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Alice L. Rodriguez, Ph.D. - Publications

Affiliations: 
2003 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
steroid hormones
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Year Citation  Score
2023 Qi A, Kling HE, Billard N, Rodriguez AL, Peng L, Dickerson JW, Engers JL, Bender AM, Moehle MS, Lindsley CW, Rook JM, Niswender CM. . Molecular Pharmacology. PMID 37595966 DOI: 10.1124/molpharm.122.000643  0.36
2023 Lei X, Hofmann C, Rodriguez AL, Niswender C. Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7. Molecular Pharmacology. PMID 37105671 DOI: 10.1124/molpharm.123.000678  0.385
2022 Kalbfleisch JJ, Rodriguez AL, Lei X, Weiss K, Blobaum AL, Boutaud O, Niswender CM, Lindsley CW. Persistent challenges in the development of an mGlu PAM in vivo tool compound: The discovery of VU6046980. Bioorganic & Medicinal Chemistry Letters. 80: 129106. PMID 36528230 DOI: 10.1016/j.bmcl.2022.129106  0.368
2022 Orsi DL, Felts AS, Rodriguez AL, Vinson PN, Cho HP, Chang S, Blobaum AL, Niswender CM, Jeffrey Conn P, Jones CK, Lindsley CW, Han C. Discovery of a potent M antagonist with improved clearance profile. Part 2: pyrrolidine amide-based antagonists. Bioorganic & Medicinal Chemistry Letters. 129021. PMID 36228968 DOI: 10.1016/j.bmcl.2022.129021  0.346
2022 Capstick RA, Whomble D, Orsi DL, Felts AS, Rodriguez AL, Vinson PN, Chang S, Blobaum AL, Niswender CM, Conn PJ, Jones CK, Lindsley CW, Han C. Discovery of a potent M antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists. Bioorganic & Medicinal Chemistry Letters. 76: 128988. PMID 36113671 DOI: 10.1016/j.bmcl.2022.128988  0.346
2022 Reed CW, Rodriguez AL, Kalbfleisch JJ, Seto M, Jenkins MT, Blobaum AL, Chang S, Lindsley CW, Niswender CM. Development and profiling of mGlu NAMs with a range of saturable inhibition of agonist responses in vitro. Bioorganic & Medicinal Chemistry Letters. 74: 128923. PMID 35944850 DOI: 10.1016/j.bmcl.2022.128923  0.422
2021 Barbaro L, Rodriguez AL, Blevins AN, Dickerson JW, Billard N, Boutaud O, Rook JL, Niswender CM, Conn PJ, Engers DW, Lindsley CW. Discovery of "Molecular Switches" within a Series of mGlu Allosteric Ligands Driven by a "Magic Methyl" Effect Affording Both PAMs and NAMs with Activity, Derived from an M PAM Chemotype. Acs Bio & Med Chem Au. 1: 21-30. PMID 37101980 DOI: 10.1021/acsbiomedchemau.1c00024  0.363
2021 Bender AM, Carter TR, Spock M, Rodriguez AL, Dickerson JW, Rook JM, Chang S, Qi A, Presley CC, Engers DW, Harp JM, Bridges TM, Niswender CM, Conn PJ, Lindsley CW. Synthesis and Characterization of Chiral 6-Azaspiro[2.5]Octanes as Potent and Selective Antagonists of the M Muscarinic Acetylcholine Receptor. Bioorganic & Medicinal Chemistry Letters. 128479. PMID 34838649 DOI: 10.1016/j.bmcl.2021.128479  0.369
2021 Yamada Y, Gilliland K, Xiang Z, Haymer D, Crocker KE, Loch MT, Schulte ML, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Melancon BJ. Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds. Bioorganic & Medicinal Chemistry Letters. 128342. PMID 34461178 DOI: 10.1016/j.bmcl.2021.128342  0.37
2021 Moehle MS, Bender AM, Dickerson JW, Foster DJ, Qi A, Cho HP, Donsante Y, Peng W, Bryant Z, Stillwell KJ, Bridges TM, Chang S, Watson KJ, O'Neill JC, Engers JL, ... ... Rodriguez AL, et al. Discovery of the First Selective M Muscarinic Acetylcholine Receptor Antagonists with Antiparkinsonian and Antidystonic Efficacy. Acs Pharmacology & Translational Science. 4: 1306-1321. PMID 34423268 DOI: 10.1021/acsptsci.0c00162  0.328
2021 Spock M, Carter TR, Bollinger KA, Han C, Baker LA, Rodriguez AL, Peng L, Dickerson JW, Qi A, Rook JM, O'Neill JC, Watson KJ, Chang S, Bridges TM, Engers JL, et al. Discovery of VU6028418: A Highly Selective and Orally Bioavailable M Muscarinic Acetylcholine Receptor Antagonist. Acs Medicinal Chemistry Letters. 12: 1342-1349. PMID 34413964 DOI: 10.1021/acsmedchemlett.1c00363  0.348
2021 Spearing PK, Cho HP, Luscombe VB, Blobaum AL, Boutaud O, Engers DW, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Bender AM. Discovery of a Novel Class of Heteroaryl-Pyrrolidinones as Positive Allosteric Modulators of the Muscarinic Acetylcholine Receptor M. Bioorganic & Medicinal Chemistry Letters. 128193. PMID 34118412 DOI: 10.1016/j.bmcl.2021.128193  0.302
2020 Davis DC, Bungard JD, Chang S, Rodriguez AL, Blobaum AL, Boutaud O, Melancon BJ, Niswender CM, Jeffrey Conn P, Lindsley CW. Lead optimization of the VU0486321 series of mGlu PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs. Bioorganic & Medicinal Chemistry Letters. 127724. PMID 33253881 DOI: 10.1016/j.bmcl.2020.127724  0.459
2020 Reed CW, Kalbfleisch JJ, Wong MJ, Washecheck JP, Hunter A, Rodriguez AL, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu Positive Allosteric Modulator Tool Compound. Acs Medicinal Chemistry Letters. 11: 1773-1779. PMID 32944146 DOI: 10.1021/Acsmedchemlett.0C00432  0.371
2020 Kalbfleisch JJ, Reed CW, Park C, Spearing PK, Quitalig MC, Jenkins MT, Rodriguez AL, Blobaum AL, Jeffrey Conn P, Niswender CM, Lindsley CW. Synthesis and SAR of a series of mGlu NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core. Bioorganic & Medicinal Chemistry Letters. 127529. PMID 32890686 DOI: 10.1016/J.Bmcl.2020.127529  0.431
2020 Fulton MG, Loch MT, Rodriguez AL, Lin X, Javitch JA, Conn PJ, Niswender CM, Lindsley CW. Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu heterodimeric receptor results in a compound with mGlu homodimer selectivity. Bioorganic & Medicinal Chemistry Letters. 127212. PMID 32371100 DOI: 10.1016/J.Bmcl.2020.127212  0.534
2019 Fulton MG, Loch MT, Cuoco CA, Rodriguez AL, Days E, Vinson PN, Kozek KA, Weaver CD, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Challenges in the Discovery and Optimization of mGlu Heterodimer Positive Allosteric Modulators. Letters in Drug Design & Discovery. 16: 1387-1394. PMID 32201485 DOI: 10.2174/1570180815666181017131349  0.312
2019 Temple KJ, Long MF, Engers JL, Watson KJ, Chang S, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Jeffrey Conn P, Engers DW, Lindsley CW. Discovery of structurally distinct tricyclic M positive allosteric modulator (PAM) chemotypes. Bioorganic & Medicinal Chemistry Letters. 126811. PMID 31787491 DOI: 10.1016/J.Bmcl.2019.126811  0.306
2019 Temple KJ, Engers JL, Long MF, Watson KJ, Chang S, Luscombe VB, Jenkins MT, Rodriguez AL, Niswender CM, Bridges TM, Jeffrey Conn P, Engers DW, Lindsley CW. Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M positive allosteric modulator (PAM) chemotype. Bioorganic & Medicinal Chemistry Letters. 126812. PMID 31784320 DOI: 10.1016/J.Bmcl.2019.126812  0.342
2019 Yamada Y, Yohn SE, Gilliland K, Loch MT, Schulte ML, Rodriguez AL, Blobaum AL, Niswender CM, Jeffrey Conn P, Lindsley CW. Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy. Bioorganic & Medicinal Chemistry Letters. PMID 31358468 DOI: 10.1016/J.Bmcl.2019.07.030  0.385
2019 Chopko TC, Han C, Gregro AR, Engers DW, Felts AS, Poslusney MS, Bollinger KA, Morrison RD, Bubser M, Lamsal A, Luscombe VB, Cho HP, Schnetz-Boutaud NC, Rodriguez AL, Chang S, et al. SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M PAMs. Bioorganic & Medicinal Chemistry Letters. PMID 31248774 DOI: 10.1016/J.Bmcl.2019.06.032  0.355
2019 Butkiewicz M, Rodriguez AL, Rainey SE, Wieting JM, Luscombe VB, Stauffer SR, Lindsley CW, Conn PJ, Meiler J. Identification of novel allosteric modulators of mGlu5 acting at site distinct from MPEP binding. Acs Chemical Neuroscience. PMID 31132237 DOI: 10.1021/Acschemneuro.8B00227  0.5
2019 Engers DW, Melancon BJ, Gregro AR, Bertron JL, Bollinger SR, Felts AS, Konkol LC, Wood MR, Bollinger KA, Luscombe VB, Rodriguez AL, Jones CK, Bubser M, Yohn SE, Wood MW, et al. VU6005806/AZN-00016130, an advanced M positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorganic & Medicinal Chemistry Letters. PMID 31113706 DOI: 10.1016/J.Bmcl.2019.05.026  0.354
2019 Reed CW, Washecheck JP, Quitlag MC, Jenkins MT, Rodriguez AL, Engers DW, Blobaum AL, Jeffrey Conn P, Niswender CM, Lindsley CW. Surveying heterocycles as amide bioisosteres within a series of mGlu NAMs: Discovery of VU6019278. Bioorganic & Medicinal Chemistry Letters. PMID 30910459 DOI: 10.1016/J.Bmcl.2019.03.016  0.363
2019 Panarese JD, Engers DW, Wu YJ, Bronson JJ, Macor JE, Chun A, Rodriguez AL, Felts AS, Engers JL, Loch MT, Emmitte KA, Castelhano AL, Kates MJ, Nader MA, Jones CK, et al. Discovery of VU2957 (Valiglurax): An mGlu Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease. Acs Medicinal Chemistry Letters. 10: 255-260. PMID 30891122 DOI: 10.1021/Acsmedchemlett.8B00426  0.332
2019 Reed CW, Yohn S, Washecheck JP, Roenfanz HF, Quitalig MC, Luscombe VB, Jenkins MT, Rodriguez AL, Engers DW, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 Negative Allosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962). Journal of Medicinal Chemistry. PMID 30608678 DOI: 10.1021/Acs.Jmedchem.8B01810  0.392
2018 Poslusney MS, Salovich JM, Wood MR, Melancon BJ, Bollinger KA, Luscombe VB, Rodriguez AL, Engers DW, Bridges TM, Niswender CM, Jeffrey Conn P, Lindsley CW. Novel M positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands. Bioorganic & Medicinal Chemistry Letters. PMID 30580918 DOI: 10.1016/J.Bmcl.2018.12.039  0.316
2018 Panarese JD, Engers DW, Wu YJ, Guernon JM, Chun A, Gregro AR, Bender AM, Capstick RA, Wieting JM, Bronson JJ, Macor JE, Westphal R, Soars M, Engers JE, Felts AS, ... Rodriguez AL, et al. The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu PAM development candidate. Bioorganic & Medicinal Chemistry Letters. PMID 30503632 DOI: 10.1016/J.Bmcl.2018.10.050  0.377
2018 Felts AS, Bollinger KA, Brassard CJ, Rodriguez AL, Morrison RD, Scott Daniels J, Blobaum AL, Niswender CM, Jones CK, Jeffrey Conn P, Emmitte KA, Lindsley CW. Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters. PMID 30446311 DOI: 10.1016/J.Bmcl.2018.11.017  0.421
2018 Childress ES, Wieting JM, Felts AS, Breiner MM, Long MF, Luscombe VB, Rodriguez AL, Cho HP, Blobaum AL, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW. Discovery of novel central nervous system penetrant metabotropic glutamate receptor subtype 2 (mGlu) Negative Allosteric Modulators (NAMs) based on functionalized pyrazolo[1,5- a]pyrimidine-5-carboxamide and thieno[3,2- b]pyridine-5-carboxamide cores. Journal of Medicinal Chemistry. PMID 30350962 DOI: 10.1021/Acs.Jmedchem.8B01266  0.483
2018 Bollinger S, Engers DW, Panarese JD, West M, Engers JL, Loch MT, Rodriguez AL, Blobaum AL, Jones CK, Thompson Gray A, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. The discovery, SAR and biological characterization of a novel series of 6-((1H-pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). Journal of Medicinal Chemistry. PMID 30247901 DOI: 10.1021/Acs.Jmedchem.8B00994  0.401
2018 Tarr JC, Wood MR, Noetzel MJ, Melancon BJ, Lamsal A, Luscombe VB, Rodriguez AL, Byers FW, Chang S, Cho HP, Engers DW, Jones CK, Niswender CM, Wood MW, Brandon NJ, et al. Corrigendum to "Challenges in the development of an M PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184]. Bioorganic & Medicinal Chemistry Letters. PMID 30076050 DOI: 10.1016/J.Bmcl.2018.07.022  0.348
2018 Engers DW, Bollinger SR, Engers JL, Panarese JD, Breiner MM, Gregro A, Blobaum AL, Bronson JJ, Wu YJ, Macor JE, Rodriguez AL, Zamorano R, Conn PJ, Lindsley CW, Niswender CM, et al. Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu positive allosteric modulators that mitigate CYP1A2 induction liability. Bioorganic & Medicinal Chemistry Letters. PMID 29958762 DOI: 10.1016/J.Bmcl.2018.06.034  0.409
2018 Felts AS, Rodriguez AL, Morrison RD, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA. Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters. PMID 29705142 DOI: 10.1016/J.Bmcl.2018.04.053  0.489
2017 Reed CW, McGowan KM, Spearing PK, Stansley BJ, Roenfanz HF, Engers DW, Rodriguez AL, Engelberg EM, Luscombe VB, Loch MT, Remke DH, Rook JM, Blobaum AL, Conn PJ, Niswender CM, et al. VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides. Acs Medicinal Chemistry Letters. 8: 1326-1330. PMID 29259756 DOI: 10.1021/Acsmedchemlett.7B00429  0.338
2017 Tarr JC, Wood MR, Noetzel MJ, Melancon BJ, Lamsal A, Luscombe VB, Rodriguez AL, Byers FW, Chang S, Cho HP, Engers DW, Jones CK, Niswender CM, Wood MW, Brandon NJ, et al. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides. Bioorganic & Medicinal Chemistry Letters. PMID 29089231 DOI: 10.1016/J.Bmcl.2017.10.053  0.405
2017 Abe M, Seto M, Gogliotti RG, Loch MT, Bollinger KA, Chang S, Engelberg EM, Luscombe VB, Harp JM, Bubser M, Engers DW, Jones CK, Rodriguez AL, Blobaum AL, Conn PJ, et al. Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines. Acs Medicinal Chemistry Letters. 8: 1110-1115. PMID 29057060 DOI: 10.1021/Acsmedchemlett.7B00317  0.492
2017 Long MF, Engers JL, Chang S, Zhan X, Weiner RL, Luscombe VB, Rodriguez AL, Cho HP, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorganic & Medicinal Chemistry Letters. PMID 29037946 DOI: 10.1016/J.Bmcl.2017.10.016  0.355
2017 Felts AS, Rodriguez AL, Morrison RD, Bollinger KA, Venable DF, Blobaum AL, Byers FW, Thompson Gray A, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters. PMID 28958625 DOI: 10.1016/J.Bmcl.2017.09.042  0.478
2017 Engers JL, Bollinger KA, Weiner RL, Rodriguez AL, Long MF, Breiner MM, Chang S, Bollinger SR, Bubser M, Jones CK, Morrison RD, Bridges TM, Blobaum AL, Niswender CM, Conn PJ, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. Acs Medicinal Chemistry Letters. 8: 925-930. PMID 28947938 DOI: 10.1021/Acsmedchemlett.7B00249  0.372
2017 Bollinger KA, Felts AS, Brassard CJ, Engers JL, Rodriguez AL, Weiner RL, Cho HP, Chang S, Bubser M, Jones CK, Blobaum AL, Niswender CM, Conn PJ, Emmitte KA, Lindsley CW. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core. Acs Medicinal Chemistry Letters. 8: 919-924. PMID 28947937 DOI: 10.1021/Acsmedchemlett.7B00279  0.398
2017 Bewley BR, Spearing PK, Weiner RL, Luscombe VB, Zhan X, Chang S, Cho HP, Rodriguez AL, Niswender CM, Conn PJ, Bridges TM, Engers DW, Lindsley CW. Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core. Bioorganic & Medicinal Chemistry Letters. PMID 28866269 DOI: 10.1016/J.Bmcl.2017.08.043  0.35
2017 Bender AM, Weiner RL, Luscombe VB, Ajmera S, Cho HP, Chang S, Zhan X, Rodriguez AL, Niswender CM, Engers DW, Bridges TM, Conn PJ, Lindsley CW. Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 28633897 DOI: 10.1016/J.Bmcl.2017.05.042  0.443
2017 Felts AS, Rodriguez AL, Blobaum AL, Morrison RD, Bates BS, Thompson Gray A, Rook JM, Tantawy MN, Byers FW, Chang S, Venable DF, Luscombe VB, Tamagnan GD, Niswender CM, Daniels JS, et al. Discovery of N-(5-fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation. Journal of Medicinal Chemistry. PMID 28530802 DOI: 10.1021/Acs.Jmedchem.7B00410  0.483
2017 Tarr JC, Wood MR, Noetzel MJ, Bertron JL, Weiner RL, Rodriguez AL, Lamsal A, Byers FW, Chang S, Cho HP, Jones CK, Niswender CM, Wood MW, Brandon NJ, Duggan ME, et al. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides. Bioorganic & Medicinal Chemistry Letters. PMID 28522253 DOI: 10.1016/J.Bmcl.2017.05.014  0.409
2017 Wood MR, Noetzel MJ, Melancon BJ, Poslusney MS, Nance KD, Hurtado MA, Luscombe VB, Weiner RL, Rodriguez AL, Lamsal A, Chang S, Bubser M, Blobaum AL, Engers DW, Niswender CM, et al. Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia. Acs Medicinal Chemistry Letters. 8: 233-238. PMID 28197318 DOI: 10.1021/Acsmedchemlett.6B00461  0.41
2016 Wood MR, Noetzel MJ, Tarr JC, Rodriguez AL, Lamsal A, Chang S, Foster JJ, Smith E, Chase P, Hodder PS, Engers DW, Niswender CM, Brandon NJ, Wood MW, Duggan ME, et al. Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. Bioorganic & Medicinal Chemistry Letters. PMID 27476142 DOI: 10.1016/J.Bmcl.2016.07.042  0.384
2016 Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ. Development and antiparkinsonian activity of VU0418506, a selective positive allosteric modulator of metabotropic glutamate receptor 4 homomers without activity at mGlu2/4 heteromers. Acs Chemical Neuroscience. PMID 27441572 DOI: 10.1021/Acschemneuro.6B00036  0.483
2016 Gogliotti RD, Blobaum AL, Morrison RM, Daniels JS, Salovich JM, Cheung YY, Rodriguez AL, Loch MT, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). Bioorganic & Medicinal Chemistry Letters. PMID 27234146 DOI: 10.1016/J.Bmcl.2016.05.029  0.418
2016 Felts AS, Rodriguez AL, Morrison RD, Venable DF, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents. Bioorganic & Medicinal Chemistry Letters. PMID 26988308 DOI: 10.1016/J.Bmcl.2016.03.026  0.486
2015 Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA. Design of 4-oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as selective negative allosteric modulators of metabotropic glutamate receptor subtype 2. Journal of Medicinal Chemistry. PMID 26524606 DOI: 10.1021/Acs.Jmedchem.5B01371  0.516
2015 Engers JL, Rodriguez AL, Konkol LC, Morrison RD, Thompson AD, Byers FW, Blobaum AL, Chang S, Venable DF, Loch MT, Niswender CM, Daniels JS, Jones CK, Conn PJ, Lindsley CW, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. Journal of Medicinal Chemistry. 58: 7485-500. PMID 26335039 DOI: 10.1021/Acs.Jmedchem.5B01005  0.463
2015 Gould RW, Amato RJ, Bubser M, Joffe ME, Nedelcovych MT, Thompson AD, Nickols HH, Yuh JP, Zhan X, Felts AS, Rodriguez AL, Morrison RD, Byers FW, Rook JM, Daniels JS, et al. Partial mGlu5 Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26315507 DOI: 10.1038/Npp.2015.265  0.34
2014 Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW. Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. Acs Chemical Biology. 9: 2334-46. PMID 25137254 DOI: 10.1021/Cb500560H  0.427
2014 Bates BS, Rodriguez AL, Felts AS, Morrison RD, Venable DF, Blobaum AL, Byers FW, Lawson KP, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorganic & Medicinal Chemistry Letters. 24: 3307-14. PMID 24969015 DOI: 10.1016/j.bmcl.2014.06.003  0.352
2014 Cho HP, Engers DW, Venable DF, Niswender CM, Lindsley CW, Conn PJ, Emmitte KA, Rodriguez AL. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. Acs Chemical Neuroscience. 5: 597-610. PMID 24798819 DOI: 10.1021/Cn5000343  0.475
2013 Felts AS, Rodriguez AL, Morrison RD, Venable DF, Manka JT, Bates BS, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorganic & Medicinal Chemistry Letters. 23: 5779-85. PMID 24074843 DOI: 10.1016/J.Bmcl.2013.09.001  0.454
2013 Manka JT, Rodriguez AL, Morrison RD, Venable DF, Cho HP, Blobaum AL, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA. Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1. Bioorganic & Medicinal Chemistry Letters. 23: 5091-6. PMID 23932792 DOI: 10.1016/J.Bmcl.2013.07.029  0.43
2013 Lovell KM, Felts AS, Rodriguez AL, Venable DF, Cho HP, Morrison RD, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA. N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorganic & Medicinal Chemistry Letters. 23: 3713-8. PMID 23727046 DOI: 10.1016/J.Bmcl.2013.05.020  0.408
2013 Le U, Melancon BJ, Bridges TM, Vinson PN, Utley TJ, Lamsal A, Rodriguez AL, Venable D, Sheffler DJ, Jones CK, Blobaum AL, Wood MR, Daniels JS, Conn PJ, Niswender CM, et al. Discovery of a selective Mâ‚„ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorganic & Medicinal Chemistry Letters. 23: 346-50. PMID 23177787 DOI: 10.1016/J.Bmcl.2012.10.073  0.473
2013 D'Amore V, Santolini I, van Rijn CM, Biagioni F, Molinaro G, Prete A, Conn PJ, Lindsley CW, Zhou Y, Vinson PN, Rodriguez AL, Jones CK, Stauffer SR, Nicoletti F, van Luijtelaar G, et al. Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology. 66: 330-8. PMID 22705340 DOI: 10.1016/J.Neuropharm.2012.05.044  0.418
2012 Rodriguez AL, Zhou Y, Williams R, Weaver CD, Vinson PN, Dawson ES, Steckler T, Lavreysen H, Mackie C, Bartolomé JM, Macdonald GJ, Daniels JS, Niswender CM, Jones CK, Conn PJ, et al. Discovery and SAR of a novel series of non-MPEP site mGluâ‚… PAMs based on an aryl glycine sulfonamide scaffold. Bioorganic & Medicinal Chemistry Letters. 22: 7388-92. PMID 23142615 DOI: 10.1016/J.Bmcl.2012.10.068  0.435
2012 Gregory KJ, Noetzel MJ, Rook JM, Vinson PN, Stauffer SR, Rodriguez AL, Emmitte KA, Zhou Y, Chun AC, Felts AS, Chauder BA, Lindsley CW, Niswender CM, Conn PJ. Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships. Molecular Pharmacology. 82: 860-75. PMID 22863693 DOI: 10.1124/Mol.112.080531  0.519
2012 Morrison RD, Blobaum AL, Byers FW, Santomango TS, Bridges TM, Stec D, Brewer KA, Sanchez-Ponce R, Corlew MM, Rush R, Felts AS, Manka J, Bates BS, Venable DF, Rodriguez AL, et al. The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1834-45. PMID 22711749 DOI: 10.1124/Dmd.112.046136  0.381
2012 Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, et al. Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluâ‚…): from an artificial neural network virtual screen to an in vivo tool compound. Chemmedchem. 7: 406-14. PMID 22267125 DOI: 10.1002/Cmdc.201100510  0.415
2012 Noetzel MJ, Rook JM, Vinson PN, Cho HP, Days E, Zhou Y, Rodriguez AL, Lavreysen H, Stauffer SR, Niswender CM, Xiang Z, Daniels JS, Jones CK, Lindsley CW, Weaver CD, et al. Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Molecular Pharmacology. 81: 120-33. PMID 22021324 DOI: 10.1124/Mol.111.075184  0.455
2012 Alagille D, DaCosta H, Chen Y, Hemstapat K, Rodriguez A, Baldwin RM, Jeffrey Conn P, Tamagnan GD. Erratum to “Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series” [Bioorg. Med. Chem. Lett. 21 (2011) 3243–3247] Bioorganic & Medicinal Chemistry Letters. 22: 2130. DOI: 10.1016/J.Bmcl.2012.01.054  0.372
2011 Lindsley CW, Bates BS, Menon UN, Jadhav SB, Kane AS, Jones CK, Rodriguez AL, Conn PJ, Olsen CM, Winder DG, Emmitte KA. (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. Acs Chemical Neuroscience. 2: 471-482. PMID 21927650 DOI: 10.1021/Cn100099N  0.485
2011 Alagille D, DaCosta H, Chen Y, Hemstapat K, Rodriguez A, Baldwin RM, Conn PJ, Conn JP, Tamagnan GD. Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorganic & Medicinal Chemistry Letters. 21: 3243-7. PMID 21546249 DOI: 10.1016/J.Bmcl.2011.04.047  0.393
2011 Williams R, Manka JT, Rodriguez AL, Vinson PN, Niswender CM, Weaver CD, Jones CK, Conn PJ, Lindsley CW, Stauffer SR. Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold. Bioorganic & Medicinal Chemistry Letters. 21: 1350-3. PMID 21315585 DOI: 10.1016/J.Bmcl.2011.01.044  0.453
2011 Zou MF, Cao J, Rodriguez AL, Conn PJ, Newman AH. Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters. 21: 2650-4. PMID 21295978 DOI: 10.1016/J.Bmcl.2010.12.110  0.49
2011 Lamb JP, Engers DW, Niswender CM, Rodriguez AL, Venable DF, Conn PJ, Lindsley CW. Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists. Bioorganic & Medicinal Chemistry Letters. 21: 2711-4. PMID 21183344 DOI: 10.1016/J.Bmcl.2010.11.119  0.415
2010 Zhou Y, Manka JT, Rodriguez AL, Weaver CD, Days EL, Vinson PN, Jadhav S, Hermann EJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR. Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. Acs Medicinal Chemistry Letters. 1: 433-438. PMID 23308336 DOI: 10.1021/Ml100181A  0.46
2010 Hammond AS, Rodriguez AL, Townsend SD, Niswender CM, Gregory KJ, Lindsley CW, Conn PJ. Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology. Acs Chemical Neuroscience. 1: 702-716. PMID 20981342 DOI: 10.1021/Cn100051M  0.5
2010 Rodriguez AL, Grier MD, Jones CK, Herman EJ, Kane AS, Smith RL, Williams R, Zhou Y, Marlo JE, Days EL, Blatt TN, Jadhav S, Menon UN, Vinson PN, Rook JM, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Molecular Pharmacology. 78: 1105-23. PMID 20923853 DOI: 10.1124/Mol.110.067207  0.501
2010 Lowe EW, Ferrebee A, Rodriguez AL, Conn PJ, Meiler J. 3D-QSAR CoMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 5922-4. PMID 20732812 DOI: 10.1016/J.Bmcl.2010.07.061  0.385
2010 Felts AS, Lindsley SR, Lamb JP, Rodriguez AL, Menon UN, Jadhav S, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats. Bioorganic & Medicinal Chemistry Letters. 20: 4390-4. PMID 20598884 DOI: 10.1016/J.Bmcl.2010.06.064  0.422
2010 Mueller R, Rodriguez AL, Dawson ES, Butkiewicz M, Nguyen TT, Oleszkiewicz S, Bleckmann A, Weaver CD, Lindsley CW, Conn PJ, Meiler J. Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening. Acs Chemical Neuroscience. 1: 288-305. PMID 20414370 DOI: 10.1021/Cn9000389  0.425
2010 Zhang P, Zou MF, Rodriguez AL, Conn PJ, Newman AH. Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry. 18: 3026-35. PMID 20382541 DOI: 10.1016/J.Bmc.2010.03.053  0.496
2009 Zhou Y, Rodriguez AL, Williams R, Weaver CD, Conn PJ, Lindsley CW. Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorganic & Medicinal Chemistry Letters. 19: 6502-6. PMID 19875287 DOI: 10.1016/J.Bmcl.2009.10.059  0.355
2009 Felts AS, Saleh SA, Le U, Rodriguez AL, Weaver CD, Conn PJ, Lindsley CW, Emmitte KA. Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorganic & Medicinal Chemistry Letters. 19: 6623-6. PMID 19854049 DOI: 10.1016/J.Bmcl.2009.10.024  0.509
2009 Sharma S, Kedrowski J, Rook JM, Smith RL, Jones CK, Rodriguez AL, Conn PJ, Lindsley CW. Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines. Journal of Medicinal Chemistry. 52: 4103-6. PMID 19537763 DOI: 10.1021/Jm900654C  0.502
2009 Kulkarni SS, Zou MF, Cao J, Deschamps JR, Rodriguez AL, Conn PJ, Newman AH. Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists. Journal of Medicinal Chemistry. 52: 3563-75. PMID 19445453 DOI: 10.1021/Jm900172F  0.477
2009 Rodriguez AL, Williams R, Zhou Y, Lindsley SR, Le U, Grier MD, Weaver CD, Conn PJ, Lindsley CW. Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype. Bioorganic & Medicinal Chemistry Letters. 19: 3209-13. PMID 19443219 DOI: 10.1016/J.Bmcl.2009.04.110  0.423
2009 Engers DW, Rodriguez AL, Williams R, Hammond AS, Venable D, Oluwatola O, Sulikowski GA, Conn PJ, Lindsley CW. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. Chemmedchem. 4: 505-11. PMID 19197923 DOI: 10.1002/Cmdc.200800357  0.402
2009 Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Molecular Pharmacology. 75: 577-88. PMID 19047481 DOI: 10.1124/Mol.108.052886  0.493
2008 Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, et al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular Pharmacology. 74: 1345-58. PMID 18664603 DOI: 10.1124/Mol.108.049551  0.444
2008 Sharma S, Rodriguez AL, Conn PJ, Lindsley CW. Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold. Bioorganic & Medicinal Chemistry Letters. 18: 4098-101. PMID 18550372 DOI: 10.1016/J.Bmcl.2008.05.091  0.458
2008 Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nature Chemical Biology. 4: 42-50. PMID 18059262 DOI: 10.1038/Nchembio.2007.55  0.432
2007 Rodriguez AL, Williams R. Recent progress in the development of allosteric modulators of mGluR5. Current Opinion in Drug Discovery & Development. 10: 715-22. PMID 17987523  0.353
2005 Rodriguez AL, Nong Y, Sekaran NK, Alagille D, Tamagnan GD, Conn PJ. A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators. Molecular Pharmacology. 68: 1793-802. PMID 16155210 DOI: 10.1124/Mol.105.016139  0.528
2005 Zhang Y, Rodriguez AL, Conn PJ. Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. The Journal of Pharmacology and Experimental Therapeutics. 315: 1212-9. PMID 16135701 DOI: 10.1124/Jpet.105.090308  0.317
2005 Galici R, Echemendia NG, Rodriguez AL, Conn PJ. A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity. The Journal of Pharmacology and Experimental Therapeutics. 315: 1181-7. PMID 16123306 DOI: 10.1124/Jpet.105.091074  0.486
2005 Poisik O, Raju DV, Verreault M, Rodriguez A, Abeniyi OA, Conn PJ, Smith Y. Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology. 49: 57-69. PMID 15993439 DOI: 10.1016/J.Neuropharm.2005.03.006  0.346
2005 Tamrazi A, Carlson KE, Rodriguez AL, Katzenellenbogen JA. Coactivator proteins as determinants of estrogen receptor structure and function: spectroscopic evidence for a novel coactivator-stabilized receptor conformation. Molecular Endocrinology (Baltimore, Md.). 19: 1516-28. PMID 15661830 DOI: 10.1210/Me.2004-0458  0.753
2004 Nettles KW, Sun J, Radek JT, Sheng S, Rodriguez AL, Katzenellenbogen JA, Katzenellenbogen BS, Greene GL. Allosteric Control of Ligand Selectivity between Estrogen Receptors α and β: Implications for Other Nuclear Receptors Molecular Cell. 13: 317-327. PMID 14967140 DOI: 10.1016/S1097-2765(04)00054-1  0.616
2004 Rodriguez AL, Tamrazi A, Collins ML, Katzenellenbogen JA. Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding. Journal of Medicinal Chemistry. 47: 600-11. PMID 14736241 DOI: 10.1021/Jm030404C  0.753
2002 Nishiguchi GA, Rodriguez AL, Katzenellenbogen JA. Diaryl-dialkyl-substituted pyrazoles: regioselective synthesis and binding affinity for the estrogen receptor. Bioorganic & Medicinal Chemistry Letters. 12: 947-50. PMID 11959000 DOI: 10.1016/S0960-894X(02)00057-4  0.621
2002 Mull ES, Sattigeri VJ, Rodriguez AL, Katzenellenbogen JA. Aryl cyclopentadienyl tricarbonyl rhenium complexes: novel ligands for the estrogen receptor with potential use as estrogen radiopharmaceuticals. Bioorganic & Medicinal Chemistry. 10: 1381-98. PMID 11886802 DOI: 10.1016/S0968-0896(01)00406-0  0.605
2001 Mortensen DS, Rodriguez AL, Carlson KE, Sun J, Katzenellenbogen BS, Katzenellenbogen JA. Synthesis and biological evaluation of a novel series of furans: ligands selective for estrogen receptor alpha. Journal of Medicinal Chemistry. 44: 3838-48. PMID 11689070 DOI: 10.1021/Jm010211U  0.755
2001 Mortensen DS, Rodriguez AL, Sun J, Katzenellenbogen BS, Katzenellenbogen JA. Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha. Bioorganic & Medicinal Chemistry Letters. 11: 2521-4. PMID 11549460 DOI: 10.1016/S0960-894X(01)00488-7  0.759
Low-probability matches (unlikely to be authored by this person)
2021 Long MF, Capstick RA, Spearing PK, Engers JL, Gregro AR, Bollinger SR, Chang S, Luscombe VB, Rodriguez AL, Cho HP, Niswender CM, Bridges TM, Jeffrey Conn P, Lindsley CW, Engers DW, et al. Development of structurally distinct tricyclic M positive allosteric modulator (PAM) chemotypes - Part 2. Bioorganic & Medicinal Chemistry Letters. 128416. PMID 34710625 DOI: 10.1016/j.bmcl.2021.128416  0.277
2013 Amato RJ, Felts AS, Rodriguez AL, Venable DF, Morrison RD, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Jones CK, Emmitte KA. Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. Acs Chemical Neuroscience. 4: 1217-28. PMID 23682684 DOI: 10.1021/Cn400070K  0.276
2019 Temple KJ, Engers JL, Long MF, Gregro AR, Watson KJ, Chang S, Jenkins MT, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Discovery of a novel 3,4-dimethylcinnoline carboxamide M positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorganic & Medicinal Chemistry Letters. 126678. PMID 31537424 DOI: 10.1016/j.bmcl.2019.126678  0.267
2022 Garrison AT, Orsi DL, Capstick RA, Whomble D, Li J, Carter TR, Felts AS, Vinson PN, Rodriguez AL, Han A, Hajari K, Cho HP, Teal LB, Ragland MG, Ghamari-Langroudi M, et al. Development of : A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder. Journal of Medicinal Chemistry. PMID 35417155 DOI: 10.1021/acs.jmedchem.2c00192  0.265
2019 Presley CC, Perry CK, Childress ES, Mulder MJ, Luscombe VB, Rodriguez AL, Niswender CM, Conn PJ, Lindsley CW. Evaluation of Synthetic Cytochrome P-Mimetic Metalloporphyrins To Facilitate "Biomimetic" Biotransformation of a Series of mGlu Allosteric Ligands. Acs Omega. 4: 12782-12789. PMID 31460402 DOI: 10.1021/acsomega.9b02017  0.25
2003 Fort Y, Rodriguez AL. First regioselective ortho-lithiation induced by a 2-chloropyridyl group complexation. The Journal of Organic Chemistry. 68: 4918-22. PMID 12790600 DOI: 10.1021/jo026788g  0.214
2021 Kent CN, Fulton MG, Stillwell KJ, Dickerson JW, Loch MT, Rodriguez AL, Blobaum AL, Boutaud O, Rook JL, Niswender CM, Jeffrey Conn P, Lindsley CW. Discovery and optimization of a novel CNS penetrant series of mGlu PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model. Bioorganic & Medicinal Chemistry Letters. 127838. PMID 33556572 DOI: 10.1016/j.bmcl.2021.127838  0.203
2003 López R, Garcia J, Puentes A, Curtidor H, Ocampo M, Vera R, Rodriguez LE, Suarez J, Urquiza M, Rodríguez AL, Reyes CA, Granados CG, Patarroyo ME. Identification of specific Hep G2 cell binding regions in Plasmodium falciparum sporozoite-threonine-asparagine-rich protein (STARP). Vaccine. 21: 2404-11. PMID 12744871 DOI: 10.1016/S0264-410X(03)00063-X  0.199
2014 Modepalli VN, Rodriguez AL, Li R, Pavuluri S, Nicholas KR, Barrow CJ, Nisbet DR, Williams RJ. In vitro response to functionalized self-assembled peptide scaffolds for three-dimensional cell culture. Biopolymers. 102: 197-205. PMID 24488709 DOI: 10.1002/Bip.22469  0.149
2005 Herve A, Rodriguez AL, Fouquet E. Stille cross-coupling of activated alkyltin reagents under "ligandless" conditions. The Journal of Organic Chemistry. 70: 1953-6. PMID 15730332 DOI: 10.1021/jo047907q  0.138
2000 Rodriguez AL, Bunlaksananusorn T, Knochel P. Potassium tert-butoxide catalyzed addition of carbonyl derivatives to styrenes Organic Letters. 2: 3285-7. PMID 11029191 DOI: 10.1021/Ol000174L  0.101
2012 Cornelis H, Rodriguez AL, Coop AD, Bower JM. Python as a federation tool for GENESIS 3.0. Plos One. 7: e29018. PMID 22276101 DOI: 10.1371/journal.pone.0029018  0.1
2015 Maclean FL, Rodriguez AL, Parish C, Williams RJ, Nisbet DR. Integrating Biomaterials and Stem Cells for Neural Regeneration. Stem Cells and Development. PMID 26577681 DOI: 10.1089/scd.2015.0314  0.094
2013 Cai H, Hong C, Lilburn TG, Rodriguez AL, Chen S, Gu J, Kuang R, Wang Y. A novel subnetwork alignment approach predicts new components of the cell cycle regulatory apparatus in Plasmodium falciparum. Bmc Bioinformatics. 14: S2. PMID 24267797 DOI: 10.1186/1471-2105-14-S12-S2  0.085
2015 Wang TY, Bruggeman KF, Kauhausen JA, Rodriguez AL, Nisbet DR, Parish CL. Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease. Biomaterials. 74: 89-98. PMID 26454047 DOI: 10.1016/j.biomaterials.2015.09.039  0.082
2012 Morande PE, Zanetti SR, Borge M, Nannini P, Jancic C, Bezares RF, Bitsmans A, González M, Rodríguez AL, Galmarini CM, Gamberale R, Giordano M. The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells. Investigational New Drugs. 30: 1830-40. PMID 21887502 DOI: 10.1007/s10637-011-9740-3  0.082
2015 Johnson J, Lee W, Frazier AE, Vaghjiani V, Laskowski A, Rodriguez AL, Cagnone G, McKenzie M, White SJ, Nisbet DR, Thorburn DR, St John J. Deletion of the complex I subunit NDUFS4 adversely modulates cellular differentiation. Stem Cells and Development. PMID 26608563 DOI: 10.1089/scd.2015.0211  0.078
2015 Rodriguez AL, Townsend VR. Survey of cuticular structures on leg IV of cosmetid harvestmen (Opiliones: Laniatores: Gonyleptoidea) Journal of Arachnology. 43: 194-206. DOI: 10.1636/0161-8202-43.2.194  0.074
2003 Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, Light B, Spapen H, Stone J, Seibert A, Peckelsen C, et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. Jama. 290: 238-47. PMID 12851279 DOI: 10.1001/jama.290.2.238  0.07
2020 Schmidt P, Rodriguez A, Yanamandra K, Behera RK, Iovita R. The mineralogy and structure of use-wear polish on chert. Scientific Reports. 10: 21512. PMID 33299032 DOI: 10.1038/s41598-020-78490-0  0.068
2000 Rodriguez AL, Koradin C, Dohle W, Knochel P. Versatile Indole Synthesis by a 5-endo-dig Cyclization Mediated by Potassium or Cesium Bases We thank the DFG (Leibniz-Programm) and the Fonds der Chemischen Industrie for generous financial support. A.L.R. and C. K. thank the Humboldt-Foundation and the BASF AG, respectively, for fellowships. W.D. was supported by the BMBF program (03 D 0056 2). We thank Dr. J. Henkelmann (BASF AG) for helpful discussions and the BASF AG for the generous gift of chemicals. Angewandte Chemie (International Ed. in English). 39: 2488-2490. PMID 10941112 DOI: 10.1002/1521-3773(20000717)39:14<2488::Aid-Anie2488>3.0.Co;2-E  0.068
2004 Martinez MJ, Roy S, Archuletta AB, Wentzell PD, Anna-Arriola SS, Rodriguez AL, Aragon AD, Quiñones GA, Allen C, Werner-Washburne M. Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes. Molecular Biology of the Cell. 15: 5295-305. PMID 15456898 DOI: 10.1091/Mbc.E03-11-0856  0.067
2014 Poblete-Castro I, Rodriguez AL, Lam CM, Kessler W. Improved production of medium-chain-length polyhydroxyalkanoates in glucose-based fed-batch cultivations of metabolically engineered Pseudomonas putida strains. Journal of Microbiology and Biotechnology. 24: 59-69. PMID 24150495 DOI: 10.4014/jmb.1308.08052  0.066
2007 Nunes DF, Rodriguez AL, da Silva Hoffmann F, Luz C, Braga Filho AP, Muller MC, Bauer ME. Relaxation and guided imagery program in patients with breast cancer undergoing radiotherapy is not associated with neuroimmunomodulatory effects. Journal of Psychosomatic Research. 63: 647-55. PMID 18061756 DOI: 10.1016/J.Jpsychores.2007.07.004  0.064
2003 Martinez MJ, Aragon AD, Rodriguez AL, Weber JM, Timlin JA, Sinclair MB, Haaland DM, Werner-Washburne M. Identification and removal of contaminating fluorescence from commercial and in-house printed DNA microarrays. Nucleic Acids Research. 31: e18. PMID 12582263 DOI: 10.1093/Nar/Gng018  0.061
2013 Mellado-Sanchez G, Ramirez K, Drachenberg CB, Diaz-McNair J, Rodriguez AL, Galen JE, Nataro JP, Pasetti MF. Characterization of systemic and pneumonic murine models of plague infection using a conditionally virulent strain. Comparative Immunology, Microbiology and Infectious Diseases. 36: 113-28. PMID 23195858 DOI: 10.1016/J.Cimid.2012.10.005  0.059
2003 Hazbón MH, Guarín N, Ferro BE, Rodríguez AL, Labrada LA, Tovar R, Riska PF, Jacobs WR. Photographic and luminometric detection of luciferase reporter phages for drug susceptibility testing of clinical Mycobacterium tuberculosis isolates. Journal of Clinical Microbiology. 41: 4865-9. PMID 14532245 DOI: 10.1128/Jcm.41.10.4865-4869.2003  0.058
2012 Forouzannia A, Harness JK, Carpenter MM, Ash RB, Williams V, Gonzalez MM, Fischer S, Rodriguez A, Wagman LD. Intraoperative electron radiotherapy boost as a component of adjuvant radiation for breast cancer in the community setting. The American Surgeon. 78: 1071-4. PMID 23025943  0.057
2012 Forouzannia A, Harness JK, Carpenter MM, Ash RB, Williams V, Gonzalez MM, Fischer S, Rodriguez A, Wagman LD. Intraoperative Electron Radiotherapy Boost as a Component of Adjuvant Radiation for Breast Cancer in the Community Setting The American Surgeon. 78: 1071-1074. DOI: 10.1177/000313481207801013  0.057
2012 Rodriguez AL, Wojcik BM, Wrobleski SK, Myers DD, Wakefield TW, Diaz JA. Statins, inflammation and deep vein thrombosis: a systematic review. Journal of Thrombosis and Thrombolysis. 33: 371-82. PMID 22278047 DOI: 10.1007/s11239-012-0687-9  0.053
2007 Rodriguez AL, Tariman JD, Enecio T, Estrella SM. The role of high-dose chemotherapy supported by hematopoietic stem cell transplantation in patients with multiple myeloma: implications for nursing. Clinical Journal of Oncology Nursing. 11: 579-89. PMID 17723970 DOI: 10.1188/07.Cjon.579-589  0.052
2014 Rodriguez AL, Townsend VR, Johnson MB, White TB. Interspecific variation in the microanatomy of cosmetid harvestmen (Arachnida, Opiliones, Laniatores). Journal of Morphology. 275: 1386-405. PMID 25046592 DOI: 10.1002/Jmor.20312  0.051
2015 Ferreira da Rosa SC, Moraes JAR, Rodriguez AL, Silva ALE, Machado EL, Kist LT, Burin HP. Alternative use of polyethylene arising from recycling cooperatives | Uso alternativo do polietileno oriundo de cooperativas de catadoress Espacios. 36: 20.  0.051
2008 Baillie LW, Rodriguez AL, Moore S, Atkins HS, Feng C, Nataro JP, Pasetti MF. Towards a human oral vaccine for anthrax: the utility of a Salmonella Typhi Ty21a-based prime-boost immunization strategy. Vaccine. 26: 6083-91. PMID 18805452 DOI: 10.1016/J.Vaccine.2008.09.010  0.047
2015 Soto-Alonso G, Cruz-Medina JA, Caballero-Pérez J, Arvizu-Hernández I, Ávalos-Esparza LM, Cruz-Hernández A, Romero-Gómez S, Rodríguez AL, Pastrana-Martínez X, Fernández F, Loske AM, Campos-Guillén J. Isolation of a conjugative F-like plasmid from a multidrug-resistant Escherichia coli strain CM6 using tandem shock wave-mediated transformation. Journal of Microbiological Methods. 114: 1-8. PMID 25914035 DOI: 10.1016/J.Mimet.2015.04.007  0.047
2004 Rodríguez AL, Ferro BE, Varona MX, Santafé M. [Exposure to Leptospira in stray dogs in the city of Cali]. BioméDica : Revista Del Instituto Nacional De Salud. 24: 291-5. PMID 15551881  0.047
2012 Lioi AB, Rodriguez AL, Funderburg NT, Feng Z, Weinberg A, Sieg SF. Membrane damage and repair in primary monocytes exposed to human β-defensin-3. Journal of Leukocyte Biology. 92: 1083-91. PMID 22837529 DOI: 10.1189/jlb.0112046  0.046
2009 Rodriguez AL, Stefani FS, de Oliveira Praes CE, Piaceski A, Oliveira MP, Martins P, da Silva VD, Bonorino C, Bauer ME. Effects of ultraviolet radiation on human cutaneous nerve fibres. Cell Proliferation. 42: 562-7. PMID 19508327 DOI: 10.1111/J.1365-2184.2009.00620.X  0.044
2008 Aragon AD, Rodriguez AL, Meirelles O, Roy S, Davidson GS, Tapia PH, Allen C, Joe R, Benn D, Werner-Washburne M. Characterization of differentiated quiescent and nonquiescent cells in yeast stationary-phase cultures. Molecular Biology of the Cell. 19: 1271-80. PMID 18199684 DOI: 10.1091/Mbc.E07-07-0666  0.042
1957 RODRIGUEZ AL, GENIS-GALVEZ JM. [Variety of the thoracic duct not described in man; thoracic duct passing through ansa of Vieussens]. Acta Anatomica. 31: 61-5. PMID 13478389  0.042
2014 Rodriguez AL, Wang TY, Bruggeman KF, Horgan CC, Li R, Williams RJ, Parish CL, Nisbet DR. In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and the implications for tissue repair Journal of Materials Chemistry B. 2: 7771-7778. DOI: 10.1039/c4tb01391c  0.041
2015 Sancho A, Carrera S, Arietaleanizbeascoa M, Arce V, Gallastegui NM, Giné March A, Sanz-Guinea A, Eskisabel A, Rodriguez AL, Martín RA, Lopez-Vivanco G, Grandes G. Supervised physical exercise to improve the quality of life of cancer patients: the EFICANCER randomised controlled trial. Bmc Cancer. 15: 40. PMID 25655792 DOI: 10.1186/s12885-015-1055-x  0.04
2022 Rodriguez A, Yanamandra K, Witek L, Wang Z, Behera RK, Iovita R. The effect of worked material hardness on stone tool wear. Plos One. 17: e0276166. PMID 36264949 DOI: 10.1371/journal.pone.0276166  0.038
2015 Li R, Horgan CC, Long B, Rodriguez AL, Mather L, Barrow CJ, Nisbet DR, Williams RJ. Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control over the gelation mechanism through regulation of ionic strength and the rate of pH change Rsc Advances. 5: 301-307. DOI: 10.1039/c4ra13266a  0.036
2006 Ferro BE, Rodríguez AL, Pérez M, Travi BL. [Seroprevalence of Leptospira infection in habitants of peripheral neighborhoods in Cali, Colombia]. BioméDica : Revista Del Instituto Nacional De Salud. 26: 250-7. PMID 16925097  0.036
2021 Di Somma C, Scarano E, Barrea L, Solari D, Riccio E, Arianna R, Cavallo LM, Romano F, Di Benedetto E, Rodriguez A, de Alteriis G, Colao A. Craniopharyngioma, Chronotypes and Metabolic Risk Profile. Nutrients. 13. PMID 34684445 DOI: 10.3390/nu13103444  0.033
1970 Vélez-García E, Fradera J, Maldonado N, Rodríguez AL, Santiago-Borrero PJ. Glanzmann's thrombasthenia. (Report of 3 cases). BoletíN De La AsociacióN MéDica De Puerto Rico. 62: 86-91. PMID 5270992  0.032
1996 Esquivel RO, Rodríguez AL, Sagar RP, Hô M, Smith VH. Physical interpretation of information entropy: Numerical evidence of the Collins conjecture. Physical Review. A. 54: 259-265. PMID 9913476 DOI: 10.1103/Physreva.54.259  0.031
2015 Sherif A, Hasan MN, Radecka E, Rodriguez AL, Shabo S, Karlsson M, Schumacher MC, Marits P, Winqvist O. Pilot study of adoptive immunotherapy with sentinel node-derived T cells in muscle-invasive urinary bladder cancer. Scandinavian Journal of Urology. 1-10. PMID 26144252 DOI: 10.3109/21681805.2015.1059880  0.029
2012 Del Pozo Sacristán R, Rodríguez AL, Sierens A, Vranckx K, Boyen F, Dereu A, Haesebrouck F, Maes DG. Efficacy of in-feed medication with chlortetracycline in a farrow-to-finish herd against a clinical outbreak of respiratory disease in fattening pigs. The Veterinary Record. 171: 645. PMID 23136309 DOI: 10.1136/vr.100976  0.027
2015 Rodriguez AL, Guerreiro Hernández AM, Merlin Linares JC, Villaescusa Blanco R, Arce Hernández AA. Hepatitis C in patients with sickle cell anemia | Hepatitis C en pacientes con drepanocitosis Revista Cubana De Hematologia, Inmunologia Y Hemoterapia. 31.  0.026
2006 Aragon AD, Quiñones GA, Allen C, Thomas J, Roy S, Davidson GS, Wentzell PD, Millier B, Jaetao JE, Rodriguez AL, Werner-Washburne M. An automated, pressure-driven sampling device for harvesting from liquid cultures for genomic and biochemical analyses. Journal of Microbiological Methods. 65: 357-60. PMID 16198434 DOI: 10.1016/J.Mimet.2005.08.015  0.026
2012 Knechtle B, Morales NP, González ER, Gutierrez AA, Sevilla JN, Gómez RA, Robledo AR, Rodríguez AL, Fraire OS, Andonie JL, Lopez LC, Kohler G, Rosemann T. Effect of a multistage ultraendurance triathlon on aldosterone, vasopressin, extracellular water and urine electrolytes. Scottish Medical Journal. 57: 26-32. PMID 22408212 DOI: 10.1258/smj.2011.011287  0.023
2014 Nogues X, Luz Rentero M, Rodríguez AL. Use of an educational support program to assist patients receiving injectable osteoporosis treatment: experience with teriparatide. Current Medical Research and Opinion. 30: 287-96. PMID 24102317 DOI: 10.1185/03007995.2013.851659  0.017
2014 Saha D, Del Pozo Sacristán R, Van Renne N, Huang L, Decaluwe R, Michiels A, Rodriguez AL, Rodríguez MJ, Durán MG, Declerk I, Maes D, Nauwynck HJ. Anti-porcine circovirus type 2 (PCV2) antibody placental barrier leakage from sow to fetus: impact on the diagnosis of intra-uterine PCV2 infection. Virologica Sinica. 29: 136-8. PMID 24643939 DOI: 10.1007/s12250-014-3432-z  0.012
2015 Rodriguez AL. Three stories about living without migration in dakar: Coming to terms with the contradictions of the moral economy Africa. 85: 333-355. DOI: 10.1017/S0001972015000042  0.01
2014 Wong WSY, Nasiri N, Rodriguez AL, Nisbet DR, Tricoli A. Hierarchical amorphous nanofibers for transparent inherently super-hydrophilic coatings Journal of Materials Chemistry A. 2: 15575-15581. DOI: 10.1039/c4ta03278k  0.01
2011 Rodríguez AL, Rijsselaere T, Bijttebier J, Vyt P, Van Soom A, Maes D. Effectiveness of the sperm quality analyzer (SQA-Vp) for porcine semen analysis. Theriogenology. 75: 972-7. PMID 21144570 DOI: 10.1016/j.theriogenology.2010.10.024  0.01
2009 Slater JP, Guarino T, Stack J, Vinod K, Bustami RT, Brown JM, Rodriguez AL, Magovern CJ, Zaubler T, Freundlich K, Parr GV. Cerebral oxygen desaturation predicts cognitive decline and longer hospital stay after cardiac surgery. The Annals of Thoracic Surgery. 87: 36-44; discussion 44. PMID 19101265 DOI: 10.1016/j.athoracsur.2008.08.070  0.01
2007 Rivero Fernández M, Moreira Vicente V, Rodríguez AL, Ruiz del Arbol Olmos L. [Severe hyperkalaemia caused by ginger in cirrhotic patient]. Medicina ClíNica. 129: 398-9. PMID 17915140 DOI: 10.1157/13110220  0.01
2006 Fernández MJ, García JC, Paredes BC, Blanco AG, Rodríguez AL. Spontaneous rupture of axillary vein simulating elder physical abuse. Emergency Medicine Journal : Emj. 23: 658. PMID 16858111 DOI: 10.1136/emj.2006.034488  0.01
2006 Rebollo MA, Rodríguez AL. [Difficulties in learning mathematics]. Revista De Neurologia. 42: S135-8. PMID 16555207  0.01
2006 Kiehart DP, Tokutake Y, Chang MS, Hutson MS, Wiemann J, Peralta XG, Toyama Y, Wells AR, Rodriguez A, Edwards GS. Ultraviolet Laser Microbeam for Dissection of Drosophila Embryos Cell Biology, Four-Volume Set. 3: 87-103. DOI: 10.1016/B978-012164730-8/50137-4  0.01
1973 Rodriguez AL. Injuries to the collateral ligaments of the proximal interphalangeal joints. The Hand. 5: 55-7. PMID 4694158  0.01
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