Layla Azam, Ph.D. - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
Brain development, drug abuse, nicotine

19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Hone AJ, McIntosh JM, Azam L, Lindstrom J, Lucero L, Whiteaker P, Passas J, Blázquez J, Albillos A. α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells. Molecular Pharmacology. 88: 881-93. PMID 26330550 DOI: 10.1124/mol.115.100982  0.76
2015 Azam L, Papakyriakou A, Zouridakis M, Giastas P, Tzartos SJ, McIntosh JM. Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor. Molecular Pharmacology. 87: 855-64. PMID 25740413 DOI: 10.1124/mol.114.096511  0.76
2015 Zhang MM, Gajewiak J, Azam L, Bulaj G, Olivera BM, Yoshikami D. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ Biochemistry. 54: 3911-3920. DOI: 10.1021/acs.biochem.5b00390  0.76
2014 Gajewiak J, Azam L, Imperial J, Walewska A, Green BR, Bandyopadhyay PK, Raghuraman S, Ueberheide B, Bern M, Zhou HM, Minassian NA, Hagan RH, Flinspach M, Liu Y, Bulaj G, et al. A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proceedings of the National Academy of Sciences of the United States of America. 111: 2758-63. PMID 24497506 DOI: 10.1073/pnas.1324189111  0.76
2013 Hone AJ, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, McIntosh JM. Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 288: 25428-39. PMID 23846688 DOI: 10.1074/jbc.M113.482059  0.76
2013 Zhang MM, Wilson MJ, Azam L, Gajewiak J, Rivier JE, Bulaj G, Olivera BM, Yoshikami D. Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. British Journal of Pharmacology. 168: 1597-610. PMID 23146020 DOI: 10.1111/bph.12051  0.76
2011 Wilson MJ, Yoshikami D, Azam L, Gajewiak J, Olivera BM, Bulaj G, Zhang MM. μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proceedings of the National Academy of Sciences of the United States of America. 108: 10302-7. PMID 21652775 DOI: 10.1073/pnas.1107027108  0.76
2011 Wilson MJ, Zhang MM, Azam L, Olivera BM, Bulaj G, Yoshikami D. Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB. The Journal of Pharmacology and Experimental Therapeutics. 338: 687-93. PMID 21586605 DOI: 10.1124/jpet.110.178343  0.76
2010 Azam L, Maskos U, Changeux JP, Dowell CD, Christensen S, De Biasi M, McIntosh JM. α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 5113-23. PMID 20739611 DOI: 10.1096/fj.10-166272  0.76
2009 Zhang MM, McArthur JR, Azam L, Bulaj G, Olivera BM, French RJ, Yoshikami D. Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin, Tex.). 3: 32-8. PMID 19221510 DOI: 10.4161/chan.3.1.7500  0.76
2009 Holford M, Zhang MM, Gowd KH, Azam L, Green BR, Watkins M, Ownby JP, Yoshikami D, Bulaj G, Olivera BM. Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon : Official Journal of the International Society On Toxinology. 53: 90-8. PMID 18950653 DOI: 10.1016/j.toxicon.2008.10.017  0.76
2008 Yao S, Zhang MM, Yoshikami D, Azam L, Olivera BM, Bulaj G, Norton RS. Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry. 47: 10940-9. PMID 18798648 DOI: 10.1021/bi801010u  0.76
2008 Fiedler B, Zhang MM, Buczek O, Azam L, Bulaj G, Norton RS, Olivera BM, Yoshikami D. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochemical Pharmacology. 75: 2334-44. PMID 18486102 DOI: 10.1016/j.bcp.2008.03.019  0.76
2007 Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, Terlau H, McArthur JR, French RJ, Gulyas J, Rivier JE, Smith BJ, Norton RS, Olivera BM, Yoshikami D, et al. Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. The Journal of Biological Chemistry. 282: 30699-706. PMID 17724025 DOI: 10.1074/jbc.M704616200  0.76
2007 Azam L, Chen Y, Leslie FM. Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons. Neuroscience. 144: 1347-60. PMID 17197101 DOI: 10.1016/j.neuroscience.2006.11.011  0.76
2005 Azam L, Dowell C, Watkins M, Stitzel JA, Olivera BM, McIntosh JM. Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 280: 80-7. PMID 15520009 DOI: 10.1074/jbc.M406281200  0.76
2004 McIntosh JM, Azam L, Staheli S, Dowell C, Lindstrom JM, Kuryatov A, Garrett JE, Marks MJ, Whiteaker P. Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. Molecular Pharmacology. 65: 944-52. PMID 15044624 DOI: 10.1124/mol.65.4.944  0.76
2003 Azam L, Winzer-Serhan U, Leslie FM. Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons. Neuroscience. 119: 965-77. PMID 12831856 DOI: 10.1016/S0306-4522(03)00220-3  0.76
2002 Azam L, Winzer-Serhan UH, Chen Y, Leslie FM. Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. The Journal of Comparative Neurology. 444: 260-74. PMID 11840479 DOI: 10.1002/cne.10138  0.76
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