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Kelvin Yen, Ph.D. - Publications

Affiliations: 
2008 Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
glucose, aging, diabetes, metabolism
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Miller B, Kim SJ, Kumagai H, Mehta HH, Xiang W, Liu J, Yen K, Cohen P. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications. Experimental Cell Research. 112056. PMID 32387288 DOI: 10.1016/J.Yexcr.2020.112056  0.327
2019 Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiological Reports. 7: e14171. PMID 31293078 DOI: 10.14814/Phy2.14171  0.408
2019 Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K. Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics : Official Journal of the Metabolomic Society. 15: 88. PMID 31172328 DOI: 10.1007/S11306-019-1549-7  0.338
2019 Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. GRSF1 is an age-related regulator of senescence. Scientific Reports. 9: 5546. PMID 30944385 DOI: 10.1038/S41598-019-42064-6  0.35
2018 Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, et al. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Scientific Reports. 8: 14212. PMID 30242290 DOI: 10.1038/S41598-018-32616-7  0.301
2018 Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Lerman LO, Cohen P, Lerman A. Chronic Treatment With the Mitochondrial Peptide Humanin Prevents Age-related Myocardial Fibrosis in mice. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30004252 DOI: 10.1152/Ajpheart.00685.2017  0.314
2017 Kim SJ, Xiao J, Cohen P, Yen K. Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment. Journal of Visualized Experiments : Jove. PMID 28994791 DOI: 10.3791/56496  0.308
2017 Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Scientific Reports. 7: 7802. PMID 28798389 DOI: 10.1038/S41598-017-08372-5  0.304
2017 Kim SJ, Wan J, Cohen P, Yen K. Mitochondrial derived peptides as novel regulators of metabolism. The Journal of Physiology. PMID 28574175 DOI: 10.1113/Jp274472  0.379
2016 Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. PMID 27384491 DOI: 10.18632/Oncotarget.10380  0.354
2016 Teranishi K, Okada A, Yen K, Cohen P, Langen R. Mitochondrially-Derived Peptides as Defense Against Amyloid Protein Misfolding Biophysical Journal. 110: 401a. DOI: 10.1016/J.Bpj.2015.11.2165  0.312
2015 Bansal A, Zhu LJ, Yen K, Tissenbaum HA. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proceedings of the National Academy of Sciences of the United States of America. 112: E277-86. PMID 25561524 DOI: 10.1073/Pnas.1412192112  0.366
2014 Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 13: 958-61. PMID 25040290 DOI: 10.1111/Acel.12243  0.371
2013 Lee C, Yen K, Cohen P. Humanin: a harbinger of mitochondrial-derived peptides? Trends in Endocrinology and Metabolism: Tem. 24: 222-8. PMID 23402768 DOI: 10.1016/J.Tem.2013.01.005  0.322
2013 Perrin AJ, Gunda M, Yu B, Yen K, Ito S, Forster S, Tissenbaum HA, Derry WB. Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death and Differentiation. 20: 97-107. PMID 22935616 DOI: 10.1038/Cdd.2012.101  0.326
2012 Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin B, McCrimmon R, Sherwin R, Musatov S, Mobbs CV. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. American Journal of Physiology. Endocrinology and Metabolism. 302: E987-91. PMID 22318949 DOI: 10.1152/Ajpendo.00474.2011  0.575
2011 Lublin A, Isoda F, Patel H, Yen K, Nguyen L, Hajje D, Schwartz M, Mobbs C. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. Plos One. 6: e27762. PMID 22114686 DOI: 10.1371/Journal.Pone.0027762  0.63
2011 Narasimhan SD, Yen K, Bansal A, Kwon ES, Padmanabhan S, Tissenbaum HA. PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. Plos Genetics. 7: e1001377. PMID 21533078 DOI: 10.1371/Journal.Pgen.1001377  0.334
2011 Yen K, Narasimhan SD, Tissenbaum HA. DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road. Antioxidants & Redox Signaling. 14: 623-34. PMID 20673162 DOI: 10.1089/Ars.2010.3490  0.335
2010 Yen K, Le TT, Bansal A, Narasimhan SD, Cheng JX, Tissenbaum HA. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. Plos One. 5. PMID 20862331 DOI: 10.1371/Journal.Pone.0012810  0.339
2010 Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA. A new DAF-16 isoform regulates longevity. Nature. 466: 498-502. PMID 20613724 DOI: 10.1038/Nature09184  0.32
2010 Yen K, Mobbs CV. Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordrecht, Netherlands). 32: 39-49. PMID 19662517 DOI: 10.1007/S11357-009-9110-7  0.553
2009 Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. Plos Biology. 7: e1000245. PMID 19924292 DOI: 10.1371/Journal.Pbio.1000245  0.633
2009 Narasimhan SD, Yen K, Tissenbaum HA. Converging pathways in lifespan regulation. Current Biology : Cb. 19: R657-66. PMID 19674551 DOI: 10.1016/J.Cub.2009.06.013  0.36
2009 Yen K, Patel HB, Lublin AL, Mobbs CV. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mechanisms of Ageing and Development. 130: 173-8. PMID 19059428 DOI: 10.1016/J.Mad.2008.11.003  0.558
2008 Yen K, Steinsaltz D, Mobbs CV. Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan. Experimental Gerontology. 43: 1044-51. PMID 18832022 DOI: 10.1016/J.Exger.2008.09.006  0.534
2008 Yen K, Mobbs CV. Chemosensory and caloric mechanisms influence distinct components of mortality rate. Experimental Gerontology. 43: 1058-60. PMID 18790043 DOI: 10.1016/J.Exger.2008.08.048  0.56
2007 Mobbs CV, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M, Isoda F. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox. Appetite. 48: 135-8. PMID 17141367 DOI: 10.1016/J.Appet.2006.06.007  0.578
2007 Mobbs CV, Mastaitis JW, Zhang M, Isoda F, Cheng H, Yen K. Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease. Interdisciplinary Topics in Gerontology. 35: 39-68. PMID 17063032 DOI: 10.1159/000096555  0.619
2005 Mobbs CV, Isoda F, Makimura H, Mastaitis J, Mizuno T, Shu IW, Yen K, Yang XJ. Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis. Physiology & Behavior. 85: 3-23. PMID 15924903 DOI: 10.1016/J.Physbeh.2005.04.005  0.689
2004 Yen K, Mastitis JW, Mobbs CV. Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans. Experimental Gerontology. 39: 947-9. PMID 15217699 DOI: 10.1016/J.Exger.2004.03.016  0.552
2004 Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochemical Research. 29: 1093-103. PMID 15176466 DOI: 10.1023/B:Nere.0000023596.49140.E0  0.577
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