Shelly B. Flagel - Publications

University of Michigan, Ann Arbor, Ann Arbor, MI 
Behavioral Neuroscience, Addiction

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lopez SA, Mubarak E, Yang C, Parsegian A, Klumpner M, Campus P, Flagel SB. Male goal-tracker and sign-tracker rats do not differ in neuroendocrine or behavioral measures of stress-reactivity. Eneuro. PMID 33731330 DOI: 10.1523/ENEURO.0384-20.2021  0.6
2021 King CP, Tripi JA, Hughson AR, Horvath AP, Lamparelli AC, Holl KL, Chitre AS, Polesskaya O, Ishiwari K, Solberg Woods LC, Palmer AA, Robinson TE, Flagel SB, Meyer PJ. Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats. Scientific Reports. 11: 2223. PMID 33500444 DOI: 10.1038/s41598-020-80798-w  0.96
2020 Chitre AS, Polesskaya O, Holl K, Gao J, Cheng R, Bimschleger H, Garcia Martinez A, George T, Gileta AF, Han W, Horvath A, Hughson A, Ishiwari K, King CP, Lamparelli A, ... ... Flagel SB, et al. Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose. Obesity (Silver Spring, Md.). PMID 32860487 DOI: 10.1002/oby.22927  0.96
2020 Haight JL, Campus P, Maria-Rios CE, Johnson AM, Klumpner MS, Kuhn BN, Covelo IR, Morrow JD, Flagel SB. The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues. Psychopharmacology. PMID 32852601 DOI: 10.1007/s00213-020-05651-4  1
2019 Campus P, Covelo IR, Kim Y, Parsegian A, Kuhn BN, Lopez SA, Neumaier JF, Ferguson SM, Solberg Woods LC, Sarter M, Flagel SB. The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats. Elife. 8. PMID 31502538 DOI: 10.7554/eLife.49041  0.76
2019 Hughson AR, Horvath AP, Holl K, Palmer AA, Solberg Woods LC, Robinson TE, Flagel SB. Incentive salience attribution, "sensation-seeking" and "novelty-seeking" are independent traits in a large sample of male and female heterogeneous stock rats. Scientific Reports. 9: 2351. PMID 30787409 DOI: 10.1038/s41598-019-39519-1  0.96
2017 Kuhn BN, Klumpner MS, Covelo IR, Campus P, Flagel SB. Transient inactivation of the paraventricular nucleus of the thalamus enhances cue-induced reinstatement in goal-trackers, but not sign-trackers. Psychopharmacology. PMID 29285634 DOI: 10.1007/s00213-017-4816-1  0.6
2017 Mabrouk OS, Han JL, Wong JT, Akil H, Kennedy RT, Flagel SB. In vivo neurochemical profile of selectively bred high-responder and low-responder rats reveals baseline, cocaine- and novelty-evoked differences in monoaminergic systems. Acs Chemical Neuroscience. PMID 29161023 DOI: 10.1021/acschemneuro.7b00294  1
2017 Turner CA, Flagel SB, Blandino P, Watson SJ, Akil H. Utilizing a unique animal model to better understand human temperament. Current Opinion in Behavioral Sciences. 14: 108-114. PMID 28966969 DOI: 10.1016/j.cobeha.2017.02.002  1
2017 Flagel SB, Robinson TE. Neurobiological Basis of Individual Variation in Stimulus-Reward Learning. Current Opinion in Behavioral Sciences. 13: 178-185. PMID 28670608 DOI: 10.1016/j.cobeha.2016.12.004  0.96
2017 García-Fuster MJ, Parsegian A, Watson SJ, Akil H, Flagel SB. Adolescent cocaine exposure enhances goal-tracking behavior and impairs hippocampal cell genesis selectively in adult bred low-responder rats. Psychopharmacology. PMID 28210781 DOI: 10.1007/s00213-017-4566-0  1
2016 Haight JL, Fuller ZL, Fraser KM, Flagel SB. A food-predictive cue attributed with incentive salience engages subcortical afferents and efferents of the paraventricular nucleus of the thalamus. Neuroscience. PMID 27793779 DOI: 10.1016/j.neuroscience.2016.10.043  1
2016 Flagel SB, Chaudhury S, Waselus M, Kelly R, Sewani S, Clinton SM, Thompson RC, Watson SJ, Akil H. Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114539 DOI: 10.1073/pnas.1520491113  1
2016 Fraser KM, Haight JL, Gardner EL, Flagel SB. Examining the role of dopamine D2 and D3 receptors in Pavlovian conditioned approach behaviors. Behavioural Brain Research. PMID 26909847 DOI: 10.1016/j.bbr.2016.02.022  1
2016 Morrow JD, Flagel SB. Neuroscience of resilience and vulnerability for addiction medicine: From genes to behavior. Progress in Brain Research. 223: 3-18. PMID 26806768 DOI: 10.1016/bs.pbr.2015.09.004  1
2015 Haight JL, Fraser KM, Akil H, Flagel SB. Lesions of the paraventricular nucleus of the thalamus differentially affect sign- and goal-tracking conditioned responses. The European Journal of Neuroscience. 42: 2478-88. PMID 26228683 DOI: 10.1111/ejn.13031  1
2015 Pitchers KK, Flagel SB, O'Donnell EG, Woods LC, Sarter M, Robinson TE. Individual variation in the propensity to attribute incentive salience to a food cue: influence of sex. Behavioural Brain Research. 278: 462-9. PMID 25446811 DOI: 10.1016/j.bbr.2014.10.036  1
2015 Yager LM, Pitchers KK, Flagel SB, Robinson TE. Individual variation in the motivational and neurobiological effects of an opioid cue. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1269-77. PMID 25425322 DOI: 10.1038/npp.2014.314  1
2015 Lesaint F, Sigaud O, Clark JJ, Flagel SB, Khamassi M. Experimental predictions drawn from a computational model of sign-trackers and goal-trackers. Journal of Physiology, Paris. 109: 78-86. PMID 24954026 DOI: 10.1016/j.jphysparis.2014.06.001  1
2014 Huys QJ, Tobler PN, Hasler G, Flagel SB. The role of learning-related dopamine signals in addiction vulnerability. Progress in Brain Research. 211: 31-77. PMID 24968776 DOI: 10.1016/B978-0-444-63425-2.00003-9  1
2014 Haight JL, Flagel SB. A potential role for the paraventricular nucleus of the thalamus in mediating individual variation in Pavlovian conditioned responses. Frontiers in Behavioral Neuroscience. 8: 79. PMID 24672443 DOI: 10.3389/fnbeh.2014.00079  1
2014 Lesaint F, Sigaud O, Flagel SB, Robinson TE, Khamassi M. Modelling individual differences in the form of Pavlovian conditioned approach responses: a dual learning systems approach with factored representations. Plos Computational Biology. 10: e1003466. PMID 24550719 DOI: 10.1371/journal.pcbi.1003466  1
2014 Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA. Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology. 76: 250-8. PMID 23791960 DOI: 10.1016/j.neuropharm.2013.05.047  1
2014 Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H. Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology. 76: 425-36. PMID 23639434 DOI: 10.1016/j.neuropharm.2013.04.033  1
2013 Fitzpatrick CJ, Gopalakrishnan S, Cogan ES, Yager LM, Meyer PJ, Lovic V, Saunders BT, Parker CC, Gonzales NM, Aryee E, Flagel SB, Palmer AA, Robinson TE, Morrow JD. Variation in the form of Pavlovian conditioned approach behavior among outbred male Sprague-Dawley rats from different vendors and colonies: sign-tracking vs. goal-tracking. Plos One. 8: e75042. PMID 24098363 DOI: 10.1371/journal.pone.0075042  1
2013 Waselus M, Flagel SB, Jedynak JP, Akil H, Robinson TE, Watson SJ. Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats. Neuroscience. 248: 571-84. PMID 23811073 DOI: 10.1016/j.neuroscience.2013.06.042  1
2013 Perez-Sepulveda JA, Flagel SB, Garcia-Fuster MJ, Slusky RJ, Aldridge JW, Watson S, Akil H. Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality. Neuroscience. 248: 436-47. PMID 23806722 DOI: 10.1016/j.neuroscience.2013.06.015  1
2012 García-Fuster MJ, Flagel SB, Mahmood ST, Watson SJ, Akil H. Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. Plos One. 7: e42092. PMID 22860061 DOI: 10.1371/journal.pone.0042092  1
2012 Clinton SM, Turner CA, Flagel SB, Simpson DN, Watson SJ, Akil H. Neonatal fibroblast growth factor treatment enhances cocaine sensitization. Pharmacology, Biochemistry, and Behavior. 103: 6-17. PMID 22819969 DOI: 10.1016/j.pbb.2012.07.006  1
2012 Meyer PJ, Lovic V, Saunders BT, Yager LM, Flagel SB, Morrow JD, Robinson TE. Quantifying individual variation in the propensity to attribute incentive salience to reward cues. Plos One. 7: e38987. PMID 22761718 DOI: 10.1371/journal.pone.0038987  1
2011 Flagel SB, Cameron CM, Pickup KN, Watson SJ, Akil H, Robinson TE. A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience. 196: 80-96. PMID 21945724 DOI: 10.1016/j.neuroscience.2011.09.004  1
2011 García-Fuster MJ, Flagel SB, Mahmood ST, Mayo LM, Thompson RC, Watson SJ, Akil H. Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2303-17. PMID 21796105 DOI: 10.1038/npp.2011.119  1
2011 Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PE, Akil H. A selective role for dopamine in stimulus-reward learning. Nature. 469: 53-7. PMID 21150898 DOI: 10.1038/nature09588  1
2011 Burghardt PR, Flagel SB, Burghardt KJ, Britton SL, Gerard-Koch L, Watson SJ, Akil H. Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 390-401. PMID 20927049 DOI: 10.1038/npp.2010.144  1
2010 Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PE, Akil H. An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 388-400. PMID 19794408 DOI: 10.1038/npp.2009.142  1
2009 Turner CA, Capriles N, Flagel SB, Perez JA, Clinton SM, Watson SJ, Akil H. Neonatal FGF2 alters cocaine self-administration in the adult rat. Pharmacology, Biochemistry, and Behavior. 92: 100-4. PMID 19014962 DOI: 10.1016/j.pbb.2008.10.018  1
2009 Robinson TE, Flagel SB. Dissociating the predictive and incentive motivational properties of reward-related cues through the study of individual differences. Biological Psychiatry. 65: 869-73. PMID 18930184 DOI: 10.1016/j.biopsych.2008.09.006  1
2009 Flagel SB, Akil H, Robinson TE. Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction. Neuropharmacology. 56: 139-48. PMID 18619474 DOI: 10.1016/j.neuropharm.2008.06.027  1
2008 Turner CA, Flagel SB, Clinton SM, Akil H, Watson SJ. Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat. Neuroscience Letters. 446: 105-7. PMID 18824081 DOI: 10.1016/j.neulet.2008.09.037  1
2008 Briand LA, Flagel SB, Garcia-Fuster MJ, Watson SJ, Akil H, Sarter M, Robinson TE. Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2969-80. PMID 18305460 DOI: 10.1038/npp.2008.18  1
2008 Briand LA, Flagel SB, Seeman P, Robinson TE. Cocaine self-administration produces a persistent increase in dopamine D2 High receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 18: 551-6. PMID 18284941 DOI: 10.1016/j.euroneuro.2008.01.002  1
2008 Flagel SB, Watson SJ, Akil H, Robinson TE. Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Behavioural Brain Research. 186: 48-56. PMID 17719099 DOI: 10.1016/j.bbr.2007.07.022  1
2007 Flagel SB, Robinson TE. Quantifying the psychomotor activating effects of cocaine in the rat. Behavioural Pharmacology. 18: 297-302. PMID 17551322 DOI: 10.1097/FBP.0b013e3281f522a4  1
2007 Flagel SB, Watson SJ, Robinson TE, Akil H. Individual differences in the propensity to approach signals vs goals promote different adaptations in the dopamine system of rats. Psychopharmacology. 191: 599-607. PMID 16972103 DOI: 10.1007/s00213-006-0535-8  1
2003 Flagel SB, Vázquez DM, Robinson TE. Manipulations during the second, but not the first, week of life increase susceptibility to cocaine self-administration in female rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1741-51. PMID 12888774 DOI: 10.1038/sj.npp.1300228  1
2002 Flagel SB, Vázquez DM, Watson SJ, Neal CR. Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 282: R55-63. PMID 11742823  1
1999 Liberzon I, Abelson JL, Flagel SB, Raz J, Young EA. Neuroendocrine and psychophysiologic responses in PTSD: a symptom provocation study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 40-50. PMID 10379518 DOI: 10.1016/S0893-133X(98)00128-6  1
1999 Liberzon I, López JF, Flagel SB, Vázquez DM, Young EA. Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder. Journal of Neuroendocrinology. 11: 11-7. PMID 9918224 DOI: 10.1046/j.1365-2826.1999.00288.x  1
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