Stephen R. Morairty - Publications

SRI International, Menlo Park, CA, United States 
sleep neurobiology

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Neylan TC, Richards A, Metzler TJ, Ruoff LM, Varbel J, O'Donovan A, Sivasubramanian M, Motraghi T, Hlavin J, Batki SL, Inslicht SS, Samuelson K, Morairty SR, Kilduff TS. Acute Cognitive Effects of the Hypocretin Receptor Antagonist Almorexant Relative to Zolpidem and Placebo: A Randomized Clinical Trial. Sleep. PMID 32303763 DOI: 10.1093/sleep/zsaa080  1
2019 Goonawardena AV, Morairty SR, Orellana GA, Willoughby AR, Wallace TL, Kilduff TS. Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques. Neurobiology of Sleep and Circadian Rhythms. 6: 9-23. PMID 31236518 DOI: 10.1016/j.nbscr.2018.08.001  1
2019 Goonawardena AV, Morairty SR, Dell R, Orellana GA, Hoener MC, Wallace TL, Kilduff TS. Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30954024 DOI: 10.1038/s41386-019-0386-8  1
2016 Schwartz MD, Black SW, Fisher SP, Palmerston JB, Morairty SR, Hoener MC, Kilduff TS. Trace Amine-Associated Receptor 1 Regulates Wakefulness and Eeg Spectral Composition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27658486 DOI: 10.1038/npp.2016.216  1
2016 Schwartz MD, Nguyen AT, Warrier DR, Palmerston JB, Thomas AM, Morairty SR, Neylan TC, Kilduff TS. Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep. Eneuro. 3. PMID 27022631 DOI: 10.1523/ENEURO.0018-16.2016  1
2016 Fisher SP, Schwartz MD, Wurts-Black S, Thomas AM, Chen TM, Miller MA, Palmerston JB, Kilduff TS, Morairty SR. Quantitative electroencephalographic analysis provides an early-stage indicator of disease onset and progression in the zQ175 knock-in mouse model of huntington's disease Sleep. 39: 379-391. DOI: 10.5665/sleep.5448  1
2015 Fisher SP, Schwartz MD, Wurts-Black S, Thomas AM, Chen TM, Miller MA, Palmerston JB, Kilduff TS, Morairty SR. Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington Disease. Sleep. PMID 26446107  1
2015 Parks GS, Warrier DR, Dittrich L, Schwartz MD, Palmerston JB, Neylan TC, Morairty SR, Kilduff TS. The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26289145 DOI: 10.1038/npp.2015.256  1
2015 Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, et al. Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression. The Journal of Pharmacology and Experimental Therapeutics. 353: 213-33. PMID 25665805 DOI: 10.1124/jpet.114.222463  1
2015 Dittrich L, Morairty SR, Warrier DR, Kilduff TS. Homeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 632-9. PMID 25139062 DOI: 10.1038/npp.2014.212  1
2014 Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS. GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6485-94. PMID 24806675 DOI: 10.1523/JNEUROSCI.0080-14.2014  1
2014 Morairty SR, Wilk AJ, Lincoln WU, Neylan TC, Kilduff TS. The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. Frontiers in Neuroscience. 8: 3. PMID 24550767 DOI: 10.3389/fnins.2014.00003  1
2013 Morairty SR, Dittrich L, Pasumarthi RK, Valladao D, Heiss JE, Gerashchenko D, Kilduff TS. A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity. Proceedings of the National Academy of Sciences of the United States of America. 110: 20272-7. PMID 24191004 DOI: 10.1073/pnas.1314762110  1
2013 Fisher SP, Black SW, Schwartz MD, Wilk AJ, Chen TM, Lincoln WU, Liu HW, Kilduff TS, Morairty SR. Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease. Brain : a Journal of Neurology. 136: 2159-72. PMID 23801738 DOI: 10.1093/brain/awt132  1
2013 Black SW, Morairty SR, Fisher SP, Chen TM, Warrier DR, Kilduff TS. Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy. Sleep. 36: 325-36. PMID 23449602 DOI: 10.5665/sleep.2442  1
2013 Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Molecular Psychiatry. 18: 543-56. PMID 22641180 DOI: 10.1038/mp.2012.57  1
2012 Morairty SR, Revel FG, Malherbe P, Moreau JL, Valladao D, Wettstein JG, Kilduff TS, Borroni E. Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone. Plos One. 7: e39131. PMID 22768296 DOI: 10.1371/journal.pone.0039131  1
2012 Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velázquez-Sánchez C, Sotnikova TD, Morairty SR, Harmeier A, Groebke Zbinden K, Norcross RD, Bradaia A, Kilduff TS, Biemans B, Pouzet B, Caron MG, et al. Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biological Psychiatry. 72: 934-42. PMID 22705041 DOI: 10.1016/j.biopsych.2012.05.014  1
2011 Morairty SR, Wisor J, Silveira K, Sinko W, Kilduff TS. The wake-promoting effects of hypocretin-1 are attenuated in old rats. Neurobiology of Aging. 32: 1514-27. PMID 19781813 DOI: 10.1016/j.neurobiolaging.2009.07.017  1
2010 Teegarden BR, Li H, Jayakumar H, Strah-Pleynet S, Dosa PI, Selaya SD, Kato N, Elwell KH, Davidson J, Cheng K, Saldana H, Frazer JM, Whelan K, Foster J, Espitia S, ... ... Morairty SR, et al. Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. Journal of Medicinal Chemistry. 53: 1923-36. PMID 20143782 DOI: 10.1021/jm9007328  1
2008 Morairty SR, Hedley L, Flores J, Martin R, Kilduff TS. Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. Sleep. 31: 34-44. PMID 18220076  1
2006 Wisor JP, Morairty SR, Huynh NT, Steininger TL, Kilduff TS. Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep. Neuroscience. 141: 371-8. PMID 16690212 DOI: 10.1016/j.neuroscience.2006.03.028  1
2006 Xie X, Crowder TL, Yamanaka A, Morairty SR, Lewinter RD, Sakurai T, Kilduff TS. GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. The Journal of Physiology. 574: 399-414. PMID 16627567 DOI: 10.1113/jphysiol.2006.108266  1
2004 Terao A, Steininger TL, Morairty SR, Kilduff TS. Age-related changes in histamine receptor mRNA levels in the mouse brain. Neuroscience Letters. 355: 81-4. PMID 14729240 DOI: 10.1016/j.neulet.2003.10.061  1
2004 Morairty S, Rainnie D, McCarley R, Greene R. Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: A new mechanism for sleep promotion Neuroscience. 123: 451-457. PMID 14698752 DOI: 10.1016/j.neuroscience.2003.08.066  1
2002 Terao A, Apte-Deshpande A, Dousman L, Morairty S, Eynon BP, Kilduff TS, Freund YR. Immune response gene expression increases in the aging murine hippocampus. Journal of Neuroimmunology. 132: 99-112. PMID 12417439 DOI: 10.1016/S0165-5728(02)00317-X  1
2002 Terao A, Apte-Deshpande A, Morairty S, Freund YR, Kilduff TS. Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neuroscience Letters. 332: 190-4. PMID 12399012 DOI: 10.1016/S0304-3940(02)00953-9  1
2000 Strecker RE, Morairty S, Thakkar MM, Porkka-Heiskanen T, Basheer R, Dauphin LJ, Rainnie DG, Portas CM, Greene RW, McCarley RW. Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behavioural Brain Research. 115: 183-204. PMID 11000420 DOI: 10.1016/S0166-4328(00)00258-8  1
1997 Hays T, Morairty S, Szymusiak R, McGinty D. The effects of temperature and synaptic blockade in vitro on neurons of the horizontal limb of the diagonal band of Broca in the rat basal forebrain Brain Research. 746: 52-58. PMID 9037483 DOI: 10.1016/S0006-8993(96)01138-9  1
1993 Morairty SR, Szymusiak R, Thomson D, McGinty DJ. Selective increases in non-rapid eye movement sleep following whole body heating in rats. Brain Research. 617: 10-6. PMID 8374732 DOI: 10.1016/0006-8993(93)90606-N  1
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