Bruce L. Kagan - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 
Area:
Channel forming toxins/ Amyloid/Planar lipid bilayers
Website:
http://faculty.bri.ucla.edu/institution/personnel?personnel_id=8399

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R. Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels. Methods in Molecular Biology (Clifton, N.J.). 1345: 251-68. PMID 26453217 DOI: 10.1007/978-1-4939-2978-8_16  1
2015 Patel N, Ramachandran S, Azimov R, Kagan BL, Lal R. Ion Channel Formation by Tau Protein: Implications for Alzheimer's Disease and Taupathies. Biochemistry. PMID 26575330 DOI: 10.1021/acs.biochem.5b00988  1
2014 Lee J, Gillman AL, Jang H, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F. Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability. Biochemistry. 53: 4704-14. PMID 24950761 DOI: 10.1021/bi500587p  1
2014 Gillman AL, Jang H, Lee J, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F. Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores. The Journal of Physical Chemistry. B. 118: 7335-44. PMID 24922585 DOI: 10.1021/jp5040954  1
2014 Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs. Chemical Society Reviews. 43: 6750-64. PMID 24566672 DOI: 10.1039/c3cs60459d  1
2013 Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment. The Journal of Physical Chemistry. B. 117: 11518-29. PMID 24000923 DOI: 10.1021/jp405389n  1
2013 Jang H, Connelly L, Arce FT, Ramachandran S, Lal R, Kagan BL, Nussinov R. Alzheimer's disease: which type of amyloid-preventing drug agents to employ? Physical Chemistry Chemical Physics : Pccp. 15: 8868-77. PMID 23450150 DOI: 10.1039/c3cp00017f  1
2013 Jang H, Connelly L, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane. Journal of Chemical Theory and Computation. 9: 822-833. PMID 23316126 DOI: 10.1021/ct300916f  1
2013 Arce FT, Jang H, Connelly L, Ramachandran S, Kagan BL, Nussinov R, Lal R. Structure-Function Studies of Amyloid Pores in Alzheimer's Disease as a Case Example of Neurodegenerative Diseases Bio-Nanoimaging: Protein Misfolding and Aggregation. 397-408. DOI: 10.1016/B978-0-12-394431-3.00036-5  1
2012 Kagan BL. Membrane pores in the pathogenesis of neurodegenerative disease. Progress in Molecular Biology and Translational Science. 107: 295-325. PMID 22482454 DOI: 10.1016/B978-0-12-385883-2.00001-1  1
2012 Capone R, Jang H, Kotler SA, Connelly L, Teran Arce F, Ramachandran S, Kagan BL, Nussinov R, Lal R. All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers. Journal of Chemical Theory and Computation. 8: 1143-1152. PMID 22423218 DOI: 10.1021/ct200885r  1
2012 Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R. Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations. Biochemistry. 51: 3031-8. PMID 22413858 DOI: 10.1021/bi300257e  1
2012 Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R. Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions. Biochemistry. 51: 776-85. PMID 22242635 DOI: 10.1021/bi2017427  1
2012 Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology. The Journal of Physical Chemistry. B. 116: 1728-35. PMID 22217000 DOI: 10.1021/jp2108126  1
2012 Kagan BL, Jang H, Capone R, Teran Arce F, Ramachandran S, Lal R, Nussinov R. Antimicrobial properties of amyloid peptides. Molecular Pharmaceutics. 9: 708-17. PMID 22081976 DOI: 10.1021/mp200419b  1
2011 Hirakura Y, Azimov R, Azimova R, Javier F, Schweitzer ES, Kagan BL. Transthyretin channel formation in lipid membranes: implications for pathogenesis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 18: 8-10. PMID 21838414 DOI: 10.3109/13506129.2011.574354002  1
2011 Kagan BL. Antimicrobial amyloids? Biophysical Journal. 100: 1597-8. PMID 21463571 DOI: 10.1016/j.bpj.2011.02.023  1
2010 Kagan BL, Thundimadathil J. Amyloid peptide pores and the beta sheet conformation. Advances in Experimental Medicine and Biology. 677: 150-67. PMID 20687488 DOI: 10.1007/978-1-4419-6327-7_13  1
2010 Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R. Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107: 6538-43. PMID 20308552 DOI: 10.1073/pnas.0914251107  1
2008 Epand RF, Zhang YL, Mirzabekov T, Kagan B, Silberstein A, Hubbell WL, Epand RM, Chakraborti S, Dimitrov DS, Anderson WF, Rozenberg-Adler Y. Membrane activity of an amphiphilic alpha-helical membrane-proximal cytoplasmic domain of the MoMuLV envelope glycoprotein. Experimental and Molecular Pathology. 84: 9-17. PMID 18206141 DOI: 10.1016/j.yexmp.2007.11.003  1
2008 Kagan B. Oligomers and Cellular Toxicity Amyloid Proteins: the Beta Sheet Conformation and Disease. 1: 318-342. DOI: 10.1002/9783527619344.ch14  1
2006 Fagan T, Kagan B, Corbin D, Hwang W, Glabe C, Nault L, Lal R, Teplow D, Albensi B, Sokolov Y. Alzheimer Research Forum Live Discussion: Now you see them, now you don't: The amyloid channel hypothesis. Journal of Alzheimer's Disease : Jad. 9: 219-24. PMID 16873968  1
2005 Quist A, Doudevski I, Lin H, Azimova R, Ng D, Frangione B, Kagan B, Ghiso J, Lal R. Amyloid ion channels: a common structural link for protein-misfolding disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 10427-32. PMID 16020533 DOI: 10.1073/pnas.0502066102  1
2005 Kagan BL. Amyloidosis and protein folding. Science (New York, N.Y.). 307: 42-3; author reply 4. PMID 15641174  1
2005 Kagan BL, Azimov R. Channels Formed in Planar Lipid Bilayers by Amyloid Peptides Advances in Planar Lipid Bilayers and Liposomes. 1: 207-220. DOI: 10.1016/S1554-4516(05)01007-0  1
2004 Kagan BL, Azimov R, Azimova R. Amyloid peptide channels. The Journal of Membrane Biology. 202: 1-10. PMID 15702375 DOI: 10.1007/s00232-004-0709-4  1
2002 Kagan BL, Hirakura Y, Azimov R, Azimova R, Lin MC. The channel hypothesis of Alzheimer's disease: current status. Peptides. 23: 1311-5. PMID 12128087 DOI: 10.1016/S0196-9781(02)00067-0  1
2002 Lin MC, Kagan BL. Electrophysiologic properties of channels induced by Abeta25-35 in planar lipid bilayers. Peptides. 23: 1215-28. PMID 12128079 DOI: 10.1016/S0196-9781(02)00057-8  1
2002 Hirakura Y, Carreras I, Sipe JD, Kagan BL. Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 9: 13-23. PMID 12000193  1
2001 Kagan BL, Hirakura Y, Azimov R, Azimova R. The channel hypothesis of Huntington's disease. Brain Research Bulletin. 56: 281-4. PMID 11719262 DOI: 10.1016/S0361-9230(01)00654-2  1
2001 Hirakura Y, Kagan BL. Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 94-100. PMID 11409039  1
2000 Hirakura Y, Yiu WW, Yamamoto A, Kagan BL. Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block). Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 194-9. PMID 11019860  1
2000 Hirakura Y, Azimov R, Azimova R, Kagan BL. Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of Huntington and other CAG repeat diseases. Journal of Neuroscience Research. 60: 490-4. PMID 10797551 DOI: 10.1002/(SICI)1097-4547(20000515)60:4<490::AID-JNR7>3.0.CO;2-9  1
2000 Chen QS, Kagan BL, Hirakura Y, Xie CW. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. Journal of Neuroscience Research. 60: 65-72. PMID 10723069 DOI: 10.1002/(SICI)1097-4547(20000401)60:1<65::AID-JNR7>3.0.CO;2-Q  1
1999 Sokolov Y, Mirzabekov T, Martin DW, Lehrer RI, Kagan BL. Membrane channel formation by antimicrobial protegrins. Biochimica Et Biophysica Acta. 1420: 23-9. PMID 10446287 DOI: 10.1016/S0005-2736(99)00086-3  1
1999 Hirakura Y, Lin MC, Kagan BL. Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red. Journal of Neuroscience Research. 57: 458-66. PMID 10440895 DOI: 10.1002/(SICI)1097-4547(19990815)57:4<458::AID-JNR5>3.0.CO;2-4  1
1999 Schendel SL, Azimov R, Pawlowski K, Godzik A, Kagan BL, Reed JC. Ion channel activity of the BH3 only Bcl-2 family member, BID. The Journal of Biological Chemistry. 274: 21932-6. PMID 10419515 DOI: 10.1074/jbc.274.31.21932  1
1999 Koo SP, Bayer AS, Kagan BL, Yeaman MR. Membrane permeabilization by thrombin-induced platelet microbicidal protein 1 is modulated by transmembrane voltage polarity and magnitude. Infection and Immunity. 67: 2475-81. PMID 10225910  1
1999 Kagan BL, Leskin G, Haas B, Wilkins J, Foy D. Elevated lipid levels in Vietnam veterans with chronic posttraumatic stress disorder. Biological Psychiatry. 45: 374-7. PMID 10023518 DOI: 10.1016/S0006-3223(98)00059-6  1
1999 Mirzabekov TA, Silberstein AY, Kagan BL. Use of planar lipid bilayer membranes for rapid screening of membrane active compounds. Methods in Enzymology. 294: 661-74. PMID 9916254 DOI: 10.1016/S0076-6879(99)94038-7  1
1998 Hirakura Y, Satoh Y, Hirashima N, Suzuki T, Kagan BL, Kirino Y. Membrane perturbation by the neurotoxic Alzheimer amyloid fragment beta 25-35 requires aggregation and beta-sheet formation. Biochemistry and Molecular Biology International. 46: 787-94. PMID 9844740  1
1998 Shang ES, Skare JT, Exner MM, Blanco DR, Kagan BL, Miller JN, Lovett MA. Isolation and characterization of the outer membrane of Borrelia hermsii. Infection and Immunity. 66: 1082-91. PMID 9488399  1
1997 Skare JT, Mirzabekov TA, Shang ES, Blanco DR, Erdjument-Bromage H, Bunikis J, Bergström S, Tempst P, Kagan BL, Miller JN, Lovett MA. The Oms66 (p66) protein is a Borrelia burgdorferi porin. Infection and Immunity. 65: 3654-61. PMID 9284133  1
1997 Sellman BR, Kagan BL, Tweten RK. Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin. Molecular Microbiology. 23: 551-8. PMID 9044288  1
1997 Lin MC, Mirzabekov T, Kagan BL. Channel formation by a neurotoxic prion protein fragment. The Journal of Biological Chemistry. 272: 44-7. PMID 8995224 DOI: 10.1074/jbc.272.1.44  1
1997 Lin MC, Kagan BL. Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein [AβP-(1-40)] in bilayer membranes - Zn 2+ interaction with Alzheimer amyloid β-protein calcium channels Chemtracts. 10: 251-254.  1
1996 Skare JT, Champion CI, Mirzabekov TA, Shang ES, Blanco DR, Erdjument-Bromage H, Tempst P, Kagan BL, Miller JN, Lovett MA. Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi. Journal of Bacteriology. 178: 4909-18. PMID 8759855  1
1996 Mirzabekov TA, Lin MC, Kagan BL. Pore formation by the cytotoxic islet amyloid peptide amylin. The Journal of Biological Chemistry. 271: 1988-92. PMID 8567648 DOI: 10.1074/jbc.271.4.1988  1
1996 Foy DW, Kagan B, McDermott C, Leskin G, Sipprelle RC, Paz G. Practical parameters in the use of flooding for treating chronic PTSD Clinical Psychology and Psychotherapy. 3: 169-175.  1
1995 Skare JT, Shang ES, Foley DM, Blanco DR, Champion CI, Mirzabekov T, Sokolov Y, Kagan BL, Miller JN, Lovett MA. Virulent strain associated outer membrane proteins of Borrelia burgdorferi. The Journal of Clinical Investigation. 96: 2380-92. PMID 7593626 DOI: 10.1172/JCI118295  1
1995 Baldwin RL, Mirzabekov T, Kagan BL, Wisnieski BJ. Conformation and ion channel activity of lymphotoxin at neutral and low pH. Journal of Immunology (Baltimore, Md. : 1950). 154: 790-8. PMID 7529287  1
1994 Kagan BL, Sokolov Y. Use of lipid bilayer membranes to detect pore formation by toxins. Methods in Enzymology. 235: 691-705. PMID 7520122 DOI: 10.1016/0076-6879(94)35182-1  1
1994 Mirzabekov T, Lin MC, Yuan WL, Marshall PJ, Carman M, Tomaselli K, Lieberburg I, Kagan BL. Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide. Biochemical and Biophysical Research Communications. 202: 1142-8. PMID 7519420 DOI: 10.1006/bbrc.1994.2047  1
1994 Kagan BL, Ganz T, Lehrer RI. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology. 87: 131-49. PMID 7512758 DOI: 10.1016/0300-483X(94)90158-9  1
1993 Kagan BL, Mirzabekov T, Munoz D, Baldwin RL, Wisnieski B. The role of channel formation in the mechanism of action of tumor necrosis factors. Annals of the New York Academy of Sciences. 707: 317-27. PMID 9137562  1
1993 Ballard J, Sokolov Y, Yuan WL, Kagan BL, Tweten RK. Activation and mechanism of Clostridium septicum alpha toxin. Molecular Microbiology. 10: 627-34. PMID 7968539  1
1992 Kagan BL, Baldwin RL, Munoz D, Wisnieski BJ. Formation of ion-permeable channels by tumor necrosis factor-alpha. Science (New York, N.Y.). 255: 1427-30. PMID 1371890  1
1991 Kagan BL. Inositol 1,4,5-trisphosphate directly opens diphtheria toxin channels. Biochimica Et Biophysica Acta. 1069: 145-50. PMID 1932055 DOI: 10.1016/0005-2736(91)90116-P  1
1991 Krantz DD, Zidovetzki R, Kagan BL, Zipursky SL. Amphipathic beta structure of a leucine-rich repeat peptide. The Journal of Biological Chemistry. 266: 16801-7. PMID 1715870  1
1990 Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. The American Journal of Psychiatry. 147: 591-5. PMID 2183633  1
1990 Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proceedings of the National Academy of Sciences of the United States of America. 87: 210-4. PMID 1688654  1
1989 Kagan BL. A molecular mechanism of panic attacks Speculations in Science and Technology. 12: 199-208.  1
1987 Altshuler LL, Kagan BL, Baxter LR, Smith G, Wilkins JN. Effect of interrupted sleep patterns and partial sleep deprivation on DST and mood in psychiatric house officers. Acta Psychiatrica Scandinavica. 75: 614-8. PMID 3618284  1
1983 Kagan BL. Mode of action of yeast killer toxins: channel formation in lipid bilayer membranes. Nature. 302: 709-11. PMID 6300695  1
1982 Kagan BL, Pollard HB, Hanna RB. Induction of ion-permeable channels by the venom of the fanged bloodworm Glycera dibranchiata. Toxicon : Official Journal of the International Society On Toxinology. 20: 887-93. PMID 6294921 DOI: 10.1016/0041-0101(82)90076-9  1
1982 Misler S, Kagan BL, Finkelstein A. Single channel conductances formed by diphtheria toxin fragments in planar bilayers Biophysical Journal. 37: 323a.  1
1981 Kagan BL, Finkelstein A, Colombini M. Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes. Proceedings of the National Academy of Sciences of the United States of America. 78: 4950-4. PMID 6272284  1
1981 Weaver CA, Kagan BL, Finkelstein A, Konisky J. Mode of action of colicin ib: formation of ion-permeable membrane channels. Biochimica Et Biophysica Acta. 645: 137-42. PMID 6266474 DOI: 10.1016/0005-2736(81)90521-6  1
1978 Schein SJ, Kagan BL, Finkelstein A. Colicin K acts by forming voltage-dependent channels in phospholipid bilayer membranes. Nature. 276: 159-63. PMID 740032 DOI: 10.1038/276159a0  1
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