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Gary Yellen - Publications

Neurobiology Harvard Medical School, Boston, MA, United States 
Ion Channel Biophysics, Metabolism and Excitability

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Díaz-García CM, Lahmann C, Martínez-François JR, Li B, Koveal D, Nathwani N, Rahman M, Keller JP, Marvin JS, Looger LL, Yellen G. Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor. Journal of Neuroscience Research. PMID 31106909 DOI: 10.1002/jnr.24433  1
2018 Díaz-García CM, Yellen G. Neurons rely on glucose rather than astrocytic lactate during stimulation. Journal of Neuroscience Research. PMID 30575090 DOI: 10.1002/jnr.24374  0.76
2018 Martínez-François JR, Fernández-Agüera MC, Nathwani N, Lahmann C, Burnham VL, Danial NN, Yellen G. BAD and KATP channels regulate neuron excitability and epileptiform activity. Elife. 7. PMID 29368690 DOI: 10.7554/eLife.32721  1
2017 Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 6. PMID 29239720 DOI: 10.7554/eLife.27293  1
2017 Foley J, Burnham V, Tedoldi M, Danial NN, Yellen G. BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy. Epilepsia. PMID 29171006 DOI: 10.1111/epi.13960  0.52
2017 Masia R, McCarty WJ, Lahmann C, Luther J, Chung RT, Yarmush ML, Yellen G. Live cell imaging of cytosolic NADH/NAD(+) ratio in hepatocytes and liver slices. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00093.2017. PMID 29025729 DOI: 10.1152/ajpgi.00093.2017  0.48
2017 Díaz-García CM, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metabolism. 26: 361-374.e4. PMID 28768175 DOI: 10.1016/j.cmet.2017.06.021  0.76
2016 Lutas A, Lahmann C, Soumillon M, Yellen G. The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. Elife. 5. PMID 27177420 DOI: 10.7554/eLife.15271  1
2016 Chen Y, Saulnier JL, Yellen G, Sabatini BL. Corrigendum: A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging. Frontiers in Pharmacology. 7: 46. PMID 26941646 DOI: 10.3389/fphar.2016.00046  1
2016 Mongeon R, Venkatachalam V, Yellen G. Cytosolic NADH-NAD+ redox visualized in brain slices by two-photon fluorescence lifetime biosensor imaging. Antioxidants & Redox Signaling. PMID 26857245 DOI: 10.1089/ars.2015.6593  0.52
2015 Schoeler NE, Leu C, White J, Plagnol V, Ellard S, Matarin M, Yellen G, Thiele EA, Mackay M, McMahon JM, Scheffer IE, Sander JW, Cross JH, Sisodiya SM. Variants in KCNJ11 and BAD do not predict response to ketogenic dietary therapies for epilepsy. Epilepsy Research. 118: 22-28. PMID 26590798 DOI: 10.1016/j.eplepsyres.2015.10.003  1
2015 Yellen G, Mongeon R. Quantitative two-photon imaging of fluorescent biosensors. Current Opinion in Chemical Biology. 27: 24-30. PMID 26079046 DOI: 10.1016/j.cbpa.2015.05.024  0.52
2015 Masia R, Krause DS, Yellen G. The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver. American Journal of Physiology. Cell Physiology. 308: C264-76. PMID 25472961 DOI: 10.1152/ajpcell.00176.2014  1
2015 Yellen G, Mongeon R. Quantitative two-photon imaging of fluorescent biosensors Current Opinion in Chemical Biology. 27: 24-30. DOI: 10.1016/j.cbpa.2015.05.024  1
2014 Lutas A, Birnbaumer L, Yellen G. Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 16336-47. PMID 25471572 DOI: 10.1523/JNEUROSCI.1357-14.2014  1
2014 Tantama M, Yellen G. Imaging changes in the cytosolic ATP-to-ADP ratio. Methods in Enzymology. 547: 355-71. PMID 25416365 DOI: 10.1016/B978-0-12-801415-8.00017-5  1
2014 Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife. 3. PMID 25009227 DOI: 10.7554/eLife.03342  1
2014 Chen Y, Saulnier JL, Yellen G, Sabatini BL. A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging. Frontiers in Pharmacology. 5: 56. PMID 24765076 DOI: 10.3389/fphar.2014.00056  1
2014 Hung YP, Yellen G. Live-cell imaging of cytosolic NADH-NAD+ redox state using a genetically encoded fluorescent biosensor. Methods in Molecular Biology (Clifton, N.J.). 1071: 83-95. PMID 24052382 DOI: 10.1007/978-1-62703-622-1_7  1
2013 Tantama M, Martínez-François JR, Mongeon R, Yellen G. Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio. Nature Communications. 4: 2550. PMID 24096541 DOI: 10.1038/ncomms3550  1
2013 Lutas A, Yellen G. The ketogenic diet: metabolic influences on brain excitability and epilepsy. Trends in Neurosciences. 36: 32-40. PMID 23228828 DOI: 10.1016/j.tins.2012.11.005  1
2012 Ryu S, Yellen G. Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate. The Journal of General Physiology. 140: 469-79. PMID 23071265 DOI: 10.1085/jgp.201210850  1
2012 Kwan DC, Prole DL, Yellen G. Structural changes during HCN channel gating defined by high affinity metal bridges. The Journal of General Physiology. 140: 279-91. PMID 22930802 DOI: 10.1085/jgp.201210838  1
2012 Giménez-Cassina A, Martínez-François JR, Fisher JK, Szlyk B, Polak K, Wiwczar J, Tanner GR, Lutas A, Yellen G, Danial NN. BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures. Neuron. 74: 719-30. PMID 22632729 DOI: 10.1016/j.neuron.2012.03.032  1
2012 Tantama M, Hung YP, Yellen G. Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain. Progress in Brain Research. 196: 235-63. PMID 22341329 DOI: 10.1016/B978-0-444-59426-6.00012-4  1
2011 Hung YP, Albeck JG, Tantama M, Yellen G. Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor. Cell Metabolism. 14: 545-54. PMID 21982714 DOI: 10.1016/j.cmet.2011.08.012  1
2011 Tanner GR, Lutas A, Martínez-François JR, Yellen G. Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8689-96. PMID 21653873 DOI: 10.1523/JNEUROSCI.5951-10.2011  1
2011 Tantama M, Hung YP, Yellen G. Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor. Journal of the American Chemical Society. 133: 10034-7. PMID 21631110 DOI: 10.1021/ja202902d  1
2009 Berg J, Hung YP, Yellen G. A genetically encoded fluorescent reporter of ATP:ADP ratio. Nature Methods. 6: 161-6. PMID 19122669 DOI: 10.1038/nmeth.1288  1
2008 Yellen G. Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet. Epilepsia. 49: 80-2. PMID 19049596 DOI: 10.1111/j.1528-1167.2008.01843.x  1
2007 Ma W, Berg J, Yellen G. Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3618-25. PMID 17409226 DOI: 10.1523/JNEUROSCI.0132-07.2007  1
2006 Dekker JP, Yellen G. Cooperative gating between single HCN pacemaker channels. The Journal of General Physiology. 128: 561-7. PMID 17043149 DOI: 10.1085/jgp.200609599  1
2006 Prole DL, Yellen G. Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6. The Journal of General Physiology. 128: 273-82. PMID 16908727 DOI: 10.1085/jgp.200609590  1
2006 Proenza C, Yellen G. Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents. The Journal of General Physiology. 127: 183-90. PMID 16446506 DOI: 10.1085/jgp.200509389  1
2005 del Camino D, Kanevsky M, Yellen G. Status of the intracellular gate in the activated-not-open state of shaker K+ channels. The Journal of General Physiology. 126: 419-28. PMID 16260836 DOI: 10.1085/jgp.200509385  1
2004 Webster SM, Del Camino D, Dekker JP, Yellen G. Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges. Nature. 428: 864-8. PMID 15103379 DOI: 10.1038/nature02468  1
2004 Shin KS, Maertens C, Proenza C, Rothberg BS, Yellen G. Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage. Neuron. 41: 737-44. PMID 15003173 DOI: 10.1016/S0896-6273(04)00083-2  1
2004 Dekker JP, Fodor A, Aldrich RW, Yellen G. A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments. Bioinformatics (Oxford, England). 20: 1565-72. PMID 14962924 DOI: 10.1093/bioinformatics/bth128  1
2003 Rothberg BS, Shin KS, Yellen G. Movements near the gate of a hyperpolarization-activated cation channel. The Journal of General Physiology. 122: 501-10. PMID 14557404 DOI: 10.1085/jgp.200308928  1
2002 Yellen G. The voltage-gated potassium channels and their relatives. Nature. 419: 35-42. PMID 12214225 DOI: 10.1038/nature00978  1
2002 Smith PL, Yellen G. Fast and slow voltage sensor movements in HERG potassium channels. The Journal of General Physiology. 119: 275-93. PMID 11865022 DOI: 10.1085/jgp.119.3.275  1
2002 Rothberg BS, Shin KS, Phale PS, Yellen G. Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel. The Journal of General Physiology. 119: 83-91. PMID 11773240 DOI: 10.1085/jgp.119.1.83  1
2001 Yellen G. Keeping K+ completely comfortable. Nature Structural Biology. 8: 1011-3. PMID 11723466 DOI: 10.1038/nsb1201-1011  1
2001 del Camino D, Yellen G. Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel. Neuron. 32: 649-56. PMID 11719205 DOI: 10.1016/S0896-6273(01)00487-1  1
2001 Yellen G. Dimers among friends: ion channel regulation by dimerization of tail domains. Trends in Pharmacological Sciences. 22: 439-41. PMID 11543856 DOI: 10.1016/S0165-6147(00)01798-3  1
2001 Shin KS, Rothberg BS, Yellen G. Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. The Journal of General Physiology. 117: 91-101. PMID 11158163 DOI: 10.1085/jgp.117.2.91  1
2000 del Camino D, Holmgren M, Liu Y, Yellen G. Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature. 403: 321-5. PMID 10659852 DOI: 10.1038/35002099  1
1999 Yellen G. The bacterial K+ channel structure and its implications for neuronal channels. Current Opinion in Neurobiology. 9: 267-73. PMID 10395571 DOI: 10.1016/S0959-4388(99)80039-7  1
1998 Yellen G. The moving parts of voltage-gated ion channels. Quarterly Reviews of Biophysics. 31: 239-95. PMID 10384687 DOI: 10.1017/S0033583598003448  1
1998 Holmgren M, Shin KS, Yellen G. The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge. Neuron. 21: 617-21. PMID 9768847 DOI: 10.1016/S0896-6273(00)80571-1  1
1998 Yellen G. Premonitions of ion channel gating. Nature Structural Biology. 5: 421. PMID 9628476  1
1997 Liu Y, Holmgren M, Jurman ME, Yellen G. Gated access to the pore of a voltage-dependent K+ channel. Neuron. 19: 175-84. PMID 9247273 DOI: 10.1016/S0896-6273(00)80357-8  1
1997 Yellen G. Single channel seeks permeant ion for brief but intimate relationship. The Journal of General Physiology. 110: 83-5. PMID 9236202 DOI: 10.1085/jgp.110.2.83  1
1997 Holmgren M, Smith PL, Yellen G. Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating. The Journal of General Physiology. 109: 527-35. PMID 9154902 DOI: 10.1085/jgp.109.5.527  1
1997 Baker K, Warren KS, Yellen G, Fishman MC. Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate. Proceedings of the National Academy of Sciences of the United States of America. 94: 4554-9. PMID 9114028 DOI: 10.1073/pnas.94.9.4554  1
1996 Holmgren M, Liu Y, Xu Y, Yellen G. On the use of thiol-modifying agents to determine channel topology. Neuropharmacology. 35: 797-804. PMID 8938712 DOI: 10.1016/0028-3908(96)00129-3  1
1996 Baukrowitz T, Yellen G. Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 93: 13357-61. PMID 8917595 DOI: 10.1073/pnas.93.23.13357  1
1996 Holmgren M, Jurman ME, Yellen G. N-type inactivation and the S4-S5 region of the Shaker K+ channel. The Journal of General Physiology. 108: 195-206. PMID 8882863  1
1996 Forman SA, Yellen G, Thiele EA. Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation. Nature Genetics. 13: 396-7. PMID 8696332 DOI: 10.1038/ng0896-396  1
1996 Liu Y, Jurman ME, Yellen G. Dynamic rearrangement of the outer mouth of a K+ channel during gating. Neuron. 16: 859-67. PMID 8608004 DOI: 10.1016/S0896-6273(00)80106-3  1
1996 Smith PL, Baukrowitz T, Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel. Nature. 379: 833-6. PMID 8587608 DOI: 10.1038/379833a0  1
1996 Baukrowitz T, Yellen G. Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel. Science (New York, N.Y.). 271: 653-6. PMID 8571129  1
1995 Baukrowitz T, Yellen G. Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms. Neuron. 15: 951-60. PMID 7576643 DOI: 10.1016/0896-6273(95)90185-X  1
1995 McLaughlin JT, Hawrot E, Yellen G. Covalent modification of engineered cysteines in the nicotinic acetylcholine receptor agonist-binding domain inhibits receptor activation. The Biochemical Journal. 310: 765-9. PMID 7575408  1
1995 Forman SA, Miller KW, Yellen G. A discrete site for general anesthetics on a postsynaptic receptor. Molecular Pharmacology. 48: 574-81. PMID 7476881  1
1994 Kienker P, Tomaselli G, Jurman M, Yellen G. Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism. Biophysical Journal. 66: 325-34. PMID 8161686  1
1994 Yellen G, Sodickson D, Chen TY, Jurman ME. An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding. Biophysical Journal. 66: 1068-75. PMID 8038379 DOI: 10.1016/S0006-3495(94)80888-4  1
1994 Boland LM, Jurman ME, Yellen G. Cysteines in the Shaker K+ channel are not essential for channel activity or zinc modulation. Biophysical Journal. 66: 694-9. PMID 8011900  1
1994 Jurman ME, Boland LM, Liu Y, Yellen G. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques. 17: 876-81. PMID 7840967  1
1993 Choi KL, Mossman C, Aubé J, Yellen G. The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron. 10: 533-41. PMID 8461140 DOI: 10.1016/0896-6273(93)90340-W  1
1993 Yellen G. Calcium channels. Structure and selectivity. Nature. 366: 109-10. PMID 7901764 DOI: 10.1038/366109a0  1
1992 Hwang PM, Glatt CE, Bredt DS, Yellen G, Snyder SH. A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. Neuron. 8: 473-81. PMID 1550672 DOI: 10.1016/0896-6273(92)90275-I  1
1992 Demo SD, Yellen G. Ion effects on gating of the Ca(2+)-activated K+ channel correlate with occupancy of the pore. Biophysical Journal. 61: 639-48. PMID 1504240 DOI: 10.1016/S0006-3495(92)81869-6  1
1991 Choi KL, Aldrich RW, Yellen G. Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 88: 5092-5. PMID 2052588  1
1991 Yellen G, Jurman ME, Abramson T, MacKinnon R. Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science (New York, N.Y.). 251: 939-42. PMID 2000494  1
1991 Demo SD, Yellen G. The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker. Neuron. 7: 743-53. PMID 1742023 DOI: 10.1016/0896-6273(91)90277-7  1
1991 Tomaselli GF, McLaughlin JT, Jurman ME, Hawrot E, Yellen G. Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor. Biophysical Journal. 60: 721-7. PMID 1718469 DOI: 10.1016/S0006-3495(91)82102-6  1
1990 MacKinnon R, Yellen G. Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science (New York, N.Y.). 250: 276-9. PMID 2218530  1
1990 Yellen G, Migeon JC. Expression of Torpedo nicotinic acetylcholine receptor subunits in yeast is enhanced by use of yeast signal sequences. Gene. 86: 145-52. PMID 2182389 DOI: 10.1016/0378-1119(90)90273-T  1
1990 Tomaselli GF, Feldman AM, Yellen G, Marban E. Human cardiac sodium channels expressed in Xenopus oocytes. The American Journal of Physiology. 258: H903-6. PMID 1690519  1
1989 Tomaselli GF, Marban E, Yellen G. Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin. The Journal of Clinical Investigation. 83: 1724-32. PMID 2468690 DOI: 10.1172/JCI114073  1
1987 Yellen G. Permeation in potassium channels: implications for channel structure. Annual Review of Biophysics and Biophysical Chemistry. 16: 227-46. PMID 2439096 DOI: 10.1146/  1
1985 Cukierman S, Yellen G, Miller C. The K+ channel of sarcoplasmic reticulum. A new look at Cs+ block. Biophysical Journal. 48: 477-84. PMID 2412606 DOI: 10.1016/S0006-3495(85)83803-0  1
1984 Yellen G. Relief of Na+ block of Ca2+-activated K+ channels by external cations. The Journal of General Physiology. 84: 187-99. PMID 6092515  1
1984 Yellen G. Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells. The Journal of General Physiology. 84: 157-86. PMID 6092514  1
1984 Yellen G. Channels from genes: the oocyte as an expression system Trends in Neurosciences. 7: 457-458.  1
1984 Yellen G. The immune system uses ion channels, too Trends in Neurosciences. 7: 179-181.  1
1982 Reuter H, Stevens CF, Tsien RW, Yellen G. Properties of single calcium channels in cardiac cell culture. Nature. 297: 501-4. PMID 6283360 DOI: 10.1038/297501a0  1
1982 Yellen G. Single Ca2+-activated nonselective cation channels in neuroblastoma. Nature. 296: 357-9. PMID 6278324  1
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