J, Davenport R, ... ... Cruchaga C, et al. P3-116: TMEM106B
PROTECTIVE VARIANT ASSOCIATED WITH INCREASED NEURONAL PROPORTION Alzheimer's & Dementia. 15: P974-P975. DOI: 10.1016/J.Jalz.2019.06.3144 |
0.783 |
|
| 2019 |
Perez JA, Mihindukulasuriya KA, Farias FH, Li Z, Dube U, Budde JP, Cruchaga C, Harari O. P2-137: AN E-QTL META-ANALYSIS OF BRAIN CORTICAL TISSUE ACROSS FIVE CONSORTIUM-BASED STUDIES Alzheimer's & Dementia. 15: P625-P625. DOI: 10.1016/J.Jalz.2019.06.2544 |
0.779 |
|
| 2019 |
Wang Q, Del-Aguila JL, Cruchaga C, Reiman EM, Su Y. P1-400: IMPACT OF REFERENCE REGION USED TO QUANTIFY AMYLOID BURDEN ON INTERPRETING THE RELATIONSHIP BETWEEN AMYLOID BURDEN AND GENETIC RISK FACTORS OF AD Alzheimer's & Dementia. 15: P411-P411. DOI: 10.1016/J.Jalz.2019.06.1005 |
0.465 |
|
| 2018 |
Mola-Caminal M, Carrera C, Soriano-Tárraga C, Giralt Steinhauer E, Diaz-Navarro RM, Tur S, Jiménez C, Medina-Dols A, Cullell N, Torres-Aguila NP, Muiño E, Rodri Guez-Campello A, Ois A, Cuadrado-Godia E, Vivanco-Hidalgo RM, ... ... Cruchaga C, et al. PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis. Circulation Research. PMID 30582445 DOI: 10.1161/Circresaha.118.313533 |
0.627 |
|
| 2018 |
Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, Martinez R, Hsu S, Fernandez MV, Cairns NJ, Harari O, Cruchaga C, Karch CM. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Translational Psychiatry. 8: 265. PMID 30546007 DOI: 10.1038/S41398-018-0319-Z |
0.812 |
|
| 2018 |
Bussy A, Snider BJ, Coble D, Xiong C, Fagan AM, Cruchaga C, Benzinger TLS, Gordon BA, Hassenstab J, Bateman RJ, Morris JC. Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network. Neurobiology of Aging. 75: 42-50. PMID 30530186 DOI: 10.1016/J.Neurobiolaging.2018.10.011 |
0.486 |
|
| 2018 |
Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. Embo Molecular Medicine. PMID 30482868 DOI: 10.15252/Emmm.201809712 |
0.861 |
|
| 2018 |
Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, ... Cruchaga C, et al. Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 10: 669-677. PMID 30417072 DOI: 10.1016/J.Dadm.2018.08.012 |
0.69 |
|
| 2018 |
Yan Q, Nho K, Del-Aguila JL, Wang X, Risacher SL, Fan KH, Snitz BE, Aizenstein HJ, Mathis CA, Lopez OL, Demirci FY, Feingold E, Klunk WE, Saykin AJ, ... Cruchaga C, et al. Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging. Molecular Psychiatry. PMID 30361487 DOI: 10.1038/S41380-018-0246-7 |
0.476 |
|
| 2018 |
Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, et al. A missense variant in SLC39A8 is associated with severe idiopathic scoliosis. Nature Communications. 9: 4171. PMID 30301978 DOI: 10.1038/S41467-018-06705-0 |
0.37 |
|
| 2018 |
Maxwell TJ, Corcoran C, Del-Aguila JL, Budde JP, Deming Y, Cruchaga C, Goate AM, Kauwe JSK. Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels. Alzheimer's Research & Therapy. 10: 86. PMID 30153862 DOI: 10.1186/S13195-018-0410-Y |
0.818 |
|
| 2018 |
Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, ... ... Cruchaga C, et al. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry. PMID 30108311 DOI: 10.1038/S41380-018-0112-7 |
0.702 |
|
| 2018 |
Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, et al. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimer's Research & Therapy. 10: 69. PMID 30045758 DOI: 10.1186/S13195-018-0400-0 |
0.741 |
|
| 2018 |
Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, ... Cruchaga C, et al. Discovery and validation of autosomal dominant Alzheimer's disease mutations. Alzheimer's Research & Therapy. 10: 67. PMID 30021643 DOI: 10.1186/S13195-018-0392-9 |
0.785 |
|
| 2018 |
Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, et al. Effect of BDNFVal66Met on disease markers in dominantly inherited AD. Annals of Neurology. PMID 30014553 DOI: 10.1002/Ana.25299 |
0.69 |
|
| 2018 |
Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, ... ... Cruchaga C, et al. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathologica. PMID 29967939 DOI: 10.1007/s00401-018-1881-4 |
0.828 |
|
| 2018 |
Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Cruchaga C, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/Science.Aap8757 |
0.566 |
|
| 2018 |
Deming Y, Li Z, Benitez BA, Cruchaga C. Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease? Expert Opinion On Therapeutic Targets. PMID 29889572 DOI: 10.1080/14728222.2018.1486823 |
0.823 |
|
| 2018 |
Diez-Fairen M, Benitez BA, Ortega-Cubero S, Lorenzo-Betancor O, Cruchaga C, Lorenzo E, Samaranch L, Carcel M, Obeso JA, Rodriguez-Oroz MC, Aguilar M, Coria F, Pastor MA, Pastor P. Pooled-DNA target sequencing of Parkinson genes reveals novel phenotypic associations in Spanish population. Neurobiology of Aging. PMID 29887346 DOI: 10.1016/J.Neurobiolaging.2018.05.008 |
0.788 |
|
| 2018 |
Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ, Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, et al. Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Medicine. 10: 43. PMID 29880032 DOI: 10.1186/S13073-018-0551-4 |
0.845 |
|
| 2018 |
Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Cruchaga C, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1 |
0.519 |
|
| 2018 |
Ibanez L, Dube U, Davis AA, Fernandez MV, Budde J, Cooper B, Diez-Fairen M, Ortega-Cubero S, Pastor P, Perlmutter JS, Cruchaga C, Benitez BA. Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease. Frontiers in Neuroscience. 12: 230. PMID 29692703 DOI: 10.3389/Fnins.2018.00230 |
0.813 |
|
| 2018 |
Mishra S, Blazey TM, Holtzman DM, Cruchaga C, Su Y, Morris JC, Benzinger TLS, Gordon BA. Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ɛ4 genotype. Brain : a Journal of Neurology. PMID 29672664 DOI: 10.1093/Brain/Awy103 |
0.426 |
|
| 2018 |
Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, Norton J, Morris JC, Goate AM, Cruchaga C. Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease. Frontiers in Neuroscience. 12: 209. PMID 29670507 DOI: 10.3389/fnins.2018.00209 |
0.805 |
|
| 2018 |
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J, Blumenau S, ... ... Cruchaga C, et al. Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging. PMID 29544907 DOI: 10.1016/j.neurobiolaging.2018.01.015 |
0.855 |
|
| 2018 |
Blue EE, Bis JC, Dorschner MO, Tsuang DW, Barral SM, Beecham G, Below JE, Bush WS, Butkiewicz M, Cruchaga C, DeStefano A, Farrer LA, Goate A, Haines J, Jaworski J, et al. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dementia and Geriatric Cognitive Disorders. 45: 1-17. PMID 29486463 DOI: 10.1159/000485503 |
0.72 |
|
| 2018 |
Del-Aguila JL, Fernández MV, Schindler S, Ibanez L, Deming Y, Ma S, Saef B, Black K, Budde J, Norton J, Chasse R, Harari O, Goate A, Xiong C, ... ... Cruchaga C, et al. Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline. Journal of Alzheimer's Disease : Jad. 62: 745-756. PMID 29480181 DOI: 10.3233/Jad-170834 |
0.845 |
|
| 2018 |
Rao S, Ghani M, Guo Z, Deming Y, Wang K, Sims R, Mao C, Yao Y, Cruchaga C, Stephan DA, Rogaeva E. An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk. Neurobiology of Aging. PMID 29395286 DOI: 10.1016/J.Neurobiolaging.2017.12.027 |
0.823 |
|
| 2018 |
Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Cruchaga C, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/S13073-018-0516-7 |
0.838 |
|
| 2018 |
Khan RR, Altmann A, Napolioni V, Kim Y, Guerreiro R, Bras JT, Carmona S, Pereira M, Santana I, Hardy J, Mead S, Cruchaga C, Fernandez MV, Holstege H, Flier WMVd, et al. P4-240: Stop-Gain Variant In Microglia-Expressed Gene Gmip Is Associated With Early-Onset Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.07.061 |
0.724 |
|
| 2018 |
Fernandez MV, Budde JP, Del-Aguila JL, Ibanez L, Deming Y, Harari O, Li Z, Dube U, Norton J, Morris JC, Goate AM, Cruchaga C, Nia-Load, Ncrad. P2-105: Nomination Of Novel Candidate Genes For Familial Late Onset Alzheimer Disease After Evaluation Of Gene-Based Family-Based Methods Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.791 |
0.806 |
|
| 2018 |
Hassenstab J, Aschenbrenner AJ, Balota DA, McDade E, Lim Y, Fagan AM, Benzinger TLS, Cruchaga C, Goate A, Morris JC, Bateman RJ. O1-04-03: Comparing Smartphone-Administered Cognitive Assessments With Conventional Tests And Biomarkers In Sporadic And Dominantly Inherited Alzheimer Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2350 |
0.607 |
|
| 2018 |
Dumitrescu L, Deming Y, Lu Q, Beecham GW, Kunkle BW, Del-Aguila JL, Fernandez MV, Budde JP, Fagan AM, Jager PLD, Albert MS, Moghekar A, Riemenschneider M, Petersen RC, Barnes LL, ... ... Cruchaga C, et al. P1-139: The Contribution Of Sex-Specific Associations In Genetic Studies Of Alzheimer'S Disease Pathology Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.142 |
0.851 |
|
| 2017 |
Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Cruchaga C, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/S13073-017-0486-1 |
0.846 |
|
| 2017 |
Ibanez L, Dube U, Saef B, Budde J, Black K, Medvedeva A, Del-Aguila JL, Davis AA, Perlmutter JS, Harari O, Benitez BA, Cruchaga C. Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels. Bmc Neurology. 17: 198. PMID 29141588 DOI: 10.1186/S12883-017-0978-Z |
0.829 |
|
| 2017 |
Fernández MV, Kim JH, Budde JP, Black K, Medvedeva A, Saef B, Deming Y, Del-Aguila J, Ibañez L, Dube U, Harari O, Norton J, Chasse R, Morris JC, Goate A, ... ... Cruchaga C, et al. Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease. Plos Genetics. 13: e1007045. PMID 29091718 DOI: 10.1371/Journal.Pgen.1007045 |
0.838 |
|
| 2017 |
Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, ... ... Cruchaga C, et al. Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. Plos One. 12: e0185777. PMID 28985224 DOI: 10.1371/Journal.Pone.0185777 |
0.785 |
|
| 2017 |
Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, ... ... Cruchaga C, et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 549: 523-527. PMID 28959956 DOI: 10.1038/Nature24016 |
0.406 |
|
| 2017 |
Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, et al. Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28943286 DOI: 10.1016/J.Jalz.2017.08.013 |
0.845 |
|
| 2017 |
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Cruchaga C, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916 |
0.851 |
|
| 2017 |
Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, ... ... Cruchaga C, et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nature Neuroscience. PMID 28628103 DOI: 10.1038/Nn.4587 |
0.844 |
|
| 2017 |
Ibanez L, Dube U, Budde J, Black K, Medvedeva A, Davis AA, Perlmutter JS, Benitez BA, Cruchaga C. TMEM230 in Parkinson's disease. Neurobiology of Aging. PMID 28457580 DOI: 10.1016/J.Neurobiolaging.2017.03.014 |
0.799 |
|
| 2017 |
Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Cruchaga C, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y |
0.857 |
|
| 2017 |
Tosto G, Bird TD, Tsuang D, Bennett DA, Boeve BF, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Bertlesen S, Graff-Radford NR, Medrano M, Lantigua R, Manly J, et al. Polygenic risk scores in familial Alzheimer disease. Neurology. PMID 28213371 DOI: 10.1212/Wnl.0000000000003734 |
0.648 |
|
| 2017 |
Fardo DW, Katsumata Y, Kauwe JS, Deming Y, Harari O, Cruchaga C, Nelson PT. CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. Experimental Gerontology. PMID 28189700 DOI: 10.1016/J.Exger.2017.01.025 |
0.804 |
|
| 2017 |
Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28183528 DOI: 10.1016/J.Jalz.2016.12.012 |
0.837 |
|
| 2017 |
Haddick PC, Larson JL, Rathore N, Bhangale TR, Phung QT, Srinivasan K, Hansen DV, Lill JR, Pericak-Vance MA, Haines J, Farrer LA, Kauwe JS, Schellenberg GD, Cruchaga C, et al. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. Journal of Alzheimer's Disease : Jad. PMID 28106546 DOI: 10.3233/Jad-160524 |
0.783 |
|
| 2017 |
Karch C, Hsu S, Martinez R, Norton J, Cirrito JR, Lee J, Cuervo M, Cruchaga C, Goate A. [O2-18-02]: PHOSPHOLIPASE D3 CONTRIBUTES TO ALZHEIMER's DISEASE RISK VIA DISRUPTION OF Aβ CLEARANCE THROUGH THE LYSOSOME Alzheimer's & Dementia. 13: P602-P603. DOI: 10.1016/J.Jalz.2017.07.248 |
0.752 |
|
| 2017 |
Harari O, Li Z, Del aguila J, Cruchaga C. CELL-TYPE PROFILING TO IDENTIFY THE TRANSCRIPTOMIC DOWNSTREAM EVENTS TRIGGERED BY EARLY-ONSET AUTOSOMAL DOMINANT AD MUTATIONS Alzheimer's & Dementia. 13: P589. DOI: 10.1016/J.Jalz.2017.07.219 |
0.804 |
|
| 2017 |
Fernandez V, Budde JP, Saef B, Del-Aguila JL, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Novel Candidate Variants In Load Detected By The Familial Alzheimer Sequencing (Fase) Project Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.07.190 |
0.584 |
|
| 2017 |
Deming Y, Kapoor M, Li Z, Harari O, Black K, Del-Aguila JL, Carrell D, Cai Y, Fernandez MV, Budde JP, Ma S, Saef B, Howells B, Huang K, Bertelsen S, ... ... Cruchaga C, et al. CEREBROSPINAL FLUID ENDOPHENOTYPES PROVIDE INSIGHT INTO BIOLOGY UNDERLYING ALZHEIMER'S DISEASE Alzheimer's & Dementia. 13: P218-P219. DOI: 10.1016/J.Jalz.2017.07.096 |
0.828 |
|
| 2017 |
Lim YY, Hassenstab J, Cruchaga C, Goate AM, Fagan AM, Benzinger TLS, Maruff P, Masters CL, McDade E, Morris JC, Bateman RJ. Bdnf Val66Met Increases Rate Of Memory Decline, Hippocampal Volume Loss And Tau Accumulation In Autosomal Dominant Alzheimer’S Disease Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.283 |
0.581 |
|
| 2017 |
Mishra S, Blazey T, Su Y, Christensen J, Jackson K, Hornbeck RC, Cruchaga C, Morris JC, Ances BM, Benzinger TL, Gordon BA. [IC-P-061]: APOE4 EFFECT ON LONGITUDINAL VOLUMETRICS AND PIB ACCUMULATION IN PRECLINICAL ALZHEIMER DISEASE Alzheimer's & Dementia. 13: P50-P50. DOI: 10.1016/J.Jalz.2017.06.2334 |
0.417 |
|
| 2017 |
Joseph-Mathurin N, Kantarci K, Jack CR, Ringman JM, Salloway S, McDade E, Clifford D, Blazey T, Friedrichsen KA, Su Y, Gordon BA, Hornbeck RC, Mills S, Ances BM, Raichle ME, ... ... Cruchaga C, et al. Clinical Risk Related To Cerebral Microhemorrhages In Autosomal Dominant Alzheimer’S Disease: Longitudinal Results From The Dian Study Alzheimers & Dementia. 13: 47. DOI: 10.1016/J.Jalz.2017.06.2330 |
0.606 |
|
| 2017 |
Day GS, Cruchaga C, Wingo T, Morris JC. [P3-257]: DECODING VARIABILITY IN AGE-AT-SYMPTOMATIC-ONSET BETWEEN PARENTS AND CHILDREN WITH SPORADIC ALZHEIMER DISEASE DEMENTIA Alzheimer's & Dementia. 13: P1041-P1042. DOI: 10.1016/J.Jalz.2017.06.1471 |
0.395 |
|
| 2017 |
Joseph-Mathurin N, Su Y, Blazey T, Jasielec MS, Vlassenko AG, Friedrichsen KA, Gordon BA, Hornbeck RC, Cash L, Ances BM, Raichle ME, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, et al. Utility Of Perfusion Pet Models As Measures Of Neurodegeneration In An Autosomal Dominant Alzheimer’S Disease Population: Report From The Dian Study Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.1027 |
0.57 |
|
| 2016 |
Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, ... ... Cruchaga C, et al. Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits. Scientific Reports. 6: 18092. PMID 36647296 DOI: 10.1038/srep18092 |
0.804 |
|
| 2016 |
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. Elife. 5. PMID 27995897 DOI: 10.7554/Elife.20391 |
0.663 |
|
| 2016 |
Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, ... ... Cruchaga C, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathologica. PMID 27933404 DOI: 10.1007/S00401-016-1652-Z |
0.823 |
|
| 2016 |
Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, ... ... Cruchaga C, et al. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. Bmc Neurology. 16: 217. PMID 27832767 DOI: 10.1186/S12883-016-0742-9 |
0.834 |
|
| 2016 |
Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, et al. TYROBP genetic variants in early-onset Alzheimer's disease. Neurobiology of Aging. PMID 27658901 DOI: 10.1016/J.Neurobiolaging.2016.07.028 |
0.55 |
|
| 2016 |
Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, Howells B, Del-Aguila JL, Ma S, Bi C, Norton J, Chasse R, Morris J, Goate A, Cruchaga C, et al. SORL1 variants across Alzheimer's disease European American cohorts. European Journal of Human Genetics : Ejhg. PMID 27650968 DOI: 10.1038/Ejhg.2016.122 |
0.854 |
|
| 2016 |
Harari O, Cruchaga C. Paving the road for the study of epigenetics in neurodegenerative diseases. Acta Neuropathologica. 132: 483-5. PMID 27638634 DOI: 10.1007/S00401-016-1614-5 |
0.812 |
|
| 2016 |
Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauzá C, Soriano-Tárrega C, Giralt-Steinhauer E, Mola M, Diaz-Navarro RM, Tur S, Muiño E, Gallego-Fabrega C, Beltran S, Roquer J, Ruiz A, ... ... Cruchaga C, et al. Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke. Thrombosis and Haemostasis. 116. PMID 27604134 DOI: 10.1160/Th16-02-0113 |
0.337 |
|
| 2016 |
Tosto G, Bird TD, Bennett DA, Boeve BF, Brickman AM, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Graff-Radford NR, Lantigua R, Manly J, Ottman R, Rosenberg R, et al. The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease. Jama Neurology. PMID 27533593 DOI: 10.1001/Jamaneurol.2016.2539 |
0.633 |
|
| 2016 |
Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, et al. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 27521573 DOI: 10.1093/Brain/Aww200 |
0.673 |
|
| 2016 |
Day GS, Musiek ES, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC. Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. Jama Neurology. PMID 27454811 DOI: 10.1016/J.Jalz.2016.06.1371 |
0.671 |
|
| 2016 |
Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD. Identification of Plexin A4 as a novel Clusterin receptor links two Alzheimer's disease risk genes. Human Molecular Genetics. PMID 27378688 DOI: 10.1093/Hmg/Ddw188 |
0.834 |
|
| 2016 |
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, ... ... Cruchaga C, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiology of Aging. PMID 27289440 DOI: 10.1016/J.Neurobiolaging.2016.04.004 |
0.857 |
|
| 2016 |
Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Morgan K, ... ... Cruchaga C, et al. Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. Plos One. 11: e0150079. PMID 27249223 DOI: 10.1371/Journal.Pone.0150079 |
0.851 |
|
| 2016 |
Benitez BA, Davis AA, Jin SC, Ibanez L, Ortega-Cubero S, Pastor P, Choi J, Cooper B, Perlmutter JS, Cruchaga C. Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease. Molecular Neurodegeneration. 11: 29. PMID 27094865 DOI: 10.1186/S13024-016-0097-0 |
0.81 |
|
| 2016 |
Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, et al. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. Jama Neurology. PMID 27088644 DOI: 10.1001/Jamaneurol.2016.0150 |
0.714 |
|
| 2016 |
Piccio L, Deming Y, Del-Águila JL, Ghezzi L, Holtzman DM, Fagan AM, Fenoglio C, Galimberti D, Borroni B, Cruchaga C. Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status. Acta Neuropathologica. PMID 26754641 DOI: 10.1007/S00401-016-1533-5 |
0.858 |
|
| 2016 |
Jin SC, Benitez BA, Deming Y, Cruchaga C. Pooled-DNA Sequencing for Elucidating New Genomic Risk Factors, Rare Variants Underlying Alzheimer's Disease. Methods in Molecular Biology (Clifton, N.J.). 1303: 299-314. PMID 26235075 DOI: 10.1007/978-1-4939-2627-5_18 |
0.8 |
|
| 2016 |
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. Author response: Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms Elife. DOI: 10.7554/Elife.20391.021 |
0.58 |
|
| 2016 |
Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, ... ... Cruchaga C, et al. Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits Scientific Reports. 6. DOI: 10.1038/Srep18092 |
0.804 |
|
| 2016 |
Petros J, Hassenstab J, Snitz BE, Zhou Y, Ringman JM, McDade E, Wang G, Balota DA, Aschenbrenner AJ, Benzinger TL, Cruchaga C, Fagan AM, Goate AM, Holtzman DM, Buckles V, et al. Dynamic Relationships Between “Big Five” Personality Traits, Alzheimer’S Disease Biomarkers, And Cognition In Autosomal Dominant Alzheimer’S Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.970 |
0.605 |
|
| 2016 |
Lim YY, Hassenstab J, Cruchaga C, Goate AM, Fagan AM, Lee Smith Benzinger T, Maruff P, Snyder PJ, Masters CL, Ricardo A, Chhatwal JP, Farlow MR, Graff-Radford NR, Laske C, Levin J, et al. F5-02-03: BDNF VAL66MET Moderates Cognitive Impairment, Neuronal Dysfunction and TAU in Preclinical Autosomal Dominant Alzheimer's Disease Alzheimer's & Dementia. 12: P369-P369. DOI: 10.1016/J.Jalz.2016.06.689 |
0.617 |
|
| 2016 |
Huang K, Jin SC, Harari O, Kapoor M, Bertelsen S, Czajkowski J, Lambert j, Chouraki V, Bellenguez C, Grenier-Boley B, Deming Y, McKenzie A, Renton AE, Budde J, Del-Aguila JL, ... ... Cruchaga C, et al. A Common Allele In Spi1 Lowers Risk And Delays Age At Onset For Alzheimer'S Disease Alzheimers & Dementia. 12: 253. DOI: 10.1016/J.Jalz.2016.06.453 |
0.83 |
|
| 2016 |
Deming Y, Harari O, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez V, Budde J, Ma S, Saef B, Bertelsen S, Kauwe J, Fagan AM, Holtzman DM, Morris JC, ... ... Cruchaga C, et al. Cerebrospinal Fluid Levels Of Amyloid Beta And Tau As Endophenotypes Reveal Novel Variants Potentially Informative For Alzheimer'S Disease Alzheimers & Dementia. 12: 252. DOI: 10.1016/J.Jalz.2016.06.452 |
0.829 |
|
| 2016 |
Fernández MV, Budde J, Saef B, Carrell D, Howells B, Del-Aguila JL, Ma S, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Novel Rare Variants In Known Genes, A Look Into The Familial Alzheimer Sequencing (Fase) Project Alzheimers & Dementia. 12: 198. DOI: 10.1016/J.Jalz.2016.06.345 |
0.702 |
|
| 2016 |
Marcora E, Renton AE, Beecham GW, Boerwinkle E, Cantwell L, Cruchaga C, Cweibel R, Felsenfeld A, Fornage M, Kapoor M, Kauwe K, Khaladkar M, Kobolt D, Ma Y, Mayeux R, et al. F1-01-02: Alzheimer's Disease Sequencing Project: Search for Alzheimer's Disease Resilience Genes That May Modify Disease Susceptibility in Specific Apoe Genotype Backgrounds Alzheimer's & Dementia. 12: P162-P163. DOI: 10.1016/J.Jalz.2016.06.272 |
0.674 |
|
| 2016 |
Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, Howells B, Del-Aguila JL, Ma S, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Sorl1 Variants Across Alzheimer’S Disease Cohorts In European Americans Alzheimers & Dementia. 12: 857. DOI: 10.1016/J.Jalz.2016.06.1756 |
0.816 |
|
| 2016 |
Kauwe K, Arano I, Bras JT, Cannon-Albright L, Cruchaga C, Goate AM, Murcia JDG, Guerreiro R, Hardy J, Hsu S, Karch C, Munger RG, Norton MC, Ridge PG, Sassi C, et al. Linkage And Whole Genome Sequence Analysis Of Alzheimer'S Disease Resilience And Risk Alzheimers & Dementia. 12: 675. DOI: 10.1016/J.Jalz.2016.06.1325 |
0.777 |
|
| 2015 |
Del-Aguila JL, Fernández MV, Jimenez J, Black K, Ma S, Deming Y, Carrell D, Saef B, Howells B, Budde J, Cruchaga C. Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European-Americans. Alzheimer's Research & Therapy. 7: 73. PMID 26654793 DOI: 10.1186/S13195-015-0154-X |
0.856 |
|
| 2015 |
Benitez BA, Cairns NJ, Schmidt RE, Morris JC, Norton JB, Cruchaga C, Sands MS. Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss. Acta Neuropathologica Communications. 3: 73. PMID 26610600 DOI: 10.1186/S40478-015-0256-5 |
0.698 |
|
| 2015 |
Davis AA, Andruska KM, Benitez BA, Racette BA, Perlmutter JS, Cruchaga C. Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression. Neurobiology of Aging. PMID 26601739 DOI: 10.1016/J.Neurobiolaging.2015.09.014 |
0.684 |
|
| 2015 |
Haller G, Alvarado D, McCall K, Yang P, Cruchaga C, Harms M, Goate A, Willing M, Morcuende JA, Baschal E, Miller NH, Wise C, Dobbs MB, Gurnett CA. A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis. Human Molecular Genetics. PMID 26566670 DOI: 10.1093/Hmg/Ddv463 |
0.62 |
|
| 2015 |
Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C. A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. Neurobiology of Aging. PMID 26545630 DOI: 10.1016/J.Jalz.2015.07.374 |
0.851 |
|
| 2015 |
Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, Morgan K, Passmore P, Holmes C, Powell J, Brayne C, Gill M, ... ... Cruchaga C, et al. Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain : a Journal of Neurology. PMID 26490334 DOI: 10.1093/Brain/Awv268 |
0.721 |
|
| 2015 |
Del-Aguila JL, Koboldt DC, Black K, Chasse R, Norton J, Wilson RK, Cruchaga C. Alzheimer's disease: rare variants with large effect sizes. Current Opinion in Genetics & Development. 33: 49-55. PMID 26311074 DOI: 10.1016/J.Gde.2015.07.008 |
0.511 |
|
| 2015 |
Jin SC, Carrasquillo MM, Benitez BA, Skorupa T, Carrell D, Patel D, Lincoln S, Krishnan S, Kachadoorian M, Reitz C, Mayeux R, Wingo TS, Lah JJ, Levey AI, Murrell J, ... ... Cruchaga C, et al. TREM2 is associated with increased risk for Alzheimer's disease in African Americans. Molecular Neurodegeneration. 10: 19. PMID 25886450 DOI: 10.1186/S13024-015-0016-9 |
0.769 |
|
| 2015 |
Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E5-6. PMID 25832412 DOI: 10.1038/Nature14037 |
0.486 |
|
| 2015 |
Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E10. PMID 25832409 DOI: 10.1038/nature14041 |
0.427 |
|
| 2015 |
Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, ... ... Cruchaga C, et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry. PMID 25778476 DOI: 10.1038/Mp.2015.23 |
0.839 |
|
| 2015 |
Louwersheimer E, Ramirez A, Cruchaga C, Becker T, Kornhuber J, Peters O, Heilmann S, Wiltfang J, Jessen F, Visser PJ, Scheltens P, Pijnenburg YA, Teunissen CE, Barkhof F, van Swieten JC, et al. The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease. Neurobiology of Aging. 36: 1605.e13-20. PMID 25659857 DOI: 10.1016/J.Neurobiolaging.2014.12.007 |
0.462 |
|
| 2015 |
Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157 |
0.832 |
|
| 2015 |
Brkanac Z, Rehker J, Rodhe J, Nesbit RR, Raskind W, Shendure J, Cruchaga C, Joseph B. App processing genes case-control screening and functional analysis in Alzheimer’s disease Alzheimers & Dementia. 11: 857. DOI: 10.1016/J.Jalz.2015.08.027 |
0.346 |
|
| 2015 |
Karch C, Hsu S, Ezerskiy L, Martinez R, Norton J, Cruchaga C, Goate AM. S2-02-04: Phospholipase D3 contributes to Alzheimer's disease risk via disruption in app trafficking and Aβ generation Alzheimer's & Dementia. 11: P163-P163. DOI: 10.1016/J.Jalz.2015.07.106 |
0.761 |
|
| 2015 |
Del-Aguila JL, Gross AL, Sutti S, Sherva R, Mukherjee S, Crane PK, Goate A, Morris JC, Green RC, Cruchaga C. Identification of genetic variants associated with Alzheimer's disease: Progression rate Alzheimers & Dementia. 11: 487. DOI: 10.1016/J.Jalz.2015.06.552 |
0.685 |
|
| 2015 |
Tsuang D, Vardarajan BN, Bird TD, Boeve B, Schaid D, Taner N, Allen M, Barral S, Bennett DA, Cruchaga C, Goate A, Graff-Radford N, Faber K, Farlow MR, Foroud TM, et al. MAPT haplotypes modify the association between head injury and risk of Alzheimer’s disease Alzheimers & Dementia. 11: 361. DOI: 10.1016/J.Jalz.2015.06.256 |
0.587 |
|
| 2015 |
Kobolt D, Lord J, Fernandez V, del-Aguila J, Kang CJ, Saef B, Wilson R, Goate A, Cruchaga C. P1-055: Exome-sequencing in a large dataset of late-onset families with Alzheimer's disease Alzheimer's & Dementia. 11: P359-P359. DOI: 10.1016/J.Jalz.2015.06.252 |
0.798 |
|
| 2015 |
Joseph-Mathurin N, Tang M, Friedrichsen KA, Owen CJ, Su Y, Hornbeck RC, Stevenson TA, Cash L, Raichle ME, Gordon B, Preboske GM, Koeppe RA, Jack CR, Goate A, Cruchaga C, et al. Amyloid load increase and cerebral microbleed prevalence differ as a function of the position of the mutation within the PSEN1 coding sequence Alzheimers & Dementia. 11: 172. DOI: 10.1016/J.Jalz.2015.06.072 |
0.55 |
|
| 2014 |
Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, ... ... Cruchaga C, et al. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nature Medicine. 20: 1452-7. PMID 25419706 DOI: 10.1038/Nm.3736 |
0.667 |
|
| 2014 |
Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/Journal.Pone.0111899 |
0.626 |
|
| 2014 |
Lord J, Lu AJ, Cruchaga C. Identification of rare variants in Alzheimer's disease. Frontiers in Genetics. 5: 369. PMID 25389433 DOI: 10.3389/Fgene.2014.00369 |
0.795 |
|
| 2014 |
Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Plos Genetics. 10: e1004758. PMID 25340798 DOI: 10.1371/Journal.Pgen.1004758 |
0.855 |
|
| 2014 |
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Cruchaga C, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491 |
0.84 |
|
| 2014 |
Lord J, Cruchaga C. The epigenetic landscape of Alzheimer's disease. Nature Neuroscience. 17: 1138-40. PMID 25157507 DOI: 10.1038/Nn.3792 |
0.749 |
|
| 2014 |
Luis EO, Ortega-Cubero S, Lamet I, Razquin C, Cruchaga C, Benitez BA, Lorenzo E, Irigoyen J, Pastor MA, Pastor P. Frontobasal gray matter loss is associated with the TREM2 p.R47H variant. Neurobiology of Aging. 35: 2681-90. PMID 25027412 DOI: 10.1016/J.Neurobiolaging.2014.06.007 |
0.824 |
|
| 2014 |
Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, et al. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Human Molecular Genetics. 23: 6644-58. PMID 25027320 DOI: 10.1093/Hmg/Ddu372 |
0.704 |
|
| 2014 |
Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 83: 11-26. PMID 24991952 DOI: 10.1016/J.Neuron.2014.05.041 |
0.802 |
|
| 2014 |
Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, ... ... Cruchaga C, et al. Frontotemporal dementia and its subtypes: a genome-wide association study. The Lancet. Neurology. 13: 686-99. PMID 24943344 DOI: 10.1016/S1474-4422(14)70065-1 |
0.754 |
|
| 2014 |
Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Cruchaga C, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661 |
0.85 |
|
| 2014 |
Jin SC, Benitez BA, Karch CM, Cooper B, Skorupa T, Carrell D, Norton JB, Hsu S, Harari O, Cai Y, Bertelsen S, Goate AM, Cruchaga C. Coding variants in TREM2 increase risk for Alzheimer's disease. Human Molecular Genetics. 23: 5838-46. PMID 24899047 DOI: 10.1093/Hmg/Ddu277 |
0.859 |
|
| 2014 |
Buchan JG, Alvarado DM, Haller GE, Cruchaga C, Harms MB, Zhang T, Willing MC, Grange DK, Braverman AC, Miller NH, Morcuende JA, Tang NL, Lam TP, Ng BK, Cheng JC, et al. Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis. Human Molecular Genetics. 23: 5271-82. PMID 24833718 DOI: 10.1093/Hmg/Ddu224 |
0.812 |
|
| 2014 |
Cruchaga C, Ebbert MT, Kauwe JS. Genetic discoveries in AD using CSF amyloid and tau. Current Genetic Medicine Reports. 2: 23-29. PMID 24729949 DOI: 10.1007/S40142-014-0031-0 |
0.783 |
|
| 2014 |
Shannon B, Soto-Ortolaza A, Rayaprolu S, Cannon HD, Labbé C, Benitez BA, Choi J, Lynch T, Boczarska-Jedynak M, Opala G, Krygowska-Wajs A, Barcikowska M, Van Gerpen JA, Uitti RJ, Springer W, ... Cruchaga C, et al. Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease. Neurobiology of Aging. 35: 1958.e1-2. PMID 24684791 DOI: 10.1016/J.Neurobiolaging.2014.03.004 |
0.715 |
|
| 2014 |
Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM. Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biological Psychiatry. 75: 723-31. PMID 24548642 DOI: 10.1016/J.Biopsych.2013.11.032 |
0.835 |
|
| 2014 |
Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. Jama Neurology. 71: 449-53. PMID 24535663 DOI: 10.1001/Jamaneurol.2013.6237 |
0.76 |
|
| 2014 |
Deming Y, Cruchaga C. TMEM106B: a strong FTLD disease modifier. Acta Neuropathologica. 127: 419-22. PMID 24488309 DOI: 10.1007/S00401-014-1249-3 |
0.816 |
|
| 2014 |
Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, ... ... Cruchaga C, et al. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of Aging. 35: 1510.e19-26. PMID 24439484 DOI: 10.1016/J.Neurobiolaging.2013.12.010 |
0.859 |
|
| 2014 |
Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505: 550-4. PMID 24336208 DOI: 10.1038/Nature12825 |
0.843 |
|
| 2014 |
Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JS. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 366-71. PMID 23727081 DOI: 10.1016/J.Jalz.2013.02.010 |
0.837 |
|
| 2014 |
Naj AC, Cruchaga C, Kunkle BW, Mukherjee S, Graham R, Wang L, Behrens T, Mayeux R, Haines J, Farrer LA, Pericak-Vance M, Schellenberg GD. Exome Array Analysis Identifies Novel Risk Variants For Alzheimer'S Disease With Onset Before 65 Years Alzheimers & Dementia. 10: 319. DOI: 10.1016/J.Jalz.2014.05.280 |
0.487 |
|
| 2014 |
Goate AM, Karch C, Hsu S, Jeng AT, Sears R, Cruchaga C. O2-12-04: ALZHEIMER'S DISEASE RISK VARIANTS IN PHOSPHOLIPASE D3 ALTER APP METABOLISM BY GAMMA-DEPENDENT AND GAMMA-INDEPENDENT MECHANISMS Alzheimer's & Dementia. 10: P192-P192. DOI: 10.1016/J.Jalz.2014.04.225 |
0.737 |
|
| 2014 |
Cruchaga C, Jin SC, Benitez BA, Karch C, Goate A. O1-04-05: NOVEL CODING VARIANTS IN TREM2 INCREASE RISK FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P136-P136. DOI: 10.1016/J.Jalz.2014.04.078 |
0.822 |
|
| 2014 |
Cruchaga C, Brkanac Z, Jin SC, Benitez BA, Rehker J, Ridge P, Kauwe J, Hardy J, Bras J, Guerreiro R, Singleton A, Goate A. O1-04-02: EXOME-SEQUENCING IN LATE-ONSET FAMILIES IDENTIFIED ADDITIONAL CANDIDATES GENES FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P135-P135. DOI: 10.1016/J.Jalz.2014.04.075 |
0.827 |
|
| 2013 |
Anasagasti A, Barandika O, Irigoyen C, Benitez BA, Cooper B, Cruchaga C, López de Munain A, Ruiz-Ederra J. Genetic highthroughput screening in retinitis pigmentosa based on high resolution melting (HRM) analysis. Experimental Eye Research. PMID 24512775 DOI: 10.1016/j.exer.2013.10.011 |
0.65 |
|
| 2013 |
Anasagasti A, Barandika O, Irigoyen C, Benitez BA, Cooper B, Cruchaga C, López de Munain A, Ruiz-Ederra J. Genetic high throughput screening in Retinitis Pigmentosa based on high resolution melting (HRM) analysis. Experimental Eye Research. 116: 386-94. PMID 24416769 DOI: 10.1016/J.Exer.2013.10.011 |
0.679 |
|
| 2013 |
Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Cruchaga C, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/Ng.2802 |
0.849 |
|
| 2013 |
Benitez BA, Cruchaga C. TREM2 and neurodegenerative disease. The New England Journal of Medicine. 369: 1567-8. PMID 24131187 DOI: 10.1056/Nejmc1306509#Sa4 |
0.711 |
|
| 2013 |
Honea RA, Cruchaga C, Perea RD, Saykin AJ, Burns JM, Weinberger DR, Goate AM. Characterizing the role of brain derived neurotrophic factor genetic variation in Alzheimer's disease neurodegeneration. Plos One. 8: e76001. PMID 24086677 DOI: 10.1371/Journal.Pone.0076001 |
0.62 |
|
| 2013 |
Benitez BA, Karch CM, Cai Y, Jin SC, Cooper B, Carrell D, Bertelsen S, Chibnik L, Schneider JA, Bennett DA, Fagan AM, Holtzman D, Morris JC, ... ... Cruchaga C, et al. The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers. Plos Genetics. 9: e1003685. PMID 23990795 DOI: 10.1371/Journal.Pgen.1003685 |
0.838 |
|
| 2013 |
Karch CM, Jeng AT, Skorupa T, Cruchaga C, Goate AM. Novel progranulin variants do not disrupt progranulin secretion and cleavage. Neurobiology of Aging. 34: 2538-40. PMID 23759146 DOI: 10.1016/J.Neurobiolaging.2013.05.004 |
0.753 |
|
| 2013 |
Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH. Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis. Neurobiology of Aging. 34: 2234.e13-9. PMID 23597494 DOI: 10.1016/J.Neurobiolaging.2013.03.006 |
0.571 |
|
| 2013 |
Harms M, Benitez BA, Cairns N, Cooper B, Cooper P, Mayo K, Carrell D, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, Mayeux R, ... ... Cruchaga C, et al. C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease. Jama Neurology. 70: 736-41. PMID 23588422 DOI: 10.1001/2013.Jamaneurol.537 |
0.794 |
|
| 2013 |
Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/J.Neuron.2013.02.026 |
0.848 |
|
| 2013 |
Benitez BA, Cooper B, Pastor P, Jin SC, Lorenzo E, Cervantes S, Cruchaga C. TREM2 is associated with the risk of Alzheimer's disease in Spanish population. Neurobiology of Aging. 34: 1711.e15-7. PMID 23391427 DOI: 10.1016/J.Neurobiolaging.2012.12.018 |
0.82 |
|
| 2013 |
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/Nejmoa1211851 |
0.857 |
|
| 2013 |
Harms MB, Neumann D, Benitez BA, Cooper B, Carrell D, Racette BA, Perlmutter JS, Goate A, Cruchaga C. Parkinson disease is not associated with C9ORF72 repeat expansions. Neurobiology of Aging. 34: 1519.e1-2. PMID 23116878 DOI: 10.1016/J.Neurobiolaging.2012.10.001 |
0.736 |
|
| 2013 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Cruchaga C, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 45: 712-712. DOI: 10.1038/Ng0613-712A |
0.72 |
|
| 2013 |
Honea R, Cruchaga C, Perea R, Swerdlow R, Weinberger D, Saykin A, Goate A. P1-281: Role of genetic variation on longitudinal imaging measures of Alzheimer's disease in the ADNI Cohort Alzheimer's & Dementia. 9: P257-P257. DOI: 10.1016/J.Jalz.2013.05.506 |
0.655 |
|
| 2013 |
Cruchaga C, Harari O, Kauwe J, Bales K, Pickering EH, Bertelsen S, Fagan A, Holtzman D, Morris J, Goate A. P4-002: Cerebrospinal heart fatty-acid-binding protein as a biomarker for Alzheimer's disease Alzheimer's & Dementia. 9: P705-P705. DOI: 10.1016/J.Jalz.2013.05.1390 |
0.812 |
|
| 2013 |
Benitez B, Karch C, Jin SC, Carrel D, Cooper B, Bertelsen S, Morris J, Holtzman D, Goate A, Cruchaga C. Rare variants in APP and PSEN1 genes associated with extreme levels of beta-amyloid 42 and tau protein in cerebrospinal fluid Alzheimers & Dementia. 9: 680. DOI: 10.1016/J.Jalz.2013.04.338 |
0.811 |
|
| 2013 |
Kauwe J, Bailey M, Ridge P, Cruchaga C, Foutz S, Perry R, Harari O, Bertelsen S, Ainscough B, Bales K, Pickering EH, Fagan A, Holtzman D, Morris J, Goate A. O4-01-01: Association of genetic variants with cerebrospinal fluid protein levels of ACE, MMP3 and other proteins and risk for Alzheimer's disease Alzheimer's & Dementia. 9: P677-P678. DOI: 10.1016/J.Jalz.2013.04.334 |
0.827 |
|
| 2013 |
Naj A, Cruchaga C, Kunkle B, Mukherjee S, Graham R, Behrens T, Mayeux R, Haines J, Farrer L, Pericak-Vance M, Schellenberg G, Wang L. Exome array analysis identifies novel risk variants for non-familial early-onset Alzheimer’s disease Alzheimers & Dementia. 9: 517. DOI: 10.1016/J.Jalz.2013.04.237 |
0.404 |
|
| 2013 |
Cruchaga C. F2-01-03: A rare coding variant in PLD3 confers high risk for Alzheimer's disease Alzheimer's & Dementia. 9: P312-P312. DOI: 10.1016/J.Jalz.2013.04.127 |
0.416 |
|
| 2013 |
Hunkapiller J, Wetzel M, Bhangale T, Maloney J, Atwal J, Ortmann W, Tessier-Lavigne M, Goate A, Behrens T, Cruchaga C, Watts R, Graham R. A rare coding variant alters UNC5C function and predisposes to Alzheimer's disease Alzheimers & Dementia. 9: 311. DOI: 10.1016/J.Jalz.2013.04.125 |
0.657 |
|
| 2012 |
Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. Plos One. 7: e50976. PMID 23226438 DOI: 10.1371/Journal.Pone.0050976 |
0.781 |
|
| 2012 |
Jin SC, Pastor P, Cooper B, Cervantes S, Benitez BA, Razquin C, Goate A, Cruchaga C. Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort. Alzheimer's Research & Therapy. 4: 34. PMID 22906081 DOI: 10.1186/Alzrt137 |
0.849 |
|
| 2012 |
Greaves J, Lemonidis K, Gorleku OA, Cruchaga C, Grefen C, Chamberlain LH. Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. The Journal of Biological Chemistry. 287: 37330-9. PMID 22902780 DOI: 10.1074/Jbc.M112.389098 |
0.301 |
|
| 2012 |
Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human Molecular Genetics. 21: 4558-71. PMID 22821396 DOI: 10.1093/Hmg/Dds296 |
0.824 |
|
| 2012 |
Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Cruchaga C, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801 |
0.837 |
|
| 2012 |
Cruchaga C, Haller G, Chakraverty S, Mayo K, Vallania FL, Mitra RD, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, St Jean P, Lawson M, et al. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. Plos One. 7: e31039. PMID 22312439 DOI: 10.1371/Journal.Pone.0031039 |
0.697 |
|
| 2012 |
Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Cruchaga C, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/Jad-2011-110824 |
0.863 |
|
| 2012 |
Bailey M, Maxwell T, Cruchaga C, Goate A, Kauwe J. P4-258: Genome-wide screen for variants that modify the known relationship between cerebrospinal fluid Beta-Amyloid 42 and ptau levels Alzheimer's & Dementia. 8: S749-S749. DOI: 10.1016/J.Jalz.2013.08.039 |
0.763 |
|
| 2012 |
Cruchaga C, Goate A, Thompson P, Kauwe J, Mayo K, Bertelsen S, Hinrichs T, Fagan A, Holtzman D. F2-02-04: Genome-wide association studies using cerebrospinal fluid biomarkers as an endophenotype for Alzheimer's disease Alzheimer's & Dementia. 8: P232-P233. DOI: 10.1016/J.Jalz.2012.05.615 |
0.805 |
|
| 2012 |
Jin SC, Cooper B, Mayo K, Benitez B, Goate A, Cruchaga C. O5-03-02: Deep resequencing of GWAS loci associated with Alzheimer's disease Alzheimer's & Dementia. 8: P735-P735. DOI: 10.1016/J.Jalz.2012.05.1982 |
0.789 |
|
| 2012 |
Jeng A, Karch C, Nowotny P, Cruchaga C, Goate A. P4-085: ABCA7 and MS4A6A expression are upregulated in Alzheimer's disease brains Alzheimer's & Dementia. 8: P663-P663. DOI: 10.1016/J.Jalz.2012.05.1787 |
0.756 |
|
| 2011 |
Benitez BA, Alvarado D, Cai Y, Mayo K, Chakraverty S, Norton J, Morris JC, Sands MS, Goate A, Cruchaga C. Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis. Plos One. 6: e26741. PMID 22073189 DOI: 10.1371/Journal.Pone.0026741 |
0.753 |
|
| 2011 |
Cruchaga C, Nowotny P, Kauwe JS, Ridge PG, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Archives of Neurology. 68: 1013-9. PMID 21825236 DOI: 10.1001/Archneurol.2011.155 |
0.83 |
|
| 2011 |
Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science Translational Medicine. 3: 89ra57. PMID 21715678 DOI: 10.1126/Scitranslmed.3002156 |
0.673 |
|
| 2011 |
Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Cruchaga C, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801 |
0.804 |
|
| 2011 |
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Cruchaga C, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/Ng.803 |
0.812 |
|
| 2011 |
Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. Plos One. 6: e15918. PMID 21347408 DOI: 10.1371/Journal.Pone.0015918 |
0.858 |
|
| 2011 |
Cruchaga C, Graff C, Chiang HH, Wang J, Hinrichs AL, Spiegel N, Bertelsen S, Mayo K, Norton JB, Morris JC, Goate A. Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Archives of Neurology. 68: 581-6. PMID 21220649 DOI: 10.1001/Archneurol.2010.350 |
0.597 |
|
| 2011 |
Ezquerra M, Pastor P, Gaig C, Vidal-Taboada JM, Cruchaga C, Muñoz E, Martà MJ, Valldeoriola F, Aguilar M, Calopa M, Hernandez-Vara J, Tolosa E. Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy. Neurobiology of Aging. 32: 547.e11-6. PMID 19879020 DOI: 10.1016/J.Neurobiolaging.2009.09.011 |
0.709 |
|
| 2011 |
Kauwe J, Cruchaga C, McKean D, Bailey M, Patty D, Mayo K, Bertelsen S, Hinrichs A, Disease Genetics Consortium TA, Disease Neuroimaging Initiative TA, Fagan A, Holtzman D, Goate A. P4-453: Genome-wide association analysis using cerebrospinal fluid Abeta42 levels as an endophenotype for Alzheimer's disease Alzheimer's & Dementia. 7: e69-e70. DOI: 10.1016/J.Jalz.2011.09.148 |
0.822 |
|
| 2011 |
Bailey M, Kauwe J, Cruchaga C, McKean D, Mayo K, Bertelsen S, Hinrichs T, Fagan A, Holtzman D, Goate A. P2-018: Association study of recently reported AD risk variants with cerebrospinal fluid AD biomarker levels Alzheimer's & Dementia. 7: S313-S313. DOI: 10.1016/J.Jalz.2011.05.908 |
0.82 |
|
| 2011 |
Leverenz J, Bird T, Rumbaugh M, Yu C, Cruchaga C, Steinbart E, Ravits J. Is the Arg5His MAPT variant pathogenic for dementia and motor neuron disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.569 |
0.352 |
|
| 2011 |
Peterson D, Kauwe J, Crowley J, Corcoran C, Cruchaga C, Goate A, Norton M, Green R, Munger R, Breitner J, Welsh-Bohmer K, Lyketsos K, Tschanz J. Support for Genetic Association Between Variants in PPP3R1 and MAPT and Rate of Progression of Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.533 |
0.805 |
|
| 2011 |
Cruchaga C, Nowotny P, Kauwe J, Mayo K, Bertelsen S, Hinrichs T, Fagan A, Holtzman D, Morris J, Goate A. P1-224: APOE Genotype is Associated with Cerebrospinal Fluid and Plasma APOE Levels But Not with APOE Expression Levels Alzheimer's & Dementia. 7: S182-S183. DOI: 10.1016/J.Jalz.2011.05.504 |
0.776 |
|
| 2011 |
Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Hinrichs T, Peskind E, Li G, Leverenz J, Galasko D, Fagan A, Holtzman D, Goate A. Genome-Wide Association Analyses Using Cerebrospinal Fluid Tau and Phospho-Tau Levels As An Endophenotype for Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.503 |
0.804 |
|
| 2011 |
Benitez B, Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Hinrichs A, Fagan A, Holtzman D, Goate A. Rare Genetic Variants in APP, PSEN1, PSEN2, GRN, APOE and MAPT Associated with CSF Aß and tau/ptau181 Levels in Patients with Late-Onset Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.492 |
0.845 |
|
| 2011 |
Goate A, Holtzman D, Morris J, Cruchaga C, Nowotny P, Kauwe J, Fagan A, Mayo K, Bertelsen S, Hinrichs T. Association and expression analyses with SNPs in TOMM40 in Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.227 |
0.818 |
|
| 2011 |
Kauwe J, Cruchaga C, McKean D, Bailey M, Patty D, Mayo K, Bertelsen S, Hinrichs A, Fagan A, Holtzman D, Goate A. Genome-wide association studies of CSF biomarkers Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.202 |
0.772 |
|
| 2010 |
Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Cruchaga C, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/Journal.Pone.0013950 |
0.82 |
|
| 2010 |
Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MM, Williams J, Lovestone S, Peskind ER, Li G, et al. SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. Plos Genetics. 6: e1001101. PMID 20862329 DOI: 10.1371/Journal.Pgen.1001101 |
0.849 |
|
| 2010 |
Kauwe JS, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Journal of Alzheimer's Disease : Jad. 21: 833-42. PMID 20634593 DOI: 10.3233/Jad-2010-091711 |
0.832 |
|
| 2010 |
Kauwe JS, Bertelsen S, Mayo K, Cruchaga C, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S, Morris JC, Goate AM. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 955-9. PMID 20029940 DOI: 10.1002/Ajmg.B.31053 |
0.826 |
|
| 2010 |
Wang J, Van Damme P, Cruchaga C, Gitcho MA, Vidal JM, Seijo-Martínez M, Wang L, Wu JY, Robberecht W, Goate A. Pathogenic cysteine mutations affect progranulin function and production of mature granulins Journal of Neurochemistry. 112: 1305-1315. PMID 20028451 DOI: 10.1111/J.1471-4159.2009.06546.X |
0.578 |
|
| 2010 |
Cruchaga C, Graff C, Chiang H, Wang J, Hinrichs AL, Mayo K, Norton J, Morris JC, Goate AM. P1-091: TMEM106B gene polymorphism is associated with age at onset in granulin mutation carriers and plasma granulin protein levels in healthy individuals Alzheimer's & Dementia. 6: S200-S200. DOI: 10.1016/J.Jalz.2010.05.639 |
0.588 |
|
| 2010 |
Karch CM, Jeng A, Cruchaga C, Kauwe JS, Renaud N, Fagan AM, Holtzman DM, Morris JC, Goate AM. P1-090: The effects of Alzheimer's disease associated transferrin variants on APP metabolism Alzheimer's & Dementia. 6: S200-S200. DOI: 10.1016/J.Jalz.2010.05.638 |
0.843 |
|
| 2010 |
Cruchaga C, Chakraverty S, Haller G, Kevin M, Vallania FL, Robi MD, Bird TD, Diaz-Arrestia R, Boeve B, Bradley B, Graff-Radford NR, Mayeux R, Goate A. Implications and frequency of APP, PSEN1, PSEN2, GRN and MAPT mutation in a well-characterized series of late-onset Alzheimer families Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.615 |
0.586 |
|
| 2010 |
Cruchaga C, Kauwe JS, Mayo K, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S, Morris JC, Fagan AM, Holtzman DM, et al. SNPs associated with CSF tau levels modify rate of progression in Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.612 |
0.804 |
|
| 2010 |
Kauwe JSK, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using cerebrospinal fluid biomarker levels Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.348 |
0.654 |
|
| 2009 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Cruchaga C, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/Ng.440 |
0.831 |
|
| 2009 |
Fenoglio C, Galimberti D, Cortini F, Kauwe JS, Cruchaga C, Venturelli E, Villa C, Serpente M, Scalabrini D, Mayo K, Piccio LM, Clerici F, Albani D, Mariani C, Forloni G, et al. Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 18: 603-12. PMID 19625741 DOI: 10.3233/Jad-2009-1170 |
0.823 |
|
| 2009 |
Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, Goate AM, Cairns NJ. TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathologica. 118: 633-45. PMID 19618195 DOI: 10.1007/S00401-009-0571-7 |
0.614 |
|
| 2009 |
Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, et al. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Human Molecular Genetics. 18: 3125-35. PMID 19443489 DOI: 10.1093/Hmg/Ddp231 |
0.571 |
|
| 2009 |
Cruchaga C, Vidal-Taboada JM, Ezquerra M, Lorenzo E, Martinez-Lage P, Blazquez M, Tolosa E, Pastor P. 5'-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration. Neurobiology of Disease. 33: 164-70. PMID 19022385 DOI: 10.1016/J.Nbd.2008.09.027 |
0.709 |
|
| 2009 |
Cruchaga C, Fernández-Seara MA, Seijo-MartÃnez M, Samaranch L, Lorenzo E, Hinrichs A, Irigoyen J, Maestro C, Prieto E, MartÃ-Climent JM, Arbizu J, Pastor MA, Pastor P. Cortical atrophy and language network reorganization associated with a novel progranulin mutation. Cerebral Cortex (New York, N.Y. : 1991). 19: 1751-60. PMID 19020205 DOI: 10.1093/Cercor/Bhn202 |
0.649 |
|
| 2009 |
Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J, et al. Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Molecular Psychiatry. 14: 501-10. PMID 18414406 DOI: 10.1038/Mp.2008.42 |
0.582 |
|
| 2009 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Cruchaga C, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 41: 1156-1156. DOI: 10.1038/Ng1009-1156D |
0.72 |
|
| 2009 |
Cruchaga C, Kauwe JS, Mayo K, Bertelsen S, Nowotny P, Shah AR, Fagan AM, Holtzman DM, Morris JC, Goate AM. P4-136: SNPs in catalytic and regulatory subunits of calcineurin are associated with CSF tau levels and mRNA levels Alzheimer's & Dementia. 5: P471-P472. DOI: 10.1016/J.Jalz.2009.04.804 |
0.77 |
|
| 2008 |
Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM, Holtzman DM, Goate AM. Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition. Proceedings of the National Academy of Sciences of the United States of America. 105: 8050-4. PMID 18541914 DOI: 10.1073/Pnas.0801227105 |
0.821 |
|
| 2008 |
Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Shah AR, Morris JC, Fagan AM, Holtzman DM, Goate AM. O2-06-06: SNPS in MAPT are associated with cerebrospinal fluid Tau levels, MAPT mRNA levels, and age at onset of late-onset Alzheimer's disease Alzheimer's & Dementia. 4: T145-T145. DOI: 10.1016/J.Jalz.2008.05.354 |
0.649 |
|
| 2008 |
Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Nowotny P, Shah AR, Fagan AM, Holtzman DM, Morris JC, Goate A. P3-214: Cerebrospinal fluid tau levels, an endophenotype for genetic studies of Alzheimer's disease Alzheimer's & Dementia. 4: T583-T583. DOI: 10.1016/J.Jalz.2008.05.1781 |
0.827 |
|
| 2006 |
Day GS, Cruchaga C, Wingo T, Schindler SE, Coble DW, Morris JC. P2-295: QUANTIFYING THE CONTRIBUTIONS OF HERITABLE AND NON-HERITABLE FACTORS TO AGE-AT-ONSET OF ALZHEIMER DEMENTIA IN ADULT CHILDREN OF AFFECTED PARENTS Alzheimer's & Dementia. 14: P794-P795. DOI: 10.1016/J.Jalz.2018.06.984 |
0.344 |
|
| 2006 |
Jiang S, Li Z, Harari O, Budde JP, Dube U, Del Aguila J, Cruchaga C, Karch C. O5-04-03: IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES AND POTENTIALLY NOVEL DRUGS FOR FRONTOTEMPORAL LOBAR DEMENTIA WITH TAU INCLUSIONS BY A DEPENDABLE ANALYSIS APPROACH Alzheimer's & Dementia. 14: P1651-P1652. DOI: 10.1016/J.Jalz.2018.06.3015 |
0.796 |
|
| 2006 |
Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Harari O, Cruchaga C. O4-01-04: CIRCULAR RNAS IN ALZHEIMER'S DISEASE BRAIN TISSUES Alzheimer's & Dementia. 14: P1401-P1401. DOI: 10.1016/J.Jalz.2018.06.2912 |
0.806 |
|
| 2006 |
Cruchaga C, Del aguila J, Fernandez V, Ibanez L, Budde JP, Deming Y, Harari O. S1-02-01: REVIEW OF GWAS GENES AND POLYGENIC RISK SCORES Alzheimer's & Dementia. 14: P198-P198. DOI: 10.1016/J.Jalz.2018.06.2298 |
0.791 |
|
| 2006 |
Del-Aguila JL, Li Z, Dube U, Budde JP, Morris JC, Harari O, Cruchaga C. P1-173: BRAIN TRANSCRIPTOMICS STUDY REVEALS DIFFERENTIAL EXPRESSION OF THE THREE TREM2
TRANSCRIPT IN AD AND TREM2
MUTATION CARRIERS Alzheimer's & Dementia. 14: P345-P345. DOI: 10.1016/J.Jalz.2018.06.177 |
0.81 |
|
| 2006 |
Wen N, Li Z, Harari O, Cruchaga C, Karch C. P3-125: NUCLEOSKELETON DYSREGULATION IS MEDIATED BY LMNA IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1115-P1115. DOI: 10.1016/J.Jalz.2018.06.1482 |
0.839 |
|
| Show low-probability matches. |