| Year |
Citation |
Score |
| 2020 |
Lu S, Haskali MB, Ruley KM, Dreyfus NJ, DuBois SL, Paul S, Liow JS, Morse CL, Kowalski A, Gladding RL, Gilmore J, Mogg AJ, Morin SM, Lindsay-Scott PJ, Ruble JC, ... ... Barth VN, et al. PET ligands [F]LSN3316612 and [C]LSN3316612 quantify -linked-β--acetyl-glucosamine hydrolase in the brain. Science Translational Medicine. 12. PMID 32404505 DOI: 10.1126/Scitranslmed.Aau2939 |
0.305 |
|
| 2019 |
Knopp KL, Simmons RMA, Guo W, Adams BL, Gardinier KM, Gernert DL, Ornstein PL, Porter W, Reel J, Ding C, Wang H, Qian Y, Burris KD, Need A, Barth V, et al. Modulation of TARP γ8-containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. The Journal of Pharmacology and Experimental Therapeutics. PMID 30910921 DOI: 10.1124/Jpet.118.250126 |
0.522 |
|
| 2019 |
Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker LJ, Jesudason CD, Barth VN, Navarro A, et al. Evaluation of C-LSN3172176 as a novel PET tracer for imaging M muscarinic acetylcholine receptors in non-human primates. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 30733324 DOI: 10.2967/jnumed.118.222034 |
0.37 |
|
| 2018 |
Broad LM, Sanger HE, Mogg AJ, Colvin EM, Zwart R, Evans DA, Pasqui F, Sher E, Wishart GN, Barth VN, Felder CC, Goldsmith PJ. Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant M1 muscarinic acetylcholine receptor agonist. British Journal of Pharmacology. PMID 30276808 DOI: 10.1111/Bph.14510 |
0.382 |
|
| 2016 |
Witkin JM, Rorick-Kehn LM, Benvenga MJ, Adams BL, Gleason SD, Knitowski KM, Li X, Chaney S, Falcone JF, Smith JW, Foss J, Lloyd K, Catlow JT, McKinzie DL, Svensson KA, ... Barth VN, et al. Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors. Pharmacology Research & Perspectives. 4: e00275. PMID 28097008 DOI: 10.1002/Prp2.275 |
0.365 |
|
| 2016 |
Raddad E, Chappell A, Meyer J, Wilson A, Ruegg CE, Tauscher J, Statnick MA, Barth V, Zhang X, Verfaille SJ. Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27353045 DOI: 10.1124/dmd.116.070359 |
0.348 |
|
| 2016 |
Gardinier KM, Gernert DL, Porter WJ, Reel JK, Ornstein PL, Spinazze P, Stevens FC, Hahn P, Hollinshead SP, Mayhugh D, Schkeryantz J, Khilevich A, De Frutos O, Gleason SD, Kato AS, ... ... Barth VN, et al. The Discovery of The First α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent Upon Transmembrane AMPA Receptor Regulatory Protein (TARP) Gamma-8. Journal of Medicinal Chemistry. PMID 27067148 DOI: 10.1021/Acs.Jmedchem.6B00125 |
0.568 |
|
| 2015 |
Post A, Smart TS, Krikke-Workel J, Dawson GR, Harmer CJ, Browning M, Jackson K, Kakar R, Mohs R, Statnick M, Wafford K, McCarthy A, Barth V, Witkin JM. A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26585287 DOI: 10.1038/Npp.2015.348 |
0.348 |
|
| 2015 |
Bakker G, Vingerhoets WA, van Wieringen JP, de Bruin K, Eersels J, de Jong J, Chahid Y, Rutten BP, DuBois S, Watson M, Mogg AJ, Xiao H, Crabtree M, Collier DA, Felder CC, ... Barth VN, et al. 123I-iododexetimide preferentially binds to the muscarinic receptor subtype M1 in vivo. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 56: 317-22. PMID 25593117 DOI: 10.2967/Jnumed.114.147488 |
0.361 |
|
| 2014 |
Joshi EM, Need A, Schaus J, Chen Z, Benesh D, Mitch C, Morton S, Raub TJ, Phebus L, Barth V. Efficiency gains in tracer identification for nuclear imaging: can in vivo LC-MS/MS evaluation of small molecules screen for successful PET tracers? Acs Chemical Neuroscience. 5: 1154-63. PMID 25247893 DOI: 10.1021/cn500073j |
0.548 |
|
| 2014 |
Zheng MQ, Kim SJ, Holden D, Lin SF, Need A, Rash K, Barth V, Mitch C, Navarro A, Kapinos M, Maloney K, Ropchan J, Carson RE, Huang Y. An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 55: 1185-91. PMID 24854795 DOI: 10.2967/jnumed.114.138701 |
0.531 |
|
| 2014 |
Barth V, Need A. Identifying novel radiotracers for PET imaging of the brain: application of LC-MS/MS to tracer identification. Acs Chemical Neuroscience. 5: 1148-53. PMID 24828747 DOI: 10.1021/cn500072r |
0.515 |
|
| 2014 |
Toledo MA, Pedregal C, Lafuente C, Diaz N, Martinez-Grau MA, Jiménez A, Benito A, Torrado A, Mateos C, Joshi EM, Kahl SD, Rash KS, Mudra DR, Barth VN, Shaw DB, et al. Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold. Journal of Medicinal Chemistry. 57: 3418-29. PMID 24678969 DOI: 10.1021/Jm500117R |
0.446 |
|
| 2014 |
Lohith TG, Zoghbi SS, Morse CL, Araneta MD, Barth VN, Goebl NA, Tauscher JT, Pike VW, Innis RB, Fujita M. Retest imaging of [11C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans. Neuroimage. 87: 89-95. PMID 24225488 DOI: 10.1016/j.neuroimage.2013.10.068 |
0.322 |
|
| 2013 |
Wang C, Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelamegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. American Journal of Nuclear Medicine and Molecular Imaging. 4: 29-38. PMID 24380043 |
0.379 |
|
| 2013 |
Zanotti-Fregonara P, Barth VN, Zoghbi SS, Liow JS, Nisenbaum E, Siuda E, Gladding RL, Rallis-Frutos D, Morse C, Tauscher J, Pike VW, Innis RB. 11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains. Ejnmmi Research. 3: 47. PMID 23758896 DOI: 10.1186/2191-219X-3-47 |
0.355 |
|
| 2013 |
Zheng MQ, Nabulsi N, Kim SJ, Tomasi G, Lin SF, Mitch C, Quimby S, Barth V, Rash K, Masters J, Navarro A, Seest E, Morris ED, Carson RE, Huang Y. Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 455-63. PMID 23353688 DOI: 10.2967/Jnumed.112.109512 |
0.401 |
|
| 2013 |
Barth V, Need AB, Tzavara ET, Giros B, Overshiner C, Gleason SD, Wade M, Johansson AM, Perry K, Nomikos GG, Witkin JM. In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder. The Journal of Pharmacology and Experimental Therapeutics. 344: 501-10. PMID 23197772 DOI: 10.1124/Jpet.112.198895 |
0.378 |
|
| 2013 |
Zanotti-Fregonara P, Barth VN, Liow JS, Zoghbi SS, Clark DT, Rhoads E, Siuda E, Heinz BA, Nisenbaum E, Dressman B, Joshi E, Luffer-Atlas D, Fisher MJ, Masters JJ, Goebl N, et al. Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain. European Journal of Nuclear Medicine and Molecular Imaging. 40: 245-53. PMID 23135321 DOI: 10.1007/S00259-012-2269-7 |
0.431 |
|
| 2012 |
Pedregal C, Joshi EM, Toledo MA, Lafuente C, Diaz N, Martinez-Grau MA, Jiménez A, Benito A, Navarro A, Chen Z, Mudra DR, Kahl SD, Rash KS, Statnick MA, Barth VN. Development of LC-MS/MS-based receptor occupancy tracers and positron emission tomography radioligands for the nociceptin/orphanin FQ (NOP) receptor. Journal of Medicinal Chemistry. 55: 4955-67. PMID 22541041 DOI: 10.1021/jm201629q |
0.517 |
|
| 2012 |
Fisher MJ, Backer RT, Barth VN, Garbison KE, Gruber JM, Heinz BA, Iyengar S, Hollinshead SP, Kingston A, Kuklish SL, Li L, Nisenbaum ES, Peters SC, Phebus L, Simmons RM, et al. 3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity. Bioorganic & Medicinal Chemistry Letters. 22: 2514-7. PMID 22386665 DOI: 10.1016/j.bmcl.2012.02.003 |
0.357 |
|
| 2012 |
Lohith TG, Zoghbi SS, Morse CL, Araneta MF, Barth VN, Goebl NA, Tauscher JT, Pike VW, Innis RB, Fujita M. Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 53: 385-92. PMID 22312136 DOI: 10.2967/jnumed.111.097162 |
0.406 |
|
| 2011 |
Mitch CH, Quimby SJ, Diaz N, Pedregal C, de la Torre MG, Jimenez A, Shi Q, Canada EJ, Kahl SD, Statnick MA, McKinzie DL, Benesh DR, Rash KS, Barth VN. Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer. Journal of Medicinal Chemistry. 54: 8000-12. PMID 21958337 DOI: 10.1021/jm200789r |
0.439 |
|
| 2011 |
Kimura Y, Fujita M, Hong J, Lohith TG, Gladding RL, Zoghbi SS, Tauscher JA, Goebl N, Rash KS, Chen Z, Pedregal C, Barth VN, Pike VW, Innis RB. Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 52: 1638-45. PMID 21880575 DOI: 10.2967/jnumed.111.091181 |
0.363 |
|
| 2011 |
Pike VW, Rash KS, Chen Z, Pedregal C, Statnick MA, Kimura Y, Hong J, Zoghbi SS, Fujita M, Toledo MA, Diaz N, Gackenheimer SL, Tauscher JT, Barth VN, Innis RB. Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomography. Journal of Medicinal Chemistry. 54: 2687-700. PMID 21438532 DOI: 10.1021/jm101487v |
0.467 |
|
| 2010 |
Zheng M, Nabulsi N, Tomasi G, Mitch C, Quimby S, Barth V, Rash K, Masters J, Navarro A, Seest E, Carson RE, Huang Y. Synthesis and evaluation of [C-11]LY2795050, an antagonist PET imaging tracer for the kappa opioid receptors Neuroimage. 52: S120. DOI: 10.1016/J.Neuroimage.2010.04.098 |
0.373 |
|
| 2009 |
Fell MJ, Perry KW, Falcone JF, Johnson BG, Barth VN, Rash KS, Lucaites VL, Threlkeld PG, Monn JA, McKinzie DL, Marek GJ, Svensson KA, Nelson DL. In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268). The Journal of Pharmacology and Experimental Therapeutics. 331: 1126-36. PMID 19755662 DOI: 10.1124/Jpet.109.160598 |
0.35 |
|
| 2006 |
Barth VN, Chernet E, Martin LJ, Need AB, Rash KS, Morin M, Phebus LA. Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer. Life Sciences. 78: 3007-12. PMID 16434058 DOI: 10.1016/j.lfs.2005.11.031 |
0.588 |
|
| 2005 |
Chernet E, Martin LJ, Li D, Need AB, Barth VN, Rash KS, Phebus LA. Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 receptors as examples. Life Sciences. 78: 340-6. PMID 16139310 DOI: 10.1016/j.lfs.2005.04.075 |
0.602 |
|
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