Jeffery M Tharp
Affiliations: | Yale University, New Haven, CT |
Area:
Genetic Code Expansion, Phage Display, Synthetic BiologyGoogle:
"Jeffery Tharp"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Dieter Söll | grad student | 2018- | Yale |
| Wenshe Liu | grad student | 2012-2018 | Texas A & M |
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Publications
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| Krahn N, Zhang J, Melnikov SV, et al. (2023) tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut. Nucleic Acids Research |
| Jiang HK, Tharp JM. (2023) Reprogramming Initiator and Nonsense Codons to Simultaneously Install Three Distinct Noncanonical Amino Acids into Proteins in E. coli. Methods in Molecular Biology (Clifton, N.J.). 2676: 101-116 |
| Jiang HK, Ambrose NL, Chung CZ, et al. (2023) Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219758120 |
| Hampton JT, Lalonde TJ, Tharp JM, et al. (2022) Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2. Acs Chemical Biology |
| Guo LT, Amikura K, Jiang HK, et al. (2022) Ancestral Archaea Expanded the Genetic Code with Pyrrolysine. The Journal of Biological Chemistry. 102521 |
| Fischer JT, Söll D, Tharp JM. (2022) Directed Evolution of Pyrrolysyl-tRNA Synthetase Generates a Hyperactive and Highly Selective Variant. Frontiers in Molecular Biosciences. 9: 850613 |
| Tharp JM, Walker JA, Söll D, et al. (2021) Initiating protein synthesis with noncanonical monomers in vitro and in vivo. Methods in Enzymology. 656: 495-519 |
| Tharp JM, Vargas-Rodriguez O, Schepartz A, et al. (2021) Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons. Acs Chemical Biology |
| Krahn N, Tharp JM, Crnković A, et al. (2020) Engineering aminoacyl-tRNA synthetases for use in synthetic biology. The Enzymes. 48: 351-395 |
| Tharp JM, Hampton JT, Reed CA, et al. (2020) An amber obligate active site-directed ligand evolution technique for phage display. Nature Communications. 11: 1392 |