Karl W. K. Tsim - Publications

Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 
AChE, neuromuscular junctions

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Gong G, Ganesan K, Zheng Y, Xiao J, Dong T, Tsim K. Nepetin Attenuates Atopic Dermatitis in HaCaT Cells and BALB/c Mice Through MyD88-MKK3/6-Akt Signaling. Current Medicinal Chemistry. PMID 38310399 DOI: 10.2174/0109298673244967231101114033  0.459
2023 Xia CX, Gao AX, Zhu Y, Dong TT, Tsim KW. Flavonoids from Seabuckthorn ( L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice. Food & Function. 14: 7426-7438. PMID 37485660 DOI: 10.1039/d3fo01332d  0.327
2023 Gao AX, Xia TC, Peng ZT, Wu QY, Zhu Y, Dong TT, Tsim KW. The ethanolic extract of peanut shell attenuates the depressive-like behaviors of mice through modulation of inflammation and gut microbiota. Food Research International (Ottawa, Ont.). 168: 112765. PMID 37120215 DOI: 10.1016/j.foodres.2023.112765  0.35
2020 Gong G, Yu H, Zheng Y, Qi B, He H, Yin T, Dong TT, Tsim KW. Astragaloside IV, a saponin from Astragalus membranaceus var. mongholicus, induces expressions of heme recycle proteins via signaling of Nrf2/ARE in cultured macrophages. Journal of Ethnopharmacology. 113389. PMID 32920134 DOI: 10.1016/J.Jep.2020.113389  0.459
2019 Gong G, Huang J, Yang Y, Qi B, Han G, Zheng Y, He H, Chan K, Tsim KW, Dong TT. Saussureae Involucratae Herba (Snow Lotus): Review of Chemical Compositions and Pharmacological Properties. Frontiers in Pharmacology. 10: 1549. PMID 32009958 DOI: 10.3389/Fphar.2019.01549  0.459
2019 Gong G, Xie F, Zheng Y, Hu W, Qi B, He H, Dong TT, Tsim KW. The effect of methanol extract from Saussurea involucrata in the lipopolysaccharide-stimulated inflammation in cultured RAW 264.7 cells. Journal of Ethnopharmacology. 112532. PMID 31884036 DOI: 10.1016/J.Jep.2019.112532  0.454
2017 Zhu Y, Chao C, Duan X, Cheng X, Liu P, Su S, Duan J, Dong TT, Tsim KW. Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus. Scientific Reports. 7: 1467. PMID 28469194 DOI: 10.1038/S41598-017-01561-2  0.355
2016 Zhu Y, Duan X, Cheng X, Cheng X, Li X, Zhang L, Liu P, Shulan S, Duan JA, Dong TT, Tsim KW, Huang F. Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron. Journal of Ethnopharmacology. PMID 27660009 DOI: 10.1016/J.Jep.2016.09.037  0.38
2016 Zhu Y, Duan X, Huang F, Cheng X, Zhang L, Liu P, Shulan S, Duan JA, Dong TT, Tsim KW. Kai-Xin-San, a traditional Chinese medicine formula, induces neuronal differentiation of cultured PC12 Cells: modulating neurotransmitter regulation enzymes and potentiating NGF inducing neurite outgrowth. Journal of Ethnopharmacology. PMID 27530376 DOI: 10.1016/J.Jep.2016.08.013  0.408
2016 Yan L, Hu Q, Mak MS, Lou J, Xu SL, Bi CW, Zhu Y, Wang H, Dong TT, Tsim KW. A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons. Scientific Reports. 6: 30014. PMID 27444820 DOI: 10.1038/Srep30014  0.399
2015 Miernisha A, Bi CW, Cheng LK, Xing JG, Liu J, Maiwulanjiang M, Aisa HA, Dong TT, Lin H, Huang Y, Tsim KW. Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells. Phytotherapy Research : Ptr. PMID 26486882 DOI: 10.1002/ptr.5494  0.674
2015 Maiwulanjiang M, Bi CW, Lee PS, Xin G, Miernisha A, Lau KM, Xiong A, Li N, Dong TT, Aisa HA, Tsim KW. The volatile oil of Nardostachyos Radix et Rhizoma induces endothelial nitric oxide synthase activity in HUVEC cells. Plos One. 10: e0116761. PMID 25643147 DOI: 10.1371/Journal.Pone.0116761  0.668
2015 Yan L, Xu SL, Zhu KY, Lam KY, Xin G, Maiwulanjiang M, Li N, Dong TT, Lin H, Tsim KW. Optimizing the compatibility of paired-herb in an ancient Chinese herbal decoction Kai-Xin-San in activating neurofilament expression in cultured PC12 cells. Journal of Ethnopharmacology. 162: 155-62. PMID 25560671 DOI: 10.1016/J.Jep.2014.12.049  0.672
2014 Xin GZ, Lam YC, Maiwulanjiang M, Chan GK, Zhu KY, Tang WL, Dong TT, Shi ZQ, Li P, Tsim KW. Authentication of Bulbus Fritillariae Cirrhosae by RAPD-derived DNA markers. Molecules (Basel, Switzerland). 19: 3450-9. PMID 24658569 DOI: 10.3390/Molecules19033450  0.645
2014 Maiwulanjiang M, Chen J, Xin G, Gong AG, Miernisha A, Du CY, Lau KM, Lee PS, Chen J, Dong TT, Aisa HA, Tsim KW. The volatile oil of Nardostachyos Radix et Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte. Journal of Ethnopharmacology. 153: 491-8. PMID 24632018 DOI: 10.1016/J.Jep.2014.03.010  0.669
2014 Chen J, Maiwulanjiang M, Lam KY, Zhang WL, Zhan JY, Lam CT, Xu SL, Zhu KY, Yao P, Lau DT, Dong TT, Tsim KW. A standardized extract of the fruit of Ziziphus jujuba (Jujube) induces neuronal differentiation of cultured PC12 cells: a signaling mediated by protein kinase A. Journal of Agricultural and Food Chemistry. 62: 1890-7. PMID 24520858 DOI: 10.1021/Jf405093F  0.7
2014 Zou XH, Xie HQ, Zha GC, Chen VP, Sun YJ, Zheng YZ, Tsim KW, Dong TT, Choi RC, Luk WK. Characterizations of cholinesterases in golden apple snail (Pomacea canaliculata). Journal of Molecular Neuroscience : Mn. 53: 424-8. PMID 24217797 DOI: 10.1007/S12031-013-0168-4  0.452
2013 Xu SL, Zhu KY, Bi CW, Choi RC, Miernisha A, Yan AL, Maiwulanjiang M, Men SW, Dong TT, Tsim KW. Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron. Planta Medica. 79: 1710-4. PMID 24243544 DOI: 10.1055/S-0033-1351023  0.696
2013 Maiwulanjiang M, Zhu KY, Chen J, Miernisha A, Xu SL, Du CY, Lau KK, Choi RC, Dong TT, Aisa HA, Tsim KW. Song bu li decoction, a traditional uyghur medicine, protects cell death by regulation of oxidative stress and differentiation in cultured PC12 cells. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 687958. PMID 24198845 DOI: 10.1155/2013/687958  0.705
2013 Chen J, Li Z, Maiwulanjiang M, Zhang WL, Zhan JY, Lam CT, Zhu KY, Yao P, Choi RC, Lau DT, Dong TT, Tsim KW. Chemical and biological assessment of Ziziphus jujuba fruits from China: different geographical sources and developmental stages. Journal of Agricultural and Food Chemistry. 61: 7315-24. PMID 23841724 DOI: 10.1021/Jf402379U  0.672
2013 Choi RC, Chu GK, Siow NL, Yung AW, Yung LY, Lee PS, Lo CC, Simon J, Dong TT, Barnard EA, Tsim KW. Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation. Molecular Pharmacology. 84: 50-61. PMID 23592515 DOI: 10.1124/mol.112.084160  0.502
2012 Chan WK, Chen VP, Luk WK, Choi RC, Tsim KW. N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase. Neuroscience Letters. 523: 71-5. PMID 22750213 DOI: 10.1016/j.neulet.2012.06.045  0.635
2012 Xu H, Su ZR, Huang W, Choi RC, Zheng YZ, Lau DT, Dong TT, Wang ZT, Tsim KW. Er Zhi Wan, an ancient herbal decoction for woman menopausal syndrome, activates the estrogenic response in cultured MCF-7 cells: an evaluation of compatibility in defining the optimized preparation method. Journal of Ethnopharmacology. 143: 109-15. PMID 22710293 DOI: 10.1016/J.Jep.2012.06.009  0.469
2011 Chen VP, Luk WK, Chan WK, Leung KW, Guo AJ, Chan GK, Xu SL, Choi RC, Tsim KW. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in Molecular Neuroscience. 4: 36. PMID 22046147 DOI: 10.3389/fnmol.2011.00036  0.647
2011 Chen VP, Choi RC, Chan WK, Leung KW, Guo AJ, Chan GK, Luk WK, Tsim KW. The assembly of proline-rich membrane anchor (PRiMA)-linked acetylcholinesterase enzyme: glycosylation is required for enzymatic activity but not for oligomerization. The Journal of Biological Chemistry. 286: 32948-61. PMID 21795704 DOI: 10.1074/jbc.M111.261248  0.644
2011 Zheng KY, Choi RC, Cheung AW, Guo AJ, Bi CW, Zhu KY, Fu Q, Du Y, Zhang WL, Zhan JY, Duan R, Lau DT, Dong TT, Tsim KW. Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α. Journal of Agricultural and Food Chemistry. 59: 1697-704. PMID 21309574 DOI: 10.1021/jf104018u  0.547
2010 Siow NL, Choi RC, Xie HQ, Kong LW, Chu GK, Chan GK, Simon J, Barnard EA, Tsim KW. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Molecular Pharmacology. 78: 1059-71. PMID 20847060 DOI: 10.1124/mol.110.066506  0.505
2010 Chen VP, Xie HQ, Chan WK, Leung KW, Chan GK, Choi RC, Bon S, Massoulié J, Tsim KW. The PRiMA-linked cholinesterase tetramers are assembled from homodimers: hybrid molecules composed of acetylcholinesterase and butyrylcholinesterase dimers are up-regulated during development of chicken brain. The Journal of Biological Chemistry. 285: 27265-78. PMID 20566626 DOI: 10.1074/jbc.M110.113647  0.644
2010 Xie HQ, Leung KW, Chen VP, Chan GK, Xu SL, Guo AJ, Zhu KY, Zheng KY, Bi CW, Zhan JY, Chan WK, Choi RC, Tsim KW. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chemico-Biological Interactions. 187: 78-83. PMID 20178777 DOI: 10.1016/j.cbi.2010.02.018  0.661
2010 Chen VP, Xie HQ, Chan WK, Leung KW, Choi RC, Tsim KW. An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells. Chemico-Biological Interactions. 187: 106-9. PMID 20176004 DOI: 10.1016/j.cbi.2010.02.024  0.63
2010 Xie HQ, Liang D, Leung KW, Chen VP, Zhu KY, Chan WK, Choi RC, Massoulié J, Tsim KW. Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons. The Journal of Biological Chemistry. 285: 11537-46. PMID 20147288 DOI: 10.1074/jbc.M109.038711  0.639
2010 Zheng YZ, Choi RC, Li J, Xie HQ, Cheung AW, Duan R, Guo AJ, Zhu JT, Chen VP, Bi CW, Zhu Y, Lau DD, Dong TT, Lau BW, Tsim KW. Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. Planta Medica. 76: 439-43. PMID 19847742 DOI: 10.1055/S-0029-1186222  0.321
2009 Cheung JK, Li J, Cheung AW, Zhu Y, Zheng KY, Bi CW, Duan R, Choi RC, Lau DT, Dong TT, Lau BW, Tsim KW. Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines. Journal of Ethnopharmacology. 124: 61-8. PMID 19446414 DOI: 10.1016/J.Jep.2009.04.010  0.395
2008 Choi RC, Simon J, Tsim KW, Barnard EA. Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding. The Journal of Biological Chemistry. 283: 11050-63. PMID 18270199 DOI: 10.1074/jbc.M709266200  0.458
2004 Tung EK, Choi RC, Siow NL, Jiang JX, Ling KK, Simon J, Barnard EA, Tsim KW. P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Molecular Pharmacology. 66: 794-806. PMID 15258260 DOI: 10.1124/mol.104.003269  0.486
2004 Lee HH, Choi RC, Ting AK, Siow NL, Jiang JX, Massoulié J, Tsim KW. Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters. The Journal of Biological Chemistry. 279: 27098-107. PMID 15102835 DOI: 10.1074/jbc.M402596200  0.339
2003 Tsim KW, Choi RC, Siow NL, Cheng AW, Ling KK, Jiang JX, Tung EK, Lee HH, Xie QH, Simon J, Barnard EA. ATP induces post-synaptic gene expressions in vertebrate skeletal neuromuscular junctions. Journal of Neurocytology. 32: 603-17. PMID 15034256 DOI: 10.1023/B:NEUR.0000020613.25367.78  0.547
2003 Jiang JX, Choi RC, Siow NL, Lee HH, Wan DC, Tsim KW. Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP-dependent signaling. The Journal of Biological Chemistry. 278: 45435-44. PMID 12963741 DOI: 10.1074/jbc.M306320200  0.41
2003 Choi RC, Siow NL, Cheng AW, Ling KK, Tung EK, Simon J, Barnard EA, Tsim KW. ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4445-56. PMID 12805285 DOI: 10.1523/Jneurosci.23-11-04445.2003  0.477
2002 Tsim KW, Barnard EA. The signaling pathways mediated by P2Y nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junction. Neuro-Signals. 11: 58-64. PMID 11943883 DOI: 10.1159/000057322  0.496
2001 Choi RC, Man ML, Ling KK, Ip NY, Simon J, Barnard EA, Tsim KW. Expression of the P2Y1 nucleotide receptor in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9224-34. PMID 11717356 DOI: 10.1523/Jneurosci.21-23-09224.2001  0.493
2000 Choi RC, Siow NL, Zhu SQ, Tsim KW. The cAMP-dependent protein kinase mediates the expression of AChE in chick myotubes. Neuroreport. 11: 801-6. PMID 10757523  0.304
1992 Tsim KW, Greenberg I, Rimer M, Randall WR, Salpeter MM. Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells. The Journal of Cell Biology. 118: 1201-12. PMID 1512293 DOI: 10.1083/Jcb.118.5.1201  0.605
1992 Ruegg MA, Tsim KW, Horton SE, Kröger S, Escher G, Gensch EM, McMahan UJ. The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron. 8: 691-9. PMID 1314621 DOI: 10.1016/0896-6273(92)90090-Z  0.757
1992 Tsim KW, Ruegg MA, Escher G, Kröger S, McMahan UJ. cDNA that encodes active agrin. Neuron. 8: 677-89. PMID 1314620 DOI: 10.1016/0896-6273(92)90089-V  0.753
1988 Tsim KW, Randall WR, Barnard EA. An asymmetric form of muscle acetylcholinesterase contains three subunit types and two enzymic activities in one molecule. Proceedings of the National Academy of Sciences of the United States of America. 85: 1262-6. PMID 3422489 DOI: 10.1073/Pnas.85.4.1262  0.468
1988 Tsim KW, Randall WR, Barnard EA. Identification of a 17 S asymmetric butyrylcholinesterase in chick muscle by monoclonal antibodies. Neuroscience Letters. 86: 245-9. PMID 3368125 DOI: 10.1016/0304-3940(88)90579-4  0.456
1988 Tsim KW, Randall WR, Barnard EA. Monoclonal antibodies specific for the different subunits of asymmetric acetylcholinesterase from chick muscle. Journal of Neurochemistry. 51: 95-104. PMID 3288716 DOI: 10.1111/J.1471-4159.1988.Tb04840.X  0.435
1988 Tsim KW, Randall WR, Barnard EA. Synaptic acetylcholinesterase of chicken muscle changes during development from a hybrid to a homogeneous enzyme. The Embo Journal. 7: 2451-6. PMID 3056716 DOI: 10.1002/J.1460-2075.1988.Tb03091.X  0.458
1988 Weetman AP, Tse CK, Randall WR, Tsim KW, Barnard EA. Acetylcholinesterase antibodies and thyroid autoimmunity. Clinical and Experimental Immunology. 71: 96-9. PMID 2450705  0.384
1987 Randall WR, Tsim KW, Lai J, Barnard EA. Monoclonal antibodies against chicken brain acetylcholinesterase. Their use in immunopurification and immunochemistry to demonstrate allelic variants of the enzyme. European Journal of Biochemistry / Febs. 164: 95-102. PMID 3830186 DOI: 10.1111/J.1432-1033.1987.Tb10998.X  0.46
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