| Year |
Citation |
Score |
| 2017 |
Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, McIntosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235. PMID 28819330 DOI: 10.1002/Jhet.2696 |
0.575 |
|
| 2013 |
Podolsky AT, Sandweiss A, Hu J, Bilsky EJ, Cain JP, Kumirov VK, Lee YS, Hruby VJ, Vardanyan RS, Vanderah TW. Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life Sciences. 93: 1010-6. PMID 24084045 DOI: 10.1016/J.Lfs.2013.09.016 |
0.505 |
|
| 2011 |
Mayorov AV, Cai M, Palmer ES, Tanaka DK, Cain JP, Dedek MM, Tan B, Trivedi D, Hruby VJ. Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 21: 3099-102. PMID 21486697 DOI: 10.1016/J.Bmcl.2011.03.019 |
0.779 |
|
| 2011 |
Hruby VJ, Cai M, Cain J, Nyberg J, Trivedi D. Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge. European Journal of Pharmacology. 660: 88-93. PMID 21208601 DOI: 10.1016/J.Ejphar.2010.10.109 |
0.752 |
|
| 2010 |
Mayorov AV, Cai M, Palmer ES, Liu Z, Cain JP, Vagner J, Trivedi D, Hruby VJ. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides. 31: 1894-905. PMID 20688117 DOI: 10.1016/J.Peptides.2010.06.026 |
0.771 |
|
| 2008 |
Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ. Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. Journal of Medicinal Chemistry. 51: 187-95. PMID 18088090 DOI: 10.1021/Jm070461W |
0.737 |
|
| 2008 |
Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/Bip.20814 |
0.681 |
|
| 2007 |
Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor. Current Topics in Medicinal Chemistry. 7: 1107-19. PMID 17584128 DOI: 10.2174/156802607780906645 |
0.732 |
|
| 2006 |
Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/J.Tetlet.2006.01.096 |
0.744 |
|
| 2006 |
Cain JP, Mayorov AV, Cai M, Wang H, Tan B, Chandler K, Lee Y, Petrov RR, Trivedi D, Hruby VJ. Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5462-7. PMID 16931008 DOI: 10.1016/J.Bmcl.2006.07.015 |
0.762 |
|
| 2005 |
Gu X, Ying J, Min B, Cain JP, Davis P, Willey P, Navratilova E, Yamamura HI, Porreca F, Hruby VJ. Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers. 80: 151-63. PMID 15660379 DOI: 10.1002/Bip.20208 |
0.717 |
|
| 2004 |
Cowell SM, Lee YS, Cain JP, Hruby VJ. Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands. Current Medicinal Chemistry. 11: 2785-98. PMID 15544476 DOI: 10.2174/0929867043364270 |
0.572 |
|
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