Xin Lin, Ph.D
Affiliations: | 1997-2006 | Duquesne University, Pittsburgh, PA, United States |
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Parents
Sign in to add mentor| Aleem Gangjee | grad student | 1997-2005 | Duquesne University (Chemistry Tree) |
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| Shah K, Lin X, Queener SF, et al. (2018) Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents. Bioorganic & Medicinal Chemistry |
| Gangjee A, Lin X, Biondo LR, et al. (2010) CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application. Bioorganic & Medicinal Chemistry. 18: 1684-701 |
| Gangjee A, Jain HD, Phan J, et al. (2006) Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). Journal of Medicinal Chemistry. 49: 1055-65 |
| Gangjee A, Lin X, Kisliuk RL, et al. (2005) Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents. Journal of Medicinal Chemistry. 48: 7215-22 |
| Gangjee A, Lin X. (2005) CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. Journal of Medicinal Chemistry. 48: 1448-69 |
| Gangjee A, Lin X, Queener SF. (2004) Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors. Journal of Medicinal Chemistry. 47: 3689-92 |