Penelope Hallett

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2002-2006 Neurology Harvard Medical School, Boston, MA, United States 
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"Penelope Hallett"
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Rocha EM, Smith GA, Park E, et al. (2015) Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease
Rocha EM, Smith GA, Park E, et al. (2015) Chronic pharmacological glucocerebrosidase inhibition induces α-synuclein aggregation, microglial and complement activation and synaptic protein changes in mice. Antioxidants & Redox Signaling
Smith GA, Rocha EM, Rooney T, et al. (2015) A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). Plos One. 10: e0121072
Hallett PJ, Deleidi M, Astradsson A, et al. (2015) Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 16: 269-74
Hallett PJ, Cooper O, Sadi D, et al. (2014) Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell Reports. 7: 1755-61
McLean JR, Smith GA, Rocha EM, et al. (2014) ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental Neurology. 261: 217-29
McLean JR, Smith GA, Rocha EM, et al. (2014) Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters. 576: 73-8
Smith GA, Rocha EM, McLean JR, et al. (2014) Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human Molecular Genetics. 23: 4510-27
Davies SE, Hallett PJ, Moens T, et al. (2014) Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiology of Disease. 64: 79-87
Sundberg M, Bogetofte H, Lawson T, et al. (2013) Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells (Dayton, Ohio). 31: 1548-62
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