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Sean R. Marcsisin, Ph.D. - Publications

Affiliations: 
2011 Chemistry Northeastern University, Boston, MA, United States 
Area:
Bioanalytical chemistry, mass spectrometry, hydrogen/deuterium exchange
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16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, ... ... Marcsisin S, et al. Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. Journal of Medicinal Chemistry. PMID 32390431 DOI: 10.1021/Acs.Jmedchem.0C00539  0.305
2019 Dodean RA, Kancharla P, Li Y, Melendez V, Read L, Bane C, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, ... ... Marcsisin S, et al. Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials. Journal of Medicinal Chemistry. PMID 30852885 DOI: 10.1021/Acs.Jmedchem.8B01961  0.323
2017 Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S. Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure (London, England : 1993). PMID 28648608 DOI: 10.1016/J.Str.2017.05.020  0.497
2016 Milner EE, Berman J, Caridha D, Dickson SP, Hickman M, Lee PJ, Marcsisin SR, Read LT, Roncal N, Vesely BA, Xie LH, Zhang J, Zhang P, Li Q. Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei. Malaria Journal. 15: 588. PMID 27923405 DOI: 10.1186/S12936-016-1632-8  0.321
2016 Jin X, Potter B, Luong TL, Nelson J, Vuong C, Potter C, Xie L, Zhang J, Zhang P, Sousa J, Li Q, Pybus BS, Kreishman-Deitrick M, Hickman M, Smith PL, ... ... Marcsisin SR, et al. Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants. Malaria Journal. 15: 280. PMID 27188854 DOI: 10.1186/S12936-016-1329-Z  0.337
2016 Marcsisin SR, Reichard G, Pybus BS. Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art. Pharmacology & Therapeutics. PMID 27016470 DOI: 10.1016/J.Pharmthera.2016.03.011  0.354
2015 Marcsisin SR, Liptak C, Marineau J, Bradner JE, Engen JR. Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe. Analytical Chemistry. 87: 6349-56. PMID 26023704 DOI: 10.1021/Acs.Analchem.5B01220  0.526
2015 Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, ... ... Marcsisin SR, et al. Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics. Antimicrobial Agents and Chemotherapy. 59: 3864-9. PMID 25870069 DOI: 10.1128/Aac.00343-15  0.324
2015 Potter BM, Xie LH, Vuong C, Zhang J, Zhang P, Duan D, Luong TL, Bandara Herath HM, Dhammika Nanayakkara NP, Tekwani BL, Walker LA, Nolan CK, Sciotti RJ, Zottig VE, Smith PL, ... ... Marcsisin SR, et al. Differential CYP 2D6 metabolism alters primaquine pharmacokinetics. Antimicrobial Agents and Chemotherapy. 59: 2380-7. PMID 25645856 DOI: 10.1128/Aac.00015-15  0.322
2014 Fasinu PS, Tekwani BL, Nanayakkara NP, Avula B, Herath HM, Wang YH, Adelli VR, Elsohly MA, Khan SI, Khan IA, Pybus BS, Marcsisin SR, Reichard GA, McChesney JD, Walker LA. Enantioselective metabolism of primaquine by human CYP2D6. Malaria Journal. 13: 507. PMID 25518709 DOI: 10.1186/1475-2875-13-507  0.308
2014 Marcsisin SR, Sousa JC, Reichard GA, Caridha D, Zeng Q, Roncal N, McNulty R, Careagabarja J, Sciotti RJ, Bennett JW, Zottig VE, Deye G, Li Q, Read L, Hickman M, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malaria Journal. 13: 2. PMID 24386891 DOI: 10.1186/1475-2875-13-2  0.329
2013 Marcsisin SR, Jin X, Bettger T, McCulley N, Sousa JC, Shanks GD, Tekwani BL, Sahu R, Reichard GA, Sciotti RJ, Melendez V, Pybus BS. CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. Malaria Journal. 12: 214. PMID 23800033 DOI: 10.1186/1475-2875-12-214  0.348
2013 Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JC, Li Q, Caridha D, Zeng Q, Reichard GA, Ockenhouse C, Bennett J, Walker LA, Ohrt C, Melendez V. The metabolism of primaquine to its active metabolite is dependent on CYP 2D6. Malaria Journal. 12: 212. PMID 23782898 DOI: 10.1186/1475-2875-12-212  0.336
2011 Marcsisin SR, Narute PS, Emert-Sedlak LA, Kloczewiak M, Smithgall TE, Engen JR. On the solution conformation and dynamics of the HIV-1 viral infectivity factor. Journal of Molecular Biology. 410: 1008-22. PMID 21763503 DOI: 10.1016/J.Jmb.2011.04.053  0.53
2010 Marcsisin SR, Engen JR. Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif. Journal of Molecular Biology. 402: 892-904. PMID 20728451 DOI: 10.1016/J.Jmb.2010.08.026  0.514
2010 Marcsisin SR, Engen JR. Hydrogen exchange mass spectrometry: what is it and what can it tell us? Analytical and Bioanalytical Chemistry. 397: 967-72. PMID 20195578 DOI: 10.1007/S00216-010-3556-4  0.517
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