| Year |
Citation |
Score |
| 2023 |
Wurl JA, Mac Nair CE, Dietz JA, Shestopalov VI, Nickells RW. Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity. International Journal of Molecular Sciences. 24. PMID 37958624 DOI: 10.3390/ijms242115641 |
0.326 |
|
| 2023 |
Maes ME, Donahue RJ, Schlamp CL, Marola OJ, Libby RT, Nickells RW. BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps. Molecular Neurodegeneration. 18: 67. PMID 37752598 DOI: 10.1186/s13024-023-00659-8 |
0.37 |
|
| 2023 |
Maes ME, Donahue RJ, Schlamp CL, Marola OJ, Libby RT, Nickells R. BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps. Research Square. PMID 37292963 DOI: 10.21203/rs.3.rs-2846437/v1 |
0.38 |
|
| 2021 |
Schmitt HM, Fehrman RL, Maes ME, Yang H, Guo LW, Schlamp CL, Pelzel HR, Nickells RW. Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression. Investigative Ophthalmology & Visual Science. 62: 14. PMID 34398198 DOI: 10.1167/iovs.62.10.14 |
0.796 |
|
| 2021 |
Donahue RJ, Fehrman RL, Gustafson JR, Nickells RW. BCLX gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma. Cell Death & Disease. 12: 781. PMID 34376637 DOI: 10.1038/s41419-021-04068-x |
0.365 |
|
| 2021 |
Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease. Cells. 10. PMID 34201955 DOI: 10.3390/cells10071593 |
0.314 |
|
| 2020 |
Schmitt HM, Grosser JA, Schlamp CL, Nickells RW. Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma. Experimental Eye Research. 200: 108244. PMID 32971093 DOI: 10.1016/j.exer.2020.108244 |
0.45 |
|
| 2019 |
Donahue RJ, Maes ME, Grosser JA, Nickells RW. BAX-Depleted Retinal Ganglion Cells Survive and Become Quiescent Following Optic Nerve Damage. Molecular Neurobiology. PMID 31673950 DOI: 10.1007/S12035-019-01783-7 |
0.506 |
|
| 2017 |
Schmitt HM, Schlamp CL, Nickells RW. Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 29211617 DOI: 10.1089/Jop.2017.0059 |
0.469 |
|
| 2017 |
Nickells RW, Schmitt HM, Maes ME, Schlamp CL. AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury. Investigative Ophthalmology & Visual Science. 58: 6091-6104. PMID 29204649 DOI: 10.1167/Iovs.17-22634 |
0.517 |
|
| 2017 |
Maes ME, Schlamp CL, Nickells RW. Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis. Plos One. 12: e0184434. PMID 28880942 DOI: 10.1371/Journal.Pone.0184434 |
0.383 |
|
| 2017 |
Farnoodian M, Wang S, Dietz J, Nickells RW, Sorenson CM, Sheibani N. Negative regulators of angiogenesis: important targets for treatment of exudative AMD. Clinical Science (London, England : 1979). 131: 1763-1780. PMID 28679845 DOI: 10.1042/Cs20170066 |
0.343 |
|
| 2017 |
Maes ME, Schlamp CL, Nickells RW. BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells. Progress in Retinal and Eye Research. PMID 28064040 DOI: 10.1016/J.Preteyeres.2017.01.002 |
0.498 |
|
| 2017 |
Zhao L, Chen G, Li J, Fu Y, Mavlyutov TA, Yao A, Nickells RW, Gong S, Guo LW. An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28063892 DOI: 10.1016/J.Jconrel.2016.12.038 |
0.334 |
|
| 2016 |
Mac Nair CE, Schlamp CL, Montgomery AD, Shestopalov VI, Nickells RW. Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways. Journal of Neuroinflammation. 13: 93. PMID 27126275 DOI: 10.1186/S12974-016-0558-Y |
0.459 |
|
| 2015 |
Schmitt HM, Schlamp CL, Nickells RW. Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells. Neuroscience Letters. PMID 26733303 DOI: 10.1016/J.Neulet.2015.12.012 |
0.522 |
|
| 2015 |
Nickells RW. The Long-Term Effects on the Retina Damaged by Optic Nerve Axotomy. Investigative Ophthalmology & Visual Science. 56: 6113. PMID 26393670 DOI: 10.1167/Iovs.15-17997 |
0.356 |
|
| 2015 |
Mac Nair CE, Nickells RW. Neuroinflammation in Glaucoma and Optic Nerve Damage. Progress in Molecular Biology and Translational Science. 134: 343-63. PMID 26310164 DOI: 10.1016/Bs.Pmbts.2015.06.010 |
0.461 |
|
| 2015 |
Nickells RW, Pelzel HR. Tools and resources for analyzing gene expression changes in glaucomatous neurodegeneration. Experimental Eye Research. PMID 25999234 DOI: 10.1016/J.Exer.2015.05.009 |
0.77 |
|
| 2014 |
Mac Nair CE, Fernandes KA, Schlamp CL, Libby RT, Nickells RW. Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush. Journal of Neuroinflammation. 11: 194. PMID 25407441 DOI: 10.1186/S12974-014-0194-3 |
0.474 |
|
| 2014 |
Schmitt HM, Pelzel HR, Schlamp CL, Nickells RW. Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury. Molecular Neurodegeneration. 9: 39. PMID 25261965 DOI: 10.1186/1750-1326-9-39 |
0.812 |
|
| 2014 |
Dietz JA, Maes ME, Huang S, Yandell BS, Schlamp CL, Montgomery AD, Allingham RR, Hauser MA, Nickells RW. Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage. Plos One. 9: e93564. PMID 24699552 DOI: 10.1371/Journal.Pone.0093564 |
0.491 |
|
| 2013 |
Schlamp CL, Montgomery AD, Mac Nair CE, Schuart C, Willmer DJ, Nickells RW. Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina. Molecular Vision. 19: 1387-96. PMID 23825918 |
0.369 |
|
| 2013 |
Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, ... ... Nickells RW, et al. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proceedings of the National Academy of Sciences of the United States of America. 110: 4045-50. PMID 23431148 DOI: 10.1073/Pnas.1211284110 |
0.781 |
|
| 2013 |
Janssen KT, Mac Nair CE, Dietz JA, Schlamp CL, Nickells RW. Nuclear atrophy of retinal ganglion cells precedes the bax-dependent stage of apoptosis. Investigative Ophthalmology & Visual Science. 54: 1805-15. PMID 23422829 DOI: 10.1167/Iovs.11-9310 |
0.472 |
|
| 2012 |
Toops KA, Hagemann TL, Messing A, Nickells RW. The effect of glial fibrillary acidic protein expression on neurite outgrowth from retinal explants in a permissive environment. Bmc Research Notes. 5: 693. PMID 23259929 DOI: 10.1186/1756-0500-5-693 |
0.791 |
|
| 2012 |
Nickells RW. The cell and molecular biology of glaucoma: mechanisms of retinal ganglion cell death. Investigative Ophthalmology & Visual Science. 53: 2476-81. PMID 22562845 DOI: 10.1167/Iovs.12-9483H |
0.496 |
|
| 2012 |
Nickells RW, Howell GR, Soto I, John SW. Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annual Review of Neuroscience. 35: 153-79. PMID 22524788 DOI: 10.1146/Annurev.Neuro.051508.135728 |
0.45 |
|
| 2012 |
Nickells RW, Merbs SL. The potential role of epigenetics in ocular diseases. Archives of Ophthalmology (Chicago, Ill. : 1960). 130: 508-9. PMID 22491920 DOI: 10.1001/Archopthalmol.2011.1423 |
0.601 |
|
| 2012 |
Toops KA, Berlinicke C, Zack DJ, Nickells RW. Hydrocortisone stimulates neurite outgrowth from mouse retinal explants by modulating macroglial activity. Investigative Ophthalmology & Visual Science. 53: 2046-61. PMID 22395888 DOI: 10.1167/Iovs.11-8646 |
0.787 |
|
| 2012 |
Pelzel HR, Schlamp CL, Waclawski M, Shaw MK, Nickells RW. Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity. Investigative Ophthalmology & Visual Science. 53: 1428-35. PMID 22297488 DOI: 10.1167/Iovs.11-8872 |
0.814 |
|
| 2011 |
Pelzel HR, Nickells RW. A role for epigenetic changes in the development of retinal neurodegenerative conditions. Journal of Ocular Biology, Diseases, and Informatics. 4: 104-10. PMID 23515137 DOI: 10.1007/S12177-012-9079-9 |
0.761 |
|
| 2011 |
Nickells RW. WITHDRAWN: Reprint of: Variations in the rheostat model of apoptosis: What studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental Eye Research. PMID 21819979 DOI: 10.1016/J.Exer.2011.07.013 |
0.438 |
|
| 2011 |
Mavlyutov TA, Nickells RW, Guo LW. Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor. Molecular Vision. 17: 1034-43. PMID 21541278 |
0.329 |
|
| 2010 |
Semaan SJ, Nickells RW. The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein. Bmc Cancer. 10: 554. PMID 20942963 DOI: 10.1186/1471-2407-10-554 |
0.773 |
|
| 2010 |
Pelzel HR, Schlamp CL, Nickells RW. Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis. Bmc Neuroscience. 11: 62. PMID 20504333 DOI: 10.1186/1471-2202-11-62 |
0.809 |
|
| 2010 |
Semaan SJ, Li Y, Nickells RW. A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death. Asn Neuro. 2: e00032. PMID 20360947 DOI: 10.1042/An20100003 |
0.784 |
|
| 2010 |
Nickells RW. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental Eye Research. 91: 2-8. PMID 20230818 DOI: 10.1016/J.Exer.2010.03.004 |
0.429 |
|
| 2009 |
Cordeiro MF, Nickells R, Drexler W, Borrás T, Ritch R. High-resolution ocular imaging: Combining advanced optics and microtechnology Ophthalmic Surgery Lasers and Imaging. 40: 480-488. PMID 19772272 DOI: 10.3928/15428877-20090901-07 |
0.364 |
|
| 2009 |
McKinnon SJ, Schlamp CL, Nickells RW. Mouse models of retinal ganglion cell death and glaucoma. Experimental Eye Research. 88: 816-24. PMID 19105954 DOI: 10.1016/J.Exer.2008.12.002 |
0.422 |
|
| 2008 |
Nickells RW, Semaan SJ, Schlamp CL. Involvement of the Bcl2 gene family in the signaling and control of retinal ganglion cell death. Progress in Brain Research. 173: 423-35. PMID 18929125 DOI: 10.1016/S0079-6123(08)01129-1 |
0.789 |
|
| 2008 |
Dietz JA, Li Y, Chung LM, Yandell BS, Schlamp CL, Nickells RW. Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. Bmc Neuroscience. 9: 74. PMID 18671875 DOI: 10.1186/1471-2202-9-74 |
0.459 |
|
| 2007 |
Nickells RW. Ganglion cell death in glaucoma: from mice to men. Veterinary Ophthalmology. 10: 88-94. PMID 17973839 DOI: 10.1111/J.1463-5224.2007.00564.X |
0.471 |
|
| 2007 |
Nickells RW. From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma. Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie. 42: 278-87. PMID 17392853 DOI: 10.3129/Can.J.Ophthalmol.I07-036 |
0.464 |
|
| 2007 |
Li Y, Semaan SJ, Schlamp CL, Nickells RW. Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice. Bmc Neuroscience. 8: 19. PMID 17338819 DOI: 10.1186/1471-2202-8-19 |
0.771 |
|
| 2007 |
Nickells RW, Schlamp CL, Li Y, Kaufman PL, Heatley G, Peterson JC, Faha B, Ver Hoeve JN. Surgical lowering of elevated intraocular pressure in monkeys prevents progression of glaucomatous disease. Experimental Eye Research. 84: 729-36. PMID 17291496 DOI: 10.1016/J.Exer.2006.12.011 |
0.35 |
|
| 2006 |
Pelzel HR, Schlamp CL, Poulsen GL, Ver Hoeve JA, Nork TM, Nickells RW. Decrease of cone opsin mRNA in experimental ocular hypertension. Molecular Vision. 12: 1272-82. PMID 17110910 |
0.764 |
|
| 2006 |
Schlamp CL, Li Y, Dietz JA, Janssen KT, Nickells RW. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. Bmc Neuroscience. 7: 66. PMID 17018142 DOI: 10.1186/1471-2202-7-66 |
0.512 |
|
| 2005 |
Libby RT, Li Y, Savinova OV, Barter J, Smith RS, Nickells RW, John SW. Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. Plos Genetics. 1: 17-26. PMID 16103918 DOI: 10.1371/Journal.Pgen.0010004 |
0.406 |
|
| 2004 |
Farkas RH, Chowers I, Hackam AS, Kageyama M, Nickells RW, Otteson DC, Duh EJ, Wang C, Valenta DF, Gunatilaka TL, Pease ME, Quigley HA, Zack DJ. Increased expression of iron-regulating genes in monkey and human glaucoma. Investigative Ophthalmology & Visual Science. 45: 1410-7. PMID 15111596 DOI: 10.1167/Iovs.03-0872 |
0.78 |
|
| 2004 |
Schlamp CL, Thliveris AT, Li Y, Kohl LP, Knop C, Dietz JA, Larsen IV, Imesch P, Pinto LH, Nickells RW. Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice. Molecular and Cellular Biology. 24: 3794-803. PMID 15082774 DOI: 10.1128/Mcb.24.9.3794-3803.2004 |
0.391 |
|
| 2004 |
Nickells RW. The molecular biology of retinal ganglion cell death: caveats and controversies. Brain Research Bulletin. 62: 439-46. PMID 15036555 DOI: 10.1016/J.Brainresbull.2003.07.007 |
0.453 |
|
| 2004 |
Heatley G, Kiland J, Faha B, Seeman J, Schlamp CL, Dawson DG, Gleiser J, Maneval D, Kaufman PL, Nickells RW. Gene therapy using p21WAF-1/Cip-1 to modulate wound healing after glaucoma trabeculectomy surgery in a primate model of ocular hypertension. Gene Therapy. 11: 949-55. PMID 14985792 DOI: 10.1038/Sj.Gt.3302253 |
0.341 |
|
| 2002 |
Li Y, Schlamp CL, Poulsen GL, Jackson MW, Griep AE, Nickells RW. p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate. Molecular Vision. 8: 341-50. PMID 12355059 |
0.309 |
|
| 2001 |
Schlamp CL, Johnson EC, Li Y, Morrison JC, Nickells RW. Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Molecular Vision. 7: 192-201. PMID 11509915 |
0.419 |
|
| 2000 |
Nork TM, Poulsen GL, Nickells RW, Ver Hoeve JN, Cho NC, Levin LA, Lucarelli MJ. Protection of ganglion cells in experimental glaucoma by retinal laser photocoagulation. Archives of Ophthalmology (Chicago, Ill. : 1960). 118: 1242-50. PMID 10980770 DOI: 10.1001/Archopht.118.9.1242 |
0.461 |
|
| 2000 |
Li Y, Schlamp CL, Poulsen KP, Nickells RW. Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuli. Experimental Eye Research. 71: 209-13. PMID 10930325 DOI: 10.1006/exer.2000.0873 |
0.342 |
|
| 2000 |
Nork TM, Ver Hoeve JN, Poulsen GL, Nickells RW, Davis MD, Weber AJ, Vaegan, Sarks SH, Lemley HL, Millecchia LL. Swelling and loss of photoreceptors in chronic human and experimental glaucomas. Archives of Ophthalmology (Chicago, Ill. : 1960). 118: 235-45. PMID 10676789 DOI: 10.1001/Archopht.118.2.235 |
0.356 |
|
| 1999 |
Nickells RW. Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death. Survey of Ophthalmology. 43: S151-61. PMID 10416758 DOI: 10.1016/S0039-6257(99)00029-6 |
0.53 |
|
| 1999 |
Li Y, Schlamp CL, Nickells RW. Experimental induction of retinal ganglion cell death in adult mice. Investigative Ophthalmology & Visual Science. 40: 1004-8. PMID 10102300 |
0.47 |
|
| 1998 |
Perez-Mediavilla LA, Chew C, Campochiaro PA, Nickells RW, Notario V, Zack DJ, Becerra SP. Sequence and expression analysis of bovine pigment epithelium-derived factor. Biochimica Et Biophysica Acta. 1398: 203-14. PMID 9689919 DOI: 10.1016/S0167-4781(98)00055-4 |
0.536 |
|
| 1997 |
Levin LA, Schlamp CL, Spieldoch RL, Geszvain KM, Nickells RW. Identification of the bcl-2 family of genes in the rat retina. Investigative Ophthalmology & Visual Science. 38: 2545-53. PMID 9375574 |
0.428 |
|
| 1997 |
Schlamp CL, Poulsen GL, Nork TM, Nickells RW. Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells. Journal of the National Cancer Institute. 89: 1530-6. PMID 9337350 DOI: 10.1093/Jnci/89.20.1530 |
0.394 |
|
| 1996 |
Nickells RW, Zack DJ. Apoptosis in ocular disease: a molecular overview. Ophthalmic Genetics. 17: 145-65. PMID 9010866 DOI: 10.3109/13816819609057889 |
0.609 |
|
| 1996 |
Nickells RW. Retinal ganglion cell death in glaucoma: the how, the why, and the maybe. Journal of Glaucoma. 5: 345-56. PMID 8897235 DOI: 10.1097/00061198-199610000-00010 |
0.503 |
|
| 1996 |
Levin LA, Spieldoch RL, Geszvain KM, Schlamp CL, Nickells RW. Expression of bcl-2 family gene(S) after retinal ganglion cell axotomy Investigative Ophthalmology and Visual Science. 37: S1121. |
0.379 |
|
| 1995 |
Nickells RW, Burgoyne CF, Quigley HA, Zack DJ. Cloning and characterization of rod opsin cDNA from the Old World monkey, Macaca fascicularis. Investigative Ophthalmology & Visual Science. 36: 72-82. PMID 7822161 |
0.445 |
|
| 1995 |
Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, Zack DJ. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Investigative Ophthalmology & Visual Science. 36: 774-86. PMID 7706025 |
0.588 |
|
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