Franck Polleux

2013- Neuroscience Columbia University, New York, NY 
 2013- Zuckerman Mind Brain Behavior Institute 
Developmental Neuroscience
"Franck Polleux"

Research in our laboratory focuses on three important questions relevant to brain development, aging and evolution:

I- What are the cellular and molecular mechanisms patterning the connectivity of cortical circuits during mammalian development?

II- What are the signaling mechanisms underlying synaptic loss during early stages of Alzheimer’s Disease?

III- What are the genetic mechanisms that led to the evolution of human cortical circuits?

Our work provides new insights into the cellular and molecular mechanisms underlying the establishment and maintenance of brain connectivity and has significant implications for our understanding of the pathophysiological mechanisms underlying socially-devastating neurodevelopmental disorders and neurodegenerative diseases.

Mean distance: 14.27 (cluster 11)
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Blockus H, Polleux F. (2021) Developmental mechanisms underlying circuit wiring: Novel insights and challenges ahead. Current Opinion in Neurobiology. 66: 205-211
Iascone DM, Li Y, Sümbül U, et al. (2020) Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking. Neuron
Lewis TL, Kwon SK, Lee A, et al. (2018) MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size. Nature Communications. 9: 5008
Courchet V, Roberts AJ, Meyer-Dilhet G, et al. (2018) Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice. Nature Communications. 9: 4289
Lee A, Hirabayashi Y, Kwon SK, et al. (2018) Emerging roles of mitochondria in synaptic transmission and neurodegeneration. Current Opinion in Physiology. 3: 82-93
Hirabayashi Y, Tapia JC, Polleux F. (2018) Correlated Light-Serial Scanning Electron Microscopy (CoLSSEM) for ultrastructural visualization of single neurons in vivo. Scientific Reports. 8: 14491
Kwon SK, Sando R, Lewis TL, et al. (2018) Correction: LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons. Plos Biology. 16: e3000040
Blockus H, Polleux F. (2018) Circuit Wiring: Neurite Speed Dating versus Stable Synaptic Matchmaking. Developmental Cell. 45: 423-424
Shi F, Kawano F, Park SE, et al. (2017) Optogenetic Control of Endoplasmic Reticulum-Mitochondria Tethering. Acs Synthetic Biology
Hirabayashi Y, Kwon SK, Paek H, et al. (2017) ER-mitochondria tethering by PDZD8 regulates Ca(2+) dynamics in mammalian neurons. Science (New York, N.Y.). 358: 623-630
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