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Xin Lin, Ph.D - Publications

Affiliations: 
1997-2006 Duquesne University, Pittsburgh, PA, United States 
Area:
Chemistry
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6 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Shah K, Lin X, Queener SF, Cody V, Pace J, Gangjee A. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents. Bioorganic & Medicinal Chemistry. PMID 29691153 DOI: 10.1016/J.Bmc.2018.04.032  0.473
2010 Gangjee A, Lin X, Biondo LR, Queener SF. CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application. Bioorganic & Medicinal Chemistry. 18: 1684-701. PMID 20117005 DOI: 10.1016/J.Bmc.2009.12.066  0.471
2006 Gangjee A, Jain HD, Phan J, Lin X, Song X, McGuire JJ, Kisliuk RL. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). Journal of Medicinal Chemistry. 49: 1055-65. PMID 16451071 DOI: 10.1021/Jm058276A  0.48
2005 Gangjee A, Lin X, Kisliuk RL, McGuire JJ. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents. Journal of Medicinal Chemistry. 48: 7215-22. PMID 16279780 DOI: 10.1021/Jm058234M  0.481
2005 Gangjee A, Lin X. CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. Journal of Medicinal Chemistry. 48: 1448-69. PMID 15743188 DOI: 10.1021/Jm040153N  0.442
2004 Gangjee A, Lin X, Queener SF. Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors. Journal of Medicinal Chemistry. 47: 3689-92. PMID 15214795 DOI: 10.1021/Jm0306327  0.477
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