| Year |
Citation |
Score |
| 2022 |
Nguyen DM, Chen TY. Structure and Function of Calcium-Activated Chloride Channels and Phospholipid Scramblases in the TMEM16 Family. Handbook of Experimental Pharmacology. PMID 35792944 DOI: 10.1007/164_2022_595 |
0.376 |
|
| 2022 |
Kwon HC, Fairclough RH, Chen TY. Biophysical and Pharmacological Insights to CLC Chloride Channels. Handbook of Experimental Pharmacology. PMID 35768555 DOI: 10.1007/164_2022_594 |
0.443 |
|
| 2021 |
Fu SJ, Hu MC, Hsiao CT, Cheng AT, Chen TY, Jeng CJ, Tang CY. Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect. International Journal of Molecular Sciences. 22. PMID 34070744 DOI: 10.3390/ijms22115859 |
0.369 |
|
| 2021 |
Nguyen DM, Kwon HC, Chen TY. Divalent Cation Modulation of Ion Permeation in TMEM16 Proteins. International Journal of Molecular Sciences. 22. PMID 33672260 DOI: 10.3390/ijms22042209 |
0.341 |
|
| 2020 |
Kwon HC, Yu Y, Fairclough RH, Chen TY. Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel. Plos One. 15: e0240704. PMID 33362212 DOI: 10.1371/journal.pone.0240704 |
0.537 |
|
| 2020 |
Fu SJ, Hu MC, Peng YJ, Fang HY, Hsiao CT, Chen TY, Jeng CJ, Tang CY. CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells. 9. PMID 32466489 DOI: 10.3390/cells9061332 |
0.447 |
|
| 2020 |
Nguyen DM, Chen LS, Jeng G, Yu WP, Chen TY. Cobalt ion interaction with TMEM16A calcium-activated chloride channel: Inhibition and potentiation. Plos One. 15: e0231812. PMID 32302365 DOI: 10.1371/Journal.Pone.0231812 |
0.627 |
|
| 2020 |
Jeng CJ, Fu SJ, You CY, Peng YJ, Hsiao CT, Chen TY, Tang CY. Defective Gating and Proteostasis of Human ClC-1 Chloride Channel: Molecular Pathophysiology of Myotonia Congenita. Frontiers in Neurology. 11: 76. PMID 32117034 DOI: 10.3389/fneur.2020.00076 |
0.46 |
|
| 2019 |
Nguyen DM, Chen LS, Yu WP, Chen TY. Comparison of ion transport determinants between a TMEM16 chloride channel and phospholipid scramblase. The Journal of General Physiology. PMID 30670476 DOI: 10.1085/jgp.201812270 |
0.649 |
|
| 2018 |
Peng YJ, Lee YC, Fu SJ, Chien YC, Liao YF, Chen TY, Jeng CJ, Tang CY. FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane. International Journal of Molecular Sciences. 19. PMID 30487393 DOI: 10.3390/ijms19123783 |
0.395 |
|
| 2018 |
Nguyen DM, Chen LS, Yu W, Chen T. Comparing Ion Transport between a Chloride Channel and a Phospholipid Scramblase in the TMEM16 Family Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.733 |
0.632 |
|
| 2017 |
O'Halloran DM, Altshuler-Keylin S, Zhang XD, He C, Morales-Phan C, Yu Y, Kaye JA, Brueggemann C, Chen TY, L'Etoile ND. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Scientific Reports. 7: 169. PMID 28279024 DOI: 10.1038/S41598-017-00126-7 |
0.375 |
|
| 2016 |
Jeng G, Aggarwal M, Yu WP, Chen TY. Independent activation of distinct pores in dimeric TMEM16A channels. The Journal of General Physiology. 148: 393-404. PMID 27799319 DOI: 10.1085/jgp.201611651 |
0.695 |
|
| 2016 |
Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Scientific Reports. 6: 32444. PMID 27580824 DOI: 10.1038/srep32444 |
0.391 |
|
| 2016 |
Pedersen TH, Riisager A, de Paoli FV, Chen TY, Nielsen OB. Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. The Journal of General Physiology. 147: 291-308. PMID 27022190 DOI: 10.1085/jgp.201611582 |
0.384 |
|
| 2016 |
Riisager A, de Paoli FV, Yu WP, Pedersen TH, Chen TY, Nielsen OB. Protein kinase C dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating. The Journal of Physiology. PMID 26857341 DOI: 10.1113/JP271556 |
0.594 |
|
| 2016 |
Jeng G, Aggarwal M, Yu W, Chen T. Activating Individual Subunits of TMEM16A Calcium-Activated Chloride Channels Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1571 |
0.696 |
|
| 2015 |
Yu Y, Tsai MF, Yu WP, Chen TY. Modulation of the slow/common gating of CLC channels by intracellular cadmium. The Journal of General Physiology. 146: 495-508. PMID 26621774 DOI: 10.1085/jgp.201511413 |
0.751 |
|
| 2015 |
Chen YA, Peng YJ, Hu MC, Huang JJ, Chien YC, Wu JT, Chen TY, Tang CY. The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Scientific Reports. 5: 10667. PMID 26021757 DOI: 10.1038/srep10667 |
0.526 |
|
| 2015 |
Yu Y, Chen TY. Purified human brain calmodulin does not alter the bicarbonate permeability of the ANO1/TMEM16A channel. The Journal of General Physiology. 145: 79-81. PMID 25548138 DOI: 10.1085/jgp.201411294 |
0.463 |
|
| 2014 |
Yu Y, Kuan AS, Chen TY. Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel. The Journal of General Physiology. 144: 115-24. PMID 24981232 DOI: 10.1085/jgp.201411179 |
0.584 |
|
| 2014 |
Ni YL, Kuan AS, Chen TY. Activation and inhibition of TMEM16A calcium-activated chloride channels. Plos One. 9: e86734. PMID 24489780 DOI: 10.1371/journal.pone.0086734 |
0.618 |
|
| 2014 |
Kuan A, Ni Y, Chen T. Electrophysiological Properties of TMEM16A Calcium-Activated Chloride Channels Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.838 |
0.602 |
|
| 2013 |
Lee TT, Zhang XD, Chuang CC, Chen JJ, Chen YA, Chen SC, Chen TY, Tang CY. Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. Plos One. 8: e55930. PMID 23424641 DOI: 10.1371/journal.pone.0055930 |
0.527 |
|
| 2012 |
Chen TY. Single myotonia mutation strikes multiple mechanisms of a chloride channel. The Journal of Physiology. 590: 3407. PMID 22855049 DOI: 10.1113/jphysiol.2012.238337 |
0.463 |
|
| 2012 |
Richman DP, Yu Y, Lee TT, Tseng PY, Yu WP, Maselli RA, Tang CY, Chen TY. Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromolecular Medicine. 14: 328-37. PMID 22790975 DOI: 10.1007/S12017-012-8190-1 |
0.679 |
|
| 2012 |
Bennetts B, Yu Y, Chen TY, Parker MW. Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. The Journal of Biological Chemistry. 287: 25808-20. PMID 22689570 DOI: 10.1074/jbc.M111.327551 |
0.573 |
|
| 2012 |
Yu T, Wang XQ, Sang JP, Pan CX, Zou XW, Chen TY, Zou X. Influences of mutations on the electrostatic binding free energies of chloride ions in Escherichia coli ClC. The Journal of Physical Chemistry. B. 116: 6431-8. PMID 22612693 DOI: 10.1021/jp300430f |
0.412 |
|
| 2012 |
Yu Y, Yu W, Chen T. Inhibition of a Dimer Interface Mutant of CLC-0 by Intracellular Cadmium Ion Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1823 |
0.711 |
|
| 2011 |
Tang CY, Chen TY. Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. Journal of Biomedicine & Biotechnology. 2011: 685328. PMID 22187529 DOI: 10.1155/2011/685328 |
0.577 |
|
| 2011 |
Tseng PY, Yu WP, Liu HY, Zhang XD, Zou X, Chen TY. Binding of ATP to the CBS domains in the C-terminal region of CLC-1. The Journal of General Physiology. 137: 357-68. PMID 21444658 DOI: 10.1085/jgp.201010495 |
0.536 |
|
| 2010 |
Wang XQ, Yu T, Sang JP, Zou XW, Chen TY, Bolser D, Zou X. A three-state multi-ion kinetic model for conduction properties of ClC-0 chloride channel. Biophysical Journal. 99: 464-71. PMID 20643064 DOI: 10.1016/j.bpj.2010.04.047 |
0.434 |
|
| 2010 |
Zhang XD, Yu WP, Chen TY. Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. Biophysical Journal. 98: 377-85. PMID 20141750 DOI: 10.1016/j.bpj.2009.09.066 |
0.557 |
|
| 2010 |
Tseng P, Chen T. Analysis of the CLC-1 ATP Binding Site by Structure-Guided Mutagenesis Biophysical Journal. 98: 320a. DOI: 10.1016/J.Bpj.2009.12.1739 |
0.506 |
|
| 2010 |
Zhang X, Yu W, Chen T. The Preference of the CLC-0 Pore for Charged Methanethiosulfonate Reagents Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1733 |
0.601 |
|
| 2009 |
Zhang XD, Chen TY. Amphiphilic blockers punch through a mutant CLC-0 pore. The Journal of General Physiology. 133: 59-68. PMID 19088382 DOI: 10.1085/jgp.200810005 |
0.392 |
|
| 2009 |
Zhang XD, Tseng PY, Yu WP, Chen TY. Blocking pore-open mutants of CLC-0 by amphiphilic blockers. The Journal of General Physiology. 133: 43-58. PMID 19088381 DOI: 10.1085/jgp.200810004 |
0.669 |
|
| 2008 |
Zhang XD, Tseng PY, Chen TY. ATP inhibition of CLC-1 is controlled by oxidation and reduction. The Journal of General Physiology. 132: 421-8. PMID 18824589 DOI: 10.1085/jgp.200810023 |
0.407 |
|
| 2008 |
Chen TY, Hwang TC. CLC-0 and CFTR: chloride channels evolved from transporters. Physiological Reviews. 88: 351-87. PMID 18391167 DOI: 10.1152/physrev.00058.2006 |
0.52 |
|
| 2007 |
Tseng PY, Bennetts B, Chen TY. Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. The Journal of General Physiology. 130: 217-21. PMID 17664348 DOI: 10.1085/jgp.200709817 |
0.511 |
|
| 2006 |
Bykova EA, Zhang XD, Chen TY, Zheng J. Large movement in the C terminus of CLC-0 chloride channel during slow gating. Nature Structural & Molecular Biology. 13: 1115-9. PMID 17115052 DOI: 10.1038/nsmb1176 |
0.483 |
|
| 2006 |
Chen TY, Takeuchi H, Kurahashi T. Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly. The Journal of General Physiology. 128: 365-71. PMID 16940558 DOI: 10.1085/Jgp.200609577 |
0.616 |
|
| 2006 |
Zhang XD, Li Y, Yu WP, Chen TY. Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations. The Journal of General Physiology. 127: 435-47. PMID 16567465 DOI: 10.1085/jgp.200509460 |
0.718 |
|
| 2005 |
Li Y, Yu WP, Lin CW, Chen TY. Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels. Biophysical Journal. 88: 3936-45. PMID 15778445 DOI: 10.1529/biophysj.104.055012 |
0.731 |
|
| 2005 |
Chen TY. Structure and function of clc channels. Annual Review of Physiology. 67: 809-39. PMID 15709979 DOI: 10.1146/annurev.physiol.67.032003.153012 |
0.577 |
|
| 2003 |
Chen TY, Chen MF, Lin CW. Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels. The Journal of General Physiology. 122: 641-51. PMID 14581587 DOI: 10.1085/jgp.200308846 |
0.713 |
|
| 2003 |
Lin CW, Chen TY. Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. The Journal of General Physiology. 122: 147-59. PMID 12885876 DOI: 10.1085/jgp.200308845 |
0.717 |
|
| 2003 |
Chen MF, Chen TY. Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. The Journal of General Physiology. 122: 133-45. PMID 12885875 DOI: 10.1085/jgp.200308844 |
0.584 |
|
| 2003 |
Chen TY. Coupling gating with ion permeation in ClC channels. Science's Stke : Signal Transduction Knowledge Environment. 2003: pe23. PMID 12824475 DOI: 10.1126/stke.2003.188.pe23 |
0.616 |
|
| 2001 |
Chen MF, Chen TY. Different fast-gate regulation by external Cl- and H+ of the muscle-type ClC chloride channels Journal of General Physiology. 118: 23-32. PMID 11429442 DOI: 10.1085/jgp.118.1.23 |
0.468 |
|
| 2000 |
Lin CW, Chen TY. Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. The Journal of General Physiology. 116: 535-46. PMID 11004203 DOI: 10.1085/jgp.116.4.535 |
0.63 |
|
| 1999 |
Lin YW, Lin CW, Chen TY. Elimination of the slow gating of ClC-0 chloride channel by a point mutation. The Journal of General Physiology. 114: 1-12. PMID 10398688 DOI: 10.1085/JGP.114.1.1 |
0.617 |
|
| 1998 |
Chen TY. Extracellular zinc ion inhibits ClC-0 chloride channels by facilitating slow gating Journal of General Physiology. 112: 715-726. PMID 9834141 DOI: 10.1085/jgp.112.6.715 |
0.537 |
|
| 1996 |
Chen TY, Miller C. Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel. The Journal of General Physiology. 108: 237-50. PMID 8894974 DOI: 10.1085/Jgp.108.4.237 |
0.645 |
|
| 1994 |
Yellen G, Sodickson D, Chen TY, Jurman ME. An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding. Biophysical Journal. 66: 1068-75. PMID 8038379 DOI: 10.1016/S0006-3495(94)80888-4 |
0.718 |
|
| 1994 |
Chen TY, Yau KW. Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature. 368: 545-8. PMID 7511217 DOI: 10.1038/368545a0 |
0.635 |
|
| 1990 |
Chiu TH, Chen TY, Ho CL, Chiang ST. Electrophysiological effects of dermorphin on locus coeruleus neurons of rat Neuropharmacology. 29: 747-755. PMID 1980348 DOI: 10.1016/0028-3908(90)90128-E |
0.309 |
|
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