Philippe Huot, Ph.D. - Publications

Affiliations: 
Medical Science University of Toronto, Toronto, ON, Canada 

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kang W, Frouni I, Kwan C, Desbiens L, Hamadjida A, Huot P. Activation of mGlu 2/3 receptors with the orthosteric agonist LY-404,039 alleviates dyskinesia in experimental parkinsonism. Behavioural Pharmacology. PMID 38563661 DOI: 10.1097/FBP.0000000000000765  0.469
2023 Frouni I, Kwan C, Bédard D, Kang W, Hamadjida A, Nuara SG, Gourdon JC, Huot P. Effect of the mGlu positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset. Psychopharmacology. PMID 37516708 DOI: 10.1007/s00213-023-06428-1  0.445
2023 Kwan C, Frouni I, Bédard D, Hamadjida A, Nuara SG, Gourdon JC, Huot P. The 5-HT inverse agonist nelotanserin alleviates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset. The European Journal of Neuroscience. PMID 37515363 DOI: 10.1111/ejn.16104  0.483
2023 Kang W, Nuara SG, Bédard D, Frouni I, Kwan C, Hamadjida A, Gourdon JC, Gaudette F, Beaudry F, Huot P. The mGluR orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 37410156 DOI: 10.1007/s00210-023-02587-2  0.484
2023 Al-Kassmy J, Sun C, Huot P. 5-HT agonists for levodopa-induced dyskinesia in Parkinson's disease. Neurodegenerative Disease Management. 13: 101-112. PMID 37140165 DOI: 10.2217/nmt-2022-0039  0.376
2022 Kwan C, Kang W, Kim E, Belliveau S, Frouni I, Huot P. Metabotropic glutamate receptors in Parkinson's disease. International Review of Neurobiology. 168: 1-31. PMID 36868628 DOI: 10.1016/bs.irn.2022.10.001  0.364
2022 Frouni I, Kwan C, Belliveau S, Hamadjida A, Bédard D, Nuara SG, Gourdon JC, Huot P. Anti-parkinsonian effect of the mGlu positive allosteric modulator LY-487,379 as monotherapy and adjunct to a low L-DOPA dose in the MPTP-lesioned marmoset. European Journal of Pharmacology. 939: 175429. PMID 36502960 DOI: 10.1016/j.ejphar.2022.175429  0.379
2022 Frouni I, Kang W, Bédard D, Belliveau S, Kwan C, Hadj-Youssef S, Bourgeois-Cayer É, Ohlund L, Sleno L, Hamadjida A, Huot P. Effect of glycine transporter 1 inhibition with bitopertin on parkinsonism and L-DOPA induced dyskinesia in the 6-OHDA-lesioned rat. European Journal of Pharmacology. 175090. PMID 35780824 DOI: 10.1016/j.ejphar.2022.175090  0.494
2021 Kwan C, Lévesque C, Bédard D, Frouni I, Yesuf JM, Hamadjida A, Lévesque D, Clarke PB, Huot P. Autoradiographic labelling of 5-HT receptors in the hemi-parkinsonian rat brain. Neuroscience Research. PMID 34954302 DOI: 10.1016/j.neures.2021.12.004  0.394
2021 Nuara SG, Gourdon JC, Maddaford S, Huot P. Additive effects of mGluR positive allosteric modulation, mGluR orthosteric stimulation and 5-HTR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 34550406 DOI: 10.1007/s00210-021-02162-7  0.322
2021 Frouni I, Belliveau S, Maddaford S, Nuara SG, Gourdon JC, Huot P. Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. European Journal of Pharmacology. 910: 174452. PMID 34480885 DOI: 10.1016/j.ejphar.2021.174452  0.478
2021 Kwan C, Nuara SG, Gourdon JC, Huot P. Further characterisation of psychosis-like behaviours induced by L-DOPA in the MPTP-lesioned marmoset. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 33963876 DOI: 10.1007/s00210-021-02090-6  0.426
2021 Kwan C, Frouni I, Nuara SG, Belliveau S, Kang W, Hamadjida A, Bédard D, Beaudry F, Panisset M, Gourdon JC, Huot P. Combined 5-HT and mGlu modulation for the treatment of dyskinesia and psychosis in Parkinson's disease. Neuropharmacology. 108465. PMID 33485945 DOI: 10.1016/j.neuropharm.2021.108465  0.413
2021 Kwan C, Frouni I, Bédard D, Hamadjida A, Huot P. Granisetron, a selective 5-HT3 antagonist, reduces L-3,4-dihydroxyphenylalanine-induced abnormal involuntary movements in the 6-hydroxydopamine-lesioned rat. Behavioural Pharmacology. 32: 43-53. PMID 33399295 DOI: 10.1097/FBP.0000000000000601  0.451
2021 Frouni I, Kwan C, Nuara SG, Belliveau S, Kang W, Hamadjida A, Bédard D, Gourdon JC, Huot P. Effect of the mGlu positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 33392826 DOI: 10.1007/s00702-020-02287-8  0.461
2020 Kwan C, Nuara SG, Bédard D, Gaudette F, Gourdon JC, Beaudry F, Huot P. Selective blockade of the 5-HT receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset. Neuropharmacology. 108386. PMID 33152452 DOI: 10.1016/j.neuropharm.2020.108386  0.515
2020 Hamadjida A, Nuara SG, Kwan C, Frouni I, Bédard D, Gourdon JC, Huot P. Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 32621059 DOI: 10.1007/S00210-020-01933-Y  0.563
2020 Hamadjida A, Nuara SG, Frouni I, Kwan C, Bédard D, Gourdon JC, Huot P. Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 32601846 DOI: 10.1007/S00210-020-01927-W  0.514
2020 Nuara SG, Hamadjida A, Gourdon JC, Huot P. The mGlu antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 32333122 DOI: 10.1007/s00702-020-02196-w  0.428
2020 Nuara SG, Hamadjida A, Kwan C, Bédard D, Frouni I, Gourdon JC, Huot P. Combined mGlu orthosteric stimulation and positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the parkinsonian marmoset. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 32246204 DOI: 10.1007/s00702-020-02185-z  0.485
2020 Sid-Otmane L, Huot P, Panisset M. Effect of Antidepressants on Psychotic Symptoms in Parkinson Disease: A Review of Case Reports and Case Series. Clinical Neuropharmacology. PMID 32217864 DOI: 10.1097/Wnf.0000000000000384  0.385
2020 Kwan C, Bedard D, Frouni I, Gaudette F, Beaudry F, Hamadjida A, Huot P. Pharmacokinetic profile of the selective 5-HT3 receptor antagonist ondansetron in the rat: an original study and a mini-review of the behavioural pharmacological literature in the rat. Canadian Journal of Physiology and Pharmacology. PMID 32017606 DOI: 10.1139/Cjpp-2019-0551  0.335
2020 Sid-Otmane L, Hamadjida A, Nuara SG, Bédard D, Gaudette F, Gourdon JC, Michaud V, Beaudry F, Panisset M, Huot P. Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset. European Journal of Pharmacology. 172957. PMID 32004527 DOI: 10.1016/J.Ejphar.2020.172957  0.553
2020 Hamadjida A, Sid-Otmane L, Kwan C, Frouni I, Nafade V, Bédard D, Gagnon D, Wallman MJ, Rouillard C, Parent A, Parent M, Huot P. The highly-selective mGlu receptor positive allosteric modulator, LY-487,379 alleviates L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The European Journal of Neuroscience. PMID 31944461 DOI: 10.1111/Ejn.14679  0.534
2020 Kwan C, Frouni I, Bédard D, Hamadjida A, Huot P. Ondansetron, a highly selective 5-HT receptor antagonist, reduces L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease. European Journal of Pharmacology. 172914. PMID 31926127 DOI: 10.1016/J.Ejphar.2020.172914  0.557
2019 Frouni I, Hamadjida A, Kwan C, Bédard D, Nafade V, Gaudette F, Nuara SG, Gourdon JC, Beaudry F, Huot P. Activation of mGlu receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism. Neuropharmacology. 158: 107725. PMID 31351976 DOI: 10.1016/J.Neuropharm.2019.107725  0.5
2018 Kwan C, Frouni I, Bédard D, Nuara SG, Gourdon JC, Hamadjida A, Huot P. 5-HT blockade for dyskinesia and psychosis in Parkinson's disease: is there a limit to the efficacy of this approach? A study in the MPTP-lesioned marmoset and a literature mini-review. Experimental Brain Research. PMID 30443669 DOI: 10.1007/S00221-018-5434-9  0.573
2018 Frouni I, Kwan C, Bédard D, Belliveau S, Bourgeois-Cayer É, Gaudette F, Beaudry F, Hamadjida A, Huot P. Effect of the selective 5-HT receptor antagonist EMD-281,014 on L-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat. Experimental Brain Research. PMID 30298296 DOI: 10.1007/S00221-018-5390-4  0.576
2018 Hamadjida A, Frouni I, Kwan C, Huot P. Classic animal models of Parkinson's disease: a historical perspective. Behavioural Pharmacology. PMID 30216234 DOI: 10.1097/FBP.0000000000000441  0.328
2018 Hamadjida A, Nuara SG, Bédard D, Frouni I, Kwan C, Gourdon JC, Huot P. Nefazodone reduces dyskinesia, but not psychosis-like behaviours, in the parkinsonian marmoset. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 30088028 DOI: 10.1007/S00210-018-1549-6  0.575
2018 Gaudette F, Hamadjida A, Bédard D, Nuara SG, Gourdon JC, Michaud V, Beaudry F, Huot P. Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1093: 1-7. PMID 29980099 DOI: 10.1016/J.Jchromb.2018.06.036  0.303
2018 Hamadjida A, Nuara SG, Bedard D, Gaudette F, Beaudry F, Gourdon JC, Huot P. The highly selective 5-HT antagonist EMD-281,014 reduces dyskinesia and psychosis in the L-DOPA-treated parkinsonian marmoset. Neuropharmacology. PMID 29969592 DOI: 10.1016/J.Neuropharm.2018.06.038  0.535
2017 Hamadjida A, Nuara SG, Gourdon JC, Huot P. Trazodone alleviates both dyskinesia and psychosis in the parkinsonian marmoset model of Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 29247391 DOI: 10.1007/S00702-017-1830-8  0.567
2017 Hamadjida A, Nuara SG, Gourdon JC, Huot P. The effect of mianserin on the severity of psychosis and dyskinesia in the parkinsonian marmoset. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 28882428 DOI: 10.1016/J.Pnpbp.2017.09.001  0.567
2017 Huot P, Sgambato-Faure V, Fox SH, McCreary AC. Serotonergic approaches in Parkinson's disease: translational perspectives, an update. Acs Chemical Neuroscience. PMID 28460160 DOI: 10.1021/Acschemneuro.6B00440  0.494
2017 Hamadjida A, Nuara SG, Veyres N, Frouni I, Kwan C, Sid-Otmane L, Harraka MJ, Gourdon JC, Huot P. The effect of mirtazapine on dopaminergic psychosis and dyskinesia in the parkinsonian marmoset. Psychopharmacology. PMID 28130646 DOI: 10.1007/S00213-017-4530-Z  0.464
2016 Huot P, Fox SH, Brotchie JM. Dopamine Reuptake Inhibitors in Parkinson's Disease: A Review of Nonhuman Primate Studies and Clinical Trials. The Journal of Pharmacology and Experimental Therapeutics. 357: 562-9. PMID 27190169 DOI: 10.1124/Jpet.116.232371  0.528
2016 Huynh NT, Sid-Otmane L, Panisset M, Huot P. A Man With Persistent Dopamine Agonist Withdrawal Syndrome After 7 Years Being Off Dopamine Agonists. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 1-2. PMID 26842385 DOI: 10.1017/Cjn.2015.389  0.324
2015 Pourcher E, Huot P. Adenosine 2A Receptor Antagonists for the Treatment of Motor Symptoms in Parkinson's Disease. Movement Disorders Clinical Practice. 2: 331-340. PMID 30363540 DOI: 10.1002/Mdc3.12187  0.494
2015 Huot P. The pons and human affective processing - Implications for Parkinson's disease. Ebiomedicine. 2: 1592-3. PMID 26870780 DOI: 10.1016/J.Ebiom.2015.10.031  0.357
2015 Huot P, Hutchison WD. Serotonin/dopamine transporter ratio as a predictor of l-dopa-induced dyskinesia. Neurology. 85: 840-1. PMID 26253446 DOI: 10.1212/WNL.0000000000001915  0.431
2015 Huot P, Johnston TH, Fox SH, Newman-Tancredi A, Brotchie JM. The highly-selective 5-HT1A agonist F15599 reduces l-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque. Neuropharmacology. 97: 306-11. PMID 26071982 DOI: 10.1016/J.Neuropharm.2015.05.033  0.517
2015 Huot P, Fox SH, Brotchie JM. Monoamine reuptake inhibitors in Parkinson's disease. Parkinson's Disease. 2015: 609428. PMID 25810948 DOI: 10.1155/2015/609428  0.522
2015 Huot P. L-DOPA-induced dyskinesia, is striatal dopamine depletion a requisite? Journal of the Neurological Sciences. 351: 9-12. PMID 25758471 DOI: 10.1016/J.Jns.2015.02.041  0.54
2015 Huot P, Johnston TH, Fox SH, Brotchie JM. Pioglitazone may impair L-DOPA anti-parkinsonian efficacy in the MPTP-lesioned macaque: results of a pilot study. Synapse (New York, N.Y.). 69: 99-102. PMID 25559284 DOI: 10.1002/Syn.21801  0.503
2015 Huot P, Johnston TH, Koprich JB, Espinosa MC, Reyes MG, Fox SH, Brotchie JM. L-745,870 reduces the expression of abnormal involuntary movements in the 6-OHDA-lesioned rat. Behavioural Pharmacology. 26: 101-8. PMID 25303957 DOI: 10.1097/Fbp.0000000000000096  0.503
2014 Huynh NT, Huot P. A woman with functional tremor treated with L-DOPA for 14 years. Journal of the Neurological Sciences. 346: 358-9. PMID 25218418 DOI: 10.1016/J.Jns.2014.08.045  0.398
2014 Huot P, Johnston TH, Lewis KD, Koprich JB, Reyes MG, Fox SH, Piggott MJ, Brotchie JM. UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset. Neuropharmacology. 82: 76-87. PMID 24447715 DOI: 10.1016/J.Neuropharm.2014.01.012  0.553
2014 Huynh NT, Huot P. Therapies under investigation for treating Parkinson's disease psychosis Clinical Investigation. 4: 889-901. DOI: 10.4155/Cli.14.84  0.411
2013 Huot P, Fox SH. The serotonergic system in motor and non-motor manifestations of Parkinson's disease. Experimental Brain Research. 230: 463-76. PMID 23811734 DOI: 10.1007/S00221-013-3621-2  0.522
2013 Johnston TH, Huot P, Fox SH, Koprich JB, Szeliga KT, James JW, Graef JD, Letchworth SR, Jordan KG, Hill MP, Brotchie JM. TC-8831, a nicotinic acetylcholine receptor agonist, reduces L-DOPA-induced dyskinesia in the MPTP macaque. Neuropharmacology. 73: 337-47. PMID 23770260 DOI: 10.1016/J.Neuropharm.2013.06.005  0.498
2013 Huot P, Johnston TH, Koprich JB, Fox SH, Brotchie JM. The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease. Pharmacological Reviews. 65: 171-222. PMID 23319549 DOI: 10.1124/Pr.111.005678  0.499
2013 Koprich JB, Huot P, Fox SH, Jarvie K, Lang AE, Seeman P, Brotchie JM. The effects of fast-off-D2 receptor antagonism on L-DOPA-induced dyskinesia and psychosis in parkinsonian macaques. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 43: 151-6. PMID 23306217 DOI: 10.1016/J.Pnpbp.2012.12.008  0.513
2013 Huot P, Johnston TH, Snoeren T, Koprich JB, Hill MP, Fox SH, Brotchie JM. Use of catechol-O-methyltransferase inhibition to minimize L-3,4-dihydroxyphenylalanine-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque. The European Journal of Neuroscience. 37: 831-8. PMID 23281915 DOI: 10.1111/Ejn.12093  0.482
2013 Johnston TH, Huot P, Damude S, Fox SH, Jones SW, Rusche JR, Brotchie JM. RGFP109, a histone deacetylase inhibitor attenuates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: a proof-of-concept study. Parkinsonism & Related Disorders. 19: 260-4. PMID 22901956 DOI: 10.1016/J.Parkreldis.2012.07.001  0.509
2012 Huot P, Johnston TH, Gandy MN, Reyes MG, Fox SH, Piggott MJ, Brotchie JM. The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset. Plos One. 7: e45587. PMID 23029119 DOI: 10.1371/Journal.Pone.0045587  0.531
2012 Huot P, Johnston TH, Koprich JB, Fox SH, Brotchie JM. L-DOPA pharmacokinetics in the MPTP-lesioned macaque model of Parkinson's disease. Neuropharmacology. 63: 829-36. PMID 22722022 DOI: 10.1016/J.Neuropharm.2012.06.012  0.515
2012 Huot P, Johnston TH, Koprich JB, Aman A, Fox SH, Brotchie JM. L-745,870 reduces L-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 342: 576-85. PMID 22619253 DOI: 10.1124/Jpet.112.195693  0.547
2012 Huot P, Johnston TH, Visanji NP, Darr T, Pires D, Hazrati LN, Brotchie JM, Fox SH. Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 735-42. PMID 22419526 DOI: 10.1002/Mds.24964  0.427
2012 Johnston TH, Millar Z, Huot P, Wagg K, Thiele S, Salomonczyk D, Yong-Kee CJ, Gandy MN, McIldowie M, Lewis KD, Gomez-Ramirez J, Lee J, Fox SH, Martin-Iverson M, Nash JE, et al. A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2154-63. PMID 22345403 DOI: 10.1096/Fj.11-195016  0.5
2012 Huot P, Johnston TH, Koprich JB, Winkelmolen L, Fox SH, Brotchie JM. Regulation of cortical and striatal 5-HT1A receptors in the MPTP-lesioned macaque. Neurobiology of Aging. 33: 207.e9-19. PMID 21051107 DOI: 10.1016/J.Neurobiolaging.2010.09.011  0.511
2012 Huot P, Johnston TH, Winkelmolen L, Fox SH, Brotchie JM. 5-HT2A receptor levels increase in MPTP-lesioned macaques treated chronically with L-DOPA. Neurobiology of Aging. 33: 194.e5-15. PMID 20561716 DOI: 10.1016/J.Neurobiolaging.2010.04.035  0.5
2012 Koprich J, Johnston T, Huot P, Brotchie J. 3.118 PRIMATE AND RODENT MODELS OF PARKINSON'S DISEASE BASED ON VIRAL VECTOR MEDIATED OVEREXPRESSION OF ALPHA SYNUCLEIN Parkinsonism & Related Disorders. 18: S193. DOI: 10.1016/S1353-8020(11)70834-3  0.307
2012 Huot P, Koprich J, Johnston T, Fox S, Brotchie J. 2.217 PHARMACOKINETIC PROFILE OF THE SELECTIVE DOPAMINE D4 RECEPTOR ANTAGONIST L-745,870 IN THE MPTP-LESIONED NON-HUMAN PRIMATE MODEL OF PARKINSON'S DISEASE Parkinsonism & Related Disorders. 18: S119. DOI: 10.1016/S1353-8020(11)70541-7  0.475
2011 Huot P, Fox SH, Brotchie JM. The serotonergic system in Parkinson's disease. Progress in Neurobiology. 95: 163-212. PMID 21878363 DOI: 10.1016/J.Pneurobio.2011.08.004  0.475
2011 Huot P, Brotchie JM. 5-HT(1A) receptor stimulation and L-DOPA-induced dyskinesia in Parkinson's disease: bridging the gap between serotonergic and glutamatergic mechanisms. Experimental Neurology. 231: 195-8. PMID 21819982 DOI: 10.1016/J.Expneurol.2011.07.006  0.466
2011 Huot P, Fox SH, Newman-Tancredi A, Brotchie JM. Anatomically selective serotonergic type 1A and serotonergic type 2A therapies for Parkinson's disease: an approach to reducing dyskinesia without exacerbating parkinsonism? The Journal of Pharmacology and Experimental Therapeutics. 339: 2-8. PMID 21784889 DOI: 10.1124/Jpet.111.184093  0.431
2011 Huot P, Johnston TH, Lewis KD, Koprich JB, Reyes MG, Fox SH, Piggott MJ, Brotchie JM. Characterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7190-8. PMID 21562283 DOI: 10.1523/Jneurosci.1171-11.2011  0.511
2011 Koprich JB, Johnston TH, Huot P, Reyes MG, Espinosa M, Brotchie JM. Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein. Plos One. 6: e17698. PMID 21408191 DOI: 10.1371/Journal.Pone.0017698  0.42
2011 Johnston TH, Huot P, Fox SH, Wakefield JD, Sykes KA, Bartolini WP, Milne GT, Pearson JP, Brotchie JM. Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 336: 423-30. PMID 20966038 DOI: 10.1124/Jpet.110.169532  0.538
2011 Huot P, Fox SH. Nondopaminergic treatments for Parkinson’s disease Neurodegenerative Disease Management. 1: 491-512. DOI: 10.2217/Nmt.11.62  0.449
2010 Huot P, Johnston TH, Darr T, Hazrati LN, Visanji NP, Pires D, Brotchie JM, Fox SH. Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 1399-408. PMID 20629135 DOI: 10.1002/Mds.23083  0.44
2010 Fox SH, Visanji N, Reyes G, Huot P, Gomez-Ramirez J, Johnston T, Brotchie JM. Neuropsychiatric behaviors in the MPTP marmoset model of Parkinson's disease. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 37: 86-95. PMID 20169779 DOI: 10.1017/S0317167100009707  0.435
2008 Huot P, Lévesque M, Morissette M, Calon F, Dridi M, Di Paolo T, Parent A. L-Dopa treatment abolishes the numerical increase in striatal dopaminergic neurons in parkinsonian monkeys. Journal of Chemical Neuroanatomy. 35: 77-84. PMID 17706922 DOI: 10.1016/J.Jchemneu.2007.06.004  0.44
2007 Huot P, Parent A. Dopaminergic neurons intrinsic to the striatum. Journal of Neurochemistry. 101: 1441-7. PMID 17286588 DOI: 10.1111/J.1471-4159.2006.04430.X  0.359
2007 Huot P, Lévesque M, Parent A. The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea. Brain : a Journal of Neurology. 130: 222-32. PMID 17142832 DOI: 10.1093/Brain/Awl332  0.363
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