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Yu Lei

Affiliations: 
2011 Oral Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
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"Yu Lei"
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Jenny P-Y Ting grad student 2011 UNC Chapel Hill
 (Biochemical and Functional Characterization of the Mitochondrial Immune Signaling Protein Complex.)

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Publications

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Barnett KC, Xie Y, Asakura T, et al. (2022) An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2. Cell Host & Microbe
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382
Deng M, Tam JW, Wang L, et al. (2020) TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nature Communications. 11: 2193
Lei Y, Wen H, Ting JP. (2013) The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy. Autophagy. 9: 432-3
Lei Y, Wen H, Yu Y, et al. (2012) The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 36: 933-46
Allen IC, Moore CB, Schneider M, et al. (2011) NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity. 34: 854-65
Taxman DJ, Holley-Guthrie EA, Huang MT, et al. (2011) The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. The Journal of Biological Chemistry. 286: 19605-16
Wen H, Gris D, Lei Y, et al. (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nature Immunology. 12: 408-15
Wen H, Lei Y, Eun SY, et al. (2010) Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm. The Journal of Experimental Medicine. 207: 2943-57
Ting JP, Duncan JA, Lei Y. (2010) How the noninflammasome NLRs function in the innate immune system. Science (New York, N.Y.). 327: 286-90
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