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David E. Lenz - Publications

Affiliations: 
2004- Physiology  U.S. Army Medical Research Institute of Chemical Defense 
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cerasoli DM, Armstrong SJ, Reeves TE, Hodgins SM, Kasten SA, Lee-Stubbs RB, Linn Cadieux C, Otto TC, Capacio BR, Lenz DE. Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication. Biochemical Pharmacology. 113670. PMID 31628910 DOI: 10.1016/J.Bcp.2019.113670  0.717
2017 Lenz DE, Cerasoli D, Maxwell DM. Radiolabelled Soman Binding to Sera from Rats, Guinea Pigs and Monkeys. Toxicology Letters. PMID 29155040 DOI: 10.1016/J.Toxlet.2017.11.016  0.672
2017 Reed BA, Sabourin CL, Lenz DE. Human butyrylcholinesterase efficacy against nerve agent exposure. Journal of Biochemical and Molecular Toxicology. PMID 28225154 DOI: 10.1002/Jbt.21886  0.427
2012 Sarkar M, Harsch CK, Matic GT, Hoffman K, Norris JR, Otto TC, Lenz DE, Cerasoli DM, Magliery TJ. Solubilization and humanization of paraoxonase-1. Journal of Lipids. 2012: 610937. PMID 22720164 DOI: 10.1155/2012/610937  0.666
2011 Mumford H, E Price M, Lenz DE, Cerasoli DM. Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs. Clinical Toxicology (Philadelphia, Pa.). 49: 287-97. PMID 21563904 DOI: 10.3109/15563650.2011.568944  0.674
2010 Sanan TT, Muthukrishnan S, Beck JM, Tao P, Hayes CJ, Otto TC, Cerasoli DM, Lenz DE, Hadad CM. Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights. Journal of Physical Organic Chemistry. 23: 357-369. PMID 24077808 DOI: 10.1002/Poc.1678  0.705
2010 Geyer BC, Kannan L, Garnaud PE, Broomfield CA, Cadieux CL, Cherni I, Hodgins SM, Kasten SA, Kelley K, Kilbourne J, Oliver ZP, Otto TC, Puffenberger I, Reeves TE, Robbins N, ... ... Lenz DE, et al. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proceedings of the National Academy of Sciences of the United States of America. 107: 20251-6. PMID 21059932 DOI: 10.1073/Pnas.1009021107  0.707
2010 Lenz DE, Clarkson ED, Schulz SM, Cerasoli DM. Butyrylcholinesterase as a therapeutic drug for protection against percutaneous VX. Chemico-Biological Interactions. 187: 249-52. PMID 20513442 DOI: 10.1016/J.Cbi.2010.05.014  0.659
2010 Cadieux CL, Broomfield CA, Kirkpatrick MG, Kazanski ME, Lenz DE, Cerasoli DM. Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation. Chemico-Biological Interactions. 187: 229-33. PMID 20433814 DOI: 10.1016/J.Cbi.2010.04.020  0.708
2010 Suzuki SM, Stevens RC, Richter RJ, Cole TB, Park S, Otto TC, Cerasoli DM, Lenz DE, Furlong CE. Engineering human PON1 in an E. coli expression system. Advances in Experimental Medicine and Biology. 660: 37-45. PMID 20221869 DOI: 10.1007/978-1-60761-350-3_5  0.672
2010 Mumford H, Price ME, Cerasoli DM, Teschner W, Ehrlich H, Schwarz HP, Lenz DE. Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig. Chemico-Biological Interactions. 187: 304-8. PMID 20176007 DOI: 10.1016/J.Cbi.2010.02.020  0.682
2010 Otto TC, Kasten SA, Kovaleva E, Liu Z, Buchman G, Tolosa M, Davis D, Smith JR, Balcerzak R, Lenz DE, Cerasoli DM. Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae. Chemico-Biological Interactions. 187: 388-92. PMID 20176005 DOI: 10.1016/J.Cbi.2010.02.022  0.678
2010 Haigh JR, Adler M, Apland JP, Deshpande SS, Barham CB, Desmond P, Koplovitz I, Lenz DE, Gordon RK. Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. Chemico-Biological Interactions. 187: 416-20. PMID 20144889 DOI: 10.1016/J.Cbi.2010.02.003  0.436
2009 Otto TC, Harsch CK, Yeung DT, Magliery TJ, Cerasoli DM, Lenz DE. Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes. Biochemistry. 48: 10416-22. PMID 19764813 DOI: 10.1021/Bi901161B  0.757
2009 Bruno JG, Carrillo MP, Cadieux CL, Lenz DE, Cerasoli DM, Phillips T. DNA aptamers developed against a soman derivative cross-react with the methylphosphonic acid core but not with flanking hydrophobic groups. Journal of Molecular Recognition : Jmr. 22: 197-204. PMID 19051203 DOI: 10.1002/Jmr.932  0.671
2009 Hu X, Jiang X, Lenz DE, Cerasoli DM, Wallqvist A. In silico analyses of substrate interactions with human serum paraoxonase 1. Proteins. 75: 486-98. PMID 18951406 DOI: 10.1002/Prot.22264  0.664
2008 Sun W, Doctor BP, Lenz DE, Saxena A. Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys. Chemico-Biological Interactions. 175: 428-30. PMID 18674756 DOI: 10.1016/J.Cbi.2008.04.036  0.369
2008 Masson P, Nachon F, Broomfield CA, Lenz DE, Verdier L, Schopfer LM, Lockridge O. A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters. Chemico-Biological Interactions. 175: 273-80. PMID 18508040 DOI: 10.1016/J.Cbi.2008.04.005  0.328
2008 Huang YJ, Lundy PM, Lazaris A, Huang Y, Baldassarre H, Wang B, Turcotte C, Côté M, Bellemare A, Bilodeau AS, Brouillard S, Touati M, Herskovits P, Bégin I, Neveu N, ... ... Lenz DE, et al. Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin. Bmc Biotechnology. 8: 50. PMID 18485214 DOI: 10.1186/1472-6750-8-50  0.664
2008 Yeung DT, Smith JR, Sweeney RE, Lenz DE, Cerasoli DM. A gas chromatographic-mass spectrometric approach to examining stereoselective interaction of human plasma proteins with soman. Journal of Analytical Toxicology. 32: 86-91. PMID 18269799 DOI: 10.1093/Jat/32.1.86  0.716
2007 Huang YJ, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, Bilodeau AS, Bellemare A, Côté M, Herskovits P, Touati M, Turcotte C, Valeanu L, Lemée N, Wilgus H, ... ... Lenz DE, et al. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proceedings of the National Academy of Sciences of the United States of America. 104: 13603-8. PMID 17660298 DOI: 10.1073/Pnas.0702756104  0.701
2007 Yeung DT, Smith JR, Sweeney RE, Lenz DE, Cerasoli DM. Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase. The Febs Journal. 274: 1183-91. PMID 17286579 DOI: 10.1111/J.1742-4658.2006.05650.X  0.743
2007 Lenz DE, Yeung D, Smith JR, Sweeney RE, Lumley LA, Cerasoli DM. Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review. Toxicology. 233: 31-9. PMID 17188793 DOI: 10.1016/J.Tox.2006.11.066  0.769
2006 Saxena A, Sun W, Luo C, Myers TM, Koplovitz I, Lenz DE, Doctor BP. Bioscavenger for protection from toxicity of organophosphorus compounds. Journal of Molecular Neuroscience : Mn. 30: 145-8. PMID 17192662 DOI: 10.1385/Jmn:30:1:145  0.459
2006 Welch R, Campbell J, Toledo A, Davis D, Latzgo H, Haupt G, Love K, Sly J, Cohen G, Eisenberg R, Whitbeck J, Aldaz-Carroll L, Lou H, Lenz D, Patel P, et al. Rapid Production of Recombinant Proteins Utilizing the PERLXpress Platform Bioprocessing Journal. 5: 63-70. DOI: 10.12665/J52.Welch  0.598
2005 Cerasoli DM, Griffiths EM, Doctor BP, Saxena A, Fedorko JM, Greig NH, Yu QS, Huang Y, Wilgus H, Karatzas CN, Koplovitz I, Lenz DE. In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chemico-Biological Interactions. 157: 363-5. PMID 16429486 DOI: 10.1016/J.Cbi.2005.10.052  0.737
2005 Lenz DE, Maxwell DM, Koplovitz I, Clark CR, Capacio BR, Cerasoli DM, Federko JM, Luo C, Saxena A, Doctor BP, Olson C. Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys. Chemico-Biological Interactions. 157: 205-10. PMID 16289064 DOI: 10.1016/J.Cbi.2005.10.025  0.711
2005 Gordon RK, Haigh JR, Garcia GE, Feaster SR, Riel MA, Lenz DE, Aisen PS, Doctor BP. Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman. Chemico-Biological Interactions. 157: 239-46. PMID 16256090 DOI: 10.1016/J.Cbi.2005.10.031  0.408
2005 Yeung DT, Lenz DE, Cerasoli DM. Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates. The Febs Journal. 272: 2225-30. PMID 15853807 DOI: 10.1111/J.1742-4658.2005.04646.X  0.737
2005 Johnson JK, Cerasoli DM, Lenz DE. Role of immunogen design in induction of soman-specific monoclonal antibodies. Immunology Letters. 96: 121-7. PMID 15585315 DOI: 10.1016/J.Imlet.2004.08.003  0.623
2005 Cerasoli DM, Griffiths EM, Doctor BP, Saxena A, Fedorko JM, Greig NH, Yu QS, Huang Y, Wilgus H, Karatzas CN, Koplovitz I, Lenz DE. (07) in vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia™) as a potential nerve agent bioscavenger Chemico-Biological Interactions. 157: 362-365. DOI: 10.1016/j.cbi.2005.10.052  0.683
2004 Yeung DT, Josse D, Nicholson JD, Khanal A, McAndrew CW, Bahnson BJ, Lenz DE, Cerasoli DM. Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model. Biochimica Et Biophysica Acta. 1702: 67-77. PMID 15450851 DOI: 10.1016/J.Bbapap.2004.08.002  0.73
2002 Cerasoli DM, Lenz DE. Nerve Agent Bioscavengers: Protection with Reduced Behavioral Effects Military Psychology. 14: 121-143. DOI: 10.1207/S15327876Mp1402_4  0.686
1999 Gordon RK, Feaster SR, Russell AJ, LeJeune KE, Maxwell DM, Lenz DE, Ross M, Doctor BP. Organophosphate skin decontamination using immobilized enzymes. Chemico-Biological Interactions. 119: 463-70. PMID 10421484 DOI: 10.1016/S0009-2797(99)00059-9  0.394
1990 Little JS, Maxwell DM, Fox-Talbot MK, Brecht K, Lenz DE. Hepatic subcellular localization of cresylbenzodioxaphosphorin oxide (CBDP)-sensitive soman binding sites. Biochemical Pharmacology. 40: 1733-7. PMID 2242010 DOI: 10.1016/0006-2952(90)90349-P  0.323
1989 Little JS, Broomfield CA, Fox-Talbot MK, Boucher LJ, MacIver B, Lenz DE. Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP). Biochemical Pharmacology. 38: 23-9. PMID 2910306 DOI: 10.1016/0006-2952(89)90144-5  0.386
1988 Ray R, Boucher LJ, Broomfield CA, Lenz DE. Specific soman-hydrolyzing enzyme activity in a clonal neuronal cell culture. Biochimica Et Biophysica Acta. 967: 373-81. PMID 2848588 DOI: 10.1016/0304-4165(88)90100-6  0.373
1985 Lenz DE, Barney BA. The effects of soman, in vivo and in vitro, on aldolase activity. Toxicology Letters. 28: 105-10. PMID 4071559 DOI: 10.1016/0378-4274(85)90017-7  0.322
1973 Lenz DE, Deguehery LE, Holton JS. On the nature of the serum enzyme catalyzing paraoxon hydrolysis. Biochimica Et Biophysica Acta. 321: 189-96. PMID 4356304 DOI: 10.1016/0005-2744(73)90073-9  0.377
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