Franck Polleux

2013- Neuroscience Columbia University, New York, NY 
 2013- Zuckerman Mind Brain Behavior Institute 
Developmental Neuroscience
"Franck Polleux"

Research in our laboratory focuses on three important questions relevant to brain development, aging and evolution:

I- What are the cellular and molecular mechanisms patterning the connectivity of cortical circuits during mammalian development?

II- What are the signaling mechanisms underlying synaptic loss during early stages of Alzheimer’s Disease?

III- What are the genetic mechanisms that led to the evolution of human cortical circuits?

Our work provides new insights into the cellular and molecular mechanisms underlying the establishment and maintenance of brain connectivity and has significant implications for our understanding of the pathophysiological mechanisms underlying socially-devastating neurodevelopmental disorders and neurodegenerative diseases.

Mean distance: 14.27 (cluster 11)
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Virga DM, Hamilton S, Osei B, et al. (2023) Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons. Biorxiv : the Preprint Server For Biology
Pilaz LJ, Liu J, Joshi K, et al. (2023) Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development. Neuron. 111: 839-856.e5
O'Hare JK, Gonzalez KC, Herrlinger SA, et al. (2022) Compartment-specific tuning of dendritic feature selectivity by intracellular Ca release. Science (New York, N.Y.). 375: eabm1670
Rolotti SV, Ahmed MS, Szoboszlay M, et al. (2021) Local feedback inhibition tightly controls rapid formation of hippocampal place fields. Neuron
Geiller T, Sadeh S, Rolotti SV, et al. (2021) Local circuit amplification of spatial selectivity in the hippocampus. Nature
Blockus H, Rolotti SV, Szoboszlay M, et al. (2021) Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function. Cell Reports. 37: 109828
Izadifar A, Courchet J, Virga DM, et al. (2021) Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed. Neuron
Blockus H, Polleux F. (2021) Developmental mechanisms underlying circuit wiring: Novel insights and challenges ahead. Current Opinion in Neurobiology. 66: 205-211
Iascone DM, Li Y, Sümbül U, et al. (2020) Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking. Neuron
Schmidt ERE, Kupferman JV, Stackmann M, et al. (2019) The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development. Scientific Reports. 9: 18692
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