Franck Polleux
Affiliations: | 2013- | Neuroscience | Columbia University, New York, NY |
| 2013- | Zuckerman Mind Brain Behavior Institute |
Area:
Developmental NeuroscienceWebsite:
http://polleuxlab.comGoogle:
"Franck Polleux"Bio:
Research in our laboratory focuses on three important questions relevant to brain development, aging and evolution:
I- What are the cellular and molecular mechanisms patterning the connectivity of cortical circuits during mammalian development?
II- What are the signaling mechanisms underlying synaptic loss during early stages of Alzheimer’s Disease?
III- What are the genetic mechanisms that led to the evolution of human cortical circuits?
Our work provides new insights into the cellular and molecular mechanisms underlying the establishment and maintenance of brain connectivity and has significant implications for our understanding of the pathophysiological mechanisms underlying socially-devastating neurodevelopmental disorders and neurodegenerative diseases.
Mean distance: 14.27 (cluster 11) | S | N | B | C | P |
Children
Sign in to add trainee| Ashton Winfield Powell | grad student | 2002-2007 | UNC Chapel Hill |
| Dante S. Bortone | grad student | 2003-2008 | UNC Chapel Hill |
| Randal A. Hand | grad student | 2003-2009 | UNC Chapel Hill |
| Sabrice G. Guerrier | grad student | 2004-2009 | UNC Chapel Hill |
| Jaeda Coutinho-Budd | grad student | 2007-2012 | UNC Chapel Hill |
| Daniel Maxim Iascone | grad student | 2014-2019 | Columbia |
| Carlos Diaz-Salazar | post-doc | ||
| Heike Blockus | post-doc | 2016- | Columbia |
| Martina Proietti Onori | post-doc | 2020- | Columbia |
| Juyoun Yoo | post-doc | 2024- | Columbia |
| Anthony Paul Barnes | post-doc | 2004-2008 | UNC Chapel Hill |
| Takayuki Sassa | post-doc | 2005-2009 | UNC Chapel Hill |
| Julien Courchet | post-doc | 2008-2014 | Columbia |
| Kaumudi V. Joshi | post-doc | 2010-2014 | The Scripps Research Institute, La Jolla, CA |
| Tommy L. Lewis Jr | post-doc | 2010-2018 | Columbia |
| Seok-Kyu Kwon | post-doc | 2012-2018 | Columbia |
| Seok-Kyu Kwon | post-doc | 2012-2018 | Columbia |
| Yusuke Hirabayashi | post-doc | 2013-2018 | Columbia |
| Abhishek Sahasrabudhe | post-doc | 2016-2018 | Columbia |
Collaborators
Sign in to add collaborator| Jason J Yi | collaborator | Duke | |
| Brendan N. Lilley | collaborator | 2006- | Center for Brain Science, Harvard University |
| Baptiste Libé-Philippot | collaborator | 2017-2024 |
Publications
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| Gonzalez KC, Negrean A, Liao Z, et al. (2024) Synaptic basis of feature selectivity in hippocampal neurons. Nature |
| Libé-Philippot B, Iwata R, Recupero AJ, et al. (2024) Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition. Neuron |
| Libé-Philippot B, Polleux F, Vanderhaeghen P. (2024) If you please, draw me a neuron - linking evolutionary tinkering with human neuron evolution. Current Opinion in Genetics & Development. 89: 102260 |
| Diaz-Salazar C, Krzisch M, Yoo J, et al. (2024) Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation. Biorxiv : the Preprint Server For Biology |
| Nakamura K, Aoyama-Ishiwatari S, Nagao T, et al. (2024) PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity. Biorxiv : the Preprint Server For Biology |
| Virga DM, Hamilton S, Osei B, et al. (2024) Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo. Nature Communications. 15: 2142 |
| Hirabayashi Y, Lewis TL, Du Y, et al. (2024) Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP. Biorxiv : the Preprint Server For Biology |
| Virga DM, Hamilton S, Osei B, et al. (2023) Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons. Biorxiv : the Preprint Server For Biology |
| Pilaz LJ, Liu J, Joshi K, et al. (2023) Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development. Neuron. 111: 839-856.e5 |
| Lee A, Kondapalli C, Virga DM, et al. (2022) Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Nature Communications. 13: 4444 |