Anthony G Coyne
Affiliations: | University of Cambridge, Cambridge, England, United Kingdom |
Area:
Fragment-based drug discoveryGoogle:
"Anthony Coyne"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Richard N. Butler | grad student | NUI Galway | |
| Christopher Abell | post-doc | Cambridge | |
| Martin D. Smith | post-doc | Cambridge |
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Publications
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| El Bakali J, Blaszczyk M, Evans JC, et al. (2023) Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference. Angewandte Chemie (International Ed. in English) |
| Bedwell E, McCarthy WJ, Coyne AG, et al. (2022) Development of potent inhibitors by fragment-linking strategies. Chemical Biology & Drug Design |
| Thomas SE, McCarthy WJ, El Bakali J, et al. (2022) Structural Characterization of Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design. Frontiers in Molecular Biosciences. 9: 880432 |
| Acebrón-García-de-Eulate M, Mayol-Llinàs J, Holland MTO, et al. (2022) Discovery of Novel Inhibitors of Uridine Diphosphate--Acetylenolpyruvylglucosamine Reductase (MurB) from , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. Journal of Medicinal Chemistry |
| Frederickson M, Selvam IR, Evangelopoulos D, et al. (2022) A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen). European Journal of Medicinal Chemistry. 230: 114105 |
| Charoensutthivarakul S, Thomas SE, Curran A, et al. (2022) Development of Inhibitors of SAICAR Synthetase (PurC) from Using a Fragment-Based Approach. Acs Infectious Diseases |
| Scott DE, Francis-Newton NJ, Marsh ME, et al. (2021) A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology |
| Sabbah M, Mendes V, Vistal RG, et al. (2020) Correction to Fragment-Based Design of InhA Inhibitors. Journal of Medicinal Chemistry |
| Ribeiro JA, Hammer AJS, Libreros-Z Uacute Ntilde Iga GAES, et al. (2020) Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. Acs Infectious Diseases |
| Thomas SE, Whitehouse AJ, Brown K, et al. (2020) Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Research |