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Ryan M. Spengler, Ph.D. - Publications

Affiliations: 
2013 Molecular & Cell Biology University of Iowa, Iowa City, IA 
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Cheng C, Spengler RM, Keiser MS, Monteys AM, Rieders JM, Ramachandran S, Davidson BL. The long noncoding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease-gene dependent toxicities. Human Molecular Genetics. PMID 30239724 DOI: 10.1093/Hmg/Ddy331  0.528
2018 Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, et al. Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nature Biotechnology. 36: 899. PMID 30188530 DOI: 10.1038/nbt0918-899b  0.415
2018 Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, et al. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nature Biotechnology. PMID 30010675 DOI: 10.1038/Nbt.4183  0.32
2018 Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nature Genetics. PMID 29662165 DOI: 10.1038/s41588-018-0104-1  0.338
2016 Ramachandran S, Coffin SL, Tang TY, Jobaliya CD, Spengler RM, Davidson BL. Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts. Human Molecular Genetics. 25: 4939-4950. PMID 28171541 DOI: 10.1093/Hmg/Ddw317  0.635
2016 Ramachandran S, Coffin SL, Tang TY, Jobaliya CD, Spengler RM, Davidson BL. Cis-Acting Single Nucleotide Polymorphisms Alter MicroRNA-Mediated Regulation of Human Brain-Expressed Transcripts. Human Molecular Genetics. PMID 27638890 DOI: 10.1093/hmg/ddw317  0.637
2016 Spengler RM, Zhang X, Cheng C, McLendon JM, Skeie JM, Johnson FL, Davidson BL, Boudreau RL. Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. Nucleic Acids Research. PMID 27418678 DOI: 10.1093/Nar/Gkw640  0.697
2015 Monteys AM, Wilson MJ, Boudreau RL, Spengler RM, Davidson BL. Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo. Molecular Therapy. Nucleic Acids. 4: e234. PMID 25849618 DOI: 10.1038/Mtna.2015.7  0.703
2014 Monteys AM, Spengler RM, Dufour BD, Wilson MS, Oakley CK, Sowada MJ, McBride JL, Davidson BL. Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain. Nucleic Acids Research. 42: 13315-27. PMID 25332397 DOI: 10.1093/Nar/Gku979  0.69
2014 Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL. Transcriptome-wide discovery of microRNA binding sites in human brain. Neuron. 81: 294-305. PMID 24389009 DOI: 10.1016/J.Neuron.2013.10.062  0.738
2014 McLoughlin HS, Wan J, Spengler RM, Xing Y, Davidson BL. Human-specific microRNA regulation of FOXO1: implications for microRNA recognition element evolution. Human Molecular Genetics. 23: 2593-603. PMID 24368418 DOI: 10.1093/Hmg/Ddt655  0.728
2014 Spengler RM, Oakley CK, Davidson BL. Functional microRNAs and target sites are created by lineage-specific transposition. Human Molecular Genetics. 23: 1783-93. PMID 24234653 DOI: 10.1093/Hmg/Ddt569  0.699
2013 Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL. siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse. Nucleic Acids Research. 41: e9. PMID 22941647 DOI: 10.1093/Nar/Gks797  0.688
2011 Boudreau RL, Spengler RM, Davidson BL. Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 2169-77. PMID 21952166 DOI: 10.1038/Mt.2011.185  0.708
2010 Monteys AM, Spengler RM, Wan J, Tecedor L, Lennox KA, Xing Y, Davidson BL. Structure and activity of putative intronic miRNA promoters. Rna (New York, N.Y.). 16: 495-505. PMID 20075166 DOI: 10.1261/Rna.1731910  0.687
2009 Borchert GM, Gilmore BL, Spengler RM, Xing Y, Lanier W, Bhattacharya D, Davidson BL. Adenosine deamination in human transcripts generates novel microRNA binding sites. Human Molecular Genetics. 18: 4801-7. PMID 19776031 DOI: 10.1093/Hmg/Ddp443  0.741
2009 Keck K, Volper EM, Spengler RM, Long DD, Chan CY, Ding Y, McCaffrey AP. Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 538-47. PMID 19088704 DOI: 10.1038/Mt.2008.273  0.571
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